Modeling the acoustic radiation force in microfluidic chambers

A procedure is demonstrated to quantitatively evaluate the acoustic radiation forces in microfluidic particle manipulation chambers. Typical estimates of the acoustic pressure and the acoustic radiation force are based on an analytical solution for a simple one-dimensional standing wave pattern. The complexities of a typical microfluidic channel limit the usefulness of this approach. By leveraging finite elements, and a generalized equation for the acoustic radiation force, channel designs can be investigated in two and three dimensions. Calculations and experimental observations in this report and the literature, confirm these claims.     

利用声辐射模态对声场进行重构

声辐射模态是定义在振动表面上的一组互相独立的基函数,描绘了振动表面的多极子辐射模式。本文利用声辐射模态对平板辐射的声场进行重构，并同时就频率和模态数对误差的影响进行了分析。针对复杂振动表面幅射的声场，重构时需正则化处理。数值计算结果和对应的理论值达到很好的吻合。     

Multifrequency radiation force of acoustic waves in fluids

In this article we introduce the concept of multifrequency radiation force produced by a polychromatic acoustic beam propagating in a fluid. This force is a generalization of dynamic radiation force due to a bichromatic wave. We analyse the force exerted on a rigid sphere by a plane wave with N frequency components. Our approach is based on solving the related scattering problem, taking into account the nonlinearity of the fluid. The radiation force is calculated by integrating the excess of pressure in the quasilinear approximation over the surface of the sphere. Results reveal that the spectrum of the multifrequency radiation force is composed of up to N(N−1)/2 distinct frequency components. In addition, the radiation force generated by plane progressive waves is predominantly caused by parametric amplification. This is a phenomenon due to the nonlinear nature of wave propagation in fluids.     

On the possibility of using acoustic reverberation for remote sensing of ocean dynamics

The two-point correlation function of diffuse noise fields produced by distributed random sound sources carries useful information on the medium of sound propagation. Such information can be used for performing passive acoustic tomography of the ocean. In a number of cases that are important for practice, the noise field in the ocean is predominated by contributions of individual point sources. Here, a theoretical study is presented on the possibility of determining the sound speed and current velocity in the water column by the correlation processing of reverberation signals measured by two vertical receiving arrays. In other words, we study the possibility of replacing the diffuse noise produced by a great number of delta-correlated sources by waves generated by a localized source and scattered at the rough surface and bottom of the ocean for sensing the medium. The correlation function of scattered waves is calculated by using the method of small perturbations. It is shown that the correlation processing of the scattered waves offers an opportunity of measuring the acoustic nonreciprocity and reconstructing the field of sound speed in the fluid, without using any acoustiLc transceivers.     

On the contribution of circumferential resonance modes in acoustic radiation force experienced by cylindrical shells

A body insonified by a constant (time-varying) intensity sound field is known to experience a steady (oscillatory) force that is called the steady-state (dynamic) acoustic radiation force. Using the classical resonance scattering theorem (RST) which suggests the scattered field as a superposition of a resonance field and a background (non-resonance) component, we show that the radiation force acting on a cylindrical shell may be synthesized as a composition of three components: background part, resonance part and their interaction. The background component reveals the pure geometrical reflection effects and illustrates a regular behavior with respect to frequency, while the others demonstrate a singular behavior near the resonance frequencies. The results illustrate that the resonance effects associated to partial waves can be isolated by the subtraction of the background component from the total (steady-state or dynamic) radiation force function (i.e., residue component). In the case of steady-state radiation force, the components are exerted on the body as static forces. For the case of oscillatory amplitude excitation, the components are exerted at the modulation frequency with frequency-dependant phase shifts. The results demonstrate the dominant contribution of the non-resonance component of dynamic radiation force at high frequencies with respect to the residue component, which offers the potential application of ultrasound stimulated vibro-acoustic spectroscopy technique in low frequency resonance spectroscopy purposes. Furthermore, the proposed formulation may be useful essentially due to its intrinsic value in physical acoustics. In addition, it may unveil the contribution of resonance modes in the dynamic radiation force experienced by the cylindrical objects and its underlying physics.     

