Quinazoline-2,4(1H,3H)-diones inhibit the growth of multiple human tumor cell lines

Quinazoline-2,4( $1H,3H$ )-diones exhibit a wealth of biological activities including antitumor proliferation. We established an improved method for the synthesis of quinazoline-2,4( $1H,3H$ )-dione derivatives with three points of molecular diversity. Data indicate that compounds 60 (average $\text{ logGI}_{50} \!=\! -6.1$ ), 65 (average $\text{ logGI}_{50} \!=\! -6.13$ ), 69 (average $\text{ logGI}_{50} \!=\! -6.44$ ), 72 (average $\text{ logGI}_{50} \!=\! -6.39$ ), and 86 (average $\text{ logGI}_{50} = -6.45$ ) significantly inhibited the in vitro growth of 60 human tumor cell lines tested. Structure–activity relationship analyses indicate that chlorophenethylureido is the necessary substituent at the $\text{ D}_{3}$ diversity point (7-position of quinazoline-2,4( $1H,3H$ )-dione), in particular, $o$ -chlorophenethylurea (69) achieved optimal activity. $o$ - or $m$ -Chlorophenethyl substitutions (69 and 72) at the $\text{ D}_{2}$ diversity point (3-position of quinazo line-2,4( $1H,3H$ )-dione) gave the most potent compounds. Methoxyl and 4-methylpiperazin-1-yl substitution at the $\text{ D}_{1}$ diversity point (6-position of quinazoline-2,4( $1H,3H$ )-dione skeleton) may yield better activity than other groups. The quinazoline-2,4( $1H,3H$ )-dione scaffold can be effectively replaced by 2 $H$ -benzo[b][1,4]thiazin-3(4 $H$ )-one.     

Charmonium rescattering effects in \psi(2S) \rightarrow \gamma \eta_{c}^{} decay

Charmonium rescattering effects in the M1 transition of $ \psi$ (2S) $ \rightarrow$ $ \gamma$ $ \eta_{c}^{}$ are investigated by modeling a $ \chi_{{cJ}}^{}$ or J/ $ \psi$ rescattering into a $ \eta_{c}^{}$ final state. The absorptive and dispersive part of the transition amplitudes for the rescattering loops of $ \eta$ $ \psi$ ( $ \gamma^{{\ast}}_{}$ ) and $ \gamma$ $ \chi$ ( $ \psi$ ) are separately evaluated. The numerical results show that the contribution from the $ \gamma$ $ \chi$ ( $ \psi$ ) rescattering process is negligible. Compared with the virtual D $ \bar{{D}}$ (D ^*) rescattering processes, the $ \eta$ $ \psi$ ( $ \gamma^{{\ast}}_{}$ ) process may be regarded as the next-leading order of the hadronic loop mechanism, which only offers the partial decay width of ～ 0.045 keV to the $ \psi$ (2S) $ \rightarrow$ $ \gamma$ $ \eta_{c}^{}$ .     

Antihydrogen (hydrogen) atom formation

In this paper we show how the ATHENA data samples on the antihydrogen ( ${\bar{\rm H}}$ ) formation in very different conditions provide useful information on the two different possible mechanisms: the 3-body reaction ( $\bar{p}+{e^+}+{e^+}\rightarrow {\bar{\rm H}}+ e^+$ ) and the 2-body reaction ( $\bar{p}+{\rm e^+}\rightarrow {\bar{\rm H}}+{h\nu}$ ).     

Analysis of the \frac{1} {2}^ - and \frac{3} {2}^ - heavy and doubly heavy baryon states with QCD sum rules

In this article, we study the $\frac{1} {2}^ -$ and $\frac{3} {2}^ -$ heavy and doubly heavy baryon states $\Sigma _Q \left( {\frac{1} {2}^ - } \right)$ , $\Xi '_Q \left( {\frac{1} {2}^ - } \right)$ , $\Omega _Q \left( {\frac{1} {2}^ - } \right)$ , $\Xi _{QQ} \left( {\frac{1} {2}^ - } \right)$ , $\Omega _{QQ} \left( {\frac{1} {2}^ - } \right)$ , $\Sigma _Q^* \left( {\frac{3} {2}^ - } \right)$ , $\Xi _Q^* \left( {\frac{3} {2}^ - } \right)$ , $\Omega _Q^* \left( {\frac{3} {2}^ - } \right)$ , $\Xi _{QQ}^* \left( {\frac{3} {2}^ - } \right)$ and $\Omega _{QQ}^* \left( {\frac{3} {2}^ - } \right)$ by subtracting the contributions from the corresponding $\frac{1} {2}^ +$ and $\frac{3} {2}^ +$ heavy and doubly heavy baryon states with the QCD sum rules in a systematic way, and make reasonable predictions for their masses.     

