共查询到20条相似文献,搜索用时 15 毫秒
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LIU Zhihui WANG Yingnan SUN Jingbo YANG Yang LIU Qingwen LIU Zaiqun SONG Zhiguang 《高等学校化学研究》2015,31(4):526-533
In this study, we synthesized a series of 3-triazolo-coumarins and evaluated their antioxidant activities respectively by two methods: trapping 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical(ABTS+·) and oxidation of DNA which was induced by Cu2+/glutathione(GSH), ·OH and 2,2'-azobis(2-amidinopropane hydrochloride)(AAPH). Among the nine 3-triazolo-coumarins, compounds 6c and 6f―6i were synthesized for the first time, which exhibited the capability of terminating radical propagation-chains in oxidation of DNA induced by AAPH. In this study, we found that phenethylamine moiety, hydroxyl and ortho-methoxy are the key groups to enhance the antioxidant activities of compounds. 相似文献
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A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP)calcium channel antagonists felodipme, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde,methyl acetoacetate and ethyl 3-aminocrotonate was developed.Operational simplicity,mild reaction conditions and eco-friendliness are the key features of this protocol. 相似文献
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Xiao Yun Wu 《合成通讯》2013,43(3):454-459
l,4-Dihydropyridine derivatives were synthesized from the one-pot condensation of aldehydes, acetoacetates, and ammonium acetate in room-temperature ionic liquid n-butyl pyridinium tetrafluoroborate ([BPy][BF4]). Compared with classical Hantzsch reaction conditions, this new method has the advantage of excellent yields, short reaction time, and easy workup. The recovered ionic liquid could be recycled for at least five runs without losing its activity. 相似文献
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1,4-二氢Hantzsch吡啶衍生物的合成及其1H NMR和荧光光谱研究 总被引:3,自引:0,他引:3
报道了N-甲基-4-芳基-2,6-二甲基-3,5-二乙酯基-1,4-二氢吡啶(2a-2f),4-芳基-2,6-二苯基-3,5-二乙酯基-1,4-二氢吡啶(3a-3f)及其相应的N-甲基化合物(4a-4f)的合成(芳基p-RC6H4-;R=OCH3,CH3,H,Cl,CN,NO2).化合物4-芳基-2,6-二甲基-3,5-二乙酯基-1,4-二氢吡啶(1a-1f)可发射较强的荧光,化合物3呈现较弱的荧光,它们的氮甲基产物2和4没有荧光.化合物4氮甲基质子的化学位移值比其相对应的化合物2氮甲基质子的化学位移值向高场移动0.6~0.7.化合物3的4-位次甲基质子的化学位移变化与同碳苯基对位取代基的σ+P有相当好的关联.这些现象反映了化合物2-4的特征构象. 相似文献
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LI Kang BI Kai-shun 《高等学校化学研究》2006,22(1):56-60
IntroductionTraditionally,Di-Gu-Pi has been used as a naturaltherapeutic agent for the treatment of diabetes,hemor-rhagic inframmation,hypertension,ulcers,and feverunder the guidance of the theory of Traditional ChineseMedicinal(TCM)science[1].This fact h… 相似文献
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在Yb(NO3)3催化下, 芳香醛、 5,5-二甲基-1,3-环己二酮、 乙酰乙酸乙酯和醋酸铵在室温无溶剂条件下经超声辐射一锅法合成了一系列1,4-二氢吡啶衍生物, 反应时间为15~35 min, 产率为86%~97%. 该方法具有条件温和、 反应时间短且产率高的优点. 催化剂Yb(NO3)3对环境友好且可循环使用, 为此类化合物的合成提供了一种有效的新方法. 相似文献
