共查询到20条相似文献,搜索用时 15 毫秒
1.
T Fujihara T Hosoki Y Katafuchi T Iwai J Terao Y Tsuji 《Chemical communications (Cambridge, England)》2012,48(64):8012-8014
Aryl formates are efficient carbon monoxide sources in palladium-catalyzed esterification of aryl halides. The carbonylation readily proceeds at ambient pressure without the use of external carbon monoxide to afford the corresponding esters in high yields. 相似文献
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Ye Feng WANG Yuan ZHOU Jia Rui WANG Lei LIU Qing Xiang GUO 《中国化学快报》2006,17(10):1283-1286
Aryl thiocyanates are important compounds not only for their interesting biological properties, but also because of their use as a versatile starting material for many sulfur- containing aromatic compounds, including sulfonyl cyanides, sulfonic acids, sul… 相似文献
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Prof. Sergio Bonesi Prof. Stefano Protti Prof. Maurizio Fagnoni 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(20):6315-6323
The photochemical behaviour of selected aryl sulfonates and phosphates (ArOX) in polar and nonpolar media has been investigated by laser flash photolysis (LFP) experiments. Two main pathways have been identified, namely the photohomolysis of the ArO−X bond or the photoheterolysis of the Ar−OX bond depending on the nature of the leaving group (OX) and on the nature of the substituents on the aromatic ring. In nonpolar solvents the esters are quite photostable due to an efficient triplet deactivation. In polar solvents, the homolytic fragmentation of the ArO−S bond from the exited singlets was found in aryl sulfonates bearing moderately electron-donating groups as well as electron-withdrawing groups. In electron-rich aryl phosphates and sulfonates photoheterolysis of the Ar−OP/Ar−OS bond took place as the exclusive pathway. 相似文献
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Beletskaya I. P. Sigeev A. S. Peregudov A. S. Petrovskii P. V. 《Russian Journal of Organic Chemistry》2001,37(10):1463-1475
Tributyltin aryl selenides are highly efficient arylselenating agents in reactions with aryl iodides and aryl triflates under catalysis with Pd and Ni complexes respectively. They also may be used as efficient source of active arylselenolate anion in the presence of fluoride ions in reaction of arylselenation of alkyl halides and activated aryl fluorides. 相似文献
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芳甲酸氰基芳甲酯是重要的有机合成中间体,其现有合成方法采用剧毒氰化物为氰源来合成。 本研究以K4[Fe(CN)6]为绿色氰化试剂,芳酰氯为原料,采用一锅两步反应合成芳甲酸氰基芳甲酯。 通过改变第二步反应温度、反应时间、硼氢化钠和催化剂的用量获得最佳反应条件,以61.7%~80.3%的产率合成了10种芳甲酸氰基芳甲酯(2a~2j),产物结构通过傅里叶变换红外光谱仪(FTIR)、核磁共振波谱仪(NMR)分析确认。 根据实验结果,提出了可能的反应机理。 该法避免了对剧毒氰化剂的使用,具有产率高、操作简单、后处理方便等优点。 相似文献
6.
《Journal of fluorine chemistry》1987,36(3):313-317
A wide variety of aryl trifluoromethyl acetylenes may be prepared in high yield by allowing CF3CCZnCl, generated from CF3CCH, to react with aryl iodides a catalytic amount of tetrakis(triphenylphosphine)-palladium. 相似文献
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Two methods are proposed for the preparation of aryl aminoalkyl sulfones substituted in the aromatic ring: a method based on the oxidation of aryl aminoalkyl sulfides by hydrogen peroxide or of their bases in the presence of HClO4 and a method based on the oxidation of aryl -chloroalkyl sulfides to chlorosulfones by hydrogen peroxide followed by their condensation with amines.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2580–2585, November, 1989. 相似文献
8.
A series of aryl iodides, with a range of substituents, has been successfully coupled using 10 mol % Pd catalyst with samarium thiolates, derived from the corresponding aryl thiocyanates upon reductive cleavage with SmI(2). Reactions proceed in THF at 65 degrees C in yields ranging from good to excellent and are compatible with both electron-donating and electron-withdrawing substituents, except NO(2). The reactions may also be conducted with aryl bromides although with somewhat lower yields. 相似文献
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Dr. Jindong Ren Dr. Henning Klaasen Melanie C. Witteler Lena Viergutz Prof. Dr. Johannes Neugebauer Dr. Hong-Ying Gao Prof. Dr. Armido Studer Prof. Dr. Harald Fuchs 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(70):16727-16732
The reactivity of aryl triflates in on-surface C−C coupling is reported. It is shown that the triflate group in aryl triflates enables regioselective homo coupling with preceding or concomitant hydrodetriflation on Cu(111). Three different symmetrical π-systems with two and three triflate functionalities were used as monomers leading to oligomeric conjugated π-systems. The cascade, comprising different intermediates at different reaction temperatures as observed for one of the molecules, proceeds via initial removal of the trifluoromethyl sulfonyl group to give an aryloxy radical which in turn is deoxygenated to the corresponding aryl radical. Thermodynamically driven regioselective 1,2-hydrogen atom transfer leads to a translocated aryl radical which in turn undergoes coupling. For a sterically more hindered bistriflate, where one ortho position was blocked, dehydrogenative coupling occurred at remote position with good regioselectivity. Starting materials, intermediates as well as products were analyzed by scanning tunneling microscopy. Structures and suggested mechanism were further supported by DFT calculations. 相似文献
12.
