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1.
Shitov O. P. Korolev V. L. Bogdanov V. S. Tartakovsky V. A. 《Russian Chemical Bulletin》2003,52(3):695-699
A method for the synthesis of 1-alkyl-1,2,4-triazolium 4-nitroimides was developed based on alkylation of 4-nitramino-1,2,4-triazole Na and Ag salts with halo- and dihaloalkanes. 相似文献
2.
A general method for the synthesis of 1,2,4-triazolium 4N-nitroimides with functionalized substituents in position 1 of the heterocycle was developed. The method is based on the nitration of the corresponding 1-R-4-amino-1,2,4-triazolium nitrates. 相似文献
3.
A one-pot reaction leading to 3,5-diaryl-4-benzylideneamino-1,2,4-triazoles is described, the key step of which is the reaction of arenecarbohydrazonoyl chloride with benzylidenehydrazide. Compounds obtained in this way were hydrolyzed to 4-amino-3,5-diaryl-1,2,4-triazoles. 相似文献
4.
I. M. Bazavova V. N. Britsun A. N. Esipenko V. M. Neplyuev M. O. Lozinsky 《Chemistry of Heterocyclic Compounds》2000,36(9):1058-1061
Reaction of 4-aryl-1,2,4-triazolidine-3,5-dithiones in an alkaline medium with chloroacetic acid and its derivatives, as well as with -bromo ketones, results in their conversion to 4-aryl-1,2,4-triazole-3,5-bis(sulfides). The aminomethylation in a neutral medium leads to the formation of 1-(aminomethyl)-4-aryl-1,2,4-triazolidine-3,5-dithiones. 相似文献
5.
Barbara Milczarska Henryk Foks Urszula Dobrzycka Zofia Zwolska Ewa Augustynowicz-Kopeć 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):2793-2799
The 4-hydroxyalkyl-1,2,4-triazole-3-thiones cyclization allowed us to work out the effective method of 1,3-thiazacycloalkyl[3,2-b]-1,2,4-triazoles synthesis. Some of the compounds that were obtained were tested for their tuberculostatic activity. 相似文献
6.
Raoudha Abderrahim Khaled Boujlel 《Phosphorus, sulfur, and silicon and the related elements》2013,188(5):995-999
The imidates derived from 3-aminotriazole 1 react with isocyanates and isothiocyanates to give corresponding 1,2,4-triazolo-1,3,5-triazin-4-ones and 1,2,4-triazolo-1,3,5-triazin-4-thiones in a 60–75% overall yield. If the condensation is realized at r.t., then the intermediate 2 can be isolated. 相似文献
7.
I. M. Bazavova V. N. Britsun A. N. Esipenko M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2003,39(6):809-812
A study was carried out on the reaction of 4-amino-6-R-2,3,4,5-tetrahydro-3-thioxo-1,2,4-triazin-5-ones with halo ketones in alkaline media to yield 4-amino-6-R-4,5-dihydro-3-phenacylthio-1,2,4-triazin-5-ones, which then convert to 8H-3-R-7-aryl-1,2,4-triazino[3,4-b][1,3,4]thiadiazin-4-ones. 相似文献
8.
Hasmukh S. Patel Ketan B. Patel 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):2443-2452
4-Amino-1,2,4-triazole (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(arylidene-amino)-4H-[1,2,4]-triazole (2a–h) in good yield. Rearrangement of compounds (2a–h) with benzoyl isothiocyanate/4-chloro-benzoyl isothiocyanate/2,4-dichloro-benzoyl isothiocyanate yields corresponding 1,3,5-oxadiazine derivatives (3). Structural elucidation of these compounds was based on elementary analysis and spectral data studies. The newly synthesized compounds were evaluated for their antibacterial activities. 相似文献
9.
以1,3-二氟苯为起始原料,依次经傅-克酰基化,1H-三氮唑取代,环氧化,胺解,4H-三氮唑环化,磷酸酯化和钯碳加氢反应等7步反应合成了福司氟康唑的主要杂质--2-(2,4-二氟苯基-1-(1H-1,2,4-三氮唑-1-基)-3-(4H-1,2,4-三氮唑-4-基)-2-丙基磷酸二氢酯,纯度98%,总收率7.8%,其结构经1H NMR确证。 相似文献
10.
