Characterisation of the acoustic cavitation cloud by two laser techniques

An experimental investigation of the size and volumetric concentration of acoustic cavitation bubbles is presented. The cavitation bubble cloud is generated at 20 kHz by an immersed horn in a rectangular glass vessel containing bi-distilled water. Two laser techniques, laser diffraction and phase Doppler interferometry, are implemented and compared. These two techniques are based on different measuring principles. The laser diffraction technique analyses the light pattern scattered by the bubbles along a line-of-sight of the experimental vessel (spatial average). The phase Doppler technique is based on the analysis of the light scattered from single bubbles passing through a set of interference fringes formed by the intersection of two laser beams: bubble size and velocity distributions are extracted from a great number of single-bubble events (local and temporal average) but only size distributions are discussed here. Difficulties arising in the application of the laser diffraction technique are discussed: in particular, the fact that the acoustic wave disturbs the light scattering patterns even when there are no cavitation bubbles along the measurement volume. As a consequence, a procedure has been developed to correct the raw data in order to get a significant bubble size distribution. After this data treatment has been applied the results from the two measurement techniques show good agreement. Under the emitter surface, the Sauter mean diameter D(3, 2) is approximately 10 microm by phase Doppler measurement and 7.5 microm by laser diffraction measurement at 179 W. Note that the mean measured diameter is much smaller than the resonance diameter predicted by the linear theory (about 280 microm). The influence of the acoustic power is investigated. Axial and radial profiles of mean bubble diameters and void fraction are also presented.     

Bubble population phenomena in sonochemical reactor: I Estimation of bubble size distribution and its number density with pulsed sonication – Laser diffraction method

To characterize the bubble populations (size and its number distribution) in a sonochemical reactor, a simple but powerful technique based on the Fraunhofer laser diffraction (LD) has been proposed. In this method, the acoustic wave disturbance to the laser probe in the sonochemical reaction field was eliminated by the temporal separation using pulsed sonication (pulsed LD). With this relatively simple strategy, the temporal development of the bubble size distribution could be evaluated by pulsed LD. A number density of bubbles was estimated by using a calibration data obtained with monosized standard particles. In addition, the effect of pulse length and a surfactant on the bubble population phenomena in a multibubble system are discussed.     

Ultrasound measurements of cavitation bubble radius for femtosecond laser-induced breakdown in water

A recently developed ultrasound technique is evaluated by measuring the behavior of a cavitation bubble that is induced in water by a femtosecond laser pulse. The passive acoustic emission during optical breakdown is used to estimate the location of the cavitation bubble's origin. In turn, the position of the bubble wall is defined based on the active ultrasonic pulse-echo signal. The results suggest that the developed ultrasound technique can be used for quantitative measurements of femtosecond laser-induced microbubbles.     

The temperature dependence of intensity and the function of the transition dipole moment for the induced optical absorption bands of oxygen in the region of the Herzberg photodissociation continuum (200–230 nm)

Application of coherent interaction of laser light with a focused ultrasonic wave to the technique of acoustooptic visualization in multiple-scattering media is discussed. By analyzing spatial distribution of the optical radiation modulated by ultrasound (the photocurrent at ultrasonic frequency), images of large-sized inhomogeneities embedded into the scattering medium have been obtained. A light-absorbing half-plane and a square with sides of 5 mm were used as the inhomogeneities. The visualization was performed under optimal conditions for measuring the alternating photocurrent calculated for the proposed model of coherent interaction between the laser and acoustic beams (the Raman-Nath diffraction). The alternating current at the ultrasonic frequency was obtained as a result of mixing the waves of the diffraction fields on the detector’s photocathode. All experimental values were obtained from a single measurement without averaging the alternating photocurrent at the ultrasonic frequency of 3 MHz, with the scattering parameter varying up to μL≤37.5, where μ is the extinction coefficient and L is the thickness of the scattering medium along the laser beam axis. The measured quantities varied in the course of the measurements by more than 10 orders of magnitude.     

