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1.
A method is proposed for the synthesis of N-(1,2,4-triazol-5-yl)amidines not previously described in the literature from 5-amino-1,2,4-triazole and nitriles using tributylborane as an auxiliary reagent. The structures of the products were indicated by physicochemical methods.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2353–2355, October, 1989. 相似文献
2.
L. G. Lavrenova A. R. Amamchyan S. V. Larionov V. A. Dorokhov 《Russian Chemical Bulletin》1992,41(10):1810-1812
We have synthesized complex compounds of Co(2+) chloride with hydrochlorides of N-(1,2,4-triazol-5-yl)benzamidine and N-(tetrazol-5-yl)benzamidine. According to magnetochemistry and electron spectroscopy data, the ligands are coordinated in a bidentate fashion with the N atom of the amidine group and the N atom of the heterocycle with formation of the tetrahedral chromophore CoN2Cl2.Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk. N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow. Translated from Izvestiya Akademii Nauk, Seriya Khimicheskaya, No. 10, pp. 2311–2315, October, 1992. 相似文献
3.
Mohamed Hilmy Elnagdi Mohamed Riffaat Hamza Elmoghayer Hassan Attia Elfaham Mohamed Mohamed Sallam Hikmat Hussein Alnima 《Journal of heterocyclic chemistry》1980,17(2):209-212
The 4-bromo-3-phenylpyrazol-5-ylhydrazonyl chlorides (Ia,b) and 1,2,4-triazol-5-ylhydrazonyl chlorides (IIa,b) were prepared via coupling of diazotized 4-bromo-3-phenyl-5-aminopyrazole (III) and 5-amino-1,2,4-triazole (IV) with α-chloro derivatives of acetylacetone and of ethyl aceto-acetate. Compounds Ia and IIa,b were utilised for the synthesis of several new heterocyclic derivatives. 相似文献
4.
Kentaro Hirai Hirohiko Sugimoto Teruyuki Ishiba Toshio Fujishita Yuji Tsukinoki Katsumi Hirose 《Journal of heterocyclic chemistry》1982,19(6):1363-1369
The synthesis of (5-acylaminomethyl-3-carbamoyl-1H-1,2,4-triazol-1-yl)benzophenone derivatives 4a-i, 14a-d, 15a-d, 16a-c , is described. Acylation of the key intermediate, 1-benzoylphenylazo-1-aminoacetamide 7, followed by cyclization in the presence of acid afforded 1H-1,2,4-triazole derivatives. These compounds were evaluated for their central nervous system (CNS) activity. Some of these compounds exhibited high activities in anti-pentylene tetrazole and rotarod test in mice when orally administered. 相似文献
5.
V. A. Dorokhov A. R. Amamchyan V. S. Bogdanov T. A. Shchegoleva 《Russian Chemical Bulletin》1987,36(11):2436-2438
Conclusions A method has been proposed for the synthesis of N-(5-tetrazolyl)amidines from 5-amino-tetrazole, nitriles, and organoboranes through boron chelate compounds, namely, dialkyl-boryl[N-(5-tetrazolyl)amidinates].Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2622–2624, November, 1987. 相似文献
6.
G. I. Tsypin T. F. Sharamet T. A. Kravchenko M. S. Pevzner 《Chemistry of Heterocyclic Compounds》1980,16(2):199-201
1-(1,2,4-Triazol-3-yl)-1,2,3-triazoles were obtained by 1,3-dipolar cycloaddition of 3-azido-1,2,4-triazole to acetylene derivatives.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 262–264, February, 1980. 相似文献
7.
Isomeric dialkyl and diaralkyl[1-, 2- and 4-(alkyl, aralkyl and aryl)-3-Q-1,2,4-triazole-5-yl]iminodithiocarbonates 4a-c (R ≠ H) were synthesised and their spectral data compared. The uv, cmr and ms rules elaborated helped to prove the tautomeric structure of the non-substituted derivatives 4 (R ? H). In case of dimethyl (3-methylthio-1,2,4-triazole-5-yl)iminodithiocarbonate this is the first time ever crystalline triazole desmotropes 4a/17 and 4b/17 could be isolated. The sodium salts of 4 (R ? H) could be further alkylated and aralkylated to yield the corresponding 4 (R ? alkyl and aralkyl) type derivatives. Providing the above reaction in the presence of carbon disulfide the dithiocarbomethoxy derivative 7 was obtained. 相似文献
8.
