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1.
Ming‐Jen Cheng Bolleddula Jayaprakasam Tsutomu Ishikawa Hiroko Seki Ian‐Lih Tsai Jeh‐Jeng Wang Ih‐Sheng Chen 《Helvetica chimica acta》2002,85(7):1909-1914
Five new compounds, including a novel lactone, machilactone (=rel‐(2R,3aR,6E,6aS)‐2‐heptadecyl‐3a‐methyl‐6‐octadecylidene‐6,6a‐dihydrofuro[2,3‐d][1,3]dioxol‐5(3aH)‐one; 1 ), a new sesquiterpene, 3,4‐dihydroxy‐β‐bisabolol (=rel‐(1R,2S,4R)‐1‐[(1R)‐1,5‐dimethylhex‐4‐enyl]‐1‐methylcyclohexane‐1,2,4‐triol; 2 ), a new secobutyrolactone, methyl (2E)‐2‐(1‐hydroxy‐2‐oxopropyl)eicos‐2‐enoate ( 3 ), two new butyrolactones, machicolide A ( 4 ) and machicolide B ( 5 ) (=3E,4R,5R)‐ and (3Z,4R,5R)‐4,5‐dihydro‐4‐hydroxy‐5‐methoxy‐5‐methyl‐3‐octadecylidenefuran‐2(3H)‐one, resp.) as a mixture, together with known caryophyllene oxide (=4,12,12‐trimethyl‐9‐methylene‐5‐oxatricyclo[8.2.0.04,6]dodecane), hexacosane, tetracosanoic acid, isomahubanolide‐23 (=(3E,4R)‐4,5‐dihydro‐4‐hydroxy‐5‐methylidene‐3‐octadecylidenefuran‐2(3H)‐one), and β‐bisabolol (=(1S)‐1‐[(1S)‐1,5‐dimethylhex‐4‐enyl]‐4‐methylcyclohex‐3‐en‐1‐ol) were isolated from the stem wood of Machilus zuihoensis. The structures of these compounds were established by spectroscopic studies. The eicos‐2‐enoate ( 3 ) and β‐bisabolol exhibited marginal cytotoxicity against NUGC and HONE‐1 cancer cell lines in vitro. 相似文献
2.
An efficient method for the extraction of the carotenoids from Curtobacterium flaccumfaciens pvar poinsettiae was developed. The glucosides of C.p. 450 (=(all‐E,2R,2′R)‐2‐[4‐(β‐D ‐glucopyranosyloxy)‐3‐methylbut‐2‐enyl]‐2′‐(4‐hydroxy‐3‐methylbut‐2‐enyl)‐β, β‐carotene; 4 ) and of C.p. 473 (=(all‐E,2R,2′S)‐2‐[4‐(β‐D ‐glucopyranosyloxy)‐3‐methylbut‐2‐enyl]‐2′‐(3‐methylbut‐2‐enyl)‐3′,4′‐didehydro‐1′,2′‐dihydro‐β,ψ‐caroten‐1′‐ol; 5 ) were isolated for the first time. In addition, the hitherto unknown 3′,4′‐dihydro derivative of C.p. 450, called C.p. 460 (=(all‐E,2R,2′R)‐2‐(4‐hydroxy‐3‐methylbut‐2‐enyl)‐2′‐(3‐methylbut‐2‐enyl)‐1′,2′‐dihydro‐β,ψ‐caroten‐1′‐ol; 6 ), was identified. The structures were established by UV/VIS, CD, 1H‐ and 13C‐NMR, and mass spectra. 相似文献
3.
