Influence of cycloartanes from plants of the genusAstragalus and their synthetic analogs on the contractive function of the myocardium and the activity of Na,K-ATPase

An evaluation has been mde of the cardiotonic activities of cycloartane methylsteroids isolated from plants of the genusAstragalus and their synthetic analogs. It has been established that the compounds investigated exhibit a positive inotropic effect expressed to different degrees. The mechanism of the realization of the positive inotropic action of cycloartane glycosides differs from that of cardiosteroid drugs. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 89 14 75. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 510–514, July–August, 1994.     

Structural Studies and Biological Activity of Plant Triterpenoids from the <Emphasis Type="Italic">Thalictrum</Emphasis> Genus

Structures and chemical and spectral properties of triterpenoids isolated from plants of the Thalictrum genus were systematized for the first time. Features of ¹³C NMR spectra of cycloartane triterpenoids were discussed. Data for the biological activities of certain cycloartane and oleanane triterpenoids were given.__________Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 97–114, March–April, 2005.     

Triterpene glycosides ofAstragalus and their genins. XXI. Circular dichroism of cycloartane ketones

The CD spectra of a number of natural and synthetic cycloartane ketones have been studied. The influence of 6-hydroxy group on the Cotton effect due to a 3-keto function has been found. The Cotton effect has been determined for 6-oxo-and 11-oxocycloartanes.Institute of the Chemistry of Plant Substances of the Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 614–628, September–October, 1986.     

Triterpene glycosides ofAstragalus and their genins LV. Structure of cycloorbigenin A

The structure of the new cycloartane triterpenoid cycloorbigenin A, isolated fromAstragalus orbiculatus, has been established on the basis of spectral characteristics. Cycloorbigenin A is (23R,24S)-16,2316,24-diepoxycycloart-6-ene-3,25-diol.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 40 64 75. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 848–850, November–December, 1997.     

Triterpenoids of the cycloartane series

In this review on triterpenoids of the cycloartane series, new achievements in this field of natural compounds are considered, the literature up to 1983 and, in part, 1984 being covered.Institute of Chemistry of Plant Substance, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 431–478, July–August, 1985.     

Triterpene glycosides ofAstragalus and their genins. XVI. Cyclogaleginosides A and B fromAstraglus galegiformis

Two glycosides of the cycloartane series — cyclogaleginosides A and B — have been obtained from inflorescences ofAstragalus galegiformis L. (Leguminosae), and their structures have been established by chemical transformations and spectral characteristics as cyclogalegigenin 3-O-(2-O-acetyl)--D-xylopyranoside and cyclogalegigenin 3-O--D-xylopyranoside, respectively.I. G. Kutateladze Institute of Pharmacochemistry, Academy of Sciences of the Georgian SSR, Tbilisi. Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 477–481, July–August, 1984.     

Triterpene glycosides of Astragalus and their genins XXXV. Cycloaraloside C from Astragalus amarus

A new triterpene glycoside of the cycloartane series (cycloaraloside C) has been isolated from the roots of the plantAstragalus amarus Pall. (Leguminosae). Cycloaraloside C is a bioside of cyclosieversigenin including one D-glucose residue and one D-apiose residue. The structure of the glycoside has been shown on the basis of the chemical transformations and spectral characteristics as 20R,24S-epoxycycloartane-3,6,16,25-tetraol 3-O-[O-(D-apio--D-furanosyl)-(1 2)--D-glucopyranoside]. This is the first time that D-apiose has been found among cycloartane glycosides.Institute of Chemistry of Plant Substances, Academy of Sciences of the Uzbek, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 783–787, November–December, 1990.     

Triterpene saponins fromThalictrum minus. VII. Structure of thalicoside E

A new minor cycloartane glycoside — thalicoside E, 9,19-cyclo-20(S)-lanost-23-ene-3,16,22,25,29-pentaol 3-O--D-galactoside 29-O--D-glucopyranoside — has been isolated from the epigeal part ofThalictrum minus L. (Ranunculaceae).Irkutsk Institute of Organic Chemistry (IrIOKh). Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 567–571, July–August, 1993.     

