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1.
1-Methyl-2-(2-propenyl)-3-pyrazolidinimine ( 5 ) was obtained by treatment of 3-amino-4,5-dihydro-1-methyl- 1-(2-propenyl)-1 H-pyrazolium bromide ( 4 ) with ethanolic sodium ethoxide. Similar treatment of the analogous 2-(2-butenyl) and 2-(3-phenyl-2-propenyl)-substituted salts 12 and 15 gave 1-methyl-2-(1-methyl-2-propenyl)-3- pyrazolidinimine ( 13 ) and 1-methyl-2-(1-phenyl-1-propenyl)-3-pyrazolidinimine ( 16 ) respectively. 相似文献
2.
The interaction of the sodium salts of 3-(1-adamantyl)-1-hydroxy-1-propen-3-one and 4-(1-adamantyl)-1-hydroxy-1-buten-3-one with hydroxylamine, hydrazine, and guanidine leads to the synthesis of 5-(1-adamantyl)-5-hydroxy- and 5-(1-adamantylmethyl)-5-hydroxy-2-isoxazolines, 3-(1-adamantyl)- and 3-(1-adamantylmethyl)pyrazoles, 3-(1-adamantyl)-2-phenylpyrazole, and 4-(1-adamantyl)-2-amino- and 4-(1-adamantylmethyl)-2-aminopyrimidines. 相似文献
3.
Aminomethylation of 1-(4-butoxyphenyl)-2-phenylethanone with paraformaldehyde and substituted piperazines in ethanol medium results in 1-(4-butoxyphenyl)-3-(4-R-piperazin-1-yl)-2-phenylpropan-1-ones. The latter react with cyclohexylmagnesium halide to give 1-(4-butoxyphenyl)-1-cyclohexyl-3-(4-arylpiperazin-1-yl)-2-phenylpropan-1-ols. Reduction of the prepared β-aminoketones with lithium aluminum hydride in absolute diethyl ether leads to the secondary aminopropanols. The prepared compounds could be converted into the corresponding dihydrochlorides. 相似文献
4.
Capture, rearrangement and/or fragmentation of 1-(5-oxazolyl)-1-alkylidenes and 1-(5-isoxazolyl)-1-alkylidenes are described. 相似文献
5.
Abstract Thermal decomposition of 1-methyl-1-(4-methyl-1-naphthyl)ethyl hydroperoxide under gas chromatography-mass spectroscopy (GC–MS)
conditions gives 2-((4-methyl-1-naphthyl)oxy)propene as the main product (50.5%), without any detectable traces of the isomeric
2-((5-methyl-1-naphthyl)oxy)propene. This finding excludes the rearrangement pathway of 1-methyl-1-(1-naphthyl)ethyl hydroperoxides
to the corresponding 2-(1-naphthyloxy)propenes, which involves formation of a naphthofuran derivative as an intermediate and
transfer of the isopropenyloxy group to the 8 position. This result, as well as our previous density functional theory (DFT)
calculations, points to the rearrangement pathway involving an oxirane-type intermediate as the most plausible pathway to
2-(1-naphthyloxy)propenes. This rearrangement is responsible for the unusual inhibition effects of 1-methyl-1-(1-naphthyl)ethyl
hydroperoxide on the liquid-phase oxidation of isopropylarenes with oxygen. 相似文献
6.
An effective synthesis of 1-(6-hydroxyindol-1-yl)-2,2-dimethylpropan-1-one (4) was developed starting from 1H-indole (2). The key step involved suitable utilization of 4-(1-pyrrolidino)pyridine for the removal of the chloroacetyl moiety from chloroacetic acid 1-(2,2-dimethylpropionyl)-1H-indol-6-yl ester (3); a possible mechanism is, also, presented. Compound 4 might lead to selectively substituted derivatives, either on the phenolic-OH or the indolyl-NH, with putative biological interest. In this respect, we found that the core structure of 1H-indol-6-ol (1) possesses a degree of aldose reductase inhibitory potential, at a concentration of 100 microM. 相似文献
7.
The methanesulfonates of (α-(4-chlorophenyl)-α-[1-(2-chlorophenyl)ethenyl]-1 H-1,2,4-triazole-1-ethanol and α-[1-(2-chlorophenyl)ethenyl]-α-(2,4-difluorophenyl)-1 H-1,2,4-triazole-1-ethanol ( 1a, b ) are orally effective α-styryl carbinol derivatives developed for the treatment and prevention of systemic fungal infections. Practical new processes amenable for the large-scale production of these compounds are described. Of note is the selection of dichlorostyrene as a convenient precursor of the styryl portion, modification of a sensitive Grignard addition into a realistic preparative reaction and the use of 1,2,4-triazole simultaneously as a base transfer agent and nucleophile. 相似文献
8.
Synthetic procedure to access the first representatives of a new series of 3-monosubstitued functional derivatives of 1-alkoxy-1-triazene 2-oxides, i.e., 1-alkoxy-3-(2-hydroxyethyl)- and 1-alkoxy-3-(2-acetoxyethyl)-1-triazene 2-oxides, were elaborated. 1-Alkoxy-3,3-bis(2-hydroxyethyl)-1-triazene 2-oxides were used to derive 3-(2-acetoxyethyl)-, 3-(2-bromoethyl)- and 3-(2-cyanoethyl)substituted 1-alkoxy-3-(2-acetoxyethyl)-1-triazene 2-oxides. 相似文献
9.