Shu‐Hong Tao Jun Wu Shu‐Hua Qi Si Zhang Min‐Yi Li Qing‐Xin Li 《Helvetica chimica acta》2007,90(9):1718-1722
Two new iridoid glycosides, named scyphiphorins A ( 1 ) and B ( 2 ), together with four known compounds, geniposidic acid (=(1S,4aS,7aS)‐1‐(β‐D ‐glucopyranosyloxy)‐1,4a,5,7a‐tetrahydro‐7‐(hydroxymethyl)cyclopenta[c]pyran‐4‐carboxylic acid; 3 ), 4‐(4‐hydroxy‐3‐methoxybenzyl)butan‐2‐one, oleanolic acid (=(3β)‐3‐hydroxyolean‐12‐en‐28‐oic acid), and stigmasterol β‐D ‐glucoside (=(3β,22E)‐stigmasta‐5,22‐dien‐3‐yl β‐D ‐glucopyranoside), were isolated for the first time from the stem bark of a Chinese mangrove, Scyphiphora hydrophyllacea Gaertn . f. The structures of compounds 1 and 2 were determined as 10‐O‐benzoylgeniposidic acid and 10‐O‐[(2E,6R)‐8‐hydroxy‐2,6‐dimethyl‐1‐oxooct‐2‐en‐1‐yl]geniposidic acid, respectively, on the basis of spectroscopic data and chemical methods, including 2D NMR techniques. 相似文献
4.
Du‐Qiang Luo Yuan Gao Xiao‐Long Yang Jian‐Guo Tang Li‐Yan Zhao Ji‐Kai Liu 《Helvetica chimica acta》2007,90(6):1112-1116
Two new highly oxidized humulane sesquiterpenes, mitissimols F ( 1 ) and G ( 2 ), were isolated from the fruiting bodies of Lactarius mitissimus. Their structures were elucidated by using extensive spectroscopic techniques including 1D‐ and 2D‐NMR experiments. The absolute configuration of mitissimol F ( 1 ) was determined by 1H‐NMR resolution of its diastereoisomeric α‐methoxy‐α‐(trifluoromethyl)benzeneacetates (MTPA). It was shown to be (1S,3E,6S,8R,9R,10S,11R)‐8,9 : 10,11‐diepoxy‐1,6‐dihydroxyhumul‐3‐en‐5‐one (=(1S,2R,4R,6S,8E,11S,12R)‐6,11‐dihydroxy‐1,6,10,10‐tetramethyl‐3,13‐dioxatricyclo[10.1.0.02,4]tridec‐8‐en‐7‐one). 相似文献
5.
Pter Molnr Jzsef Deli Ferenc Zsila Andrea Steck Hanspeter Pfander Gyula Tth 《Helvetica chimica acta》2004,87(1):11-27
Violaxanthin A (=(all‐E,3S,5S,6R,3′S,5′S,6′R)‐5,6 : 5′,6′‐diepoxy‐5,6,5′,6′‐tetrahydro‐β,β‐carotene‐3,3′‐diol =syn,syn‐violaxanthin; 5 ) and violaxanthin B (=(all‐E,3S,5S,6R,3′S,5′R,6′S)‐5,6 : 5′,6′‐diepoxy‐5,6,5′,6′‐tetrahydro‐β,β‐carotene‐3,3′‐diol=syn,anti‐violaxanthin; 6 ) were prepared by epoxidation of zeaxanthin diacetate ( 1 ) with monoperphthalic acid. Violaxanthins 5 and 6 were submitted to thermal isomerization and I2‐catalyzed photoisomerization. The structure of the main products, i.e., (9Z)‐ 5 , (13Z)‐ 5 , (9Z)‐ 6 , (9′Z)‐ 6 , (13Z)‐ 6 , and (13′Z)‐ 6 , was determined by their UV/VIS, CD, 1H‐NMR, 13C‐NMR, and mass spectra. 相似文献
6.
Three new neolignans, named 1‐deoxycarinatone ( 1 ), isodihydrocarinatidin ( 2 ), and isolicarin A ( 3 ), together with the known neolignan (+)‐dehydrodiisoeugenol ( 4 ), were isolated from mace (the aril of Myristica fragrans Houtt .). Their structures were elucidated as 2‐[(1S)‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐1‐methylethyl]‐6‐methoxy‐4‐(prop‐2‐enyl)phenol ( 1 ), 4‐[(2R,3R)‐2,3‐dihydro‐7‐methoxy‐3‐methyl‐5‐(prop‐2‐enyl)benzofuran‐2‐yl]‐2‐methoxyphenol ( 2 ), and 4‐{(2S,3R)‐2,3‐dihydro‐7‐methoxy‐3‐methyl‐5‐[(1E)‐prop‐1‐enyl]benzofuran‐2‐yl}‐2‐methoxyphenol ( 3 ) on the basis of spectroscopic data. 相似文献
7.
