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1.
Nargis Jamila Melati Khairuddean Sadiq Noor Khan Naeem Khan 《Magnetic resonance in chemistry : MRC》2014,52(7):345-352
The genus Garcinia is reported to possess antimicrobial, anti‐inflammatory, anticancer, hepatoprotective and anti‐HIV activities. Garcinia hombroniana in Malaysia is used to treat itching and as a protective medicine after child birth. This study was aimed to isolate the chemical constituents from the bark of G. hombroniana and explore their possible pharmacological potential. Ethyl acetate extract afforded one new (1) and six (2–7) known 3 → 8 rotameric biflavonoids. Their structures were elucidated by UV, IR and NMR (1D and 2D) spectroscopy together with electron ionization/ESI mass spectrometric techniques and were identified as (2R, 3S) volkensiflavone‐7‐O‐rhamnopyranoside (1), volkensiflavone (2), 4″‐O‐methyl‐volkensiflavone (3), volkensiflavone‐7‐O‐glucopyranoside (4), morelloflavone (5), 3″‐O‐methyl‐morelloflavone (6) and morelloflavone‐7‐O‐glucopyranoside (7). The absolute configuration of compound 1 was assigned by circular dichroism spectroscopy as 2R, 3S. The coexistence of conformers of isolated biflavonoids in solution at 25 °C in different solvents was confirmed by variable temperature NMR studies. At room temperature (25 °C), compounds 1–7 exhibited duplicate NMR signals, while at elevated temperature (90 °C), a single set of signals was obtained. Compound 5 showed significant in vitro antioxidant activities against 1,1‐diphenyl‐2‐picrylhydrazyl and 2,2′‐azino‐bis‐3‐ethyl benzthiazoline‐6‐sulfonic acid radicals. The antibacterial studies showed that compounds 5 and 6 are the most active against Staphylococcus aureus, Bacillus subtilis and Escherichia coli. Compounds 3 and 6 also showed moderate antituberculosis activity against H38Rv. Based on the research findings, G. hombroniana could be concluded as a rich source of flavanone–flavone (3 → 8) biflavonoids that exhibit rotameric behaviour at room temperature and display significant antioxidant and antibacterial activities. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
2.
M. Concepción Lozada Simón Hernández‐Ortega María Luisa Villarreal Dino Gnecco Raúl G. Enríquez William Reynolds 《Magnetic resonance in chemistry : MRC》2012,50(1):52-57
From the stem bark of Mangifera indica, seven cycloartane‐type secondary metabolites were isolated. Compound 1 has been isolated for the first time from M. indica, whereas compounds 2 (2a and 2b, as an epimeric mixture), 3, and 4 are new triterpenoid‐type cycloartanes. Unambiguous 13C and 1H NMR assignments for these compounds and the known compounds mangiferonic acid (compound 5), isomangiferolic acid (compound 6), ambolic acid (compound 7), and friedelin (compound 8) are reported; the latter because full NMR data for these compounds are not available in the literature. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
3.
Phan Van Kiem Chau Van Minh Nguyen Xuan Nhiem Nguyen Thi Cuc Ngo Van Quang Hoang Le Tuan Anh Bui Huu Tai Pham Hai Yen Nguyen Thi Hoai Kim Young Ho Nanyoung Kim SeonJu Park Seung Hyun Kim 《Magnetic resonance in chemistry : MRC》2014,52(1-2):51-56
Seven new muurolane‐type sesquiterpenes, (4R,5R)‐muurol‐1(6),10(14)‐diene‐4,5‐diol (1), (4R,5R)‐muurol‐1(6)‐ene‐4,5‐diol (2), (4R,5R,10R)‐10‐methoxymuurol‐1(6)‐ene‐4,5‐diol (3), (4S)‐4‐hydroxy‐1,10‐seco‐muurol‐5‐ene‐1,10‐dione (4), (4R)‐4‐hydroxy‐1,10‐seco‐muurol‐5‐ene‐1,10‐dione (5), (6S,10S)‐6,10‐dihydroxy‐7,8‐seco‐2,8‐cyclo‐muurol‐4(5),7(11)‐diene‐12‐oic acid (6), and (6R,10S)‐6,10‐dihydroxy‐7,8‐seco‐2,8‐cyclo‐muurol‐4(5),7(11)‐diene‐12‐oic acid (7) were isolated from the marine sponge Dysidea cinerea. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D‐NMR, 2D‐NMR, and CD spectra as well as by comparing the NMR data with those reported in the literature. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
4.