利用k-Wave计算超声在腹壁组织的声辐射力

随着科学技术的发展,声辐射力在生物医学领域得到了更为广泛的应用,尤其是在弹性成像领域.为了使弹性成像技术更加精准,对声辐射力的预测至关重要.该文基于腹壁组织图像,利用k-Wave对超声波在腹壁组织区域传播时的声场进行数值模拟,获得了其声场分布,进而求得了组织中声辐射力分布情况,同时对面阵换能器的阵元宽度、间距、阵元个数...     

Parametric amplification of the dynamic radiation force of acoustic waves in fluids

We report on parametric amplification in dynamic radiation force produced by a bichromatic acoustic beam in a fluid. To explain this effect we develop a theory taking into account the nonlinearity of the fluid. The theory is validated through an experiment to measure the dynamic radiation force on an acrylic sphere. Results exhibit an amplification of 66 dB in water and 80 dB in alcohol as the difference of the frequencies is increased from 10 Hz to 240 kHz.     

Frequency dependence of the acoustic radiation force acting on absorbing cylindrical shells

The frequency dependence of the radiation force function Y(p) for absorbing cylindrical shells suspended in an inviscid fluid in a plane incident sound field is analysed, in relation to the thickness and the content of their interior hollow region. The theory is modified to include the effect of hysteresis type absorption of compressional and shear waves in the material. The results of numerical calculations are presented for two viscoelastic (lucite and phenolic polymer) materials, with the hollow region filled with water or air indicating how damping and change of the interior fluid inside the shell's hollow region affect the acoustic radiation force. The acoustic radiation force acting on cylindrical lucite shells immersed in a high density fluid (in this case mercury) and filled with water in their hollow region, is also studied.     

Reduction of sound radiation by using force radiation modes

The location of a vibration source within a machine is sometimes found to have a significant effect upon its radiated acoustic power. It is known that a simple reduction of vibration cannot always reduce the radiated acoustic power, so that treatments based on analysis of a structure’s vibration modes are not always effective. At the same time, radiation mode analysis is known to be a powerful tool for interpreting sound radiation since those modes are independent of a structure’s surface vibration. However, knowledge of the radiation modes alone cannot be used directly to understand the relationship between vibration source location and acoustic power radiation. In this paper, it is shown that the radiation mode concept can be extended to understand the relationship between acoustic power and driving force distribution by considering the product of the structure’s mobility matrix and the radiation modes: the resulting functions are here defined to be force radiation modes (f_rad-modes). An example is presented in which the acoustic power radiated by a simply-supported, baffled beam is reduced by using guidance provided by the structure’s force radiation modes. The results demonstrate that the force radiation modes can be used to guide the reduction of radiated acoustic power by changing the driving force location without the need to perform additional calculations or experiments.     

On the time filtering of Mössbauer radiation using thermally relaxing acoustic field

Time filtering effect of a thermally relaxing acoustic field on Mössbauer radiation has been considered theoretically. Contrary to general expectation, a relaxing acoustic field results in broadening of Mössbauer line. Origin of this line broadenig is an uncertainty in phonon energy, introduced as a result of the relaxation of the acoustic field.     

Internal deformation of a uniform elastic solid by acoustic radiation force

Tissue elasticity estimation is a growing area of ultrasound research. One proposed approach would apply acoustic radiation force to displace tissue and use ultrasonic motion tracking techniques to measure the resultant displacement. Such a technique might allow noninvasive imaging of tissue elastic properties. The potential of this method will be limited by the magnitude of displacements which can be generated at reasonable acoustic intensity levels. This paper presents methods for estimating the internal displacements induced in an elastic solid by acoustic radiation force. These methods predict displacements on the order of 400 microns in the human vitreous body, 0.008 micron in human breast, and 0.020 micron in human liver at an acoustic intensity of 1.0 W/cm2 (in water) and an operating frequency of 10 MHz. While the displacement generated in the vitreous should be readily detectable using ultrasonic methods, the displacements generated in the breast and liver will be much more difficult to detect. Methods are also developed for predicting the time dependent temperature increases associated with attenuated acoustic fields in the absence of perfusion. These results indicate promise for radiation force imaging in the vitreous, but potential difficulties in applying these techniques in other parts of the body.     