Quasi solid state dye-sensitized solar cells based on polyvinyl alcohol (PVA) electrolytes containing \mathbf{I}^{\mathbf{-}}/\mathbf{I}_{\mathbf{3}}^{\mathbf{-}} redox couple

Quasi solid state dye-sensitized solar cells (DSSCs) have been fabricated with electrolytes containing $\text{ I }^{-}/\text{ I }_{3}^{-}$ redox couple using 80 % hydrolyzed polyvinyl alcohol (PVA) doped with potassium iodide (KI) and a mixture of potassium iodide and tetrapropyl ammonium iodide ( $\text{ Pr }_{4}\text{ NI }$ ) salts. The quasi solid state gel polymer electrolytes were prepared using 1:1 ethylene carbonate (EC):propylene carbonate (PC) mixture. The solar cells have the structure of ITO/ $\text{ TiO }_{2}$ /N3-Dye/electrolyte/Pt/ITO. The conductivity of the electrolytes has been calculated from the bulk resistance value determined using the electrochemical impedance spectroscopy. The performance of the DSSCs has been studied by varying the concentration of the doping salts in the electrolyte and incident light intensity. The DSSC fabricated with the KI salt electrolyte containing 9.9 wt% PVA, 39.6 wt% EC, 39.6 wt% PC, 10.9 wt% KI $(+\text{ I }_{2})$ exhibited the best power conversion efficiency of 1.97 %. However, the DSSC with a double-salt electrolyte containing 9.9 wt% PVA: 39.6 wt% EC: 39.6 wt% PC: (6.5 wt% KI: 4.4 wt% $\text{ Pr }_{4}\text{ NI }$ ) ( $+\text{ I }_{2}$ ) exhibited a higher efficiency of 3.27% under $100 \text{ mW/cm }^{2}$ light intensity. The efficiency of this cell increased to 4.59 % under dimmer light of intensity of $54 \text{ mW/cm }^{2}$ .     

Radiative open charm decay of the Y(3940) , Z(3930) , X(4160) resonances

We determine the radiative decay amplitudes for the decay into D^* and $ \bar{{D}}$ $ \gamma$ , or D ^* _s and $ \bar{{D}}_{s}^{}$ $ \gamma$ of some of the charmonium-like states classified as X , Y , Z resonances, plus some other hidden charm states which are dynamically generated from the interaction of vector mesons with charm. The mass distributions as a function of the $ \bar{{D}}$ $ \gamma$ or $ \bar{{D}}_{s}^{}$ $ \gamma$ invariant mass show a peculiar behavior as a consequence of the D ^* $ \bar{{D}}^{*}_{}$ nature of these states. The experimental search of these magnitudes can shed light on the nature of these states.     

The Isospin Mixing in the X(3872) Decay Spectrum

The large isospin symmetry breaking found in the X(3872) decay is investigated by looking into the transfer strength from the \({{c}\bar{c}}\) quarkonium to the two-meson states: \({c\bar{c} \rightarrow D^{0}\overline{D}^{*0}, D^{+} D^{*-} , J /\psi\omega, {\rm and} \, J /\psi\rho}\) . The widths of the \({\rho}\) and \({\omega}\) mesons are taken into account in the calculation. It is found that very narrow \({J /\psi\omega}\) and \({J /\psi\rho}\) peaks appear at the \({D^{0}\overline{D}^{*0}}\) threshold. These narrow peaks appear provided that the strength of the \({D^{0}\overline{D}^{*0}}\) component is large around the threshold. The large width of the \({\rho}\) meson enhances the isospin-one component in the transfer strength considerably, which reduces the ratio \({{\rm Br}(X \rightarrow J /\psi\omega)/{\rm Br}(X \rightarrow J /\psi\rho)}\) down to 2.5.     

