A three‐component,one‐pot synthesis of oxazinoquinolin‐3‐one derivatives

Oxazino[5,6‐f]quinolin‐3‐one derivatives have been synthesized in a one‐pot, and efficient process by condensation of 6‐quinolinol, aromatic aldehydes and urea under microwave‐assisted and thermal solvent‐free conditions.     

Polyethylene glycol mediated one‐pot three‐component synthesis of new 4‐thiazolidinones

An efficient one‐pot three‐component cyclocondensation of 4‐(p‐toulyl sulfonoxy) benzaldehyde, aryl amines, and mercaptoacetic acid in polyethylene glycol 400 (PEG‐400) was conducted to obtain new 2,3‐disubstituted‐4‐thiazolidinones. This route is economical and ecofriendly. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 23:166–170, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20766     

(Bromodimethylsulfonium) bromide–catalyzed one‐pot three‐component synthesis of imidazo[1,2‐a]pyridines

(Bromodimethylsulfonium) bromide–catalyzed one‐pot multicomponent reaction of 2‐aminopyridine with aromatic aldehyde(s) and TMSCN yielding N‐benzylidene‐2‐phenylimidazo[1,2‐a]pyridines exclusively has been described. The reaction is solvent free, versatile, and takes significantly short time. J. Heterocyclic Chem., (2011).     

Triethanolamine‐catalyzed expeditious and greener synthesis of 2‐amino‐4H‐chromenes

Triethanolamine (TEOA), an inexpensive and eco‐friendly base, was used to efficiently catalyze the three‐component condensation reaction of heterocyclic/aromatic aldehyde, (α/β)‐naphthol, and malononitrile in water to give the corresponding substituted 2‐amino‐4H‐chromene derivatives with excellent yields.     

Zinc chloride‐catalyzed one‐pot,three‐component synthesis of 5,8‐dihydro‐5,8‐dioxo‐4H‐chromene derivatives

An efficient zinc chloride‐catalyzed one‐pot synthesis of 5,8‐dihydro‐5,8‐dioxo‐4H‐chromene derivatives have been achieved by the reaction of 2,5‐dihydroxy‐6‐undecyl‐1,4‐bezoquinone, cyanothioacetamide, and aromaticaldehyde, in EtOH at room temperature. The structures of the products were characterized by IR, ¹H‐NMR, mass spectra, and elemental analyses. J. Heterocyclic Chem., (2011).     

Ligand‐free,copper‐catalyzed,one‐pot,three‐component synthesis of novel 1,2,3‐triazole‐linked indoles in magnetized water

Magnetized water (MW) is used as a green and new solvent‐promoting medium for the one‐pot, three‐component synthesis of novel 1,2,3‐triazole‐linked indoles catalyzed by copper iodide. A broad range of 2‐aryl‐1‐(prop‐2‐ynyl)‐1H‐indole‐3‐carbaldehydes were reacted with alkyl halides and sodium azide via copper‐catalyzed azide–alkyne cycloaddition reactions in MW in the absence of any ligand. This method offers the advantages of short reaction times, green procedure, low cost, simple work‐up, quantitative reaction yields, and no need for any organic solvent.     

One‐pot three‐component synthesis of 2‐substituted 4‐aminoquinazolines

A facile and rapid synthesis of the title compounds via one‐pot reaction of 2‐aminobenzonitrile, orthoesters and ammonium acetate under solvent‐free and microwave condition is described.     

A facile,one‐pot,green synthesis of polysubstituted 4H‐pyrans via piperidine‐catalyzed three‐component condensation in aqueous medium

An efficient, one‐pot method was described for the synthesis of various polysubstituted 4H‐pyrans via piperidine catalyzed three‐component condensation in aqueous medium. The reaction could be promoted effectively by adding sodium dodecyl sulfate to aqueous medium. J. Heterocyclic Chem., (2010).     

Synthesis and characterization of the novel diamine‐functionalized Fe3O4@SiO2 nanocatalyst and its application for one‐pot three‐component synthesis of chromenes

Fe₃O₄@SiO₂@propyltriethoxysilane@o‐phenylendiamine as an environmentally‐benign functionalized silica‐coated magnetic organometallic nanomaterial has been synthesized and characterized by Fourier transforms infrared (FT‐IR) spectroscopy, scanning electron microscopy (SEM) images and energy dispersive X‐ray (EDX) and vibrating sample magnetometer (VSM) analyses. Then, its catalytic activity was investigated for the one‐pot three‐component condensation reaction between dimedone, malononitrile and various substituted aromatic aldehydes to afford the corresponding 2‐amino‐4H‐chromene derivatives under mild reaction conditions. This nanocatalyst can be easily recovered from the reaction mixture by using a magnet and reused for at least five times without significant decrease in catalytic activity.     

A one‐pot green synthesis of 2‐amino‐4H‐benzo[h]chromenes catalyzed by a dioxomolybdenum Schiff base complex supported on magnetic nanoparticles as an efficient and recyclable nanocatalyst

In this work, catalytic performance of a molybdenum Schiff base complex‐supported magnetic support as a nanocatalyst was evaluated for the preparation of 2‐amino‐4H‐benzo[h]chromenes through one‐pot, three component reactions of 1‐naphthol, various aldehydes, and malononitrile under solvent‐free conditions. A promising greener and eco‐friendly method with a short reaction time, high yield of products, and simple work‐up procedure was achieved. The nanocatalyst could be easily separated and regenerated from reaction media by an external magnet and reused at least seven consecutive times with small drops in its catalytic performance.     

CeCl3·7H2O‐catalyzed one‐pot Kabachnik–Fields reaction: A green protocol for three‐component synthesis of α‐aminophosphonates

CeCl₃·7H₂O has been utilized as an efficient Lewis acid catalyst for the three‐component coupling of aldehydes, aromatic amines, and diethylphosphite to produce α‐aminophosphonates under solvent‐free conditions. The advantages of this protocol are high yield, mild reaction conditions, less environmental pollution, and simple work‐up procedure. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:397–403, 2010; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20635     

An efficient one‐pot three‐component synthesis of tetrahydrofuro[3,4‐b]quinoline‐1,8(3H,4H)‐dione derivatives catalyzed by L‐proline

L ‐Proline is found to be an efficient catalyst for the synthesis of tetrahydrofuro[3,4‐b]quinoline‐1,8(3H,4H)‐dione derivatives. This protocol is novel and has the advantages of mild condition, high yield, and easy operation. J. Heterocyclic Chem., (2012).     

Design,synthesis, characterization and catalytic performance of a new cellulose‐based magnetic nanocomposite in the one‐pot three‐component synthesis of α‐aminonitriles

A sulfonated magnetic cellulose‐based nanocomposite was prepared and characterized using scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, X‐ray diffraction and Fourier transform infrared spectroscopy. Then, it was used as a green nanocatalyst for the synthesis of α‐aminonitriles by a one‐pot three‐component condensation reaction of aldehydes or ketones, amines and trimethylsilylcyanide in ethanol at room temperature. The reaction procedure is simple, yields are very high, reaction time is very short and the catalyst can be easily separated from the reaction mixture and reused in subsequent reactions without significant loss of catalytic activity. Copyright © 2016 John Wiley & Sons, Ltd.