共查询到20条相似文献,搜索用时 15 毫秒
1.
I. V. Ukrainets O. L. Kamenetskaya S. G. Taran I. Yu. Petukhova L. N. Voronina 《Chemistry of Heterocyclic Compounds》2001,37(1):100-102
Different methods of synthesizing esters of 1H-2-oxo-4-hydroxy-3-quinolineacetic acid were studied. Results are given for tests of the anti-inflammatory activity of these products. 相似文献
2.
P. A. Bezuglyi I. V. Ukrainets V. I. Treskach A. V. Turov 《Chemistry of Heterocyclic Compounds》1992,28(4):438-439
Acylation of methyl N-methylanthranilate with phenylacetyl chloride with subsequent intramolecular cyclization of the resulting anilide was used to synthesize 1-methyl-3-phenyl-4-hydroxy-2-quinolone (arboricine).See [1] for Communication 1.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 522–524, April, 1992. 相似文献
3.
4.
Abdellatif El Kihel Mohamed Benchidmi El Mokhtar Essassi Patrick Bauchat Renee Danion-bougot 《合成通讯》2013,43(14):2435-2445
6- and 7-(4-hydroxy-6-methyl-2-oxo-1-pyridyl)benzimidazoles and 1-(6- and 7-benzimidazolyl)-4-hydroxy-2-oxoquinolines were synthesized by reaction of aminobenzimidazoles with 4-hydroxy-6-methyl-2-pyrone and 4-hydroxycoumarine. 相似文献
5.
A synthesis and study of the spatial structure of 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline have been carried. 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic
acids [1-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylidene]hydrazides were prepared from this compound by two routes. A
comparative analysis of the antitubercular properties of the synthesized compounds and of the closely structurally related
N,N′-di(1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)hydrazines has been performed.
*For Communication 151 see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 214–222, February, 2009. 相似文献
6.
Purushottam Sidramappa Jamkhandi Srinivas Rajagopal 《Monatshefte für Chemie / Chemical Monthly》1968,99(4):1390-1394
Zusammenfassung Eine große Zahl von 3-acylierten 4-Hydroxy-1-thiacumarinen mit verschiedenen Halogen- oder Alkylsubstituenten am Benzolkern wurde durch Kondensation von 4-Hydroxy-1-thiacumarinen mit verschiedenen aliphatischen Säuren in Gegenwart von POCl3 synthetisiert.
Diese Veröffentlichung wird ein Teil der Dissertation vonP. S. Jamkhandi zur Erlangung des Ph.D. der Karnatak University sein. 相似文献
The synthesis of a large number of 3-acylated 4-hydroxy-1-thiacoumarins carrying various substituents in the benzenoid nucleus (halogen, alkyl) has been carried out by the condensation of 4-hydroxy-1-thiacoumarins with various aliphatic acids in the presence of phosphorus oxychloride.
Diese Veröffentlichung wird ein Teil der Dissertation vonP. S. Jamkhandi zur Erlangung des Ph.D. der Karnatak University sein. 相似文献
7.
I. V. Ukrainets P. A. Bezuglyi O. V. Gorokhova V. I. Treskach A. V. Turov 《Chemistry of Heterocyclic Compounds》1993,29(1):92-94
Condensation of 1-R-3-carbethoxy-4-hydroxy-2-quinolones with o-phenylene diamine gives the corresponding 1-R-3-(2-benzimidazolyl)-4-hydroxy-2-quinolones. Data on a study of the antithyroid activity of the synthesized compounds is presented.For Communication 6, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 105–108, January, 1993.We express our sincere thanks to A. A. Kirichenko and T. S. Bozhko for the study of the antithyroid activity. 相似文献
8.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova S. V. Slobodzyan 《Chemistry of Heterocyclic Compounds》2007,43(1):63-66
The reaction of 2-ethoxycarbonylmethyl-4H-3,1-benzoxazin-4-one with malononitrile in dry pyridine leads to 1-hydroxy-3,6-dioxo-4,6-dihydro-3H-pyrimido[1,2-a]quinoline-5-carbonitrile.
Acetoacetic and cyanoacetic esters under analogous conditions form anilides of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic
acid while diethyl malonate gives N,N′-di-2-carboxyanilides of malonic acid.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 75–79, January, 2007. 相似文献
9.