A simple route for the synthesis of novel N-alkyl-2-(alkylthio)-1H-imidazole derivatives

Novel $N$ -alkyl-2-(alkylthio)-1 $H$ -imidazole derivatives were synthesized in a single step by an efficient and simple method in high yields. Readily available starting materials, mild reaction conditions, operational simplicity and novelty are the key advantages of this method. Besides their novel structures, these compounds may have important biological activities and industrial applications.     

The Effective Resistance of the N-Cycle Graph with Four Nearest Neighbors

The exact expression for the effective resistance between any two vertices of the $N$ -cycle graph with four nearest neighbors $C_{N}(1,2)$ , is given. It turns out that this expression is written in terms of the effective resistance of the $N$ -cycle graph $C_{N}$ , the square of the Fibonacci numbers, and the bisected Fibonacci numbers. As a consequence closed form formulas for the total effective resistance, the first passage time, and the mean first passage time for the simple random walk on the the $N$ -cycle graph with four nearest neighbors are obtained. Finally, a closed form formula for the effective resistance of $C_{N}(1,2)$ with all first neighbors removed is obtained.     

Parallel synthesis of 7-heteroaryl-pyrazolo[1,5-a]pyrimidine-3-carboxamides

A simple and practical four-step protocol for the parallel synthesis of 7-heteroaryl-pyrazolo[1,5- $a$ ]pyrimidine-3-carboxamides was developed. The synthesis starts with transformation of commercially available 2-acetylpyridine and acetylpyrazine with $N,$ $N$ -dimethylformamide dimethylacetal into the corresponding $(E)$ -3-(dimethylamino)-1-(heteroaryl)prop-2-en-1-ones followed by cyclisation with methyl 5-amino-1 $H$ -pyrazole-4-carboxylate to give methyl 7-heteroarylpyrazolo[1,5- $a$ ]pyrimidine-3-carboxylates. Hydrolysis of the ester group and subsequent amidation of the so formed carboxylic acids with 12 primary and secondary aliphatic amines furnished a library of 24 title compounds in good overall yields and purity.     

Polymeric N-stage serial-cascaded four-port optical router with scalable 3N channel wavelengths for wideband signal routing application

Device architecture and design scheme of a universal \(N\) -stage cascaded polymer four-port optical router with scalable 3 \(N\) channel wavelengths are proposed. Basic cross-coupling two-microring resonator routing element based on polymer materials is optimized for single-mode transmission, low optical loss and phase-match between microring waveguide and channel waveguide. Then, a one-stage four-port optical router is constructed using four-group basic routing elements, which has 12 possible I/O routing paths and 3 channel wavelengths. The insertion losses of each channel wavelength along every routing path are within the range of 0.04–0.63 dB, the maximum crosstalk between the on-port along each routing path and other off-ports is less than \(-39\)  dB, and the device footprint size is \(\sim \) 0.13 mm \(^{2}\) . Compared with the previously reported four-port silicon optical routers, this device possesses similar ring radius ( \(\sim \) 10  \(\upmu \) m) and device size ( \(<\) 1 mm \(^{2})\) . Aiming at wideband signal routing applications, we then construct a universal \(N\) -stage cascaded polymer four-port optical router possessing scalable 3 \(N\) channel wavelengths. The proposed routing structure has potential application in photonic networks-on-chip, because of low insertion loss, low crosstalk, small footprint size, and scalable wideband 3 \(N\) routing wavelengths.     

On the production of \pi^{+}_{} \pi^{+}_{} pairs in pp collisions at 0.8 GeV

Data accumulated recently for the exclusive measurement of the pp $ \rightarrow$ pp $ \pi^{+}_{}$ $ \pi^{-}_{}$ reaction at a beam energy of 0.793GeV using the COSY-TOF spectrometer have been analyzed with respect to possible events from the pp $ \rightarrow$ nn $ \pi^{+}_{}$ $ \pi^{+}_{}$ reaction channel. The latter is expected to be the only $ \pi$ $ \pi$ production channel, which contains no major contributions from resonance excitation close to threshold and hence should be a good testing ground for chiral dynamics in the $ \pi$ $ \pi$ production process. No single event has been found, which meets all conditions for being a candidate for the pp $ \rightarrow$ nn $ \pi^{+}_{}$ $ \pi^{+}_{}$ reaction. This gives an upper limit for the cross-section of 0.16μb (90% C.L.), which is more than an order of magnitude smaller than the cross-sections of the other two-pion production channels at the same incident energy.     