Pter Molnr Jzsef Deli Zoltn Matus Gyula Tth Dorte Renneberg Hanspeter Pfander 《Helvetica chimica acta》2000,83(7):1535-1541
Cucurbitaxanthin A (=(all‐E,3S,5R,6R,3′R)‐3,6‐epoxy‐5,6‐dihydro‐β,β‐carotene‐5,3′‐diol; 1 ) was submitted to thermal isomerization and to I2‐catalysed photoisomerization. The structure of the main reaction products (9Z)‐ ( 2 ), (9′Z)‐ ( 3 ), (13Z)‐ ( 4 ), and (13′Z)‐cucurbitaxanthin A ( 5 ) was determined by their UV/VIS, CD, 1H‐NMR, and mass spectra. 相似文献
8.
Two new dolabellane diterpenoids, (1R,3R,7E,11S,12R)‐dolabella‐4(16),7‐diene‐3,18‐diol ( 1 ) and (1R,3E,7R,11S,12R)‐dolabella‐3,8(17)‐diene‐7,18‐diol ( 2 ), and the known (1R,3E,7E,11S,12R)‐dolabella‐3,7‐dien‐18‐ol ( 3 ) were isolated from Aglaia odorata, along with twelve other known compounds. Their structures were elucidated on the basis of spectroscopic data. This is the first time that dolabellane‐type diterpenoids were detected in higher plants. 相似文献
9.
Frdric Carrel Sylvain Giraud Olivier Spertini Pierre Vogel 《Helvetica chimica acta》2004,87(5):1048-1070
Wittig olefination of (2S,3R,5S,6R)‐5‐(acetyloxy)‐tetrahydro‐6‐[(methoxymethoxy)methyl]‐3‐(phenylthio)‐ 2H‐pyran‐2‐acetaldehyde ((+)‐ 10 ) with {2‐[(2S,3R,4R,5R,6S)‐tetrahydro‐3,4,5‐tris(methoxymethoxy)‐6‐methyl‐ 2H‐pyran‐2‐yl]ethyl}triphenylphosphonium iodide ((?)‐ 11 ) gave a (Z)‐alkene derivative (+)‐ 12 that was converted into (αR,2R,3S,4R,5R,6S)‐tetrahydro‐α,3‐dihydroxy‐2‐(hydroxymethyl)‐5‐(phenylthio)‐6‐{(2Z)‐4‐[(2S,3S,4R,5S,6S)‐tetrahydro‐3,4,5‐trihydroxy‐6‐methyl‐2H‐pyran‐2‐yl]but‐2‐enyl}2H‐pyran‐4‐acetic acid ( 8 ), (αR,2R,3S,4R,6S)‐tetrahydro‐α,3‐dihydroxy‐2‐(hydroxymethyl)‐6‐{4‐[(2S,3S,4R,5S,6S)‐tetrahydro‐3,4,5‐trihydroxy‐6‐methyl‐2H‐pyran‐2‐yl]butyl}‐2H‐pyran‐4‐acetic acid ( 9 ), and simpler analogues without the hydroxyacetic side chain such as (2S,3S,4R,5S,6S)‐tetrahydro‐6‐methyl‐2‐{(2Z)‐4‐[(2S,3R,5S,6R)‐tetrahydro‐5‐hydroxy‐6‐(hydroxymethyl)‐3‐(phenylthio)‐2H‐pyran‐2‐yl]but‐2‐enyl}‐2H‐pyran‐3,4,5‐triol ( 30 ), (2S,3S,4R,5S,6S)‐tetrahydro‐6‐methyl‐2‐{[(2S,5S,6R)‐tetrahydro‐5‐hydroxy‐6‐(hydroxymethyl)‐2H‐pyran‐2‐yl]butyl}‐2H‐pyran‐3,4,5‐ triol ((?)‐ 41 ) and (2S,3S,4R,5S,6S)‐tetrahydro‐6‐methyl‐2‐{(2Z/E))‐4‐[(2R,5S,6R)‐tetrahydro‐5‐hydroxy‐6‐(hydroxymethyl)‐2H‐pyran‐2‐yl]but‐2‐enyl}‐2H‐pyran‐3,4,5‐triol ( 43 ). The key intermediates (+)‐ 10 and (?)‐ 11 were derived from isolevoglucosenone and from L ‐fucose, respectively. The following IC50 values were measured in a ELISA test for the affinities of sialyl Lewis x tetrasaccharide, 8, 9, 30 , (?)‐ 41 , and 43 toward P‐selectin: 0.7, 2.5–2.8, 7.3–8.0, 5.3–5.9, 5.0–5.2, and 3.4–4.1 mM , respectively. 相似文献
10.