微波促进下3-(2-苯并呋喃基)-4-氨基-5-巯基-1,2,4-三唑 总被引:1,自引:0,他引:1
微波辐射条件下, 首先由2-苯并呋喃甲酰肼依次与二硫化碳和水合肼反应合成3-(2-苯并呋喃基)-4-氨基-5-巯基- 1,2,4-三唑, 进一步在微波辐射条件下由4-氨基-5-巯基-1,2,4-三唑分别与芳甲酸/芳氧基乙酸、α-溴代苯乙酮及芳醛反应以较高产率制得了相应的1,2,4-三唑并[3,4-b]-1,3,4-噻二唑、1,2,4-三唑并[3,4-b]-1,3,4-噻二嗪及4-芳亚甲基亚胺基-5-巯基-1,2,4-三唑. 产物结构经IR, 1H NMR, MS及元素分析进行了表征. 相似文献
11.
Kozhevnikov D. N. Kataeva N. N. Rusinov V. L. Chupakhin O. N. 《Russian Chemical Bulletin》2004,53(6):1295-1300
A simple procedure was developed for the synthesis of 1,2,4-triazines and their 4-oxides containing the ClCH2, Cl2CH, or CCl3 group at position 3 by cyclization of 2-aryl-2-hydrazono-1-oximinoethanes with the corresponding chloroacetonitriles. The reaction pathway depends on the number of halogen atoms in the acetonitrile used. The reactions with trichloroacetonitrile, monochloroacetonitrile, and dichloroacetonitrile afford 3-trichloromethyl-1,2,4-triazines, 3-chloromethyl-1,2,4-triazine 4-oxides, and a mixture of the corresponding dichloromethyltriazines and their 4-oxides, respectively. The reactions of 3-trichloromethyl-1,2,4-triazines with indoles and phenols are accompanied by tele-substitution with elimination of halogen from the trichloromethyl group to give 5-indolyl- (or 5-hydroxyphenyl)-3-dichloromethyl-1,2,4-triazines. 相似文献
12.
This study offers an access to 21 new heterocyclic compounds representing pyrrole derivatives of 4-amino-4H-1,2,4-triazole-3-thiols
or 1,3,4-oxadiazole-2-thiols. The principal synthetic approach is based on the cyclization of substituted potassium 2-(pyrrolecarbonyl)hydrazine-1-carbodithionate
with hydrazine hydrate to 5-(substituted pyrrolyl)-4-amino-4H-1,2,4-triazole-3-thiols, followed by S-alkylation with methyl
iodide or benzyl chloride. Among the resulted thirteen S-alkyl derivatives, five 1,3,4-oxadiazole derivatives have been isolated
as secondary products and their formation is explained as being the result of S-alkylation of intermediate 1,3,4-oxa-diazole-2-thiols,
generated in the alkaline medium.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 383–391, March, 2007. 相似文献
13.
Synthesis of 1-amino-1,2,4-triazolium 4-nitroimides and their reactions with electrophiles 总被引:1,自引:0,他引:1
A procedure was developed for the preparation of 1-amino-1,2,4-triazolium 4 nitroimides by amination of triethylammonium salts of 4-nitramino-1,2,4-triazoles with O-picrylhydroxylamine. The resulting nitroimides reacted with electrophilic reagents (acyl chlorides, aldehydes, phenyl isocyanate, NO2BF4, etc.) at the amino group. 相似文献
14.
Jianquan Li 《Thermochimica Acta》2007,454(2):116-127
The objective of this work is to study the behavior of an ionic liquid, 1-H-4-amino-1,2,4-triazolium nitrate, during thermal decomposition driven by an infrared laser (10.6 μm). The focus was to understand the initial decomposition reactions and subsequent reactions that lead to ring decomposition and eventually to ignition. A triple quadrupole mass spectrometer with molecular beam sampling was used to obtain gaseous decomposition species of the sample. The principal mass peaks that may contain multiple masses were analyzed through tandem mass techniques. The experiments were conducted at a laser heat flux of 100 W/cm2 in helium at 1 atm. To assist in interpreting the data, three other materials were also tested, 4-amino-1,2,4-triazolium hydrochloride, 4-amino-1,2,4-triazole, and 1-H-1,2,4-triazole. The results show that the most probable route to initiate the decomposition of the 1-H-4-amino-1,2,4-triazolium nitrate is through proton transfer from N1 site to the nitrate forming a neutral pair, nitric acid and amino-triazole. Subsequent reactions involve decomposition of the neutral pair and their interactions. 相似文献
15.
M. Khakimov R. F. Ambartsumova B. Tashkhodzhaev M. Yu. Antipin Kh. M. Shakhidoyatov 《Chemistry of Heterocyclic Compounds》2001,37(8):1005-1010
We have synthesized 3-substituted 4-alkyl-5-imino-4,5-dihydro-1,2,4-thiadiazoles by reaction of 3-alkyl(benzyl)thio-5-amino-1,2,4-thiadiazoles with methyl iodide or ethylene chlorohydrin. In the reaction with epichlorohydrin, addition of an oxirane molecule occurs with formation of tetrahydropyrimido[2,1-b]-1,2,4-thiadiazoles. 相似文献
16.