M. G. Kurella L. G. Vorontsova A. R. Amamchyan V. A. Dorokhov 《Russian Chemical Bulletin》1992,41(6):1079-1083
The crystal and molecular structures of N-(1,2,4-triazol-5-yl)benzamidine (1) and its hydrochloride (2) were determined by x-ray crystallography. In compound 1 both independent molecules are Z isomers of the anidine substituted in the imino group and 5-substituted 1H-1,2,4-triazoles. In the crystal the molecules of compound 1 are linked into a stable dimer by intermolecular hydrogen bonds. An undissociated HCl molecule was unexpectedly found in the structure of compound 2, while the structure of the base corresponded to the Z isomer of the amidine substituted in the amino group and to 2H-1,2,4-triazole substituted at position 5. The structures of compounds 1 and 2 are stabilized by an intramolecular hydrogen bond. The HCl molecule participates in the formation of intermolecular hydrogen bonds in compound 2.N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow. Translated fromIzvestiya Akademii Nauk, Seriya Khimicheskaya, No. 6, pp. 1380–1386, June, 1992. 相似文献
9.
V. M. Chernyshev A. V. Chernysheva V. A. Taranushich 《Russian Journal of Applied Chemistry》2009,82(2):276-281
The influence of the molar ratio and concentration of the reactants and of the temperature and time of the synthesis on the yield of malonic acid guanylhydrazides in the reaction of aminoguanidine with malonic acid in acidic aqueous solutions was examined, and improved procedures for preparing 5-amino-1,2,4-triazol-3-ylacetic acid and bis(5-amino-1,2,4-triazol-3-yl)methane were suggested. 相似文献
10.
Yusuf Ozdemir Olcay Bekircan Nimet Baltaş Emre Menteşe 《Journal of heterocyclic chemistry》2020,57(12):4239-4253
In this study, starting from 4-amino-5-(4-chlorobenzyl)-2,4-dihydro-3H-1,2,4-triazole-3-one ( 1 ), the 4-Amino-5-(4-chlorobenzyl)-2-undecyl-2,4-dihydro-3H-1,2,4-triazol-3-one ( 2 ) was first synthesized and this compound was converted to Schiff base derivatives ( 3a-e ). In the second step of the study, the 2-[3-(4-chlorobenzyl)-5-oxo-1-undecyl-1,5-dihydro-4H-1,2,4-triazole-4-yl]-acetohydrazide ( 6 ), which was used as a key product in the synthesis of many heterocyclic compounds was synthesized in four steps, and then this compound was converted into methylidene acetohydrazide ( 7a-e ), thiosemicarbazide ( 8a-e ), and 1,2,4-triazole-5-thione ( 9a-e ) derivatives. Also, in the last part of the study, 1,2,4-triazole-5-thione derivatives were changed into Mannich bases ( 10a-b ) bearing a 4-phenylpiperazine ring. These new compounds were tested with regard to pancreatic lipase (PL) inhibition activity, and compound 3b , 3d , 7d , 8d , and 9d showed a considerable anti-lipase activity at various concentrations. The activity of compounds 7b (IC50 = 1.45 ± 0.12 μM) was the highest in terms of IC50, comparable to that of orlistat, a well-known PL inhibitor used as an antiobesity drug. 相似文献
11.
3-Nitro-1,2,4-triazol-5-one and its monomethyl derivatives react with methyl vinyl ketone to give products of addition to the ring N1 and N4 atoms. The reaction with formaldehyde and N-methylolacetamide proceeds only at the N1 atom. The keto derivatives of 3-nitro-1,2,4-triazol-5-one undergo the Schmidt reaction to give the corresponding acetamides. A number of compounds that include functional groups in the N1-alkyl substituent of the 3-nitro ring were obtained by treatment of the bases of N1-substituted 3,5-dinitro-1,2,4-triazoles in aprotic media.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 552–558, April, 1981. 相似文献
12.