Three new compounds, (5β,9β)‐guaia‐6,10(14)‐dien‐9‐ol (=rel‐(1R,3aS,5R,8aR)‐1,2,3,3a,4,5,6,8a‐octahydro‐1‐methyl‐4‐methylene‐7‐(1‐methylethyl)azulen‐5‐ol; 1 ), 6‐acetyl‐8‐methoxy‐2,3‐dimethylchromen‐4‐one (=6‐acetyl‐8‐methoxy‐2,3‐dimethyl‐4H‐1‐benzopyran‐4‐one; 2 ), and (2S)‐3′‐hydroxy‐5′,7‐dimethoxyflavanone (=(2S)‐2,3‐dihydro‐2‐(3‐hydroxy‐5‐methoxyphenyl)‐7‐methoxy‐4H‐1‐benzopyran‐4‐one; 3 ) were isolated from the roots and rhizomes of Ligularia macrophylla, together with seven known compounds. Their structures and configurations were elucidated by spectroscopic methods, including 2D‐NMR techniques. 相似文献
11.
Pter Molnr Jzsef Deli Zoltn Matus Gyula Tth Andrea Steck Hanspeter Pfander 《Helvetica chimica acta》1999,82(11):1994-2002
Karpoxanthin (=(all-E,3S,5R,6R,3′R)-5,6-dihydro-β,β-carotene-3,5,6,3′-tetrol; 7 ), 6-epikarpoxanthin (=(all-E,3S,5R,6S,3′R)-5,6-dihydro-β,β-carotene-3,5,6,3′-tetrol; 4 ), 5-epikarpoxanthin (=(all-E,3S,5S,6R,3′-R)-5,6-dihydro-β,β-carotene-3,5,6,3′-tetrol; 11 ), cucurbitaxanthin A (=(all-E,3S,5R,6R,3′R)-3,6-epoxy-5,6-dihydro-β,β-carotene-5,3′-diol; 10 ), epicucurbitaxanthin A (=(all-E-3S,5S,6R,3′R)-3,6-epoxy-5,6-dihydro-β,β-carotene-5,3′-diol; 14 ), and the corresponding mutatoxanthin epimers 8 , 9 , 12 , and 13 were prepared in crystalline state by the acid-catalyzed hydrolysis of (3S,5R,6S,3′R)- and (3S,5S,6R,3′R)-antheraxanthin ( 5 and 6 , resp.) and characterized by their UV/VIS, CD, 1H- and 13C-NMR, and mass spectra. 相似文献
12.