P. A. Bezuglyi I. V. Ukrainets V. I. Treskach A. V. Turov 《Chemistry of Heterocyclic Compounds》1991,27(11):1237-1238
3-Alkyl-4-hydroxy-2-quinolones were obtained in high yields via the Dieckmann intramolecular condensation of substituted malonic acid ethyl ester 2-carbalkoxyanilides.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1533–1534, November, 1991. 相似文献
10.
I. V. Ukrainets P. A. Bezuglyi V. I. Treskach A. V. Turov S. V. Slobodzyan 《Chemistry of Heterocyclic Compounds》1992,28(5):534-538
1-R-3-Carbethoxy-4-hydroxy-2-quinolones were synthesized by intramolecular cyclization of N-R-2-carbalkoxymalonanilic acids by the Dieckmann reaction. The possibility and advantages of conducting this reaction in aqueous medium were demonstrated. The mutually perpendicular orientation of the heterocyclic and aryl fragments was demonstrated for the 1-phenyl derivative by ESR spectroscopy.See [1] for Communication 2.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 636–639, May, 1992. 相似文献
11.
A reverse phase HPLC method was developed and validated for the simultaneous determination of 2-hydroxy-4-methoxybenzaldehyde
and 2-hydroxy-4-methoxybenzoic acid in the root extracts of Hemidesmus indicus. A comprehensive validation of the method including sensitivity, linearity, reproducibility, accuracy, limit of detection
(LOD) and limit of quantification (LOQ) was conducted using the optimized chromatographic conditions. The method was found
to be linear (r > 0.998) in the range of 5–350 μg mL−1 for 2-hydroxy-4-methoxybenzaldehyde and for 2-hydroxy-4-methoxybenzoic acid (r > 0.999) in the range 10–300 μg mL−1. The method was found to be precise with inter-day precision values (% RSD) in the ranges of 0.61–1.76% for 2-hydroxy-4-methoxybenzaldehyde
and 1.3–2.8% for 2-hydroxy-4-ethoxybenzoic acid while intra-day precisions (% RSD) of two analytes were in the range of 0.41–1.07
and 0.95–2.5%. The limits of detection (LODs) for 2-hydroxy-4-methoxybenzaldehyde and 2-hydroxy-4-methoxybenzoic acid were
0.84 and 2.34 μg mL−1. The described method was fast, sensitive and reproducible, and thus well suited for routine analysis of these two compounds
from root extracts of H. indicus and other plants. 相似文献
12.
S. G. Taran I. V. Ukrainets N. V. Likhanova O. V. Gorokhova P. A. Bezugly 《Chemistry of Heterocyclic Compounds》2001,37(2):237-240
With the aim of investigating the relationship between chemical structure and biological activity we have synthesized and studied the effect of (2H-1,2,4-benzothiadiazine-1,1-dioxide-3-yl)methylamides of 1-R-4-hydroxy-2-oxoquinoline-3-carboxylic acids on kidney urinary output. 相似文献
13.
I. V. Ukrainets S. G. Taran N. V. Likhanova Nidal Amin Jaradat O. V. Shishkin 《Chemistry of Heterocyclic Compounds》2000,36(1):57-61
S-(–)-1-phenylethylamide of 6-bromo-4-hydroxy-1-isoamyl-2-oxo-3-quinolinecarboxylic acid was synthesized. X-ray diffraction investigation of this product was carried out to determine its absolute configuration.For communication 38, see ref. [1].National Pharmaceutical Academy of Ukraine, 310002 Kharkov, Ukraine Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 64–69, January, 2000. 相似文献
14.
Avetisyan A. A. Aleksanyan I. L. Pivazyan A. A. 《Russian Journal of Organic Chemistry》2003,39(8):1164-1166
From 4-hydroxy-2-methylquinoline-3-propionyl chlorides hydrochlorides the corresponding thiosemicarbazides were synthesized. The cyclization of the latter both in alkaline and acidic media furnished 4-hydroxy-2-methyl-3-[2-(5-mercapto-1H-1,2,4-triazol-3-yl)ethyl]quinolines. The reaction of the above propionyl chlorides with anthranilic acid afforded the corresponding 2-[2-(4-hydroxy-2-methyl-3-quinolyl)ethyl]-4H-3,1-benzoxazin-4-ones. 相似文献
15.