Two compounds, the (Z)- and (E)-isomers of 2,4-dibromo-1-p-tolyl-1-butene 2a and 3a, respectively, were isolated in 65% total yield when 1-(1-bromo-1-p-tolylmethyl)cyclopropyl bromide (1a) was heated at 150 degrees C for 1 h. 1,1-Dibromo-2-p-tolylcyclobutane (4a), previously reported to be the only product in this reaction, was not detected. The phenyl analogue of 1a reacted similarly and gave the (Z)- and (E)-isomers of 2,4-dibromo-1-phenyl-1-butene 2b and 3b, respectively, in 60% yield. A rationale for the reaction is presented. 相似文献
10.
The first syntheses of cruciferous indole phytoalexins (±)-1-methoxyspirobrassinin, (±)-1-methoxyspirobrassinol, (±)-1-methoxyspirobrassinol methyl ether as well as a new syntheses of phytoalexins (±)-spirobrassinin and cyclobrassinin were achieved by dioxane dibromide (DDB)-mediated spirocyclization of brassinin and its 1-substituted derivatives. 相似文献
11.
The reaction of 2-(1-cyclohexen-1-yl)aniline and -6-methylaniline with phthalic anhydride has afforded 2-(2-cyclohex-1-en-1-ylphenyl)- and 2-(2-cyclohex-1-en-1-ylphenyl)-6-methylphenyl)-1H-isoindole-1,3(2H)-diones. The reaction of the obtained isoindole-1,3-diones with bromine in dichloromethane in the presence of sodium bicarbonate has led to the formation of the product of pseudo-allylic halogenation. Replacement of the halogen atom by methoxy group has been performed by keeping 2-[2-(6-bromocyclohex-1-en-1-ylphenyl)-6-methylphenyl)]-1H-isoindole-1,3(2H)-dione in a methanolic solution in the presence of NaHCO3. The reaction of 2-(2-cyclohex-1-en-1-yl-6-methylphenyl)-1H-isoindole-1,3(2H)-dione with molecular bromine in the presence of methanol has given a co-halogenation product, whereas the dibromination product has been obtained in the presence of octyl alcohol. 相似文献
12.
Previously unknown 1,1-dimethyl-1-trimethoxysilylmethyl-2-(3-alkoxy-3-oxopropyl)hydrazinium and 1,1-dimethyl-1-(2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecan-1-ylmethyl)-2-(3-alkoxy-3-oxopropyl)-hydrazinium halides were synthesized, and physiological activity of 2-(3-ethoxy-3-oxopropyl)-1,1-dimethyl-1-(2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecan-1-ylmethyl)hydrazinium chloride and bromide was studied. 相似文献
13.
The synthesis has been effected, via the corresponding N-phenyl-ß-aminopropionic acids, of 1-(o-methoxyphenyl)-, 1-(o-ethoxyphenyl)-, and 1-(o-tolyl)dihydrouracils and also of 1-(o-methoxyphenyl)-, 1-(o-ethoxyphenyl)-, and 1-(o-tolyl)-2-thiodihydrouracils. The dihydrouracits and thiodihydrouracils obtained have been reduced with LiAlH 4 to the corresponding 2-oxohexahydro-, and 2-thioxohexahydropyrimidines. By the action of bromine and the subsequent splitting out of HBr, the dihydrouracils have been converted into 1-(o-methoxyphenyl)-, 1-(o-ethoxyphenyl)-, and 1-(o-tolyl)uracils. 相似文献
14.
Russian Journal of General Chemistry - In the reaction of 1-(1-adamantyl)-4,5-dihydro-1H-tetrazole-5-thione with 1-adamantyl in sulfuric acid 2-(1-adamantyl)-5-(1-adamantylsulfanyl)-2H-tetrazole... 相似文献
15.
By cycloaddition of arylazides to acetylacetone are obtained derivatives of 1,2,3-triazole. In the reaction of 1-[5-methyl-1-(R-phenyl)-1 H-1,2,3-triazol-4-yl] ethanones ( IIa–IIe) and 1-[4-(4-R-5-methyl-1 H-1,2,3-triazol-1-yl)phenyl] ethanones ( VIIa-VIIe) with isatin are obtained 2-[1-(R-phenyl)-5-methyl-1 H-1,2,3-triazol-4-yl]-4-quinolinecarboxylic acids ( IIIa–IIIe) and 2-[4-(4-R-5-methyl-1 H-1,2,3-triazol-1-yl)phenyl] -4-quinolinecarboxylic acids ( IXa, IXb), respectively. We found that 1-[5-methyl-1-(R-phenyl)-1 H-1,2,3-triazol-4-yl] ethanones ( IIa–IIe) readily transform into [5-methyl-1-(R-phenyl)-1 H-1,2,3-triazol-4-yl] acetic acids ( IVa–IVc) by the method of Wilgerodt-Kindler. The (5-methyl-1-phenyl-1 H-1,2,3-triazol-4-yl)acetic acid reacts with 5-phenyl-4-amino-4 H-1,2,4-triazol-3-thiol affording 6-[(5-methyl-1-phenyl-1 H-1,2,3-triazol-4-yl) methyl]-3-phenyl[1,2,4] triazolo[3,4- b] [1,3,4] thiadiazole ( VI).