Dan Zheng Li Han Yi Jiang Yan‐Ru Cao Jiang Liu Xiu Chen Yi‐Qing Li Xue‐Shi Huang 《Magnetic resonance in chemistry : MRC》2013,51(3):188-191
Four new prenylindole derivatives, (R)‐6‐(2,3‐dihydroxy‐3‐methylbutyl)indole (1), (R)‐6‐(2,3‐dihydroxy‐3‐methylbutyl)indolin‐2‐one (2), and an unseparated mixture of (Z)‐6‐(4‐hydroxy‐3‐methylbut‐2‐en‐1‐yl)indolin‐2‐one (3a) and (E)‐6‐(4‐hydroxy‐3‐methylbut‐2‐en‐1‐yl)indolin‐2‐one (3b) with a ratio of 3 : 2, were isolated from the culture broth of a streptomycete isolated from Ailuropoda melanoleuca feces. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic techniques. The absolute configuration of 1 was determined by Mosher's method. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
5.
Nguyen Xuan Nhiem Hwa Young Lee Nan Young Kim Seon Ju Park Eun Sil Kim Jeong Eun Han Heejung Yang Seung Hyun Kim 《Magnetic resonance in chemistry : MRC》2012,50(11):772-777
The chemical study of the leaves and twigs of Viscum album led to the isolation of five new lignan glycosides, namely, ligalbumosides A–E (2‐6) and one known lignan glycoside, alangilignoside C (1). The structures of five new lignan glycosides were determined to be (7R,8S,8'S)‐4,9,4'‐trihydroxy‐3,5,3',5'‐tetramethoxy‐7,9'‐epoxylignan 9‐O‐β‐D‐glucopyranoside (2), (7S,8S,7'S,8'R)‐4,9,4'‐trihydroxy‐3,5,3',5',7'‐pentamethoxy‐7,9'‐epoxylignan 9‐O‐β‐D‐glucopyranoside (3), (7R,8R,7'S,8'S)‐4,9,4'‐trihydroxy‐3,5,3',5',7'‐pentamethoxy‐7,9'‐epoxylignan 9‐O‐β‐D‐glucopyranoside (4), (7S,8R,7'S,8'R)‐4,9,4'‐trihydroxy‐3,5,3',5',7'‐pentamethoxy‐7,9'‐epoxylignan 9‐O‐β‐D‐glucopyranoside (5), and (7R,8S,7'R,8'S)‐4,9,4',7'‐tetrahydroxy‐3,5,3',5'‐tetramethoxy‐7,9'‐epoxylignan 9‐O‐β‐D‐glucopyranoside (6) using 1D‐, 2D‐NMR, and CD spectra, chemical methods, as well as comparing the results with those reported in the literature. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
6.
《Magnetic resonance in chemistry : MRC》2003,41(12):975-982
The reaction of 2,4‐pentanedione ( 1 ) with (R)‐(—)‐2‐phenylglycine methyl ester ( 2 ), (R)‐(—)‐2‐phenylglycinol ( 3 ) and the proteinogenic amino acids (2S,3R)‐(—)‐2‐amino‐3‐hydroxybutyric acid (L ‐threonine) ( 4 ) and (R)‐(—)‐2‐amino‐3‐mercaptopropionic acid (L ‐cysteine) ( 5 ) methyl esters was investigated. The corresponding enamines 6 , 7 and 8 were isolated and characterized spectroscopically whereas 9 , which is unstable, was transformed in situ into 13 . Treatment of 7 , 8 and 9 with boron trifluoride etherate afforded the new [1,4]oxazepines 10 , 11 and [1,4]thiazepine ( 12 ) as their BF3O? salts. The structures of the enamines and their corresponding seven‐membered heterocycles were assessed by 1D and 2D NMR spectroscopy. Variable‐temperature experiments revealed different molecular mobility behavior among these heterocycles. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
7.
Sesquiterpenoids from Chloranthus spicatus (Thunb.) Makino 总被引:2,自引:0,他引:2
Two new sesquiterpenoids, namely 1β,4β-dihydroxy-5 α,8β(H)-eudesm-7(11)Z-en-8,12-olide (1) and 1β,4α-dihydroxy-5α,8β(H)-eudesm-7(11)Z-en-8,12-olide (2), along with six known ones, homalomenol A (3), oplodiol (4), 5α,7α(H)-6,8-cycloeudesma-1β,4β-diol (5), oplopanone (6), 4β,10α-dihydroxyaromadendrane (7) and spathulenol (8), were isolated from the aerial part of Chloranthus spicatus (Thunb.) Makino, and their structures were established by spectroscopic methods. 相似文献
8.
