New Hydroxylated Spermidine Alkaloids from Pleurostylia opposita(WALL.) MERILL-METCALF

The leaves of a New Caledonian celastraceae, Pleurostylia opposita (WALL .) MERRILL -METCALF , have yielded three new spermidine alkaloids, 7-hydroxypleurostyline ( 1 ), 7-hydroxycelacinnine ( 2 ), and 7′-hydroxy-7′,8′-dihydropleurostyline ( 3 ), as minor basic constituents, together with three related alkaloids pleurostyline ( 4 ), celacinnine ( 5 ), and celallocinine ( 6 ).     

Two New Alkaloids from Flueggea virosa

Two new securinega‐type alkaloids and four known ones were isolated from the twigs and leaves of Flueggea virosa. The structures of the new compounds were elucidated by means of spectroscopic methods (UV, IR, HR‐ESI‐MS, and 1D‐ and 2D‐NMR), and the absolute configurations were assigned by CD spectra. The structures of the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature.     

Two New Alkaloids from Incarvillea sinensis

Two new alkaloids, incarvines E ( 1 ) and F ( 2 ), were isolated from the EtOH extract of the whole plant of Incarvillea sinensis. Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR.     

Two New Alkaloids from Stemona tuberosa

Two new alkaloids, named tuberostemoninol A ( 1 ) and tuberostemoninol B ( 2 ), along with the known compounds tuberostemoninol ( 3 ) and bisdehydroneotuberostemonine ( 4 ), were isolated from Stemona tuberosa Lour . The structures were elucidated by means of spectroscopic analyses, including 1D‐ and 2D‐NMR experiments. The four alkaloids 1 – 4 were analyzed by on‐line high‐performance liquid chromatography/electrospray‐ionization mass spectrometry (HPLC/ESI‐MS), and their fragmentation pathways were found to be similar. Compounds 1, 2 , and 3 are isomers with the same molecular mass but which eluted at different retention times.     

Two New Lycodine Alkaloids from Lycopodiastrum casuarinoides

Two new lycodine alkaloids, 11β‐methoxyhuperzine B ( 1 ) and 16‐oxohuperzinine ( 2 ), together with seven known ones, huperzinine N‐oxide, huperzine D, casuarinine A, huperzine B, casuarinine B, huperzinine, and N‐methyllycodine, were isolated from whole plants of Lycopodiastrum casuarinoides. Their structures were elucidated by spectroscopic methods, including NMR and MS experiments.     

Two New Aporphine Alkaloids from Litsea glutinosa

Chemical examination of the BuOH extract of the leaves and twigs of Litsea glutinosa collected from Xishuangbanna resulted in the isolation of two new aporphine alkaloids, namely litseglutine A ( 1 ) and B ( 2 ), along with two known aporphine alkaloids, boldine ( 3 ) and laurolitsine ( 4 ). The structures of the new alkaloids have been elucidated on the basis of spectra analysis as 6‐demethyl‐9‐methoxy‐1,2‐(methylenedioxy)aporphin‐10‐ol (=6,7,7a,8‐tetrahydro‐10‐methoxy‐5H‐benzo[g]‐1,3‐benzodioxolo[6,5,4‐de]quinolin‐11‐ol; 1 ) and 1,10,11‐trimethoxyaporphin‐2‐ol (=5,6,6a,7‐tetrahydro‐1,10,11‐trimethoxy‐6‐methyl‐4H‐dibenzo[de,g]quinolin‐2‐ol; 2 ).     

Two New Oxindole Alkaloids from Ervatamia yunnanensis

ErvalanIiaYunnanensiSTsianghasbeenusedasafolkmedicineinChinaforthetreatmentofhypertensi0n'.Aspart0fourc0ntinuingpr0gramonthestudyofplant-derivedbioactivecomp0unds,thechemicaIconstituents0fE.yunnanensI1vgrowinginYunnanwereinvestigated.Intheprevi0uspaper,werep0rtedthestructuresofind0lealkal0ids;l9S-hydr0xy-tacamine,tabernaemontanine,l7-demethoxy-c0rynoxineB,l7-demethoxy-hydr0c0rynoxineB,20-epi-ervatamine,19,2O-dehydroervatamine,includinganewone,l9S-hydroxy-16-epi-tacaminefr0mthisspecies'.T…     

Two New Indole Alkaloids from Emmenopterys henryi

Two new indole alkaloids, 5‐oxodolichantoside ( 1 ) and deglycocadambine ( 2 ), were isolated from the twigs and leaves of Emmenopterys henryi, together with four known indole alkaloids and five known iridoids. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analyses, including 1D‐ and 2D‐NMR experiments, and confirmed by single‐crystal X‐ray diffraction studies. This is the first report on the isolation of indole alkaloids from this species. The indole alkaloids were evaluated for their cytotoxic activities against five human cancer lines.     

小叶唐松草的两个新氧化阿朴芬类生物碱

Two new oxoaporphine alkaloids, 1,2,3,10-tetramethoxy-9-(2-hydroxy-4,5-dimethoxybenzyloxy)oxoaporphine (1) and 1,2,3,10-tetramethoxy-9-(4,5-dimethoxy-2-formylphenoxy)oxoaporphine (2), were isolated from Thalictrum elegans. Their structures were elucidated based on spectroscopic analysis including 1D, 2D NMR, IR and MS.     

