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1.
V. L. Gein I. V. Krylova E. P. Tsypliakova A. R. Gaifullina L. I. Varkentin M. I. Vakhrin 《Chemistry of Heterocyclic Compounds》2009,45(7):829-832
Methyl esters of 5-aroyl-6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acids were synthesized from three component
mixtures of methyl esters of aroylpyruvic acids, urea, and substituted benzaldehydes. 8-Hydroxy-4,5-diphenyl-3,4-dihydropyrimido[4,5-d]pyridazin-2(1H)-one was synthesized by the reaction of 5-benzoyl-2-oxo-6-phenyl-1,2,3,6-tetrahydropyrimidin-4-carboxylate
with hydrazine hydrate. 相似文献
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D. A. Rudenko S. N. Shurov M. I. Kodess M. A. Ezhikova A. N. Vasyanin 《Russian Journal of Organic Chemistry》2012,48(6):799-803
2-Substituted 7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids were synthesized by reaction of acyl- and aroylpyruvic acids with 3-amino-5,5-dimethylcyclohex-2-en-1-one. A plausible mechanism of their formation was proposed on the basis of ab initio quantum-chemical calculations. 相似文献
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Synthesis and reactions of 1-R-3-benzoyl-5-ethoxycarbonyl-6-oxo-1,2,3,6-tetrahydropyridine-2-thiones
V. N. Britsun A. N. Esipenko A. N. Chernega E. B. Rusanov M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2007,43(11):1411-1419
Cycloacylation of N-R-3-oxo-3-phenylpropanethioamides by diethyl ethoxymethylenemalonate occurs selectively to form 1-R-3-benzoyl-5-ethoxycarbonyl-6-oxo-1,2,3,6-tetrahydropyridine-2-thiones
which are convenient starting materials for the synthesis of bi-and tricyclic hetero systems including the previously unknown
9-R-7-ethoxycarbonyl-5-phenyl-8,9-dihydropyrido[2,3-d][1,2,4]triazolo[1,5-a]-pyrimidin-8-ones.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1660–1669, November, 2007. 相似文献
6.
G. Mangaiyarkarasi G. Sridevi P. Poornima Devi D. Kalaivani 《Journal of Structural Chemistry》2016,57(5):985-990
The titled complex is synthesized from the ethanolic solutions of 1-chloro-2,4-dinitrobenzene, 2-thiobarbituric acid, and 2-methylpyridine and characterized by spectral and elemental analyses. The single crystal X-ray diffraction results for the complex are compatible with the spectral observations. The titled complex exhibits anticonvulsant activity and reduces all phases of convulsion even at a low dosage. Acute toxicity studies of the complex are performed to understand the safer dose concentration for clinical trials. 相似文献
7.
Sung Hoon Kim Yong Hoon Ra Yoon Young Lee Kyongtae Kim Joong Hyup Kim 《Journal of heterocyclic chemistry》1994,31(6):1361-1368
The reactions of 1-alkylamino-1-alkylthio-3-phenylpropene-3-thiones 3 with thiophosgene and phosgene in toluene, followed by treatment of the reaction mixture with triethylamine gave 3-alkyl-2,3-dihydro-4-oxo-6-phenyl-2-thioxo- 4 , 3-alkyl-2,3-dihydro-2,4-dioxo-6-phenyl-4H-1,3-thiazines 5 , respectively in good to excellent yields. Similarly treatment of compounds 3 with N-arylimidoyl dichloride in benzene at room temperature gave 3-alkyl-2-arylimino-2,3-dihydro-4-oxo-6-phenyl-4H-1,3-thiazines 6 in excellent yields. The reactions of compounds 3 with oxalyl chloride in toluene gave also 5 in good yields. 相似文献
8.
Ten 2,5-dioxo- and 4-aryl-5-oxo-2-thioxo-1,2,3,4,5,6,7,8-octahydroquinazolines have been synthesized in three-component interactions of 1,3-cyclohexanedione or dimedone, urea or thiourea, and substituted benzaldehydes (3-bromo-, 4-bromo-, 4-fluoro-, 4-methoxy-, 3,4-methylenedioxy-, and 3-nitro-). 9-Aryl-4,5-dioxo-1,2,3,4,5,6,7,8-octahydro-9H-xanthenes were also formed in these reactions. 相似文献
9.
We have developed a liquid-phase synthesis of combinatorial libraries of new disubstituted 4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolines and trisubstituted 4-oxo-3,4-dihydroquinazoline-2-thioles. The former were prepared using two general procedures: (i) cyclization of substituted methyl anthranilates with isothiocyanates, or (ii) cyclization of substituted 2-(methylcarboxy)benzeneisothiocyanates with primary amines or hydrazines. 4-Oxo-3,4-dihydroquinazoline-2-thioles were prepared by S-alkylation of disubstituted 4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolines with alkyl or aryl halides. The hydrolysis of methyl benzimidazo[1,2-c]quinazoline-6(5H)-thione-3-carboxylate led to the corresponding acid. This acid was utilized in the synthesis of new benzimidazo[1,2-c]quinazoline-6(5H)-thione-3-carboxamide and S-substituted 6-mecaptobenzimidazo[1,2-c]quinazoline-3-carboxamide libraries. 相似文献
10.
