共查询到13条相似文献,搜索用时 15 毫秒
1.
Observation of intermolecular double-quantum coherence signal dips in nuclear magnetic resonance
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The correlated spectroscopy revamped by asymmetric Z-gradient echo detection (CRAZED) sequence is modified to investigate intermolecular double-quantum coherence nuclear magnetic resonance signal dips in highly polarized spin systems. It is found that the occurrence of intermolecular double-quantum coherence signal dips is related to sample geometry, field inhomogeneity and dipolar correlation distance. If the field inhomogeneity is refocused, the signal dip occurs at a fixed position whenever the dipolar correlation distance approaches the sample dimension. However, the position is shifted when the field inhomogeneity exists. Experiments and simulations are performed to validate our theoretic analysis. These signal features may offer a unique way to investigate porous structures and may find applications in biomedicine and material science. 相似文献
2.
Isolating quantum coherences in structural imaging using intermolecular double-quantum coherence MRI
Chin CL Tang X Bouchard LS Saha PK Warren WS Wehrli FW 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2003,165(2):309-314
Intermolecular multiple-quantum coherence (iMQC) MR imaging provides a fundamentally different contrast mechanism. It allows probing tissue microstructure by tuning the direction and strength of the correlation gradient. However, iMQC images of a specific quantum-coherence can easily be contaminated by leakage signals from undesired quantum coherences (zero, single, and triple quantum coherence in this work). Using a modified double-quantum CRAZED imaging sequence, we show that signals originating from various coherence orders (M=0, 1, 2, 3) can be predicted in k-space and effectively isolated by means of a four-step phase cycling scheme and judicious choice of flip angles. Finally, preliminary data suggest the method to be able to provide information on trabecular bone architecture such as regional mean trabecular plate separation. 相似文献
3.
Wong CK Kennedy SD Kwok E Zhong J 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2007,185(2):247-258
It has been observed recently that the finite duration of refocusing rf pulses in a multiecho acquisition of the signal formed under the influence of the dipolar field leads to significant signal attenuation [S. Kennedy, Z. Chen, C.K. Wong, E.W.-C. Kwok, J. Zhong, Investigation of multiple-echo spin-echo signal acquisition under distant dipole-dipole interactions, Proc. Int. Soc. Magn. Reson. Med. 13 (2005) 2288]. Hereto, we quantify the phenomenon by evaluating analytically the influences of both the distant dipolar field (DDF) and transverse relaxation T2 on the magnetization in a multiecho pulse sequence based on correlation spectroscopy revamped by asymmetric z-gradient echo detection (CRAZED). Analytic expressions for the magnetization were obtained, which demonstrate explicitly the origin of rephased signal in the presence of the finite pi pulses in the multiecho train. The expressions also explain the effects of the DDF and T2 during the refocusing pulses on the signal strength, and show the substantial signal dependence on the phase of the rf pulses. We show that when the DDF effect during the pulse is canceled, the signal rises primarily during the free evolution time in the acquisition period. This elucidates the signal attenuation when the rf pulses cover a significant proportion of time in the sequence. In addition, we performed an optimization on the number of refocusing pulses that maximizes the total acquired signal using parameters for water, brain white matter, and muscle. We found that maximal signal-to-noise ratio is obtained when the pulse duration approximately equals the free evolution time in the samples with a wide range of T2. 相似文献
4.
Apparent diffusion behaviour of intermolecular double-quantum coherence modulated by a distant dipolar field in solution NMR
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A modified correlated spectroscopy (COSY) revamped with
asymmetric Z-gradient echo detection sequence was designed to
investigate the influence of diffusion behaviour on intermolecular
double-quantum coherence signal attenuation during the
pre-acquisition period. Theoretical formulas were deduced and
experimental measurements and simulations were performed. It is
found that the diffusion behaviour of intermolecular double-quantum
coherence in the pre-acquisition period may be different from that of
conventional single-quantum coherence, depending on the relative
orientation of diffusion weighting gradients to coherence selection
gradients. When the orientation of the diffusion weighting gradients is
parallel or anti-parallel to the orientation of the coherence
selection gradients, the diffusion is modulated by the distant
dipolar field. This study is helpful for understanding the signal
properties in intermolecular double-quantum coherence magnetic
resonance imaging. 相似文献
5.
Charles-Edwards GD Payne GS Leach MO Bifone A 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2004,166(2):157-227
Intermolecular multiple-quantum coherences (iMQCs) have been reported to offer a sensitivity to sample structure at a specific user-defined length scale down to the order of 10 microm. When assessing this novel contrast mechanism in controlled phantom experiments, we have observed three different mechanisms whereby residual single-quantum coherences (SQCs) arising from intense high spatial frequencies, stimulated echoes and strong spatially encoding gradients can produce significant changes in signal contrast at particular length scales. These changes which only appear when components arising from SQCs and iMQCs are both present in the detected signal, are similar to changes previously attributed to iMQCs alone. We demonstrate each mechanism by which these residual SQCs arise and describe methods for their suppression. 相似文献
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7.