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油酸新戊二醇癸二酸混合酯的合成及其性能研究 总被引:1,自引:0,他引:1
以新戊二醇(NPG)和癸二酸(SA)为原料,经酯化反应合成了"寡聚物"(1),测定1的寡聚度(m)。当n(NPG)∶n(SA)=1.4~3.0时,1的m在5.44~1.61,收率95%以上。将1与油酸进行酯化得到混合酯(2),收率83%~89%。测定了2的粘度和热氧化稳定性,结果表明2的粘度随着m的增大而增大,热氧化稳定性随m的增大而提高。2在40℃的粘度为(116~273)mm2.s-1,粘度指数均超过200,凝点低于-40℃。1和2的结构经IR表征。 相似文献
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标题化合物C19H23NO5由间羟基苯甲醛、碳酸氢铵、乙酰乙酸乙酯在乙醇溶剂中回流制备.结构通过单晶X-射线衍射法测定,其晶体属三斜晶系,空间群Pi,a=7.4550(15),b=8.9780(18),c=14.099(3)(A),α=80.22(3),β=86.72(3),γ=68.62(3)°, V=865.9(3)(A)3, Z=2, Mr=345.38, Dc=1.325g/cm3, F(000)=368. 晶体结构用直接法解出,经全矩阵最小二乘法对原子参数进行修正,最终的偏离因子为R1=0.0633,wR2=0.1709[I>2σ(I)].在晶体结构中,二氢吡啶环与苯环之间的二面角为90.0(2)°,分子通过氢键形成有隧道的一维超分子结构. 相似文献
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激光染料分子——香豆素系列化合物【‘-‘1,8一经甲基香豆素衍生物【‘,’1的相变温度和相变偿分别与其母体7一位、6一位取代基团特性有着相互依赖关系.本文采用DSC法研究了2、3和4一甲氧基苯丙烯酸及个经基一3一甲氧基苯丙烯酸防们分别简称为1、D、m和w)在升温过程中的相变热力学特性,并对它们的结构与其热力学参数之间的关系进行了简要地分析.苯丙烯酸1、H、m和w的结构上。下:1实验部分1.1试样来源合成得到的试样,经鉴定其结构与分子式相符,并经元素分析测定,测定值与理论值相一致,表明试样具有较高纯度.1.2实验方法P… 相似文献
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A facile solid‐phase extraction (SPE) method based on bare Fe3O4 magnetic nanoparticles (Fe3O4 NPs) was developed to capture cinnamic acid (CA) from a well‐known traditional Chinese medicine, Ramulus cinnamomi, for high performance liquid chromatography (HPLC) analysis. The as‐prepared Fe3O4 NPs were characterized via Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). Several parameters that influence CA extraction rate, such as the amount of Fe3O4 NPs, shaking time, methanol content, eluent pH, and elution time, were investigated. The experimental results show that the CA extraction was 86.9 % at optimal condition, and the mass yield of CA extraction was found to be 0.00021 %. This study demonstrates that the developed CA extraction method is simple, cheap and environmentally friendly. Therefore, the proposed method has a potential for CA separation and purification from complex biological samples. 相似文献
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Different 4-substituted 1,4-dihydropyridines have been oxidized to pyridine derivatives by n-butyltriphenyl phosphonium peroxodisulfate in acetonitrile solution at reflux condition.Formation of two kinds of products has been observed depending on the type of 4-substituent. 相似文献
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以取代邻硝基苯甲酸为起始原料,与二氯亚砜反应制得邻硝基苯甲酰氯,再与苯胺在碱性条件下反应制得酰胺衍生物(6a~6d);以醋酸钯为催化剂,6a~6d经NBS溴代制得溴代衍生物(7a~7d); 7a~7d依次经N-烷基化反应,还原反应和分子内C-N键环合反应合成了10个新型的1,4-二苯并二氮杂酮类化合物(10a~10j),产率61%~78%,其结构经1H NMR, 13C NMR和HR-MS(ESI)表征。初步体外活性测试结果表明:10a~10j对非小细胞肺癌细胞(A549),人乳腺癌细胞(MDA-MB-231)和宫颈癌细胞(HeLa)均有抑制作用。其中,10g和10i对A549, 10g对MDA-MB-231, 10h和10i对HeLa的抑制率大于50%。 相似文献