海绵Phyllospongia Foliascens中的双高Scalarane二倍半萜

具有Scalarane碳架的二倍半萜以及C-20单甲基化或C-20和C-24双甲基化的Scalarane型高二倍半萜普遍存在于Dictyoceratida科海绵中,我们从同科海绵Phyllospongia foliascens中已分离及测定了5个结构新颖的双高二倍半萜,本文报道另外2个双高二倍半萜phyllohemiketal A(1)和B(2)的分离和结构测定。     

Acetoxy phyllofolactone A——中国南海海绵Phyllospongia foliascens中一个新二倍半萜

具有Scalarane碳架的二倍半萜以及C-20甲基化或C-20和C-24双甲基化的Scalarane型高二萜半萜是Dictyoceratida科海绵的典型代谢产物。海绵Phyllospongia foliascens属Dictyoceratida科,从这种海绵中我们已分离和测定了7种双高二倍半萜的结构,作为对这种海绵深入研究的一部分,我们对采自西沙和南沙群岛的同种海绵进行了研究,从中得到Acetoxy phyllofoldctone A(1).本文报道(1)的分离及结构测定.     

南海海绵Pachychalina sp.化学成分的研究(二)

从中国南海海绵Pachychalinasp．的正丁醇可溶部分分离获得一种核苷类化合物，其结构经IR、MS、1H－NMR、13C－NMR和1H－1HCOSY等实验分析确定为尿嘧啶脱氧核苷。该化合物是首次从我国南海海洋动物中分离获得的。     

两种新的二氢沉香呋喃倍半萜的结构

两种新的二氢沉香呋喃倍半萜的结构张王艳红陈耀祖＊（兰州大学应用有机化学开放实验室，兰州７３００００）关键词倍半萜分离圆锥红果藤卫矛科南蛇藤属植物在我国有广泛的分布，许多该类植物是人们传统使用的天然杀虫剂。［１］许多研究表明，卫矛科植物中的杀虫活性成...     

南海海绵Pachychalina sp.化学成分研究(一)

从中国南海海绵Pachychalinasp．的正丁醇可溶部分分离得到一种具有特殊香味的酯类化合物，其结构经IR、MS、1HNMR、13CNMR分析确定为对羟基苯醋酸甲酯，该化合物是首次从我国南海海洋生物中分离获得。     

两个新的海洋倍半萜

从稠密短指软珊瑚Sinularia conferta 中分离得1个新倍半萜confertol(1)。 从荑柔软珊瑚Nephthea albida分离得1个新倍半萜nephalbidol(2)和1个已知的多 羟基甾醇nephalsterol A(3)，应用波谱方法测定了的化学结构和相对构型。     

圆二色谱研究两个新的呋喃雅槛蓝型倍半萜的绝对构型

前文我们从长梗千里光(Senecio Kaschkarovii)和森林千里光(Senecio Nernenrisis)中分离得到3个10位是羟基的9-氧-呋喃型倍半萜(Ⅰ—Ⅳ),其中Ⅰ和Ⅳ为首次发现的新化合物。这3种化合物A、B环是顺式连接,而6位取代基是β构型,这仅仅是通过它们的核磁共振氢谱与类似化合物对照及NOE差谱确定的。由于此类化合物10位缺少氢,使得用核磁共振氢谱确定A、B环的连接方式尚显论据不足。为进一步证明我们前文的推断的正确性,本文制备     

两个新的海绵烷型二萜内酯

从海绵SpongiazimoccasubspeciesirregulariaLemdenfeld中分离到2个新的海绵烷型二萜(2),(3),依次命名为zimoclatoneB和zimoclactoeC。应用1D和2DNMR和X射线单晶衍射分析方法测定了这两个新二萜的化学结构及相对构型。     

南海海绵Biemna fortis中一种环二氧甾醇

从中国南海海绵Biemnafortis的乙酸乙酯可溶部分分离出一个已知的有机化合物 ,经IR ,EIMS ,1HNMR等光谱分析确定其化学结构式为 :5α ,8α -环二氧 -2 4 ξ -甲基胆甾 -6,2 2 -二烯 -3 β -醇。     

Phyllofenone A, a New Scalarane Sesterterpene from the Sponge Phyllospongia Foliascens(Pallas)

The present paper covers the structure of a new sesterterpene, phyllofenone A(1) , isolated from the South China Sea sponge Phyllospongia foliascens. Phyllofenone A is a member of the scalarane class of sesterterpenes with a (C-20, C-24)-bishomo-(C-25)-nortetra-cyclic skeleton. The structure charcterization was based on one- and two-dimensional NMR and mass spectroscopy with the assistance of molecular modeling. Phyllofenone A shows weak antifungal activity against Candida pseudotropicalis.     

