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以环己酮为原料,利用Gewald反应合成了6个3-烷基-5,6,7,8-四氢苯并[4,5]噻吩并[2,3-d]嘧啶-4-酮衍生物和17个3-亚苄基胺基四氢苯并[4,5]噻吩并[2,3-d]嘧啶-4-酮衍生物,通过1H NMR、13C NMR、IR和MS对所合成的化合物进行了结构表征,并对所合成化合物进行了抗肿瘤活性的筛选.结果表明4个化合物对人鼻咽癌细胞株(KB)和鼻咽鳞癌细胞株(CNE2)两种肿瘤细胞株表现出一定程度的抑制活性. 相似文献
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本文以等摩尔的芳醛,巴比妥酸(或1,3-二甲基巴比妥酸),5-氨基-2-甲基苯[d]噻唑为原料,以醋酸和乙二醇为溶剂,微波辐射下多组分一锅法合成了一系列新的吡啶[2,3-d]嘧啶衍生物。这种方法具有产率高,操作简便,反应时间短等优点。 相似文献
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苯并[C]吡喃并[4,3┐d]嘧啶类衍生物的合成王进军周健民陈冰子*(吉林化工学院精细化工系132022)(温州医学院基础部325027)(北京大学生命科学学院100871)3,4-二氢-1H-苯并[C]吡喃俗称异色满(isochroman),作为某... 相似文献
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应用串联氮杂Wittig反应设计合成了一系列新的2-烷氨(芳氧)基-3,8-二苯基-5-芳基-6-甲基-5,8-二氢-4H-吡唑并[4',3':5,6]吡喃并[2,3-d]嘧啶-4(3H)-酮衍生物。通过氢核磁共振谱仪(1H NMR)、傅里叶变换红外光谱仪(FTIR)和元素分析等方法对所合成的化合物进行了结构表征,用X射线单晶衍射确证了化合物2-二正丙基氨基-3,8-二苯基-5-(4-甲基苯基)-6-甲基-5,8-二氢-4H-吡唑并[4',3':5,6]吡喃并[2,3-d]嘧啶-4(3H)-酮(Ⅲi)晶体结构。室内的杀菌和杀虫活性测试结果表明:目标化合物具有一定的杀菌活性,其中部分化合物对黄瓜灰霉菌(Botrytis cinereapers)在50 mg/L剂量下抑制率达到90%以上,显示了优异的杀菌活性;对水稻褐飞虱无明显的杀虫活性,但发现对粘虫具有较高的杀灭效果,大多数抑制率达到90%以上。 相似文献
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《Journal of fluorine chemistry》1988,41(3):303-310
Flourinated 4-imino-3,5,7-trisubstituted-pyrido [2,3-d] pyrimidine-2(1H) thiones have been synthesised in good yields by the reaction of 2-amino-3-cyano-4,6- disubstituted-pyridines with various arylisothiocyanates. These new type of products have been characterised by elemental analysis, IR, 1H and 19F NMR spectral studies. 相似文献
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An efficient synthesis of hexahydropyrido[2,3-d]pyrimidinetrione derivatives is achieved via tandem Knoevenagel-Michael addition of aromatic aldehydes,methylcyanoacetate and 4(6)-aminouracil in solvent-free conditions in the presence of 10 mol%of ZrO2 nanoparticles(ZrO2 NPs) as a heterogenous catalyst.The procedure is formed in high yields,short reaction time and an environmentally friendly specificity. 相似文献
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É. É. Grinshtein É. I. Stankevich G. Ya. Dubur 《Chemistry of Heterocyclic Compounds》1972,8(3):386-389
The mutual condensation of 4-aminouracil or 2,4-diamino-6-hydroxypyrimidine with bisacetonitrile and aldehydes was used to synthesize 2,4-dioxo-5-R-7-methyl-6-cyano-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine and 2-amino-4-oxo-5-R-7-methyl-6-cyano-3,4,5,8-tetrahydropyrido[2,3-d]pyrimidine derivatives, which were oxidized with chromic anhydride to the corresponding 2,4-dioxo-5-R-7-inethyl-6-eyano-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine and 2-amino-4-oxo-5-R-7-methyl-6-cyano-3,4-dihydro[2,3-d]pyrimidines. The IR and UV spectra of the synthesized compounds were recorded.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 422–425, March, 1972. 相似文献
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M. Bararjanian S. Balalaie B. Movassag A. M. Amani 《Journal of the Iranian Chemical Society》2009,6(2):436-442
An efficient protocol has been developed for the synthesis of various pyrano[2,3-d]pyrimidinones from condensation of aromatic aldehydes, malononitrile and barbituric-or thiobarbituric acid in aqueous ethanol using L-proline as a neutral bifunctional catalyst. 相似文献
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A series of furo[2,3-d]pyrimidine derivatives were synthesized via the [3+2] cyclization of pyrimidine-4,6-diol and a variety of nitroolefins at catalyst-free conditions. The reaction is easy to perform simply mixing inexpensive starting materials in water under conventional heating at 90 °C. The reaction proceeds at a fast speed within 1.5–2 h and gives the high biological and pharmacological active substituent furo[2,3-d]pyrimidine derivatives with good to high yields. Mechanism of formation of these furo[2,3-d]pyrimidine derivatives are also proposed. 相似文献
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Fathy M. Abdelrazek Sobhi M. Gomha Hassan M. Abdel-aziz Mohamed S. Farghaly Peter Metz Ahmed Abdel-Shafy 《Journal of heterocyclic chemistry》2020,57(4):1759-1769
A novel series of 1,5-dihydropyrido-triazolo-pyrimidine derivatives were prepared by cyclocondensation of 2-thioxo-pyrido[2,3-d]pyrimidines (prepared from reaction of chalcone with 6-aminothiouracil) with a variety of hydrazonoyl chlorides. Based on spectroscopic evidence and their chemical syntheses, the structures of the newly prepared compounds were elucidated. Designated compounds are forced for molecular docking by using MOE 2014.010 Package software; one of in silico study tools. Synthesized compounds are targeting Human Cyclin-defendant Kinase 2 (CK2) PDB ID (1PXO.Protein data bank) due to its important role in controlling the human cell cycle and also for meiosis. 相似文献
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Abedini Masoumeh Shirini Farhad Mohammad-Alinejad Omran Javad Seddighi Mohadeseh Goli-Jolodar Omid 《Research on Chemical Intermediates》2016,42(5):4443-4458
Research on Chemical Intermediates - Succinimidinium N-sulfonic acid hydrogen sulfate ([SuSA-H]HSO4) as a new ionic liquid is prepared and characterized using a variety of techniques, including... 相似文献
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A series of novel 2-trifluoromethylthieno[2,3-d]pyrimidine derivatives were synthesized by a facile three-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by 1R, NMR, El-MS, elemental analysis, and X-ray diffraction. Preliminary bioassay results showed that some of the analogs exhibit excellent antitumor activity against MCF-7 and HepG2, especially compounds 3a, 3b, 3e and 3h exhibited higher activity than the positive control gefitinib. 相似文献