Trriterpene glycosides ofAstragalus and their genins LIX. Structure of cyclocanthoside F

The structure of a new cycloartane glycoside, cyclocanthoside F, has been established on the basis of spectral characteristics as 20R,25-epoxy-24S-cycloartane-3,6,16,24-tetraol 3-O-[O--D-glucopyranosyl-(12)--D-xylopyranoside] 6-O--D-glucopyranoside. The possibility in principle of using the -effects of glycosylation and¹³C NMR spectroscopy for determining a glycosyl substituent at C-6 of a cycloartane has been demonstrated.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (371) 120 64 75. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 348–353, May–June, 1999.     

Synthesis of α-aryloxy-2,4-dihydroxyacetophenone 4-O-β-D-glucopyranosides and their conversion into 3-aryloxy-7-glucosyloxychromones

The hydrolysis of the glycoside quisqualoside B, isolated from the herbAstragalus quisqualis Bunge, has given the new cycloartane triterpenoid quisquagenin, which has the structure of 20(R),24(S)-epoxycycloartane-3,16,25-triol.All-Union Scientific-Research Institute of Medicinal Plants, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 527–532, July–August, 1987.     

Triterpene glycosides ofAstragalus and their genins. VIII. Askendoside C fromAstragalus taschkendicus

A new glycoside of the cycloartane series — askendoside C — has been isolated from the roots of the plantAstragalus taschkendicus Bge., and its structure has been established on the basis of chemical transformations and spectral characteristics as 24R-cycloartane-3,6,16,24,25-pentaol 3-[0--L-arabinopyranosyl-(12)--D-xylopyranoside].Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 173–180, March–April, 1983.     

Chemical and immunochemical investigation of the lipopolysaccharides ofVibrio alginolyticus

A chemical and immunochemical study of the LPSs of the microorganismsVibrio alginolyticus (strains 1385–80, 945–80, and 2076–80) has been made. A difference in the monosaccharide composition of the LPSs of the strains studied has been shown. It had been established that the LPSs of strains 945–80 and 2076–80 possess a high serological specificity, while the LPS of strain 1385–80 differ serologically from them. A suggestion is made of the role of different monosaccharides in the formation of the immunochemical determinants of the LPSs of the strains studied.Pacific Ocean Institute of Bioorganic Chemistry of the Far-Eastern Scientific Center of the USSR Academy of Sciences, Vladivostok. Translated from Khimiya Priorodnykh Soedinenii, No. 5, pp. 652–657, September–October, 1987.     

Triterpene glycosides of Astragalus and their genins XLI. Cycloexoside from Astragalus exilis

In addition to known glycosides of the cycloartane series — cyclosieversiosides A, E, and F — a new acetylated compound of glycosidic nature — cycloexoside — has been isolated from the roots ofAstragalus exilis A. Kor. (Leguminosae). On the basis of chemical transformations and spectral characteristics, the structure of cycloexoside has been established as 20R,24S-epoxycycloartane-3,6,16,25-tetrol 3-O-(2,3-di-O-acetyl--D-xylopyranoside).Institute of Chemistry of Plant Substances, Uzbekistan Academy of Sciences, Tashkent. Pamir Biological Institute, Tadhikistan Academy of Sciences, Khorog. Translated from Khimiya Prirodnykh Soedinenii, Nos. 3,4, pp. 356–360, May–August, 1992.     

Triterpene glycosides ofAstragalus and their genins. IX. Askendoside D fromAstragalus taschkendicus

A new glycoside of the cycloartane series — askendoside D — has been isolated from the roots of the plantsAstragalus taschkendicus Bge., and on the basis of chemical transformations and spectral characteristics its structure has been established as 20S, 24R-epoxycycloartane-3, 6, 16, 25-tetraol 3-0-[0--L-arabinopyranosyl-(1 2)--D-xylopyranoside] 6-0--D-xylopyranoside.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 180–185, March–April, 1983.     