A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, 1H-, 13C-, 1?F-NMR, MS and elemental analysis. A docking study based on sulfonamides previously used against malaria identified trifluoromethyl-substituted derivatives to be the best lead compounds for new antimalarial drug development. 相似文献
13.
V. G. Granik E. O. Sochneva I. V. Persianova 《Chemistry of Heterocyclic Compounds》1978,14(3):310-312
A number of N-(4-carbethoxy-5-pyrazolyl) amidines were synthesized by the reaction of acetals of amides and lactams with 4-carbethoxy-5-aminopyrazole, and their ionization constants in 50% alcohol were measured. It is shown that the increased basicities of the amidines obtained from the lactam acetals and dimethylacetamide acetal as compared with the basicity of N-(4-carbethoxy-5-pyrazolyl)-N,N-dimethylformamidine are due to the smaller degree of steric hindrance to conjugation in the latter.Communication XXIV from the series Acetals of lactams and acid amides. See [1] for communication XXIII.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 379–381, March, 1978. 相似文献
14.
A series of 3-(3-alkyl-5-thioxo-1H-4,5-dihydro-1,2,4-triazol-4-yl)aminocarbonylchromones has been prepared by oxidation of 3-formylchromone with Jones' reagent followed by reaction with 3-alkyl-4-amino-4,5-dihydro-1,2,4-triazole-5(1H)-thione in the presence of POCl3. The structures of the compounds were confirmed by IR, LC-MS, and 1H NMR spectra and elemental analyses. 相似文献
15.
Godovikova T. I. Vorontsova S. K. Konyushkin L. D. Firgang S. I. Rakitin O. A. 《Russian Chemical Bulletin》2010,59(2):483-485
A number of 3-methyl-4-(5-R-1H-1,2,4-triazol-3-yl)-1,2,5-oxadiazoles were obtained in high yields by thermal dehydration of acylated 4-methyl-1,2,5-oxadiazole-3-carboxamide
hydrazones. 相似文献
16.
Zalomlenkov Vladimir A. Bakharev Vladimir V. Gidaspov Alexander A. Parfenov Victor E. Golovina Olga V. Slepukhin Pavel A. 《Chemistry of Heterocyclic Compounds》2017,53(6-7):822-824
Chemistry of Heterocyclic Compounds - The reaction of 3-methyl-5-trinitromethyltetrazolо[1,5-а][1, 3, 5]triazin-7-one with water led to the opening of 1,3,5-triazine ring and... 相似文献
17.
Barmin M. I. Chekrenev S. A. Kartavykh V. P. Mel'nikov V. V. 《Russian Journal of General Chemistry》2003,73(3):482-487
Procedures for synthesis of coordination compounds of copper(II) with bis(5-amino-1,2,4-triazol-3-yl)alkanes as ligands. A conclusion was drawn that the coordination polyhedron of copper(II) has different configurations depending on the structure of the ligand and on the coordination mode. 相似文献
18.
T. V. Shokol V. A. Turov A. V. Turov N. V. Krivokhizha V. V. Semenyuchenko V. P. Khilya 《Chemistry of Heterocyclic Compounds》2005,41(11):1411-1418
The condensation of 4-phenyl-1,2,4-triazol-3-ylacetonitrile with 2-methyl-, 4-ethylresorcinol, and with pyrogallol gave α-(4-phenyl-1,2,4-triazol-3-yl)-2,4-dihydroxyacetophenones.
Upon treatment with acid anhydrides and chlorides and subsequent hydrolysis these form 7-hydroxy-3-(4-phenyl)-1,2,4-triazol-3-yl)chromones
with different substituents in both the benzene and the pyrone rings.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1676–1684, November, 2005. 相似文献
19.
20.
A new series of silicon-containing derivatives of 2-aryl-3-(1H-1,2,4-triazol-1-yl)propanenitriles were synthesized and evaluated for fungicidal activities against rice sheath blight and powdery mildew on cucumber. These derivatives exhibited higher efficacy than reference fungicides. 相似文献