Yiguang Chen Xiaoling Cai Jiahui Pan Junping Gao Jing Li Jie Yuan Liwu Fu Zhigang She Yongcheng Lin 《Magnetic resonance in chemistry : MRC》2009,47(4):362-365
The structure elucidations and complete 1H and 13C NMR assignments are reported for three new anthraquinone derivatives: Fusaquinon A (1), B (2), and C (3) isolated from the fermentation medium of the marine fungus Fusarium sp. (No. ZH‐210). HREIMS, Fourier transform infrared absorption spectrometry (FT‐IR), NMR experiments including gCOSY, gHMQC, gHMBC, and NOESY were used for the determination of the structures and NMR spectral assignments. Preliminary pharmacological test showed that they exhibited low cytotoxic activity towards KB, KBv200, and MCF‐7 cell lines. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
9.
Xiao‐Dong Li Feng‐Ping Miao Xiao‐Rui Liang Nai‐Yun Ji 《Magnetic resonance in chemistry : MRC》2014,52(5):247-250
One new meroterpene, arisugacin K (1), and four known ones, arisugacin J (2), arisugacin G (3), arisugacin C (4), and territrem C (5), were isolated from the culture of Penicillium echinulatum pt‐4, an endophytic fungus isolated from the marine red alga Chondrus ocellatus. The structure and the absolute configuration of 1 were unambiguously elucidated by spectroscopic analyses and quantum chemical calculations, which further resulted in the assignments of absolute configurations for the other arisugacins and territrems. Compound 1 showed inhibitory activity against Escherichia coli with an inhibition diameter 8 mm at 30 µg/disk and 4 exhibited lethality against Artemia salina with an LC50 of 48.6 µg/ml. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
10.
Structure determination of two new indole‐diterpenoids from Penicillium sp. CM‐7 by NMR spectroscopy
Yu‐Hong Zhang Sheng‐Dong Huang Hua‐Qi Pan Xi‐Qing Bian Zai‐Ying Wang Ai‐Hong Han Jiao Bai 《Magnetic resonance in chemistry : MRC》2014,52(6):306-309
Two new indole‐diterpenoids 4b‐deoxy‐1′‐O‐acetylpaxilline (1) and 4b‐deoxypenijanthine A (2) were isolated from the fermentation broth and the mycelia of the soil fungus Penicillium sp. CM‐7, along with three known structurally related compounds, 1′‐O‐acetylpaxilline (3), paspaline (4) and 3‐deoxo‐4b‐deoxypaxilline (5). The structures of compounds 1 and 2 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
11.
Antje Bodensieck Olaf Kunert Ernst Haslinger Rudolf Bauer 《Helvetica chimica acta》2007,90(1):183-195
A total of 21 natural products, 1 – 21 , were isolated from a supercritical CO2 extract of the rhizomes of Petasites hybridus. Thereby, seven new eremophilane (= (1S,4aR,7R,8aR)‐decahydro‐1,8a‐dimethyl‐7‐(1‐methylethyl)naphthalene) sesquiterpenes, compounds 4, 5, 9, 11, 12, 15 , and 17 , were identified. The new constituent 9‐hydroxyisobakkenolide ( 15 ) is the first representative of a group of compounds closely related to the well‐known, but rare, bakkenolides. Tsoongianolide B ( 18 ) and its degradation product ligularenolide ( 19 ) were found as new Petasites constituents as well. The known eremophilanolide 2 was isolated from a plant source for the first time and the oxofuranopetasin 16 was isolated for the first time from the rhizomes of P. hybridus, together with eight other known compounds. The C(8)‐epimeric 2‐[(tigloyl)oxy]eremophilanolides 3 and 8 could clearly be differentiated. All structures were established by extensive 1D‐ and 2D‐NMR experiments (Tables 1–3), and confirmed by in‐depth GC/MS and HPLC/MS experiments. 相似文献
12.
Fazuo Wang Tianjiao Zhu Min Zhang Aiqun Lin Weiming Zhu Qianqun Gu 《Magnetic resonance in chemistry : MRC》2010,48(2):155-158
Three new furan and pyran derivatives named aspericins A? C (1–3), as well as a known asperic acid (4), have been isolated from the marine‐derived fungus Rhizopus sp. 2‐PDA‐61. The complete 1H and 13C NMR assignments for the new compounds were carried out using 1H, 13C, DEPT, COSY, HMQC, HMBC, and NOESY NMR experiments. Compounds 1–3 were evaluated for their cytotoxic activities on P388, A549, HL‐60, and BEL‐7420 cell lines by the MTT and SRB methods. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
13.