T. M. Zamaraeva T. F. Odegova A. Yu. Fedotov M. V. Tomilov V. L. Gein P. A. Slepukhin 《Russian Journal of General Chemistry》2014,84(10):1950-1952
Three-component reaction of acetoacetanilide, aromatic aldehydes, and N-methylurea afforded 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. IR, 1H NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis data confirmed the structure of the compounds obtained. Antimicrobial activity of these compounds was investigated. 相似文献
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V. L. Gein T. M. Zamaraeva E. S. Volkova M. V. Dmitriev 《Russian Journal of Organic Chemistry》2016,52(5):730-733
Reaction of diethyl oxalylacetate sodium salt with aromatic aldehydes and urea led to the formation of diethyl 6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates. 相似文献
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14.
Teruyuki Miyamoto Hiroshi Egawa Koh-Ichiro Shibamori Jun-Ichi Matsuraoto 《Journal of heterocyclic chemistry》1987,24(5):1333-1339
1-Cyclopropyl- and 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives having a sulfinyl or sulfonyl group at C-7 were synthesized from 2,6-dichloro-5-fluoronicotinic acid derivatives by the route involving the Dieckmann-type cyclization. The displacement reactions of these compounds with pyrrolidine and piperidine gave mainly the 7-(1-pyrrolidinyl)- and 7-(1-piperidinyl)-1,8-naphthyridine derivatives 24-27 , respectively. Enoxacin, a potent antibacterial agent, was also synthesized with the analogous route. 相似文献
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16.
3-Allenyl-4-aryl-7,7-dimethyl-5-oxo-2-thioxo-1,2,3,4,5,6,7,8-octahydroquinoline-3-carbonitriles were synthesized via [3,3]-sigmatropic
rearrangement of 4-aryl-7,7-dimethyl-5-oxo-2-(prop-2-yn-1-ylsulfanyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitriles. The
structure of 3-allenyl-7,7-dimethyl-4-(2-nitrophenyl)-5-oxo-2-thioxo-1,2,3,4,5,6,7,8-octahydroquinolin-3-carbonitrile was
determined by X-ray analysis. 相似文献
17.
Philippe Remuzon Daniel Bouzard Pierre Di Cesare Christian Dussy Jean-Pierre Jacquet Alexandre Jaegly 《Journal of heterocyclic chemistry》1992,29(4):985-989
The 5-hydroxymethyl and the 5-formyl-1-cyclopropyl-6-fluoro-7-piperazinyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids have been prepared via a 5-trimethylsilyl group and were tested in vitro as potential antibacterials. 相似文献
18.
M. F. Madkour Hassan Mahamed A. E. Sayed A. Hamed Ashraf M. Gaber Adel A. Hataba Abd El-Khalik 《中国化学》1991,9(3):262-269
The title compound was subjected to react with some electrophiles and nucleophiles, such as alkyl halides, ethyl chloroacetate or amines, hydrazines etc. The resulting compounds were used in further syntheses for the purpose of obtaining some new types of heterocycles with possible biological and pharmaceutical activities. 相似文献
19.
Magdi F. Iskander Josefe Stephanos Nagwa El Kady Mohyi El Essawi Ahmed El Toukhy Laila El Sayed 《Transition Metal Chemistry》1989,14(1):27-33
Summary Mono-, bis- and tris-ligand nickel(II) and cobalt(II) complexes with 4 amino-3-alkyl-5-thio-1,2,4-triazolines (HRL) (R=H, Me, or Et) and 4-amino-5-oxo-3-thioxo-6-methyl-2,3,4,5-tetrahydro-1,2,4-triazine (HL') have been prepared and characterized. In these complexes both HRL and HL' are in the neutral thione form. Nickel(II) and cobalt(II) complexes with mononegative thiolate ligands have been also isolated.The reaction of HL' with copper(II) salts in a molar ration of 11 results in the formation of [Cu(HL')X] (X=Cl or Br) and Cu(L')X (X=NO3 or CH3COO). However, in the presence of a large excess of HL' the reaction proceeds with partial reduction of CuII and both [Cu(HL')X2] and [Cu(HL')2]X have been isolated and characterized. The mechanism of copper(II) reduction by HL' is discussed. 相似文献
20.
Zhihua Sui Van N. Nguyen Jeff Fernandez John F. Barrett Kwasi A. Ohemeng 《Journal of heterocyclic chemistry》1997,34(1):153-156
A series of 4-quinazolone-5-carboxylic acids were designed as bacterial DNA gyrase inhibitors. The syntheses of the target compounds were accomplished by reacting 3-aminophthalimide with aroyl chlorides followed by rearrangement of the resulting 3-acylaminophthalimides under basic conditions. The designed compounds showed moderate DNA gyrase inhibitory activity. 相似文献