Phyllactones F and G,Further Bis-Homoscalarane Sesterterpenes from the Sponge Phyllospongia Foliaseens

Introduction In the previous papers, we reported the isolation and structural elucidation of eight 20,24-bishomoscalarane sesterterpenes from the sponge Phyllospongia foliascens collected from Xisha Islands. As a result of our continual investigation of the same sponge     

New Sesterterpenoids from the Marine Sponge Phyllospongia papyracea

Chemical investigation of an extract of the marine sponge Phyllospongia papyracea, collected from the South China Sea, led to the isolation and identification of three new scalarane‐type sesterterpenoids, compounds 1 – 3 . Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR as well as high‐resolution ESI‐MS experiments. (12α,16β)‐12‐Acetoxy‐16‐hydroxy‐20,24‐dimethyl‐25‐norscalar‐17‐en‐24‐one ( 1 ) was cytotoxic against the leukemia P388 cancer cell line, with an IC₅₀ value of 5 μg/ml.     

New Sterol Derivatives from the Marine Sponge Xestospongia sp.

Chemical examination of a marine sponge Xestospongia sp. resulted in the isolation of 20 sterol derivatives ( 1 – 20 ), including eight new sterols namely aragusterols J – L ( 1 – 3 ), (5α,7α,12β,22E)‐7,12,18‐trihydroxystigmast‐22‐en‐3‐one ( 4 ), (5α,7α,12β,24R)‐ and (5α,7α,12β,24S)‐7,12,20‐trihydroxystigmastan‐3‐one ( 5 / 6 ), and (5α,7α,12β,22E,24R)‐ and (5α,7α,12β,22E,24S)‐7,12,20‐trihydroxyergost‐22‐en‐3‐one ( 7 / 8 ). The structures of new compounds were determined through extensive spectroscopic analyses and chemical conversion. The sterol diversity was mainly characterized by the presence of a cyclopropane unit at side chain, while compound 4 with 18‐hydroxymethyl group was found in stigmasterol family for the first time. Cytotoxic test revealed the inhibitory effects of compounds 1 , 4 , and 17 against human leukemia cell line K562 with IC₅₀ values of 18.3, 24.1, and 34.3 μm , respectively.     

南中国海星骨海绵Stelletta sp.中的三萜化合物

最近,我们又从采自广西涠洲岛海域的星骨海绵Stelletta sp.中分离得到3个黄色三萜色素1,2和3(见下式).通过IR,UV,MS和1D NMR,2D NMR等方法测定了它们的结构,并对化合物1的所有C和H进行了指认.同时,通过X射线单晶衍射分析测定了化合物1的立体化学结构.初步的药理实验表明,这3个化合物对P388肿瘤细胞均有很强的抑制活性,ED₅₀值依次为0.01,0.5和1.0μg/mL,提示Stelletta属海绵中的这类三萜具有很好的药用开发前景.     

Cytotoxic polyacetylenes related to petroformyne-1 from the marine sponge Petrosia sp.

Four polyacetylenes related to petroformyne-1 were isolated from the marine sponge Petrosia sp. Their structures were determined on the basis of spectroscopic data and the modified Mosher analysis. They exhibit cytotoxic activity against P388 murine leukemia cells.     

Ent-untenospongin A, a New C21 Furanoterpene from the Indian Marine Sponge Hippospongia sp

Many marine sponges of the family Spongiidae, in particular, the genus HiPPospongiafrequently afford terpenoids containing ZI carbons and displaying two Asubstitutedfuran moieties at the end of the molecule2. These unusual compounds are probablyderived from higher terpenoids from a biogenetic point of view. During our studies onbioactive substances from marine organisms, we investigated the extracts of the indiansponge HiPPospongia sp. and isolated a new C,, furanoterpene, named enluntenos…