An efficient one‐pot synthesis of n‐carboxymethylacridine‐1,8‐dione derivatives under microwave irradiation

A series of N‐carboxymethylacridine‐1,8‐dione derivatives were synthesized by one‐pot reaction of aldehyde, dimedone and glycine in glycol under microwave irradiation without catalyst with excellent yields (78‐92%) and short reaction time (4‐8min). And the reaction was not only suitable for aromatic monoaldehyde, but also aromatic dialdehyde.     

An efficient one‐pot synthesis of polyhydrobenzoacridine‐1‐one derivatives under microwave irradiation without catalyst

A series of 3,3‐dimethyl‐9‐substituted‐1,2,3,4,9,10‐hexahydrobenzo[c] acridine‐1‐ones and 3,3‐dimethyl‐9‐substituted‐1,2,3,4,9,10‐hexahydrobenzo[a] acridine‐1‐ones were synthesized by the reaction of an aldehyde, α‐naphthylamine or β‐naphthylamine and dimedone under microwave irradiation with short times and high yields.     

One‐pot synthesis of novel N‐cyclopropyldecahydroacridine‐1,8‐dione derivatives under microwave irradiation

A series of new N‐cyclopropyldecahydroacridine‐1,8‐dione derivatives were synthesized by one‐pot reaction of aromatic aldehyde, dimedone (or 1,3‐cyclohexanedione) and cyclopropanamine in solution of glycol and water under microwave irradiation with excellent yields (78‐94%) and short reaction time (5‐10 min).     

An efficient one‐pot synthesis of novel pyrimidoquinoline derivatives under microwave irradiation without catalyst

A series of pyrimidoquinoline derivatives were synthesized through one‐pot condensation of 2,6‐diaminopyrimidin‐4‐one, aldehyde and cyclic a 1,3‐dicarbonyl compound in glycol under microwave irradiation without catalyst. The protocol in the absence of catalyst has the advantage of good yield (87‐95%), short reaction time (4‐7 min) and an environmentally friendly technique.     

An efficient one-pot synthesis of tetrahydrobenzo[a]xanthene-11-one and diazabenzo[a]anthracene-9,11-dione derivatives under solvent free condition

Indium(III) chloride catalyzed one-pot synthesis of 12-aryl/alkyl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-one and 8,10-dimethyl-12-aryl-8,12-dihydro-7-oxa-8,10-diazabenzo[a]anthracene-9,11-dione derivatives have been achieved by three component cyclocondensation of aldehydes, β-naphthol and cyclic 1,3-dicarbonyl compounds under solvent free condition in high yields. P₂O₅ too has been found as an effective catalyst towards this transformation.     

Facile three‐component one‐pot synthesis of indeno‐[1,2‐b]quinolin‐9,11(6H,10H)‐dione derivatives

One‐pot three‐component cyclocondensation of aldehydes, 1,3‐indanedione and enaminones proceeds in the presence of acetic acid to afford Indeno[1,2‐b]quinolin‐9,11(6H,10H)‐dione derivatives, The method has the advantage of excellent yields(85‐94%) and simple workup procedure.     

An efficient one‐pot synthesis of pyrazolo[3,4‐b]pyridinone derivatives catalyzed by L‐proline

A series of 3‐methyl‐1,4‐disubstituted‐4,5‐dihydro‐1H‐pyrazolo[3,4‐b]pyridine‐6(7H)‐ones was synthesized via the three‐component reaction of aldehyde, 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐amine, and Meldrum's acid catalyzed by L ‐proline. This protocol has the advantages of easier work‐up, milder reaction conditions, and high yields. J. Heterocyclic Chem., (2011).     

A facile three‐components,one‐pot synthesis of pyrimido[4,5‐d]pyrimidine‐2,5‐dione derivatives under microwave‐assisted conditions

Pyrimido[4,5‐d]pyrimidine‐2,5‐dione derivatives have been synthesized in high yields in a novel, onepot, and efficient process by condensation of 6‐amino‐3‐methyl‐2‐(methylthio)pyrimidin‐4(3H)‐one, aldehydes and urea under microwave‐assisted conditions.     

Novel synthesis of 2‐amino[1,4,5]benzoxadiazepine derivatives via a mild one‐pot reaction

The diazonium salt of 2‐aminophenol 2 was coupled in situ with malononitrile derivatives 3a‐d , 2‐cyanomethylthiazolin‐4‐one 9 , 2‐cyanomethylbenzimidazole 11a , and 2‐cyanomethylbenzothiazole 11b to give 2‐amino[1,4,5]benzoxadiazepine derivatives 6a‐d, 10 and 12a,b via a one‐pot reaction.     