Optical and acoustic monitoring of bubble cloud dynamics at a tissue-fluid interface in ultrasound tissue erosion

Short, high-intensity ultrasound pulses have the ability to achieve localized, clearly demarcated erosion in soft tissue at a tissue-fluid interface. The primary mechanism for ultrasound tissue erosion is believed to be acoustic cavitation. To monitor the cavitating bubble cloud generated at a tissue-fluid interface, an optical attenuation method was used to record the intensity loss of transmitted light through bubbles. Optical attenuation was only detected when a bubble cloud was seen using high speed imaging. The light attenuation signals correlated well with a temporally changing acoustic backscatter which is an excellent indicator for tissue erosion. This correlation provides additional evidence that the cavitating bubble cloud is essential for ultrasound tissue erosion. The bubble cloud collapse cycle and bubble dissolution time were studied using the optical attenuation signals. The collapse cycle of the bubble cloud generated by a high intensity ultrasound pulse of 4-14 micros was approximately 40-300 micros depending on the acoustic parameters. The dissolution time of the residual bubbles was tens of ms long. This study of bubble dynamics may provide further insight into previous ultrasound tissue erosion results.     

Bubble size distribution in acoustic droplet vaporization via dissolution using an ultrasound wide-beam method

Performance and efficiency of numerous cavitation enhanced applications in a wide range of areas depend on the cavitation bubble size distribution. Therefore, cavitation bubble size estimation would be beneficial for biological and industrial applications that rely on cavitation. In this study, an acoustic method using a wide beam with low pressure is proposed to acquire the time intensity curve of the dissolution process for the cavitation bubble population and then determine the bubble size distribution. Dissolution of the cavitation bubbles in saline and in phase-shift nanodroplet emulsion diluted with undegassed or degassed saline was obtained to quantify the effects of pulse duration (PD) and acoustic power (AP) or peak negative pressure (PNP) of focused ultrasound on the size distribution of induced cavitation bubbles. It was found that an increase of PD will induce large bubbles while AP had only a little effect on the mean bubble size in saline. It was also recognized that longer PD and higher PNP increases the proportions of large and small bubbles, respectively, in suspensions of phase-shift nanodroplet emulsions. Moreover, degassing of the suspension tended to bring about smaller mean bubble size than the undegassed suspension. In addition, condensation of cavitation bubble produced in diluted suspension of phase-shift nanodroplet emulsion was involved in the calculation to discuss the effect of bubble condensation in the bubble size estimation in acoustic droplet vaporization. It was shown that calculation without considering the condensation might underestimate the mean bubble size and the calculation with considering the condensation might have more influence over the size distribution of small bubbles, but less effect on that of large bubbles. Without or with considering bubble condensation, the accessible minimum bubble radius was 0.4 or 1.7 μm and the step size was 0.3 μm. This acoustic technique provides an approach to estimate the size distribution of cavitation bubble population in opaque media and might be a promising tool for applications where it is desirable to tune the ultrasound parameters to control the size distribution of cavitation bubbles.     

Importance of acoustic shielding in sonochemistry

It is well known that sonochemistry is less efficient at high acoustic intensities. Many authors have attributed this effect to decoupling losses and shielding of the acoustic wave. In this study we investigate both phenomena for a 20 kHz ultrasound field with an intensity ranging from 40 to 150 W/cm2. Visualization of the bubble cloud has demonstrated that the void fraction below the ultrasound horn increases more than proportional with increasing power input. Nevertheless, the energy coupling between the horn and the liquid remains constant; this implies that decoupling losses are not reinforced for larger bubble clouds. On the contrary, microphone measurements have shown that due to the larger bubble cloud a substantial part of the supplied energy is lost at high power inputs. In striving towards more efficient sonochemistry, reduction of shielding appears as one of the major challenges.     

