共查询到20条相似文献,搜索用时 125 毫秒
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2,3-二氢喹唑啉-4(1H)-酮是一类重要的含氮稠杂环化合物,具有广泛的药理及生物活性,在药物合成与研发领域有着重要应用价值,因而其合成方法也倍受人们关注.归纳总结了2,3-二氢喹唑啉-4(1H)-酮类化合物的合成研究进展,主要介绍了以邻氨基苯甲酰胺、靛红酸酐、邻硝基苯甲酰胺、邻叠氮基苯甲酰胺、邻溴苯甲酰胺、邻溴苯甲腈、邻氨基苯甲酸、邻氨基苯甲腈、邻氨基N-甲基-N-丙二烯基苯甲酰胺、N-烷基苯胺等为起始原料的2,3-二氢喹唑啉-4(1H)-酮类化合物的合成研究进展概况及其反应机理.最后对该类化合物的合成研究进展进行了总结,并对其发展前景进行了展望. 相似文献
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1,1-二卤代-1-烯烃是有机化学中常见的合成片断,在合成化学中已得到了广泛的应用。该综述介绍了这一类化合物常见的制备方法以及反应的适用范围,并详细讨论了该类化合物在有机合成中的应用:(1)1,1-二卤代-1-烯烃在镁、有机锂、锌/溴化亚铜、二碘化钐、零价钯等金属或金属试剂作用下,发生α-消除反应生成烯基卡宾中间体的反应;(2)1,1-二卤代-1-烯烃在合成杂环以及核苷类似物等方面的应用。对于这类化合物在钯催化下的分子内(间)的偶联反应以及利用分子内的双环碳钯化反应,合成环状化合物等等方面的研究进展,也进行了详细的讨论。 相似文献
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An efficient domino approach has been developed for the synthesis of coumarin aryl sulfides utilizing alkenyl arenes derived electrophilic alkenyl p-benzoquinones through Michael addition of thiols followed by cyclization. The reaction proceeds regioselectively under mild conditions within short reaction time to afford the title products in good to excellent yields. This catalyst-free reaction has good substrate scope. 相似文献
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The one-step reaction of salicylaldehydes with amines and alkenyl boronic acids or alkenyl trifluoroborates to form 2H-chromenes (2H-1-benzopyrans) has been investigated in more detail and new suitable conditions have been identified, including the use of tertiary amines and protic solvents including water. This process was applied to a concise synthesis of a tocopherol analog. The analogous condensation reaction between 2-sulfamidobenzaldehydes and alkenyl trifluoroborates provides an efficient synthesis of 1,2-dihydroquinoline derivatives. 相似文献
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Bertrand Schweitzer‐Chaput Joachim Demaerel Hauke Engler Dr. Martin Klussmann 《Angewandte Chemie (International ed. in English)》2014,53(33):8737-8740
Based on a mechanistic study, we have discovered a Brønsted acid catalyzed formation of ketone radicals. This is believed to proceed via thermally labile alkenyl peroxides formed in situ from ketones and hydroperoxides. The discovery could be utilized to develop a multicomponent radical addition of unactivated ketones and tert‐butyl hydroperoxide to olefins. The resulting γ‐peroxyketones are synthetically useful intermediates that can be further transformed into 1,4‐diketones, homoaldol products, and alkyl ketones. A one‐pot reaction yielding a pharmaceutically active pyrrole is also described. 相似文献
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An efficient and environmentally benign process for the synthesis of quinoxalines has been developed using glycerine–cerium chloride as a reaction medium. This method is applicable to a variety of diketones and 1,2-phenylenediamines to afford the corresponding quinoxaline derivatives in excellent yields. The reaction medium was recovered and reused for further reactions without any problem. 相似文献
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A convenient and practical InCl3 catalyzed three-component reaction of 4-hydroxy coumarin/1,3 diones, aromatic aldehyde, and secondary amine for the synthesis of α-benzylamino coumarins and diketones in good yields has been reported. 相似文献
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烷基取代的大环酮(例如,名贵香料麝香酮)是珍贵的香料,天然来源稀少,它的人工合成一直是有机合成中的一个研究热点和难点。在本文中,受四氢叶酸辅酶的一碳单元转移反应的启发,作者以双苯并咪唑盐作为四氢叶酸辅酶模型,利用格利雅试剂与双苯并咪唑盐的加成-水解反应,成功合成了二十四种作为麝香酮及类似大环酮重要前体的长链二酮,同时,提供了一种麝香酮及类似大环酮的仿生合成新方法。 相似文献
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Michael Z. Liang Simon J. Meek 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(40):14372-14377
A catalytic enantioselective method for the synthesis of 1,4‐keto‐alkenylboronate esters by a rhodium‐catalyzed conjugate addition pathway is disclosed. A variety of novel, bench‐stable alkenyl gem‐diboronate esters are synthesized. These easily accessible reagents react smoothly with a collection of cyclic α,β‐unsaturated ketones, generating a new C?C bond and stereocenter. Products are isolated in up to 99 % yield with greater than 20:1 E/Z and greater than 99:1 e.r. Mechanistic studies show the site‐selectivity of transmetalation and reactivity is ligand dependent. The utility of the approach is highlighted by gram‐scale synthesis of enantioenriched cyclic 1,4‐diketones, and stereoselective transformations of the products by hydrogenation, allylation, and isomerization. 相似文献
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《Journal of heterocyclic chemistry》2018,55(7):1783-1790
A simple, clean, and efficient method for the synthesis of spirooxindole derivatives via condensation of isatin with enolizable cyclic β‐diketones has been developed. The use of water as a solvent allows avoiding the use of toxic organic solvents, which makes this reaction safe and environmentally friendly. The mechanism of the condensation reaction has been investigated using first‐principles‐based density functional theory calculations. 相似文献
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In our earlier paper, we reported a convenient method for the synthesis of symmetricdiketones from benzimidazolium salts and his-Grignard reagents'. The yields of productobtained by the reported method are better then that of the former methods2' 3. Howeverthe method suffers from dramatic expensive material, such as o-phenyldiamine, whichmakes it not to be useful for large-scale preparation.In order to overcome this disadvantage and find a new method which can be utilizedin industry, we have e… 相似文献
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Barluenga J Calleja J Antón MJ Alvarez-Rodrigo L Rodríguez F Fañanás FJ 《Organic letters》2008,10(20):4469-4471
A new, mild, one-pot method for the synthesis of cyclobutabenzenes by the zirconium-promoted cross-coupling reaction of aryllithium compounds and alkenyl bromides is reported. Formation of an arynezirconocene complex and its regioselective coupling with an alkenyl bromide are the key steps of the process. This method allows the regio- and diastereoselective synthesis of functionalized cyclobutabenzene derivatives from simple and easily available starting materials. 相似文献