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Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily 下载免费PDF全文
Ho Yeung Dr. Christopher J. Squire Yuliana Yosaatmadja Dr. Santosh Panjikar Gemma López Prof. Dr. Antonio Molina Prof. Dr. Edward N. Baker Dr. Paul W. R. Harris Prof. Dr. Margaret A. Brimble 《Angewandte Chemie (International ed. in English)》2016,55(28):7930-7933
Proteins from the GASA/snakin superfamily are common in plant proteomes and have diverse functions, including hormonal crosstalk, development, and defense. One 63‐residue member of this family, snakin‐1, an antimicrobial protein from potatoes, has previously been chemically synthesized in a fully active form. Herein the 1.5 Å structure of snakin‐1, determined by a novel combination of racemic protein crystallization and radiation‐damage‐induced phasing (RIP), is reported. Racemic crystals of snakin‐1 and quasi‐racemic crystals incorporating an unnatural 4‐iodophenylalanine residue were prepared from chemically synthesized d ‐ and l ‐proteins. Breakage of the C?I bonds in the quasi‐racemic crystals facilitated structure determination by RIP. The crystal structure reveals a unique protein fold with six disulfide crosslinks, presenting a distinct electrostatic surface that may target the protein to microbial cell surfaces. 相似文献
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Inside Cover: A One‐Pot Chemically Cleavable Bis‐Linker Tether Strategy for the Synthesis of Heterodimeric Peptides (Angew. Chem. Int. Ed. 47/2016) 下载免费PDF全文
Nitin A. Patil Dr. Julien Tailhades Dr. John A. Karas Prof. Frances Separovic Prof. John D. Wade Dr. Mohammed Akhter Hossain 《Angewandte Chemie (International ed. in English)》2016,55(47):14472-14472
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Cover Picture: Charge‐Induced Unzipping of Isolated Proteins to a Defined Secondary Structure (Angew. Chem. Int. Ed. 10/2016) 下载免费PDF全文
Ana Isabel González Flórez Eike Mucha Dr. Doo‐Sik Ahn Sandy Gewinner Dr. Wieland Schöllkopf Prof. Dr. Kevin Pagel Dr. Gert von Helden 《Angewandte Chemie (International ed. in English)》2016,55(10):3235-3235
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Cover Picture: Protein Interactions with Polymer Coatings and Biomaterials (Angew. Chem. Int. Ed. 31/2014) 下载免费PDF全文
M. Sc. Qiang Wei M. Sc. Tobias Becherer Dr. Stefano Angioletti‐Uberti Prof. Dr. Joachim Dzubiella Dr. Christian Wischke Dr. Axel T. Neffe Prof. Dr. Andreas Lendlein Prof. Dr. Matthias Ballauff Prof. Rainer Haag 《Angewandte Chemie (International ed. in English)》2014,53(31):7959-7959
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Inside Cover: Breakable Hybrid Organosilica Nanocapsules for Protein Delivery (Angew. Chem. Int. Ed. 10/2016) 下载免费PDF全文
Dr. Eko Adi Prasetyanto Dr. Alessandro Bertucci Dr. Dedy Septiadi Prof. Roberto Corradini Dr. Pablo Castro‐Hartmann Prof. Luisa De Cola 《Angewandte Chemie (International ed. in English)》2016,55(10):3236-3236
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Cover Picture: Fast‐Geomimicking using Chemistry in Supercritical Water (Angew. Chem. Int. Ed. 34/2016) 下载免费PDF全文
Dr. Angela Dumas Marie Claverie Dr. Cédric Slostowski Guillaume Aubert Cristel Careme Dr. Christophe Le Roux Dr. Pierre Micoud Prof. François Martin Dr. Cyril Aymonier 《Angewandte Chemie (International ed. in English)》2016,55(34):9795-9795