Original Russian Text ? N.T. Pokhodylo, R.D. Savka, V.S. Matiichuk, N.D. Obushak, 2009, published in Zhurnal Obshchei Khimii,
2009, vol. 79, no. 2, pp. 320–325. 相似文献
16.
Dispersed fluorescence spectra following the excitation of the CBr2A1B1-X1A1 2 and 2 bands at visible wavelengths were acquired in a discharge supersonic free jet expansion using an intensified charge-coupled device (ICCD) detector. The dispersed fluorescence spectra show signal-to-noise ratios of up to 60 and extend out to a maximum red shift frequency of 6000 cm(-1). Complete and detailed vibrational structure of the ground singlet state (X1A1) was observed. Vibrational parameters including fundamental frequencies, anharmonicities, and coupling constants were determined for the CBr2 X1A1 state. Additional vibrational structure starting at approximately 3650 cm(-1) was observed and this indicates the singlet-triplet energy gap to be >10 kcal mol(-1). 相似文献
17.
Previously unknown potentially biologically active diethyl 1-(pyridin-3-yl)-, 1-(quinolin-3-yl)-, and 1-(quinolin-6-yl)ethylphosphonates
were synthesized by palladium-catalyzed reduction of the corresponding α,β-unsaturated precursors with ammonium formate. The
reduction of diethyl 1-(quinolin-6-yl)ethenylphosphonate was accompanied by formation of diethyl 1-(1,2,3,4-tetrahydroquinolin-6-yl)ethylphosphonate
as by-product. 相似文献
18.
用硼氢化钠还原3-芳基-1-(吡啶-3-基)-2-(1 H-1,2,4-三唑-1-基)丙烯酮, 合成了10个新型含吡啶基的三唑醇类化合物. 所有化合物均经核磁、元素分析确证. 生物活性测试结果表明, 部分化合物具有一定的杀菌活性及植物生长调节活性. 相似文献
19.
Transition probabilities were evaluated for the X(1)A(1)-A(1)B(1) and A(1)B(1)-B(1)A(1) systems of SiH(2) and SiD(2) to analyze the X-->A-->B photoexcitation. The Franck-Condon factors (FCFs) and Einstein's B coefficients were computed by quantum vibrational calculations using the three-dimensional potential energy surfaces (PESs) of the SiH(2)(X(1)A(1),A(1)B(1),B(1)A(1)) electronic states and the electronic transition moments for the X-A, X-B, and A-B system. The global PESs were determined by the multireference configuration interaction calculations with the Davidson correction and the interpolant moving least-squares method combined with the Shepard interpolation. The obtained FCFs for the X-A and A-B systems exhibit that the bending mode is strongly enhanced in the excitation since the equilibrium bond angle greatly varies with the three states; the barrier to linearity is evaluated to be 21,900 cm(-1) for the X state, 6400 cm(-1) for the A state, and 230-240 cm(-1) for the B state. The theoretical lifetimes for the pure bending levels of the A and B states were calculated from the fluorescence decay rates for the A-X, B-A, and B-X emissions. 相似文献
20.
UV Irradiation of 3-oxocyclopent-1-enyl acetate ( 17 ) and acetylene in MeCN at 0° gives, besides the product of normal enone-alkyne [2 + 2] cycloaddition ( cis-4-oxobicyclo[3.2.0] hept-6-en-1-yl acetate, 18 ) and its product of oxa-di-π-methane rearrangement (5-oxotricyclo[4.1.0.0 2,7]hept-2-yl acetate, 19 ), unexpected products of further addition of a molar equivalent of acetylene. These are indanone ( = 2,3-dihydro-1 H-inden-1-one, 16 ), in 21% yield, cis-1- cisoid-1,2- cis-2- ( 20 ) and cis-1- transoid-1,2- cis-2-7-oxotricyclo[4.3.0.0 2,5]non-3-en-1-yl acetate ( 21 ), 4-oxo-7-‘ exo’-vinyltricyclo[3.2.0.0 2,6]hept-2-yl acetate ( 22 ), cis-4-oxo-6-‘ endo’- ( 23 ) and cis-4-oxo-6-‘ exo’-vinylbicyclo[3.2.0]hept-1-yl acetate ( 24 ), and cis-4-oxo-7-‘ exo’-vinylbicyclo[3.2.0]hept-1-yl acetate ( 25 ). At least in part, indanone must be formed via intermediates 20 and 21 . In fact, on heating a 9:1 mixture 20/21 , indanone is obtained quantitatively. With 3-oxocyclopent-1-ene-1-carbonitrile ( 15 ) in place of 17 , indanone is formed in lower (8%) yield besides much tars. 相似文献
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