Joy S. Finney Peter H. Bach Mary-Clare Bushell Neil M. Gregg David G. Taylor 《Magnetic resonance imaging》1990,8(6):713-721
Renal cortical and medullary spin-lattice (T1) relaxation times were measured at various time points over a period of 56 days following the administration of a single i.p. injection of 100 mg/kg 2-bromoethanamine hydrobromide (BEA), 200 mg/kg hexachloro-1,3-butadiene (HCBD) or 100 mg/kg puromycin aminonucleoside (PAN) to male Wistar rats. Administration of a single injection of HCBD caused a dramatic, immediate rise in the cortical T1 values above control values, and these levels remained elevated until, by Day 28 postinjection the levels were back to control values. Administration of BEA also caused an elevation in cortical T1 values, but in this case these values remained above control values for the rest of the study. The administration of PAN did not produce any significant increases in cortical T1 values until 14 days postinjection. The elevated T1 values remained above control values for the rest of the study. These increases observed in cortical T1 values appeared to be mirrored by decreases in medullary T1 values. Increases in cortical T1 values were accompanied by visual changes in the NMR images and enlargement of the kidneys. The histological findings were consistent with the NMR data, confirming that morphologically the tissues did show a full recovery by Day 28 in the HCBD-treated animals. This was not the case following injection of both BEA and PAN, where necrosis was not reversible and there was no recovery of the tissues. 相似文献
8.
Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T 总被引:1,自引:0,他引:1
Li X Youngren JF Hyun B Sakkas GK Mulligan K Majumdar S Masharani UB Schambelan M Goldfine ID 《Magnetic resonance imaging》2008,26(2):188-197
OBJECTIVES: The objectives of this study were to develop protocols that measure abdominal fat and calf muscle lipids with magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), respectively, at 3 T and to examine the correlation between these parameters and insulin sensitivity. MATERIALS AND METHODS: Ten nondiabetic subjects [five insulin-sensitive (IS) subjects and five insulin-resistant (IR) subjects] were scanned at 3 T. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were segmented semiautomatically from abdominal imaging. Intramyocellular lipids (IMCL) in calf muscles were quantified with single-voxel MRS in both soleus and tibialis anterior muscles and with magnetic resonance spectroscopic imaging (MRSI). RESULTS: The average coefficient of variation (CV) of VAT/(VAT+SAT) was 5.2%. The interoperator CV was 1.1% and 5.3% for SAT and VAT estimates, respectively. The CV of IMCL was 13.7% in soleus, 11.9% in tibialis anterior and 2.9% with MRSI. IMCL based on MRSI (3.8+/-1.2%) were significantly inversely correlated with glucose disposal rate, as measured by a hyperinsulinemic-euglycemic clamp. VAT volume correlated significantly with IMCL. IMCL based on MRSI for IR subjects was significantly greater than that for IS subjects (4.5+/-0.9% vs. 2.8+/-0.5%, P=.02). CONCLUSION: MRI and MRS techniques provide a robust noninvasive measurement of abdominal fat and muscle IMCL, which are correlated with insulin action in humans. 相似文献
9.
Cathepsin D (CTSD; EC 3.4.23.5) is essential for normal development and/or maintenance of neurons in the central nervous system: its deficiency causes a devastating neurological disorder with severely shortened life span in man, sheep and mouse. Neuropathologically, the CTSD deficiencies are characterized by selective neuronal degeneration, gliosis and accumulation of autofluorescent proteinaceous storage material in neurons. Our aim was to study the dynamics behind the pathological alterations occurring in the brains of CTSD-deficient (CTSD-/-) mice by using in vivo magnetic resonance imaging (MRI) and histology. In order to do this, we measured T(2) signal intensity (SI), apparent diffusion coefficient, area and volume of multiple brain structures from MR images acquired using T(2)-, T(1)- and diffusion-weighted sequences at three time points during disease progression. MRI revealed no differences in the brains between CTSD-/- and control mice at postnatal day 15+/-1 (P15+/-1), representing an initial stage of the disease. In the intermediate stage of the disease, P19(+/-1), SI alterations in the thalami of the affected mice became evident in both T(1)- and T(2)-weighted images. The terminal stage of the disease, P25, was characterized by marked alterations in the T(2) SI, apparent diffusion coefficient and volume of multiple brain structures in CTSD-/- mice. In addition, manganese enhanced high-resolution T(1)-weighted 3D sequences (MEMRI) and histological stainings revealed that the hyperintense signal areas in MEMRI matched perfectly with areas of microglial activation in the brains of CTSD-/- mice at the terminal disease stage. In conclusion, the SI alterations in the thalami of CTSD-/- mice preceded other changes, and the degenerative process was greatly enhanced at the age P19(+/-1), leading to severely reduced brain volume in just 6 days. 相似文献
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11.