Mochul"skaya N. N. Andreiko A. A. Kodess M. I. Vasil"eva E. B. Filyakova V. I. Gubaidullin A. T. Litvinov I. A. Sinyashin O. G. Aleksandrov G. G. Charushin V. N. 《Russian Chemical Bulletin》2004,53(6):1279-1289
The reactions of 3-aryl-1,2,4-triazines with aromatic thioamides and 4-arylthiosemicarbazides in acetic anhydride at room temperature afforded cyclic products of the tandem nucleophilic addition reactions, viz., tetrahydrothiazolo[4,5-e]-annelated 1,2,4-triazines, in good yields. The latter underwent aromatization in the presence of potassium permanganate. 相似文献
17.
József Reiter László Pongó István Lukovits 《Monatshefte für Chemie / Chemical Monthly》1988,119(3):341-348
HMO calculations were performed for all possible tautomeric forms of different 1,2,4-triazole derivatives1–4 and their condensed ring analogues5–8. The resonance energies obtained showed this method useful for the differentiation of the tautomeric structure of the planar monocyclic 1,2,4-triazole derivatives but it did not give satisfactory results in case of their non-planar condensed ring analogues.
Über Triazole, 9. Mitt.: HMO-Berechnungen tautomerer 1,2,4-Triazol-Derivate
Zusammenfassung Die HMO-Methode wurde für alle möglichen tautomeren Formen der 1,2,4-Triazol-Derivate1–4 und deren kondensierte Analogen5–8 verwendet. Die berechneten Resonanzenergien bewiesen, daß dieHückel-Methode gute Resultate für die Unterscheidung verschiedener tautomerer Formen der planaren 1,2,4-Triazol-Derivate, aber nicht für deren nicht-planare kondensierte Analogen ergibt.相似文献
18.
Summary A series of hydroxamic acid ethoxycarbonylhydrazides was obtained by reactions of ester ethoxycarbonylhydrazones with hydroxylamine. The corresponding 3-substituted 4-hydroxy-4,5-dihydro-1,2,4-triazol-5-ones were synthesized by cyclization of these hydroxamic acid derivatives in basic medium.
Synthesen von 4-Hydroxy-4,5-dihydro-1,2,4-triazol-5-onen
Zusammenfassung Durch Reaktion von Esterethoxycarbonylhydrazonen und Hydroxylamin wurde eine Reihe von Hydroxamsäureethoxycarbonylhydraziden gewonnen; Cyclisierung dieser Verbindungen durch Base gab die entsprechenden 3-substituierten 4-Hydroxy-4,5-dihydro-1,2,4-triazol-5-one.相似文献
19.
Mou-Yung Yeh Fat-Fong Chan Hsien-Ju Tien Toshio Fuchigami Tsutomu Nonaka 《中国化学会会志》1989,36(2):143-148
N-Hydroxy-3-arylsydnone-4-carboxamide oximes (7) were prepared from the corresponding 3-arylsydnone-4-carbohydroximic acid chlorides (6) and hydroxylamine in high yield. The chemical reactivity of compound (2) is somewhat different from 3-arylsydnone-4-carboxamide oximes (2) in that the former compounds reacted with both aromatic and aliphatic aldehydes in the presence of acid catalyst to give 3-aryl-4-(5-aryl-1,2,4-oxadiazol-3-yl)sydnones (5) and 3-aryl-4-(5-alkyl-1,2,4-oxadiazol-3-yl)sydnones (3). 相似文献
20.
<正>4-Amino-3-mercapto-6-methyl-l,2,4-triazin-5(4H)-one 1 converted to 4-amino-6-methy-3-(methylthio)-1,2,4-triazin-5(4H)-one by methylation with methyl iodide.Controlled hydrazination of the resulting compound afforded 4-amino-3-hydrazinyl-6- methyl-l,2,4-triazin-5(4H)-one 2 as a building block,to the synthesis of some novel derivatives of[1,2,4]triazino- [4,3,b][1,2,4,5]tetrazepine 3-6,by the reaction with 3-chloropentane-2,4-dione,chloro acetonitrile,1,3-dichloroacetone,and methyl bromoacetate.This general synthetic procedure can be extended to the preparation of wide variety of tetrazepines using 1,2- bielectrophiles derivatives. 相似文献