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Somnath Dasgupta Pavel I. Kitov Joanna M. Sadowska David R. Bundle 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2014,126(6):1536-1541
A new microtiter‐plate‐based method for the rapid generation and evaluation of focused compound libraries was developed and applied to screening ligand analogues for the E. coli Shiga‐like toxin Stx2a. The method is general, it mitigates the masking of intrinsic affinity gains by multivalency and enables the discovery of potential hits when starting from ligands that exhibit extremely low affinity with proteins that depend on multivalency for their function. 相似文献