Wei Li Shisheng Wang Jiatao Feng Yuansheng Xiao Xingya Xue Hui Zhang Yaqin Wang Xinmiao Liang 《Magnetic resonance in chemistry : MRC》2009,47(10):902-908
Thirteen curcuminoids (1–13) were isolated from the rhizomes of Curcuma longa. Among them, 1,5‐dihydroxy‐1,7‐bis(4‐hydroxyphenyl)‐4,6‐heptadiene‐3‐one (1), 1,5‐dihydroxy‐1‐(4‐hydroxy‐3‐methoxyphenyl)‐7‐(4‐hydroxyphenyl)‐4,6‐heptadiene‐3‐one (2), 1,5‐dihydroxy‐1‐(4‐hydroxyphenyl)‐7‐(4‐hydroxy‐3‐methoxyphenyl)‐4,6‐heptadiene‐3‐one (3), and 3‐hydroxy‐1,7‐bis‐(4‐hydroxyphenyl)‐6‐heptene‐1,5‐dione (4) are new compounds, and 1‐(4‐hydroxyphenyl)‐7‐(3, 4‐dihydroxyphenyl)‐1, 6‐heptadiene‐3, 5‐dione (5) is isolated from natural sources for the first time. The structures of these compounds were elucidated by extensive spectroscopic analyses, especially 1D and 2D NMR spectroscopy. The 13C NMR data and complete 1H and 13C NMR assignments of some known compounds are reported for the first time. In addition, the errors of 1H and 13C assignments reported in the literature were corrected. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
14.
Xiao‐Dong Li Wei Ding Feng‐Ping Miao Nai‐Yun Ji 《Magnetic resonance in chemistry : MRC》2012,50(2):174-177
Three new halogenated chamigrane sesquiterpenes, laurokamin A (1), laurokamin B (2), and laurokamin C (3), and four known halogenated chamigrane sesquiterpenes, 10‐bromo‐α‐chamigrene (4), 10‐bromo‐β‐chamigrene (5), 2,10‐dibromo‐3‐chloro‐β‐chamigrene (6), and obtusane (7), were isolated from the marine red alga Laurencia okamurae collected from the coast of Rongcheng, China. The structures of these compounds were unambiguously identified by one‐ and two‐dimensional NMR and mass spectroscopic methods. The antimicrobial activity of compounds 1–3 was evaluated. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
15.
Zhang‐Gui Ding Jiang‐Yuan Zhao Pei‐Wen Yang Ming‐Gang Li Rong Huang Xiao‐Long Cui Meng‐Liang Wen 《Magnetic resonance in chemistry : MRC》2009,47(4):366-370
An unprecedented new natural product named nocarsin A (1), 5H‐4a,6,7a‐triazacyclopenta[cd]indene‐5,7(6H)‐dione (1), together with seven known compounds lumichrome (2), cyclo (L ‐Leu‐L ‐Tyr) (3), cyclo (L ‐Ala‐L ‐Ile) (4), cyclo (L ‐Ala‐L ‐Leu) (5), cyclo (L ‐Val‐L ‐Ala) (6), 5‐methyluracil (7) and uracil (8), was isolated from Nocardia alba sp.nov (YIM 30243T), which was isolated from a soil sample collected from Yunnan Province, P. R. China. NMR techniques including COSY, HSQC, ROESY, and HMBC were used to elucidate the structures of these compounds. We report the unambiguous assignments of the 1H and 13C NMR spectra of the new compound nocarsin A (1). Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
16.
Yue‐Ping Ma Ning Li Jian Gao Ke‐Ling Fu Ying Qin Guo‐Yu Li Jin‐Hui Wang 《Helvetica chimica acta》2011,94(10):1881-1887
A new peroxy‐multiflorane triterpene ester, (3α,5α,8α,20α)‐5,8‐epidioxymultiflora‐6,9(11)‐diene‐3,29‐diol 3,29‐dibenzoate ( 1 ), was isolated from the processed seeds of Trichosanthes kirilowii, together with the two known related derivatives 2 and 3 , and the two known steroids 4 and 5 . Compounds 2, 4 , and 5 were isolated from the genus Trichosanthes for the first time. The structure of compound 1 was established by NMR, HR‐MS, and CD analyses. Compounds 1 – 3 were tested for their in vitro cytotoxicity against human‐tumor cell lines (Hela, HL‐60, and MCF‐7) and anti‐inflammatory activity (LPS‐induced B lymphocyte cells) with the MTT method. 相似文献
17.
