共查询到3条相似文献,搜索用时 15 毫秒
1.
Sifan Du Dr. Yuqian Jiang Hejin Jiang Prof. Li Zhang Prof. Minghua Liu 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2024,136(6):e202316863
Pathway-dependent self-assembly, in which a single building block forms two or more types of self-assembled nanostructures, is an important topic due to its mimic to the complexity in biology and manipulation of diverse supramolecular materials. Here, we report a pathway-dependent self-assembly using chiral glutamide derivatives (L or D-PAG), which form chiral nanotwist and nanotube through a cooperative slow cooling and an isodesmic fast cooling process, respectively. Furthermore, pathway-dependent self-assembly can be harnessed to control over the supramolecular co-assembly of PAG with a luminophore β-DCS or a photopolymerizable PCDA. Fast cooling leads to the co-assembled PAG/β-DCS nanotube exhibiting green circularly polarized luminescence (CPL), while slow cooling to nanofiber with blue CPL. Additionally, fast cooling process promotes the photopolymerization of PCDA into a red chiral polymer, whereas slow cooling inhibits the polymerization. This work not only demonstrates the pathway-dependent control over structural characteristics but also highlights the diverse functions emerged from the different assemblies. 相似文献
2.
Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold 下载免费PDF全文
Guoliang Ke Dr. Minghui Liu Shuoxing Jiang Dr. Xiaodong Qi Yuhe Renee Yang Shaun Wootten Dr. Fei Zhang Prof. Zhi Zhu Prof. Yan Liu Prof. Chaoyong James Yang Prof. Hao Yan 《Angewandte Chemie (International ed. in English)》2016,55(26):7483-7486
Artificial multi‐enzyme systems with precise and dynamic control over the enzyme pathway activity are of great significance in bionanotechnology and synthetic biology. Herein, we exploit a spatially addressable DNA nanoplatform for the directional regulation of two enzyme pathways (G6pDH–MDH and G6pDH–LDH) through the control of NAD+ substrate channeling by specifically shifting NAD+ between the two enzyme pairs. We believe that this concept will be useful for the design of regulatory biological circuits for synthetic biology and biomedicine. 相似文献
3.
Growth and Origami Folding of DNA on Nanoparticles for High‐Efficiency Molecular Transport in Cellular Imaging and Drug Delivery 下载免费PDF全文
Dr. Juan Yan Chongya Hu Dr. Ping Wang Dr. Bin Zhao Dr. Xiangyuan Ouyang Juan Zhou Rui Liu Prof. Dannong He Prof. Chunhai Fan Prof. Shiping Song 《Angewandte Chemie (International ed. in English)》2015,54(8):2431-2435
A novel three‐dimensional (3D) superstructure based on the growth and origami folding of DNA on gold nanoparticles (AuNPs) was developed. The 3D superstructure contains a nanoparticle core and dozens of two‐dimensional DNA belts folded from long single‐stranded DNAs grown in situ on the nanoparticle by rolling circle amplification (RCA). We designed two mechanisms to achieve the loading of molecules onto the 3D superstructures. In one mechanism, ligands bound to target molecules are merged into the growing DNA during the RCA process (merging mechanism). In the other mechanism, target molecules are intercalated into the double‐stranded DNAs produced by origami folding (intercalating mechanism). We demonstrated that the as‐fabricated 3D superstructures have a high molecule‐loading capacity and that they enable the high‐efficiency transport of signal reporters and drugs for cellular imaging and drug delivery, respectively. 相似文献