BinaS. Siddiqui SyedTariq Ali Munawwer Rasheed MuhammadNadeem Kardar 《Helvetica chimica acta》2003,86(8):2787-2796
Studies on the chemical constituents of the flowers of Azadirachta indica have led to the isolation of two new flavanones, flowerine (=5‐hydroxy‐7,4′‐dimethoxy‐8‐(3‐methylbut‐2‐enyl)flavan‐4‐one; 1 ) and flowerone (=5,7,8,4′‐tetrahydroxy‐3′‐(3‐methylbut‐3‐enyl)flavan‐4‐one; 2 ), and two new triterpenoids, O‐methylazadironolide (=7α‐(acetoxy)‐23ξ‐methoxy‐21,23‐epoxy‐24,25,26,27‐tetranorapotirucalla‐1,14,20(22)‐trien‐3,21‐dione; 3 ) and diepoxyazadirol (=(20S,23S,24R)‐7‐α‐(acetoxy)‐25‐hydroxy‐21,24 : 23,24‐diepoxyapotirucalla‐1,14‐dien‐3‐one; 4 ) along with the known triterpenoid trichilenone acetate (=7α‐(acetoxy)‐14,15 : 21,23‐diepoxy‐24,25,26,27‐tetranorapotirucalla‐1,20,22‐trien‐3‐one; 5 ), two known flavanones, nimbaflavone (=5,7‐dihydroxy‐4′‐methoxy‐8,3′‐bis(3‐methylbut‐2‐enyl)‐flavan‐4‐one; 6 ) and 3′‐prenylnaringenin (=5,7,4′‐trihydroxy‐3′‐(3‐methylbut‐2‐enyl) flavan‐4‐one; 7 ), and 4‐(2‐hydroxyethyl)phenol ( 8 ). Their structures have been elucidated through spectral studies, including 2D‐NMR experiments, and chemical transformation. Compounds 5, 7 and 8 are heretofore unreported from any part of tree, while 6 has been isolated earlier from leaves. 相似文献
13.
Pter Molnr Jzsef Deli Erzsbet sz Zoltn Matus Gyula Tth Ferenc Zsila 《Helvetica chimica acta》2004,87(8):2169-2179
3′‐Epilutein (=(all‐E,3R,3′S,6′R)‐4′,5′‐didehydro‐5′,6′‐dihydro‐β,β‐carotene‐3,3′‐diol; 1 ), isolated from the flowers of Caltha palustris, was submitted to both thermal isomerization and I2‐catalyzed photoisomerization. The structures of the main products (9Z)‐ 1 , (9′Z)‐ 1 , (13Z)‐ 1 , (13′Z)‐ 1 , (15Z)‐ 1 , and (9Z,9′Z)‐ 1 were determined based on UV/VIS, CD, 1H‐NMR, and MS data. 相似文献
14.
Yun‐Wen Liao Chiy‐Rong Chen Jue‐Liang Hsu Hsueh‐Ling Cheng Wen‐Ling Shih Yueh‐Hsiung Kuo Tzou‐Chi Huang Chi‐I Chang 《中国化学会会志》2011,58(7):893-898
A new sterol, 5α,6α‐epoxy‐3β‐hydroxy‐(22E,24R)‐ergosta‐8,22‐dien‐7‐one ( 1 ), together with eight known sterols, 5α,6α‐epoxy‐(22E,24R)‐ergosta‐8,22‐diene‐3β,7α‐diol ( 2 ), 5α,6α‐epoxy‐(22E,24R)‐ergosta‐8,22‐diene‐3β,7β‐diol ( 3 ), 5α,6α‐epoxy‐(22E,24R)‐ergosta‐8(14),22‐diene‐3β,7α‐diol ( 4 ), 3β‐hydroxy‐(22E,24R)‐ergosta‐5,8,22‐trien‐7‐one ( 5 ), ergosterol peroxide ( 6 ), clerosterol ( 7 ), decortinol ( 8 ), and decortinone ( 9 ), were isolated from the stems of Momordica charantia. Their structures were elucidated by mean of extensive spectroscopic methods, including 1H, 13C, 2D‐NMR and HR‐EI‐MS, as well as comparison with the literature data. Compounds 1 , 4 , 5 , 8 , and 91 were not cytotoxic against the SK‐Hep 1 cell line. 相似文献
15.