Haixue Kuang Bingyou Yang Ling Tang Yonggang Xia Deqiang Dou 《Helvetica chimica acta》2009,92(7):1315-1323
In search for bioactive compounds from the flower of Datura metel L., three new withanolide glucosides, namely baimantuoluosides A, B, and C ( 1 – 3 , resp.) were isolated. Enzymatic hydrolysis of 1 – 3 afforded the corresponding aglycones 1a, 2a , and 3a , respectively. The structures of the new compounds were elucidated as (5α,6α,7α,12β,22R)‐5,12‐dihydroxy‐1,26‐dioxo‐6,7 : 22,26‐diepoxyergosta‐2,24‐dien‐27‐yl β‐D ‐glucopyranoside ( 1 ), (5α,6α,7α,12α,22R)‐5,12‐dihydroxy‐1,26‐dioxo‐6,7 : 22,26‐diepoxyergosta‐2,24‐dien‐27‐yl β‐D ‐glucopyranoside ( 2 ), (5α,6α,7α,22R)‐5‐hydroxy‐1,26‐dioxo‐6,7 : 22,26‐diepoxyergosta‐2,24‐dien‐27‐yl β‐D ‐glucopyranoside ( 3 ) on the basis of chemical and physicochemical evidence, and are further confirmed by the structure determination by X‐ray diffraction of withanolide aglycone 1a . 相似文献
18.
Azhar Mahmood Itrat Fatima Shaheen Kosar Rehana Ahmed Abdul Malik 《Magnetic resonance in chemistry : MRC》2010,48(2):151-154
Prunusins A (1) and B (2), the new C‐alkylated flavonoids, have been isolated from the seed kernels of Prunus domestica. Their structures were assigned from 1H and 13C nuclear magnetic resonating spectra, DEPT and by correlation spectroscopy, HMQC and HMBC experiments. 3, 5, 7, 4′‐Tetrahydroxyflavone (3) and 3, 5, 7‐trihydroxy‐8, 4′‐dimethoxyflavone (4) have also been reported from this species. Both compounds (1) and (2) showed significant antifungal activity against pathogenic fungus Trichophyton simmi. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
19.
Xiang‐Dong Qin Shu Yang Yan Zhao Li‐Xia Wang Fu‐Cai Ren Fei Wang 《Helvetica chimica acta》2016,99(3):237-240
Three new atisane diterpenoids, spiratisanins A – C ( 1 – 3 , resp.), featuring a phenylacryloxyl substituted ent‐atisane skeleton, were isolated from Spiraea japonica together with two known atisine diterpene alkaloids, spiramine A ( 4 ) and spiradine F ( 5 ). The structures of these new compounds were elucidated as (5β,7α,8α,9β,10α,12α,16β)‐16‐hydroxyatisan‐7‐yl (2E)‐3‐phenylprop‐2‐enoate ( 1 ), (5β,7α,8α,9β,10α,12α,16α)‐16‐hydroxyatisan‐7‐yl (2E)‐3‐phenylprop‐2‐enoate ( 2 ), and (5β,8α,9β,10α,12α,16β)‐16‐hydroxyatisan‐20‐yl (2E)‐3‐phenylprop‐2‐enoate ( 3 ) on the basis of spectroscopic analysis. 相似文献
20.
Hong‐zhi Huang Wen‐bin Zhou Yang Zhao Cheng‐qi Xiong Da‐wei Tan Xin‐bo Song Bai‐ping Ma 《Magnetic resonance in chemistry : MRC》2012,50(1):79-83
Five new glucosylated steroidal glycosides, cantalasaponin I‐B1 (1), I‐B2 (2), I‐B3 (3), I‐B4 (4) and I‐B5 (5), were isolated and purified from the transformed product of the cantalasaponin I by using Toruzyme 3.0 l as biocatalyst. Their structures were elucidated on the basis of high‐resolution electrospray ionization mass spectrometry, one‐dimensional (1H and 13C NMR) and two‐dimensional [COSY, heteronuclear single‐quantum correlation (HSQC), HMBC and HSQC‐TOCSY] NMR spectral analyses and chemical evidence. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献