Mössbauer spectroscopy in the investigation of new mineral–related materials

New materials based on the composition of the mineral schafarzikite, FeSb $_{2}\textit {O}_{4}$ , have been synthesised. $^{57}$ Fe- and $^{121}$ Sb- Mössbauer spectroscopy shows that iron is present as Fe $^{2+}$ and that antimony is present as Sb $^{3+}$ . The presence of Pb $^{2+}$ on the antimony sites in materials of composition FeSb $_{1.5}$ Pb $_{0.5}\textit {O}_{4}$ induces partial oxidation of Fe $^{2+}_{}$ to Fe $^{3+}$ . The quasi-one-dimensional magnetic structure of schafarzikite is retained in FeSb $_{1.5}$ Pb $_{0.5}\textit {O}_{4}$ and gives rise to weakly coupled non-magnetic Fe $^{2+}$ ions coexisting with Fe $^{3+}$ ions in a magnetically ordered state. A similar model can be applied to account for the spectra recorded from the compound Co $_{0.5}$ Fe $_{0.5}$ Sb $_{1.5}$ Pb $_{0.5}\textit {O}_{4}$ .     

Comprehensive Bayesian analysis of rare (semi)leptonic and radiative \varvec{B} decays

The available data on \(|\Delta B| = |\Delta S| = 1\) decays are in good agreement with the Standard Model when permitting subleading power corrections of about \(15\,\%\) at large hadronic recoil. Constraining new-physics effects in \(\mathcal {C}_{7}^{\mathrm {}}\) , \(\mathcal {C}_{9}^{\mathrm {}}\) , \(\mathcal {C}_{10}^{\mathrm {}}\) , the data still demand the same size of power corrections as in the Standard Model. In the presence of chirality-flipped operators, all but one of the power corrections reduce substantially. The Bayes factors are in favor of the Standard Model. Using new lattice inputs for \(B\rightarrow K^*\) form factors and under our minimal prior assumption for the power corrections, the favor shifts toward models with chirality-flipped operators. We use the data to further constrain the hadronic form factors in \(B\rightarrow K\) and \(B\rightarrow K^*\) transitions.     

F(T) gravity and k-essence

Modified teleparallel gravity theory with the torsion scalar has recently gained a lot of attention as a possible candidate of dark energy. We perform a thorough reconstruction analysis on the so-called $F(T)$ models, where $F(T)$ is some general function of the torsion term. We derive conditions for the equivalence between of $F(T)$ models with purely kinetic k-essence. We present a new class models of $F(T)$ gravity and k-essence.     

Local structure of Fe-doped In 2 O 3 films investigated by X-ray absorption fine structure spectroscopy

$(\mathrm{In}_{1-x}\mathrm{Fe}_{x})_{2}\mathrm{O}_{3}$ $(x=0.07, 0.09, 0.16, 0.22, 0.31)$ films were deposited on Si (100) substrates by RF-magnetron sputtering technique. The influence of Fe doping on the local structure of films was investigated by X-ray absorption spectroscopy (XAS) at Fe K-edge and L-edge. For the $(\mathrm{In}_{1-x}\mathrm{Fe}_{x})_{2}\mathrm{O}_{3}$ films with $x=0.07, 0.09 \mbox{ and } 0.16$ , Fe ions dissolve into $\mathrm{In}_{2}\mathrm{O}_{3}$ and substitute for $\mathrm{In}^{3+}$ sites with a mixed-valence state ( $\mathrm{Fe}^{2+}/\mathrm{Fe}^{3+}$ ) of Fe ions. However, a secondary phase of Fe metal clusters is formed in the $(\mathrm{In}_{1-x}\mathrm{Fe}_{x})_{2}\mathrm{O}_{3}$ films with $x=0.22 \mbox{ and } 0.31$ . The qualitative analyses of Fe-K edge extended X-ray absorption fine structure (EXAFS) reveal that the Fe–O bond length shortens and the corresponding Debye–Waller factor ( $\sigma^{2}$ ) increases with the increase of Fe concentration, indicating the relaxation of oxygen environment of Fe ions upon substitution. The anomalously large structural disorder and very short Fe–O distance are also observed in the films with high Fe concentration. Linear combination fittings at Fe L-edge further confirm the coexistence of $\mathrm{Fe}^{2+}$ and $\mathrm{Fe}^{3+}$ with a ratio of ${\sim}3:2$ ( $\mathrm{Fe}^{2+}: \mathrm{Fe}^{3+}$ ) for the $(\mathrm{In}_{1-x}\mathrm{Fe}_{x})_{2}\mathrm{O}_{3}$ film with $x=0.16$ . However, a significant fraction ( ${\sim}40~\mbox{at\%}$ ) of the Fe metal clusters is found in the $(\mathrm{In}_{1-x}\mathrm{Fe}_{x})_{2}\mathrm{O}_{3}$ film with $x=0.31$ .     