Isothermal vapor–liquid equilibria for binary mixtures of benzene, toluene, m-xylene, and N-methylformamide at 333.15 K and 353.15 K

Isothermal vapor–liquid equilibrium (VLE) at 333.15 K and 353.15 K for four binary mixtures of benzene + toluene, benzene + N-methylformamide, toluene + m-xylene and toluene + N-methylformamide have been obtained at pressures ranged from 0 kPa to 101.3 kPa. The NRTL, UNIQUAC and Wilson activity coefficient models have been employed to correlate experimental pressures and liquid mole fractions. The non-ideal behavior of the vapor phase has been considered by using the Soave–Redlich–Kwong equation of state in calculating the vapor mole fraction. Liquid and vapor densities were also measured by using two vibrating tube densitometers. The P–x–y diagram and the activity coefficient indicate that two mixtures of benzene + toluene and toluene + m-xylene were close to the ideal solution. However, two mixtures containing N-methylformamide present a large positive deviation from the ideal solution. The excess Gibbs energy in the benzene + toluene mixture is negative indicates that it is an exothermic system.     

Relativistic atomic natural orbital type basis sets for the alkaline and alkaline-earth atoms applied to the ground-state potentials for the corresponding dimers

New basis sets of the atomic natural orbital (ANO) type have been developed for the atoms Li–Fr and Be–Ra. The ANOs have been obtained from the average density matrix of the ground states and the lowest excited states of the atom, the positive ion, and the dimer at its equilibirium geometry. Scalar realtivisitc effects are included through the use of a Douglas–Kroll Hamiltonian. Multiconfigurational wave functions have been used with dynamic correlation included using second-order perturbation theory (CASSCF/CASPT2). The basis sets are applied in calculations of the ground-state potentials for the dimers. Computed bond energies are accurate to within 0.05 eV for the alkaline dimers and 0.02 eV for the alkaline-earth dimers (except for Be₂).Acknowledgments.ensp;B.O.R. would like to express his gratitude to Prof. Jacopo Tomasi for all the inspiration that his scientific work has given him through the years and continues to do in particular through the work on solvent effects on molecular properties. This work has been supported by a grant from the Swedish Science Research Council, VR.Contribution to the Jacopo Tomasi Honorary Issue     

A natural undecaprenol and its influence on the biochemical reactions of cotton seedling nuclei

A method has been developed for isolating polyprenols from the leaves of cotton plants of lines L-463, L-501, and L-4. The influence of an undecaprenol on the level of biosynthesis of the proteins of the nuclei of cotton seedlings has been studiedin vivo andin vitro. It has been found that they double the level of biosynthesis nuclear proteins when the seeds are first wetted in a 0.1% solution.Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 65–69, January–February, 1998.     

Triterpene glycosides of Astragalus and their genins. XXXI. Cycloorbigenin B from Astragalus orbiculatus

A new methylsteroid of the cycloartane series has been isolated from the epigeal part ofAstragalus orbiculatus Ledeb. (Leguminosae); it has the structure of a (23R,24S)-16,23; 16,24-diepoxycycloartane-3,6,25-tetraol.Institute of the Chemistry of Plant Substances, Uzbek SSR. Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Vol. 6, pp. 809–812, November–December, 1989.     

A computational study of the effect of an external electric field on the geometry of selected donor–acceptor complexes

To understand the effect of Au and thiol atoms in octane molecule, a structural and charge density analysis has been carried out by high level ab initio quantum chemical calculations using MP2 and B3PW91 methods with the basis sets 6-311G(d,p) and LANL2DZ. The optimized geometries, specifically, the geometry obtained from both levels reveal the effect of S- and Au-atoms in octane molecule. An introduction of sulfur atom in octane molecule lengthen its backbone C–C bond distances, and further adding of Au-atom at the terminals of octane dithiolate stabilizes these distances. The bond densities of the C–C bonds of octane are 1.6 eÅ⁻³, these values are decreased significantly and the charges are largely depleted, when thiol and Au-atoms added in the octane molecule. The presence of negative Laplacian ²ρ(r) at bond critical points of C–C and C–H bonds, indicate, the charges are concentrated in these bonds, confirm that these bonds exhibit an open shell type interaction. The moderate values of density and the negative Laplacian of S–C bonds confirm the covalent character. The positive ²ρ(r) value of Au–S bonds, characterize, the bonding interaction is a closed shell interaction. The combined observed low value of electron density and the positive Laplacian of Au–S bond comprises, the gold and S interaction is not a covalent interaction, but it is a very weak coordination bond interaction. The small positive value of total energy density in Au–S bond indicates, the charges in these bonds are highly depleted and this is further confirmed by the Laplacian of bond characterization.