甲苯胺蓝修饰石墨电极的电化学性质及对血红蛋白的电催化还原

本文将电子媒体甲苯胺蓝吸附在石墨电极上制备成修饰电极。在＋０．２～０．５Ｖ（ｖｓ．ＳＣＥ）范围内，吸附态的甲苯胺蓝呈现有两质子参与的可逆性两电子氧化还原行为，在ｐＨ５．５醋酸盐缓冲溶液中，其表面式量电位Ｅ＾０为－０．２２Ｖ，表观表面电子传递速率常数ｋ为１．１Ｓ＾－１，甲苯胺蓝修饰电极具有良好的稳定性，它能加速血红蛋白在固体电极上的电子传递，产生很好的电流响应。     

聚2-吡啶甲酸修饰电极伏安法测定多巴胺

用循环伏安法制备了聚２－吡啶甲酸修饰玻碳电极，研究了神经递质多巴胺（ＤＡ）在该聚合物薄膜修饰电极上的电化学行为。实验结果表明，在ｐＨ７．０的磷酸盐缓冲溶液中，ＤＡ在该电极上的线性范围为１．０×１０－７～１．０×１０－５ｍｏｌ／Ｌ。该修饰电极对抗坏血酸（ＡＡ）无响应，从而可有效消除其对ＤＡ测定的干扰。     

用聚吲哚乙酸修饰电极测定肾上腺素

报道了聚吲哚乙酸修饰电极的制备，并研究了肾上腺素在该修饰电极上的循环伏安特性及测定方法。实验表明，在ＰＨ７．０的磷酸盐缓冲溶液中，用该电极测定肾上腺素的线性范围为１．０＊１０＾－７－６．０＊１０＾－６ｍｏｌ／Ｌ，检出限为４．０＊１０＾Ｔ－８ｍｏｌ／Ｌ。将此法用于药剂中肾上腺素的测定，结果满意。     

Nafion修饰金膜玻碳电极溶出伏安法测定痕量Se（Ⅳ）的研究

提出了Ｎａｆｉｏｎ修饰膜玻碳电极测定痕量硒的新方法。在０．１ｍｏｌ．Ｌ＾－１硫酸和０．０１．Ｌ＾－１硝酸钠的介质中，Ｓｅ（Ⅳ）浓度在５．０＊１０＾－１０－２．５＊１０＾－８ｍｏｌ．Ｌ＾－１范围与二次导数峰电流呈良好线性关系，测定下限为５．０＊１０＾－１０ｍｏｌ．Ｌ＾－１。     

NADH在邻苯二酚紫修饰石墨电极上的电催化氧化

以吸附在石墨电极上的邻苯二酚紫作为电子传递媒介体构成修饰电极。在－０．４０－＋０．６０Ｖ电位区间内，吸附态的邻苯二酚紫表现出相当可逆的氧化，还原行为，电极反应为单电子过程并有１个质子参加。在ｐＨ为７．０的磷酸盐缓冲溶液中，其式量电位Ｅ＾ｏ＇为０．１０Ｖ，表观电极反应速率常数ｋｓ为５．５ｓ＾－＾１。邻苯二酚紫修饰电极对还原型烟酰胺腺嘌呤二核苷酸（ＮＡＤＨ）的电化学氧化具有明显的催化作用。可使ＮＡＤＨ     

钴—5,10,20—四（3—甲氧基—4—羟基苯基）卟啉修饰玻碳电极的L—抗坏血…

将水合５，１０，１５，２０－四－（３－甲氧基－４－羟基苯基）钴卟啉修饰在玻碳电极表面，制成ＣｏＴＭＨＰＰ修饰电极，电极稳定性好且灵敏度高，对抗坏血酸有良好的电催化氧化作用，测定线性响应范围为１．０×１０＾－５－１．０×１０＾－２ｍｏｌ／Ｌ，响应时间小于１２ｓ。本研究了电极的性质和应用，并用于药物中抗坏血酸的测定，其测定结果与碘量法一致。     

壳聚糖修饰电极开路富集测定工业废水中铅

通过共价键合的方式，制成壳聚糖修饰电极，建立了在非电解条件下，壳聚糖修饰电极络合富集测定Ｐｂ（Ⅱ）的方法，同时对壳聚糖修饰电极的作用机理进行了探讨。Ｐｂ（Ⅱ）的线性范围为０．５０￣２００μｇ·ｍｌ＾－１，相对标准偏差为７．９％，定量下限为０．５０μｇ·ｍｌ＾－１，方法的回收率为９４％￣１０５％。     

HPLC／CoPC修饰电极安培检测大鼠心肌线粒体中谷胱甘肽的研究

研究了钴酞菁修饰电极的修饰方法及其电化学性质。它可以催化氧化谷胱甘肽,降低ＧＳＨ的过电位。以ＣｏＰＣ何尝修饰电极为工作电极的安培薄层化学检测器,与高压认相色谱联用,在工作电极电位为＋０．８Ｖ时,ＧＳＨ的浓度在３．０＊１０＾－６ｍｏｌ／Ｌ－１．０＊１０＾－３ｍｏｌ／Ｌ浓度范围内与峰电流呈良好的线性关系,线性相关系数为０．９９９１,检出限为１．０＊１０＾－３ｍｏｌ／Ｌ浓度范围内与峰电流呈良好的线性关系     

聚吡咯水杨酸修饰电极的电化学行为及水杨酸含量测定

本用电化学方法制备了聚吡咯－水杨酸修饰电极；并进行了电化学行为的研究，经电化学处理该是电极对水杨酸根具有选择性响应，响应线性范围在１．０×１０＾－＾５－１．０×１０＾－＾３ｍｏｌ／Ｌ之间。电极斜率为４０ｍＶ／ｐＣ，该电极具有较好的稳定性，响应时间在１８０－３００ｓ之间；电极寿命可达６０ｄ。     

聚碱性品红修饰电极的制备及应用

研究了碱性品红在玻碳电极上聚合的最佳实验条件及其聚合机理，发现该修饰电极的多巴胺具有良好的催化作用，能大大提高多巴胺在的玻碳电极上的响应，在ｐＨ＝７．０的磷酸盐缓冲溶液中，用修饰电极测定巴胺的线性范围为２×１０＾－７～１×１０＾－５ｍｏｌ／Ｌ，检测限为１×１０＾－７ｍｏｌ／Ｌ，并且具有稳定性好，响应快，选择性等特点。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.