Analysis of the {3\over 2}^{+} heavy and doubly heavy baryon states with QCD sum rules

In this article, we study the ${3\over 2}^{+}$ heavy and doubly heavy baryon states $\varXi^{*}_{cc}$ , $\varOmega^{*}_{cc}$ , $\varXi^{*}_{bb}$ , $\varOmega^{*}_{bb}$ , $\varSigma_{c}^{*}$ , $\varXi_{c}^{*}$ , $\varOmega_{c}^{*}$ , $\varSigma_{b}^{*}$ , $\varXi_{b}^{*}$ and $\varOmega_{b}^{*}$ by subtracting the contributions from the corresponding ${3\over 2}^{-}$ heavy and doubly heavy baryon states with the QCD sum rules, and we make reasonable predictions for their masses.     

Absolute E3 and M2 transition probabilities for the electromagnetic decay of the \mathrm{\ensuremath I^{\pi}=K^{\pi}=8^{-}} isomeric state in 132Ce

The decay of the $\ensuremath I^{\pi}=K^{\pi}=8^{-}$ isomeric state at 2340keV in ¹³²Ce has been investigated in the ¹²⁰Sn(¹⁶O, 4n)¹³²Ce reaction. The measurements were carried out in e - $ \gamma$ and $ \gamma$ - $ \gamma$ coincidence modes using an electron spectrometer coupled to the OSIRIS II gamma-ray array at the Heavy Ion Laboratory of the University of Warsaw. Experimentally obtained internal conversion coefficients for the $\ensuremath 8^{-} \rightarrow 6^{+}$ and $\ensuremath 8^{-} \rightarrow 5^{+}$ transitions allowed the multipolarities, mixing ratios, reduced transition probabilities and hindrance factors to be determined.     

Quantum billiards in multidimensional models with branes

A gravitational $D$ -dimensional model with $l$ scalar fields and several forms is considered. When a cosmological-type diagonal metric is chosen, an electromagnetic composite brane ansatz is adopted and certain restrictions on the branes are imposed; the conformally covariant Wheeler–DeWitt (WDW) equation for the model is studied. Under certain restrictions asymptotic solutions to WDW equation are found in the limit of the formation of the billiard walls which reduce the problem to the so-called quantum billiard on the $(D+ l -2)$ -dimensional Lobachevsky space. Two examples of quantum billiards are considered. The first one deals with $9$ -dimensional quantum billiard for $D = 11$ model with $330$ four-forms which mimic space-like $M2$ - and $M5$ -branes of $D=11$ supergravity. The second one deals with the $9$ -dimensional quantum billiard for $D =10$ gravitational model with one scalar field, $210$ four-forms and $120$ three-forms which mimic space-like $D2$ -, $D4$ -, $FS1$ - and $NS5$ -branes in $D = 10$ $II A$ supergravity. It is shown that in both examples wave functions vanish in the limit of the formation of the billiard walls (i.e. we get a quantum resolution of the singularity for $11D$ model) but magnetic branes could not be neglected in calculations of quantum asymptotic solutions while they are irrelevant for classical oscillating behavior when all $120$ electric branes are present.     

All-carbon detector with buried graphite pillars in CVD diamond

A diamond detector of 3D architecture without any metallization is developed for spectroscopy of ionizing radiation and single particles detection. The carbon electrode system was fabricated using a femtosecond infrared laser ( $\lambda $ = 1,030 nm) to induce graphitization on the surface and inside 4.0  $\times $  4.0  $\times $  0.4 mm $^{3}$ single-crystal chemical vapor deposition diamond slab, resulting in an array of 84 buried graphite pillars of 30  $\upmu $ m diameter formed orthogonally to the surface and connected by surface graphite strips. Sensitivity to ionizing radiation with $^{90}$ Sr $\upbeta $ -source has been measured for the 3D detector and high charge collection efficiency is demonstrated.