Yu‐Bo Liu Jiang‐Jiang Qin Xiang‐Rong Cheng Jia‐Xian Zhu Fei Zhang Hui‐Zi Jin Wei‐Dong Zhang 《Helvetica chimica acta》2011,94(9):1685-1691
Three new neolignans, (7S,8S,7′E)‐4,9‐dihydroxy‐3,7,3′,9′‐tetramethoxy‐8,4′‐oxyneolign‐7′‐ene ( 1 ), (7R,8S,7′E)‐4, 9‐dihydroxy‐3,7,3′,9′‐tetramethoxy‐8,4′‐oxyneolign‐7′‐ene ( 2 ), (7S,8S,7′E)‐5, 9‐dihydroxy‐3,7,3′,5′,9′‐pentamethoxy‐8,4′‐oxyneolign‐7′‐ene ( 3 ), and one new phenylpropanoid, threo‐5‐hydroxy‐3,7‐dimethoxyphenylpropane‐8,9‐diol ( 4 ), were isolated from the leaves and stems of Toona ciliata var. pubescens. Their structures were determined on the basis of spectroscopic analysis, especially 2D‐NMR, HR‐ESI‐MS, and CD data. The antiproliferative activities of these compounds against four tumor cell lines (A549, Colo 205, QGY‐7703, and LOVO) were also evaluated by MTT (=(3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide) method. 相似文献
16.
Jzsef Deli Erzsbet sz Pter Molnr Ferenc Zsila Mikls Simonyi Gyula Tth 《Helvetica chimica acta》2001,84(12):3810-3817
(6′S)‐ and (6′R)‐‘Capsorubol‐6‐one' (=(3S,3′S,5R,5′R,6′S)‐ and (3S,3′S,5R,5′R,6′R)‐3,3′,6′‐trihydroxy‐κ,κ‐caroten‐6‐one; 8 and 9 , resp.), (6S,6′R)‐ and (6R,6′R)‐capsorubol (=3S,3′S,5R,5′R,6S,6′R)‐ and (3S,3′S,5R,5′R,6R,6′R)‐κ,κ‐carotene‐3,3′,6,6′‐tetrol; 11 and 12 , resp.) and (6′S)‐ and (6′R)‐cryptocapsol (=(3′S,5′R,6′S)‐ and (3′S,5′R,6′R)‐β,κ‐carotene‐3′,6′‐diol; 5 and 6 , resp.) were prepared in crystalline from by the reduction of capsorubin (=(3S,3′S,5R,5′R)‐3,3′‐dihydroxy‐κ,κ‐carotene‐6,6′‐dione; 7 ) and cryptocapsin (=(3′S,5′R)‐3′‐hydroxy‐β,κ‐caroten‐6′‐one; 4 ) and characterized by their UV/VIS, CD, 1H‐NMR, and mass spectra. 相似文献
17.
Molecular diversity was generated by hydrolyzing the crude root saponins of Panax notoginseng (Burk .) F. H. Chen under mild acidic condition (AcOH/EtOH 1 : 1). From the acid hydrolysate, five new dammarane glycosides, named notoginsenoside T1 (=(3β,6α,12β,20E,23RS)‐24,25‐epoxy‐6‐[(β‐D ‐glucopyranosyl)oxy]‐dammar‐20(22)‐ene‐3,12,23‐triol; 1 ), notoginsenoside T2 (=(3β,6α,12β,20E,23RS)‐24,25‐epoxy‐6‐[(β‐D ‐glucopyranosyl)oxy]‐23‐methoxydammar‐20(22)‐ene‐3,12‐diol; 2 ), notoginsenoside T3 (=(3β,6α,12β,20S)‐6‐[(β‐D ‐glucopyranosyl)oxy]‐20‐ethoxydammar‐24‐ene‐3,12‐diol; 3 ), notoginsenoside T4 (=(3β,6α,12β,20S,22E,24RS)‐6‐[(β‐D ‐glucopyranosyl)oxy]dammar‐22‐ene‐3,12,20,24,25‐pentol; 4 ), and notoginsenoside T5 (=(3β,6α,12β, 24E)‐6‐[(β‐D ‐xylopyranosyl‐(1→2)‐β‐D ‐glucopyranosyl)oxy]dammara‐20(21),24‐diene‐3,12‐diol; 5 ), were isolated, together with 15 known dammarane glycosides, and their structures were elucidated on the basis of spectroscopic evidence. Among the known compounds, ginsenosides Rg3 and Rh1 were isolated as major constituents, in addition to ginsenosides Rg5, Rh4, and a mixture of (20R)‐ and (20S)‐25‐hydroxyginsenoside Rh1, all of which were obtained from P. notoginseng for the first time. 相似文献
18.