An efficient one‐pot synthesis of dispiropyrrolidine derivatives through 1,3‐dipolar cycloaddition reactions under ultrasound irradiation

A series of dispiropyrrolidine derivatives were synthesized via the three‐component 1,3‐dipolar cycloaddition reaction of isatin, sarcosine and 5‐arylidene‐1,3‐thiazolidine‐2,4‐dione or 5‐arylidene‐4‐thioxo‐1,3‐thiazolidine‐2‐one in ethanol under ultrasound irradiation. This protocol has the advantages of mild reaction conditions, higher yields, and shorter reaction time. J. Heterocyclic Chem., (2011).     

A rapid and efficient method for synthesis of pyrimido[1,2‐a]‐benzimidazole derivatives under microwave irradiation

A rapid and efficient method for synthesis pyrimido[1,2‐a]benzimidazole derivatives from readily available starting materials is accomplished under microwave irradiation. This method has the advantages of short reaction time, operational simplicity, increased safety for small‐scale high‐speed synthesis, and minimal environment impact.     

Green and high efficient synthesis of triaza‐benzo[b]fluoren‐6‐one derivatives in water under microwave irradiation

Triaza‐benzo[b]fluoren‐6‐one derivatives were synthesized via the three‐component reaction of aldehyde, cyclohexane‐1,3‐dione compound and 2‐aminobenzimidazole in water under microwave irradiation. The new protocol has the advantages of excellent yield, low cost, reduced environment impact, wide scope and convenient procedure.     

Regioselective one pot synthesis of 2‐alkyl/aryl‐4h‐benzo[1,4] thiazine‐3‐one via microwave irradiation

A series of 2‐alkyl/aryl‐4H‐benzo[1,4]thiazine‐3‐ones have been synthesized by microwave irradiation of ethyl‐2‐bromo‐2‐alkyl/aryl acetate and 2‐amino thiophenol in the presence of 1,8‐diazabicyclo‐[5.4.0] undec‐7‐ene and N‐methylpiperidine. All compounds were characterized by ¹H NMR, ¹³C NMR and elemental analyses, and by X‐ray crystallography in the case of 2‐methyl‐4H‐benzo[1,4]thiazin‐3‐one.     

An efficient one‐pot three‐component synthesis of tetrahydrofuro[3,4‐b]quinoline‐1,8(3H,4H)‐dione derivatives catalyzed by L‐proline

L ‐Proline is found to be an efficient catalyst for the synthesis of tetrahydrofuro[3,4‐b]quinoline‐1,8(3H,4H)‐dione derivatives. This protocol is novel and has the advantages of mild condition, high yield, and easy operation. J. Heterocyclic Chem., (2012).     

Facile one‐pot synthesis of a series of 7‐aryl‐8H‐benzo[h]indeno[1,2‐b]quinoline‐8‐one derivatives catalyzed by cellulose‐based magnetic nanocomposite

A sulfonated magnetic cellulose‐based nanocomposite was applied as an efficient, inexpensive and green catalyst for the one‐pot three‐component synthesis of 7‐aryl‐8H ‐benzo[h ]indeno[1,2‐b ]quinoline‐8‐ones starting from 1,3‐indanedione, aromatic aldehydes and 1‐naphthylamine under solvent‐free conditions in high yields (79–98%) within short reaction times (2–5 min). The nanobiostructure catalyst can be easily separated from the reaction mixture by using an external magnet and reused several times.     

A three‐component,one‐pot synthesis of oxazinoquinolin‐3‐one derivatives

Oxazino[5,6‐f]quinolin‐3‐one derivatives have been synthesized in a one‐pot, and efficient process by condensation of 6‐quinolinol, aromatic aldehydes and urea under microwave‐assisted and thermal solvent‐free conditions.     

(Bromodimethylsulfonium) bromide–catalyzed one‐pot three‐component synthesis of imidazo[1,2‐a]pyridines

(Bromodimethylsulfonium) bromide–catalyzed one‐pot multicomponent reaction of 2‐aminopyridine with aromatic aldehyde(s) and TMSCN yielding N‐benzylidene‐2‐phenylimidazo[1,2‐a]pyridines exclusively has been described. The reaction is solvent free, versatile, and takes significantly short time. J. Heterocyclic Chem., (2011).     

Three‐component,one‐pot synthesis of pyrimido[4,5‐b]‐quinoline and pyrido[2,3‐d]pyrimidine derivatives

Reaction of 6‐amino‐2‐methylthiouracil and 6‐amino‐1,3‐dimethyluracil with equimoler amounts of cyclic ketones or cyclic 1,3‐diketones and the appropriate aromatic aldehydes yielded regioselectivity a series of polycyclic pyrimido[4,5‐b]quinoline and pyrido[2,3‐d]pyrimidine derivatives in good yields.