Two New Isoquinoline Alkaloids from Carduus crispus

Two new isoquinoline alkaloids: carcrisine A and B, have been isolated from the whole plant of Carduus crispus L.. Their structures were elucidated by chemical and spectroscopic methods.     

Two New Lycopodium Alkaloids from Lycopodium obscurum

Two new Lycopodium alkaloids, (+)‐cermizine D N‐oxide ( 1 ) and (8β)‐8‐(acetyloxy)obscurumine A ( 2 ), along with five known compounds, were isolated from the crude alkaloid portion of Lycopodium obscurum. Their structures were elucidated on the basis of spectroscopic data and chemical correlation. All of these alkaloids were tested in an assay for acetylcholine esterase (AChE) inhibitory activity.     

Two New Lycopodine Alkaloids from Huperzia serrata

Two new lycopodine alkaloids, (12β)‐12‐hydroxyhuperzine G ( 1 ) and (5β,6β,15α)‐15‐methyllycopodane‐5,6‐diol ( 2 ), were isolated from the whole plants of Huperzia serrata, together with six known compounds, huperzines A, B, and G, phlegmariurine B, (8β)‐8‐hydroxyphlegmariurine B, and lycoposerramine D. Their structures were elucidated on the basis of spectroscopic analysis, including HR‐ESI‐MS, ¹H‐ and ¹³C‐NMR, DEPT, ¹H,¹H‐COSY, HSQC, HMBC, and NOESY data.     

Two New Benzophenanthridine Alkaloids from Zanthoxylum nitidum

Two new benzophenanthridine alkaloids, named 8‐methoxysanguinarine ( 1 ) and 8‐methoxyisodecarine ( 2 ), were isolated from the EtOH extract of the rhizoma of Zanthoxylum nitidum. Their structures were determined on the basis of spectroscopic analysis.     

Two New Nitrone Alkaloids from Huperzia serrata

Two new nitrone alkaloids were isolated from the whole plant of Huperzia serrata (Thunb .) Trev . They are both phlegmarine‐type lycopodium alkaloids with a nitrone moiety. Their structures were elucidated on the basis of spectral evidences, and their configurations were established on the basis of optical rotation, CD, and NOESY‐NMR data.     

Two New Indole Alkaloids from Evodia rutaecarpa

The tyuit of Evodia rutaecarpa (Juss.) Benth is a Chinese traditional drug (Wu-Chu-Yu).The components of Wu-Chu-Yu have been studied by several groups, including indolealkaloids,quinolone alkaloids. limonoids and other kinds]. Further chemical investigationofthis drug led us to isolate two new indole alkaloids 1 and 2. This is the first time toisolate indolinone alkaloids from this plant.Wuchuyuamide I (l ), was isolated as colorless needles, m,p. 261 -262<> C (CHCI,MeOH), [Q].=# 0(c 0…     

Two New Daphniphyllum Alkaloids from Daphniphyllum calycinum

Two new daphniphyllum alkaloids named 2‐hydroxyyunnandaphnine D ( 1 ) and methyl 7‐hydroxyhomodaphniphyllate ( 2 ), together with eight known alkaloids, daphnioldhanin D, calyciphylline F, calyciphylline B, deoxycalyciphylline B, daphnicyclidin H, macropodumine C, 9,10‐epoxycalycine A, and yunnandaphnine A, were isolated from the stems and leaves of Daphniphyllum calycinum. Their structures and relative configurations were established on the basis of spectral evidence (including 2D‐NMR) and subsequently confirmed by a single‐crystal X‐ray crystallographic diffraction analysis.     

Two New Norditerpenoid Alkaloids from Delphinium Souliei

DelphiniumsoulieiFranch,distributedintheSouthwestofGansuProvince,WestofSichuanProvince,andtheQinghaiProvinceofChina,isreportedtopossessantipyretic,antitoxic,antidysenteric,andantidiarrhealactivities.linthisstUdy,twonewditerpenoidalkaloidswereisolatedfromthewholeplantsofD.soulidi.TheirstructUreswereestablishedassoulineA(l)andsoulineB(2)onthebasisofspectraldata.SoulineA(l)wasisolatedascolorlesscrystals.Themolecularionpeakatm/z477.2678initsHREIMSrevealedthemolecularformulaC26H39NO7(cafe…     

Two New Alkaloids from Daphniphyllum angustifolium Hutch.

Daphangustifolines A and B ( 1 and 2 ), two new Daphniphyllum alkaloids were isolated from the whole plant of Daphniphyllum angustifolium Hutch . Their structures were established on the basis of spectroscopic data. Their cytotoxicity against HL‐60, MCF‐7, and A549 cell lines was also evaluated.     

Two New Norditerpenoid Alkaloids from Aconitum spicatum Stapf

Two new norditerpenoid alkaloids, spicatine A (1) and spicatine B (2) were isolated from the root of Aconitum spicatum. The new compounds were deduced on the basis of their spectral data (IR, HREIMS, EIMS, 1D, 2D-NMR). This is the first whole report on the isolation of diterpenoid alkaloids from the A.spicatum Stapf.