Abstract A facile procedure is presented for the synthesis of (E)-1-(3′-hydroxy-2′-furanyl)-3-(3″-hydroxy-4″-methoxyphenyl)-2- propen-1-one (6). Galactosylisomaltol (1) was condensed with isovanillin (2) under strong alkaline conditions at 25 [ddot]C to form (E)-1-(3′-O-β-D-galactopyranosyloxy-2′-furanyl)-3-(3″- hydroxy-4″-methoxyphenyl)-2-propen-1-one (4). (E)-1-(3′-hydroxy-2′-furanyl)-3-(3″-hydroxy-4″-methoxyphenyl)-2-propen-1-one (6) was obtained by acid hydrolysis of 4 in a 53.9% yield. This hetero-cyclic 2-propen-1-one was characterized on the basis of spectral data (IR and 1H NMR), physicochemical properties, and conversion to a mono-O-acetyl derivative. 相似文献
16.
I. V. Ukrainets L. V. Sidorenko S. V. Slobodzyan V. B. Rybakov V. V. Chernyshev 《Chemistry of Heterocyclic Compounds》2005,41(9):1158-1166
4-Chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acids and their esters react with aminopyridines in refluxing DMF to give
the corresponding 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyridylamides. Their structures were proved by 1H NMR and mass spectroscopy, counter synthesis, and by X-ray analysis. A possible mechanism is proposed for the indicated
chemical reaction.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1362–1371, September, 2005. 相似文献
17.
H. Esterbauer 《Monatshefte für Chemie / Chemical Monthly》1971,102(3):824-827
Zusammenfassung Die Darstellung einiger 4-Hydroxy-2-alkynaldiäthylacetale (3), 4-Hydroxy-2-alkenaldiäthylacetale (4) und 4-Hydroxyalkenale (5) wird beschrieben. Propargylaldehyddiäthylacetalmagnesiumbromid wird mit Aldehyden (Octanal, Nonanal, Decanal) bzw. Ketonen (Aceton, Methyläthylketon, Methylisopropylketon, Cyclohexanon) zu den Verbindungen3 umgesetzt. Die Dreifachbindung von3 wird mit LiAlH4 zurtrans-Doppelbindung hydriert;4 wird mit verd. Citronensäure zu5 verseift.
Synthesis of some 4-hydroxy-2-alkenals
The synthesis of some 4-hydroxy-2-alkynal diethyl acetals (3), 4-hydroxy-2-alkenal diethyl acetals (4) and 4-hydroxyalkenals (5) is described. Propargylaldehyde diethyl acetalmagnesiumbromide is reacted with aldehydes (octanal, nonanal, decanal) and ketones (acetone, methyl ethyl ketone, methylisopropyl ketone, cyclohexanone) to the compounds3, the triplebound is reduced with LiAlH4 to thetrans-double-bound.4 is hydrolyzed with diluted citric acid to5.相似文献
18.
I. V. Ukrainets S. G. Taran O. V. Gorokhova N. A. Marusenko A. V. Turov 《Chemistry of Heterocyclic Compounds》1997,33(5):600-604
We propose preparative synthesis methods for 2-thio-4-hydroxy-, 2-oxo-4-mercapto-, and 2-thio-4-mercapto-1H-3-(2-benzimidazolyl)quinolines. We have studied the antithyroid activity of the synthesized compounds.Ukraine Pharmaceutical Academy, Kharkhov 310002. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 692–696, May, 1997. 相似文献
19.
Celia B. Schapira María I. Abasolo Isabel A. Perillo 《Journal of heterocyclic chemistry》1985,22(2):577-581
Reaction of some α-phthalimidoacetamides 1a-i with sodium ethoxide was carried out under drastic conditions. Compounds 1b-g afforded 4-hydroxy-1(2H)-isoquinolone-3-carboxamides 2b-g , while 1h-i afforded the acid 3a-b together with the expected isoquinolones 2h-i. Compound 1a gave phthalimide as the major product. Compounds 2 are acidic and unstable in basic media. The most acidic compounds presented the longest half-life. An explanation of these results was given. 相似文献
20.
The hydroxypyridones were found to have wide biological activities such as they can be used as iron chelators for the treatment of iron overload of transfusion-dependant patients[1]. Some hydroxypyridones were discovered to possess moderate reproducible activity against murine P-388 leukemia[2] and showed antimalarial activity[3]. Besides some nucleoside of hydroxypyridones exhibit antitumor activity[4]. The 2-ethyl-3-hydroxy-4-pyridone nucleosides were synthesized by direct condensation of the silylated 2-ethyl-3-hydroxy-4-pyridone with 1,2,3,5-tetra-o-acetyl-β-D-ribofuranose using trimethylsilyl triflate(Me3SiOTf) as catalyst. Deblocking of the protected ribofuranosyl nucleosides was performed by the standard methods. 相似文献