Diffraction of light in intermediate regime of acoustooptical interaction at oblique incidence

The diffraction of light by ultrasound in an isotropic medium at arbitrarily small angles of incidence onto the acoustic layer is calculated. The intermediate regime of diffraction is considered, for which the conditions of observation of the Raman-Nath and Bragg diffraction are not satisfied in terms of the wave parameter. The effect of the acoustooptical interaction length and angle between the incident light beam and the acoustic wave on the light intensity distribution over the diffraction peaks is studied as a function of the acoustic power. Specific features of the transition from the Raman-Nath to the Bragg diffraction regime through the intermediate regime of diffraction are analyzed.     

Efficient multiple-beam Bragg acoustooptic diffraction with phase optimization of a multifrequency acoustic wave

The subject of investigation is the formation of a highly efficient multiple-beam diffraction field resulting from acoustooptic diffraction by a periodically modulated acoustic wave and acoustic signal composed of a set of independently generated equidistant frequency components. Conditions for minimization of optical losses associated with higher diffraction orders are analyzed. A highly efficient multiple-beam diffraction field is formed by optimizing the phases and amplitudes of signal independent components. A technique of acoustooptic measurements at a high laser radiation intensity is developed, and the basics of the theory are verified experimentally. An attempt to split the power of a laser beam propagating through an optical fiber into seven channels of equal intensities is realized with a net efficiency of 80%.     

Gaussian laser beam tailoring using acoustooptic cell

Profile shaping of a Gaussian laser beam by an acoustic wave is well described using Collins integral and ABCD matrix formalism. It is shown by a numerical simulation that the relative width of the laser beam to the ultrasonic wavelength and the acoustic pressure inside the acoustooptic cell act on the light intensity diffraction pattern.Obtained results show that the output intensity profile differs from the incident Gaussian beam shape, and it is more broadened with an increase in the acoustic pressure. The intensity of a focused laser beam is transformed in a flat form in the central region if the acoustic pressure is proprely controlled.On the other hand the intensity longitudinal range (ILR) of the flat shape is discussed along the propagation axes, we have found the ILR is about 2 mm for a focal length distance f=100 mm.     

Collapse pressure measurement of single hollow glass microsphere using single-beam acoustic tweezer

Microbubbles are widely used in medical ultrasound imaging and drug delivery. Many studies have attempted to quantify the collapse pressure of microbubbles using methods that vary depending on the type and population of bubbles and the frequency band of the ultrasound. However, accurate measurement of collapse pressure is difficult as a result of non-acoustic pressure factors generated by physical and chemical reactions such as dissolution, cavitation, and interaction between bubbles. In this study, we developed a method for accurately measuring collapse pressure using only ultrasound pulse acoustic pressure. Under the proposed method, the collapse pressure of a single hollow glass microsphere (HGM) is measured using a high-frequency (20–40 MHz) single-beam acoustic tweezer (SBAT), thereby eliminating the influence of additional factors. Based on these measurements, the collapse pressure is derived as a function of the HGM size using the microspheres’ true density. We also developed a method for estimating high-frequency acoustic pressure, whose measurement using current hydrophone equipment is complicated by limitations in the size of the active aperture. By recording the transmit voltage at the moment of collapse and referencing it against the corresponding pressure, it is possible to estimate the acoustic pressure at the given transmit condition. These results of this study suggest a method for quantifying high-frequency acoustic pressure, provide a potential reference for the characterization of bubble collapse pressure, and demonstrate the potential use of acoustic tweezers as a tool for measuring the elastic properties of particles/cells.     

Adaptive correction of vortex laser beam in a closed-loop system with phase only liquid crystal spatial light modulator

We propose and demonstrate the wave front correction of a vortex laser beam by using dual phase only liquid crystal spatial light modulators (LC-SLMs) and a stochastic parallel gradient descent (SPGD) algorithm. One phase only LC-SLM is used to generate vortex laser beam by loading spiral phase screen onto the wave front of input quasi-Gaussian beam. The other phase only LC-SLM under SPGD controller based on the subzone control method adaptively compensates the wave front of vortex laser beam. Numerical simulation and experimental results show that after correction, vortex doughnut like beam is focused into a beam with airy disk pattern distribution in the far field. The adaptive corrections of vortex laser beam with different optical topological charges are studied. The results show that the optical topological charge has little influence on adaptive correction. The powers in the main lobe of far field intensity distributions of vortex laser beams with different optical topological charges are all greatly improved by adaptive correction. The technique proposed in this paper can be used in optical communication, relay mirror and atmospheric turbulence correction.     