The structural effect of biodegradable macromolecular magnetic resonance imaging (MRI) contrast agents, polydisulfide gadolinium (Gd)(III) chelates, on their in vitro degradability, and cardiovascular and tumor imaging were evaluated in mice. Polydisulfide Gd(III) chelates, Gd-DTPA cystamine copolymers (GDCC), Gd-DTPA l-cystine copolymers (GDCP), Gd-DTPA d-cystine copolymers (dGDCP) and Gd-DTPA glutathione (oxidized) copolymers (GDGP), with different sizes and narrow molecular weight distribution were prepared and evaluated both in vitro and in vivo in mice bearing MDA-MB-231 tumor xenografts. GDGP with large steric hindrance around the disulfide bonds had greater T(1) and T(2) relaxivities than GDCC, GDCP and dGDCP. The degradability of the polydisulfide by the endogenous thiols decreased with increasing steric effects around the disulfide bonds in the order of GDCC>GDCP, dGDCP>GDGP. The size and degradability of the contrast agents had a significant impact on vascular contrast enhancement kinetics. The agents with a large size and low degradability resulted in more prolonged vascular enhancement than the agents with a small size and high degradability. It seems that the size and degradability of the agents did not significantly affect tumor enhancement. All agents resulted in significant contrast enhancement in tumor tissue. This study has demonstrated that the vascular enhancement kinetics of the polydisulfide MRI contrast agents can be controlled by their sizes and structures. The polydisulfide Gd(III) chelates are promising biodegradable macromolecular MRI contrast agents for magnetic resonance angiography and cancer imaging. 相似文献
12.
Reducing ghosting due to k-space discontinuities in fast spin echo (FSE) imaging by a new combination of k-space ordering and parallel imaging 总被引:1,自引:0,他引:1
David W. Carmichael David L. Thomas Roger J. Ordidge 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2009,200(1):119-125
In multi-echo imaging sequences like fast spin echo (FSE), the point spread function (PSF) in the phase encoding direction contains significant secondary peaks (sidebands). This is due to discontinuities in adjacent k-space data obtained at different echo times caused by T2 decay, and leads to ghosting and hence reduced image quality. Recently, utilising multiple coils for signal reception has become the standard configuration for MR systems due to the additional flexibility that parallel imaging (PI) methods can provide. PI methods generally obtain more data than is required to reconstruct an image. Here, this redundancy in information is exploited to reduce discontinuity-related ghosting in FSE imaging. Adjacent phase encoded k-space lines are acquired at different echo times alternately in the regions of discontinuity (called ‘feathering’). This moves the resulting ghost artefacts to the edges of the field of view. This property of the ghost then makes them amenable to removal using PI methods. With ‘feathered’ array coil data it is possible to reconstruct data over the region of the discontinuity from both echo times. By combining this data, a significant reduction in ghosting can be achieved. We show this approach to be effective through simulated and acquired MRI data. 相似文献
13.
Sharma U Sah RG Parshad R Sharma R Seenu V Jagannathan NR 《Magnetic resonance imaging》2012,30(5):649-655
We carried out retrospective analysis of apparent diffusion coefficient (ADC) values in 48 infiltrating ductal breast cancer patients who had dynamic contrast-enhanced magnetic resonance imaging (DCEMRI; Group I) and in 53 patients (Group II) for whom DCEMRI data were not available. Twenty-three patients of Group I showed no necrosis (Group Ia), while in 25 patients, both viable (nonnecrotic) and necrotic tumor areas (Group Ib) were observed on DCEMRI. T1-weighted, fat-suppressed and short inversion recovery images were used to identify the viable and necrotic tumor areas in Group II patients, and necrosis was not seen in 11 patients (Group IIa), while 42 (Group IIb) showed both viable and necrotic tumor areas. The ADCs of the necrotic area of Group Ib (1.79±0.30 ×10(-3) mm(2)/s) and Group IIb (1.83±0.40 ×10(-3) mm(2)/s) patients were similar and significantly higher (P<.01) compared to the ADCs of the viable tumor area of Group Ia (0.96±0.21 ×10(-3) mm(2)/s) and Group IIa (0.90±0.17 ×10(-3) mm(2)/s) patients. Proton MR spectroscopy (MRS) data were also available in these patients, and the ADC values were retrospectively determined from the voxel from which MR spectrum was obtained. These values were compared with the ADC obtained for the viable and necrotic areas of the tumor. ADC of the MRS voxel was similar to that obtained for the viable tumor area in patients of both groups. This interesting observation reveals the potential utility of using ADC values to identify viable tumor area for positioning of voxel for MRS in the absence of DCEMRI data. 相似文献