Phytochemical investigation of the 95% EtOH extract of the dry fronds of Conyza japonica (Thunb .) Less. resulted in the isolation of three new labdane diterpene glycosides, (3β,13S)‐13‐O‐α‐L ‐rhamnopyranosyllabda‐8(17),14‐dien‐3‐yl α‐L ‐rhamnopyranoside ( 1 ), (3β,13S)‐13‐O‐α‐L ‐rhamnopyranosyllabda‐8(17),14‐diene‐3‐yl 2‐O‐acetyl‐α‐L ‐rhamnopyranoside ( 2 ), and (3β,13S)‐13‐O‐α‐L ‐rhamnopyranosylabda‐8(17),14‐dien‐3‐yl 6‐O‐acetyl‐β‐D ‐glucopyranosyl‐(1→2)‐α‐L ‐rhamnopyranoside ( 3 ), together with their aglycone, (13S)‐labda‐8(17),14‐diene‐3,13‐diol ( 4 ). Their structures were characterized by spectroscopic analyses and chemical correlations, including 1D‐ and 2D‐NMR, and HR‐ESI‐MS. Furthermore, compounds 1 – 3 appeared to be promising as active agents against the tested pathogen fungi and oral pathogens as they possessed moderate cytotoxic properties. 相似文献
19.
A minor, unprecedented diterpene, 3β,17‐dihydroxycleistantha‐12,15‐dien‐2‐one ( 1 ), was isolated from the CHCl3‐soluble part of the EtOH extract of the pericarp of Trewia nudiflora. The structure of 1 was elucidated by means of 1D‐ and 2D‐NMR spectroscopic analyses as well as by HR‐MS. Also isolated were two known triterpenes, glutin‐5‐en‐3‐ol and olean‐18‐en‐3‐one (germanicone), as well as three known sterols, (22E,24R)‐5α,8α‐epidioxyergosta‐6,22‐dien‐3β‐ol, (22E,24R)‐5α,8α‐epidioxyergosta‐6,9(11),22‐trien‐3β‐ol, and (22E,24R)‐6‐methoxyergosta‐7,22‐dien‐3,5‐diol. 相似文献
20.
Atta‐ur‐Rahman Zaheer‐ul‐Haq Fareeda Feroz Asaad Khalid SarfrazAhmad Nawaz M.Riaz Khan M.Iqbal Choudhary 《Helvetica chimica acta》2004,87(2):439-448
Seven new steroidal alkaloids, 2‐hydroxysalignarine‐E (=(2′E,20S)‐20‐(dimethylamino)‐2β‐hydroxy‐3β‐(tigloylamino)pregn‐4‐ene; 1 ), 5,6‐dihydrosarconidine (=(20S)‐20‐(dimethylamino)‐3β‐(methylamino)‐5α‐pregn‐16‐ene; 2 ), salignamine (=(20S)‐20‐(methylamino)‐3β‐methoxypregna‐5,16‐diene; 3 ), 2‐hydroxysalignamine (=(20S)‐20‐(dimethylamino)‐2β‐hydroxy‐3β‐methoxypregna‐5,16‐diene; 4 ), salignarine‐F (=(2′E, 20S)‐20‐(dimethylamino)‐4β‐hydroxy‐3β‐(tigloylamino)pregn‐5‐ene; 5 ), salonine‐C (=(2′E,20S)‐20‐(dimethylamino)‐3β‐(tigloylamino)pregna‐4,14‐diene; 6 ), and N‐[formyl(methyl)amino]salonine‐B (=(20S)‐20‐[formyl(methyl)amino]‐3β‐methoxypregna‐5,16‐diene; 7 ) have been isolated from the MeOH extract of Sarcococca saligna, along with the six known alkaloids dictyophlebine ( 8 ), epipachysamine‐D ( 9 ), saracosine ( 10 ), iso‐N‐formylchonemorphine ( 11 ), sarcodinine ( 12 ), and alkaloid‐C ( 13 ). The structures of 1 – 7 were deduced from spectral data. Compounds 1 – 13 demonstrated significant activity against acetyl‐ and butyrylcholinesterase. 相似文献