Optical cavitation probe using light scattering from bubble clouds

To understand the behaviour of systems containing clouds of bubbles (multibubble system) in real sonochemical reactors, a new diagnosis method, i.e., optical cavitation probe (OCP), has been proposed. When a laser beam is introduced into the cavitation bubble cloud, the scattered light intensity changes by the collective oscillation of cavitation bubbles. The frequency domain spectrum of the scattered light contains rich information on the cavitation bubble clouds, comparable with the acoustic emission spectra detected by a hydrophone. The significant merits of OCP, such as capability for spatially resolved, non-invasive measurement of the cavitation bubble clouds, robustness even in a violent cavitation field have been experimentally demonstrated.     

Cavitation clouds created by shock scattering from bubbles during histotripsy

Histotripsy is a therapy that focuses short-duration, high-amplitude pulses of ultrasound to incite a localized cavitation cloud that mechanically breaks down tissue. To investigate the mechanism of cloud formation, high-speed photography was used to observe clouds generated during single histotripsy pulses. Pulses of 5-20 cycles duration were applied to a transparent tissue phantom by a 1-MHz spherically focused transducer. Clouds initiated from single cavitation bubbles that formed during the initial cycles of the pulse, and grew along the acoustic axis opposite the propagation direction. Based on these observations, we hypothesized that clouds form as a result of large negative pressure generated by the backscattering of shockwaves from a single bubble. The positive-pressure phase of the wave inverts upon scattering and superimposes on the incident negative-pressure phase to create this negative pressure and cavitation. The process repeats with each cycle of the incident wave, and the bubble cloud elongates toward the transducer. Finite-amplitude propagation distorts the incident wave such that the peak-positive pressure is much greater than the peak-negative pressure, which exaggerates the effect. The hypothesis was tested with two modified incident waves that maintained negative pressure but reduced the positive pressure amplitude. These waves suppressed cloud formation which supported the hypothesis.     

鼓泡床中超声驻波的模拟及其对气泡的调制机理

采用计算流体动力学（CFD）的方法，数值生成了鼓泡床中一对声换能器以16kHz高频振动引发的超声场。数值计算是基于包括粘性影响的可压缩流体基本守恒方程，并耦合了水的状态方程。模拟结果表明，在本研究所用的几何布置和换能器与时间相关的速度入口边界条件下，反应器中形成了一个稳定的驻波声场；由于波的非线性以及水的粘性，压力波节点呈现出轻微的时间漂移性。模拟结果与前人的实验结果定性吻合。在模拟的声压分布的基础上，分析了驻波声场调制气泡的机理。如比较熟知，气泡在驻波声场作用下或者向压力波节点运动或者向压力波腹点运动，取决于气泡尺寸与共振尺寸的关系。     

Anisotropic acoustooptic modulator of nonpolarized light based on diffraction by a slow acoustic wave in a paratellurite crystal

The problem of anisotropic Bragg diffraction of nonpolarized light by a slow acoustic wave in a TeO₂ crystal is solved. Two independent acoustic waves are excited in the crystal. Nonpolarized light splits in the crystal into two orthogonally polarized eigenmodes, either diffracting by its associated acoustic beam. Conditions under which the angles of incidence and diffraction are the same for both diffraction processes are found. Depending on the acoustic frequency, the diffracted light at the exit from the crystal may be represented either by a single nonpolarized beam or by two orthogonally polarized beams with different directions and orthogonal polarizations. This may provide a high diffraction efficiency (up to 100%) for nonpolarized light in a TeO₂ crystal. Theoretical calculations are supported by experiments. Modulators capable of controlling a high-power laser operating at a wavelength of 1.06 μm are fabricated.     