平面行波场中多个粒子受到的声辐射力*

从粒子在行波场中的声散射出发,研究当声场中存在稀疏分布的多个粒子时粒子受到的声辐射力,并且给出了适用于声场中任意位置的粒子声辐射力计算公式。由于声辐射力为非线性力,当声场中存在多个粒子时,直接计算粒子受到的声辐射力非常复杂。结果表明,当声场中存在多个稀疏分布的粒子时,这一多粒子系统可以视为多个单独的双粒子系统的叠加,只需要分别计算各个双粒子系统的声辐射力就可以通过叠加得到声场中任意粒子的声辐射力。这一结果有助于利用声辐射力对微小粒子进行精细操控。     

Contactless and non-invasive delivery of micro-particles lying on a non-customized rigid surface by using acoustic radiation force

In the existing acoustic micro-particle delivery methods, the micro-particles always lie and slide on the surface of platform in the whole delivery process. To avoid the damage and contamination of micro-particles caused by the sliding motion, this paper deals with a novel approach to trap micro-particles from non-customized rigid surfaces and freely manipulate them. The delivery process contains three procedures: detaching, transporting, and landing. Hence, the micro-particles no longer lie on the surface, but are levitated in the fluid, during the long range transporting procedure. It is very meaningful especially for the fragile and easily contaminated targets. To quantitatively analyze the delivery process, a theoretical model to calculate the acoustic radiation force exerting upon a micro-particle near the boundary in half space is built. An experimental device is also developed to validate the delivery method. A 100 μm diameter micro-silica bead adopted as the delivery target is detached from the upper surface of an aluminum platform and levitated in the fluid. Then, it is transported along the designated path with high precision in horizontal plane. The maximum deviation is only about 3.3 μm. During the horizontal transportation, the levitation of the micro-silica bead is stable, the maximum fluctuation is less than 1 μm. The proposed method may extend the application of acoustic radiation force and provide a promising tool for microstructure or cell manipulation.     

椭球粒子声辐射力计算及分析

针对水下椭球粒子,以声散射理论为基础,采用分波序列的方法,建立了椭球粒子声辐射力的理论计算模型。进而根据声辐射力计算公式,以刚性椭球粒子和液体椭球粒子为例,计算并分析不同Bessel波束作用下椭球粒子的轴向声辐射力函数特征。数值仿真计算结果表明,对于刚性椭球粒子,扁平椭球粒子相对于细长椭球粒子更有助于激发负声辐射力;对于液体椭球粒子,细长椭球粒子相对于扁平椭球粒子更加容易产生负声辐射力;对于不同介质的椭球粒子,不同的入射波束激发的负声辐射力的效果也存在明显的差异。该结果为复杂的尺寸和介质粒子声操控技术提供了理论的可行性。     

Estimation of mechanical properties of a viscoelastic medium using a laser-induced microbubble interrogated by an acoustic radiation force

An approach to assess the mechanical properties of a viscoelastic medium using laser-induced microbubbles is presented. To measure mechanical properties of the medium, dynamics of a laser-induced cavitation microbubble in viscoelastic medium under acoustic radiation force was investigated. An objective lens with a 1.13 numerical aperture and an 8.0 mm working distance was designed to focus a 532 nm wavelength nanosecond pulsed laser beam and to create a microbubble at the desired location. A 3.5 MHz ultrasound transducer was used to generate acoustic radiation force to excite a laser-induced microbubble. Motion of the microbubble was tracked using a 25 MHz imaging transducer. Agreement between a theoretical model of bubble motion in a viscoelastic medium and experimental measurements was demonstrated. Young's modulii reconstructed using the laser-induced microbubble approach were compared with those measured using a direct uniaxial method over the range from 0.8 to 13 kPa. The results indicate good agreement between methods. Thus, the proposed approach can be used to assess the mechanical properties of a viscoelastic medium.     