While the divinyl cyclopropane Cope rearrangement is well-known, and has been broadly applied in synthesis, examples of the aryl vinyl cyclopropane Cope rearrangement are less common and generally limited in scope or reaction yield. The aryl vinyl cyclopropane Cope rearrangement gives access to the benzocycloheptene scaffold, which is present in a variety of naturally occurring and medicinally relevant products. Herein we report a method to obtain either of two regioisomeric benzocycloheptene products via an aryl vinyl cyclopropane Cope rearrangement, featuring additive-controlled regioselectivity. Mechanistic studies indicate a dynamic equilibration of cyclopropane stereoisomers, followed by rearrangement of the cis diastereomer. 相似文献
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Aryl methyl ether moiety in the molecule containing aryl aryl ether part along with aryl methyl ether part is selectively cleaved to give the desired substituted phenol in excellent yield by using 48% HBr in the presence of tetra-n-butylphosphonium bromide 相似文献
15.
Maxim Oshchepkov Leonid Kovalenko Antonida Kalistratova Maria Ivanova Galina Sherstyanykh Polina Dudina Alexey Antonov Anastasia Cherkasova Mikhail Akimov 《Molecules (Basel, Switzerland)》2022,27(11)
Natural cytokinines are a promising group of cytoprotective and anti-tumor agents. In this research, we synthesized a set of aryl carbamate, pyridyl urea, and aryl urea cytokinine analogs with alkyl and chlorine substitutions and tested their antiproliferative activity in MDA-MB-231, A-375, and U-87 MG cell lines, and cytoprotective properties in H2O2 and CoCl2 models. Aryl carbamates with the oxamate moiety were selectively anti-proliferative for the cancer cell lines tested, while the aryl ureas were inactive. In the cytoprotection studies, the same aryl carbamates were able to counteract the CoCl2 cytotoxicity by 3–8%. The possible molecular targets of the aryl carbamates during the anti-proliferative action were the adenosine A2 receptor and CDK2. The obtained results are promising for the development of novel anti-cancer therapeutics. 相似文献
16.
Junting Hong Qianyi Liu Feng Li Guangcan Bai Guoquan Liu Man Li Onkar S. Nayal Xuefeng Fu Fanyang Mo 《中国化学》2019,37(4):347-351
Herein, we report the first electrochemical strategy for the borylation of aryl iodides via a radical pathway using current as a driving force. A mild reaction condition allows an assorted range of readily available aryl iodides to be proficiently converted into synthetically valuable arylboronic esters under transition metal catalyst‐free conditions. Moreover, this method also shows good functional group tolerance. Initial control mechanistic experiments reveal the formation of aryl radical as a key intermediate and the current plays an important role in the generation of radical intermediate. 相似文献
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The Ketene‐Surrogate Coupling: Catalytic Conversion of Aryl Iodides into Aryl Ketenes through Ynol Ethers 下载免费PDF全文
Wenhan Zhang Dr. Joseph M. Ready 《Angewandte Chemie (International ed. in English)》2014,53(34):8980-8984
tert‐Butoxyacetylene is shown to undergo Sonogashira coupling with aryl iodides to yield aryl‐substituted tert‐butyl ynol ethers. These intermediates participate in a [1,5]‐hydride shift, which results in the extrusion of isobutylene and the generation of aryl ketenes. The ketenes are trapped in situ with multiple nucleophiles or undergo electrocyclic ring closure to yield hydroxynaphthalenes and quinolines. 相似文献
19.
Patrick J. Moon Anis Fahandej‐Sadi Wenyu Qian Prof. Rylan J. Lundgren 《Angewandte Chemie (International ed. in English)》2018,57(17):4612-4616
The copper‐catalyzed decarboxylative benzylation of aryl and alkenyl boronic esters with electron‐deficient aryl acetates is reported. The oxidative coupling proceeds under mild, aerobic conditions and tolerates a host of potentially reactive electrophilic functional groups that would be problematic with traditional benzylation methods (aryl iodides and bromides, protic heteroatoms, aldehydes, Michael acceptors). A reaction pathway in which a benzylic nucleophile is generated by aryl acetate decarboxylation and in turn is intercepted by the catalyst to form diarylmethane products is supported by mechanistic studies. 相似文献
20.
Xinyu Liang Kaikai Wen Prof. Qinqin Shi Bei-Bei Zhang Shurui Pei Qijie Lin Bowei Ma Song Wang Meng Zhang Xiang Li Prof. Zhi-Xiang Wang Prof. Hui Huang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(35):e202200869
Aryl sulfides are in great demands in drugs and materials sciences. To avoid using nucleophilic and noxious thiols, many efforts have been focused on exploring novel sulfide resources. Herein, a reductive Pd-catalyzed, Ni-mediated method to synthesize aryl sulfides via a sulfide transfer reaction is developed. The utility and scope of this reaction is exemplified by various aryl electrophiles and aryl sulfides. Mechanistic studies reveal two competing catalytic cycles of sulfide transfer and aryl transfer in this reaction, where the former one is favored over the later one because of the large energy barrier difference during the transmetalation. Moreover, two important chemicals are late-stage functionalized by this method, exhibiting the potential applications in drugs and materials science. 相似文献