Mode locking of argon ion laser by use of cylindrical ultrasonic waves

The phenomenon of light diffraction by a cylindrical ultrasonic wave has been investigated. The diffraction was applied in a new type of acousto-optic modulator used for laser mode locking. The paper describes the modulator and presents results on mode locking of argon ion laser. The mode locking was obtained by means of a cylindrical acoustic wave launched in water at the frequencies of ultrasound 33-34 MHz. A standing wave regime of operation of the modulator resulted in a reliable generation of laser pulses with the duration 720 ps.     

The interaction of shockwaves with a vapour bubble in boiling histotripsy: The shock scattering effect

Boiling histotripsy is a High Intensity Focused Ultrasound (HIFU) technique which uses a number of short pulses with high acoustic pressures at the HIFU focus to induce mechanical tissue fractionation. In boiling histotripsy, two different types of acoustic cavitation contribute towards mechanical tissue destruction: a boiling vapour bubble and cavitation clouds. An understanding of the mechanisms underpinning these phenomena and their dynamics is therefore paramount to predicting and controlling the overall size of a lesion produced for a given boiling histotripsy exposure condition. A number of studies have shown the effects of shockwave heating in generating a boiling bubble at the HIFU focus and have studied its dynamics under boiling histotripsy insonation. However, not much is known about the subsequent production of cavitation clouds that form between the HIFU transducer and the boiling bubble. The main objective of the present study is to examine what causes this bubble cluster formation after the generation of a boiling vapour bubble. A numerical simulation of 2D nonlinear wave propagation with the presence of a bubble at the focus of a HIFU field was performed using the k-Wave MATLAB toolbox for time domain ultrasound simulations, which numerically solves the generalised Westervelt equation. The numerical results clearly demonstrate the appearance of the constructive interference of a backscattered shockwave by a bubble with incoming incident shockwaves. This interaction (i.e., the reflected and inverted peak positive phase from the bubble with the incoming incident rarefactional phase) can eventually induce a greater peak negative pressure field compared to that without the bubble at the HIFU focus. In addition, the backscattered peak negative pressure magnitude gradually increased from 17.4 MPa to 31.6 MPa when increasing the bubble size from 0.2 mm to 1.5 mm. The latter value is above the intrinsic cavitation threshold of –28 MPa in soft tissue. Our results suggest that the formation of a cavitation cloud in boiling histotripsy is a threshold effect which primarily depends (a) the size and location of a boiling bubble, and (b) the sum of the incident field and that scattered by a bubble.     

Collinear diffraction of a divergent light beam by ultrasound in a paratellurite crystal

The collinear acousto-optical interaction of a divergent light beam with ultrasound along the approximate [110] direction in a TeO₂ paratellurite crystal is investigated theoretically and experimentally. The collinear diffraction is studied at an ultrasonic frequency f ≈ 149 MHz under exposure of the crystal to an uncollimated laser light beam at a wavelength λ = 633 nm and at an angle of divergence as large as 4°. It is shown that the collinear diffraction along the direction forbidden for acousto-optical interactions of plane waves occurs only under conditions where the light beam is uncollimated and the diffraction efficiency increases with an increase in the divergence of the light beam. It is proved that the attenuation of an acoustic wave brings about a decrease in the diffraction efficiency and an increase in the transmission bandwidth of the device used. A model of the collinear acousto-optical filter based on a paratellurite crystal with an interaction length l = 2.7 cm is analyzed. The collinear acousto-optical filter is characterized by a high resolving power (～3000), a high diffraction efficiency (I₁/I₀ ≈ 0.8), and a large angular aperture (Δ? ≈ 4°). This makes collinear diffraction promising for use in acousto-optical filters based on paratellurite crystals.