结构声辐射的振动模态分析和声辐射模态分析研究

基于辐射声功率的二次型表达式,采用有限元法、Rayleigh积分和边界元法对结构声辐射进行了振动模态分析和声辐射模态分析研究。振动模态间的耦合对辐射声功率影响的研究表明:结构各阶振动模态自身对结构辐射声功率的贡献是增大结构的辐射声功率,而振动模态间的耦合可能会增大结构辐射声功率,也可能会减小结构辐射声功率,或对辐射声功率没有影响。而且,当振动模态间的耦合作用对辐射声功率的影响不大时,采用振动模态控制可取得较好的减振降噪双重控制效果。将混合的Helmholtz积分方程方法用广义逆引入到三维复杂结构声辐射分析的声辐射模态公式中,解决了特征频率下解不唯一问题。还研究了正方形封闭空间结构声辐射模态的辐射效率和形状,并对结构声辐射的振动模态控制和声辐射模态控制进行了讨论。     

Scheme of negative acoustic radiation force based on a multiple-layered spherical structure

Acoustic radiation force(ARF), as an important particle manipulation method, has been extensively studied in recent years. With the introduction of the concept of “acoustic tweezers”, negative acoustic radiation has become a research hotspot. In this paper, a scheme of realizing negative ARF based on the multiple-layered spherical structure design is proposed. The specific structure and design idea are presented. Detailed theoretical calculation analysis is carried out.Numerical simulations have...     

Dynamic acoustic radiation force acting on cylindrical shells: theory and simulations

An object placed in an acoustic field is known to experience a force due to the transfer of momentum from the wave to the object itself. This force is known to be steady when the incident field is considered to be continuous with constant amplitude. One may define the dynamic (oscillatory) radiation force for a continuous wave-field whose intensity varies slowly with time. This paper extends the theory of the dynamic acoustic radiation force resulting from an amplitude-modulated progressive plane wave-field incident on solid cylinders to the case of solid cylindrical shells with particular emphasis on their thickness and contents of their hollow regions. A new factor corresponding to the dynamic radiation force is defined as Y(d) and stands for the dynamic radiation force per unit energy density and unit cross sectional surface. The results of numerical calculations are presented, indicating the ways in which the form of the dynamic radiation force function curves are affected by variations in the material mechanical parameters and by changes in the interior fluid inside the shell's hollow region. It was shown that the dynamic radiation force function Y(d) deviates from the static radiation force function for progressive waves Y(p) when the modulation frequency increases. These results indicate that the theory presented here is broader than the existing theory on cylinders.     

自由空间中球形粒子的负向声辐射力

针对一定声场作用下自由空间中的球形粒子,首先分析了声散射过程中的吸收声功率、散射声功率和损失声功率以及三者之间的关系,并通过计算发现了由于参数选取不当导致的负吸收现象。接着从动量守恒定律出发推导了声辐射力的一般表达式,阐释了声辐射力与声能流之间的关系,并从理论和计算两方面验证了负向声辐射力的存在。当负向声辐射力产生时,声波的背向散射被抑制。在此基础上,进一步研究了粒子的偏心特性和流体的黏度这两种常见因素对负向声辐射力的影响。利用球函数的加法公式推导了偏心球的散射系数和声辐射力公式,结果显示偏心距离、粒子的材料等都会显著改变负向声辐射力的产生条件。在低频近似下,由于流体黏度附加的正向声辐射力是否能完全抵消原来的负向声辐射力将决定最终的声辐射力方向。该结果对利用负向声辐射力制成单行波声学镊子来实现对特定粒子的操控有着理论指导意义。