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含取代嘧啶环的苯磺酰脲的合成和生物活性测定 总被引:18,自引:1,他引:18
报道了12种含不同取代嘧啶环的苯磺酰脲的合成及初步的生物活性测定结果,其中10种为新化合物,结构经^1HNMR,IR和元素分析等证实。 相似文献
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本文报道8个5-(取代苯硫基)-2,4-二氨基嘧啶类化合物的合成,测定了对E.coliMB1428 DHFR的抑制活性。对16个本类化合物进行Hansch分析表明,本类化合物对E·coli DHFR的抑制作用与3′,4′,5′-位取代基限制数值的立体参数呈线性关系,与取代基的疏水性参数呈双线性关系。 相似文献
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1—(取代异恶唑基)—1,2,4—三唑和1—(取代嘧啶基)—1,2,4—… 总被引:1,自引:0,他引:1
合成了15个新的1-(取代恶唑基)-1,2,4-三唑和1(取代嘧啶基)-1,2,4-三唑化合物,经元素分析、IR、HNMR和MS证实基,对其代表化合物进行抑菌及植物生长调节活性的初步观察。 相似文献
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以5-溴-2-十二烷基嘧啶为原料,经Sonogashira偶联等反应制得1,2-双(2-十二烷基嘧啶-5-基)乙炔(4); 1-溴-4-(2-(2-(2-甲氧基乙氧基)乙氧基)乙氧基)苯(5)与双频哪醇合二硼反应制得化合物(6); 4,4′-二溴苯偶酰与1,3-二苯基丙酮经羟醛缩合反应制得四芳基环戊二烯酮衍生物(7); 化合物4与7经Diels-Alder反应制得化合物8; 8与6〖STBZ〗通过Suzuki-Miyaura偶联反应合成新型两亲性氮杂六芳基苯(9),化合物6~9为新化合物,其结构经1H NMR, 13C NMR和HR-MS(MALDI-TOF)表征。 相似文献
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苯烷基取代的对苯二酚的合成 总被引:2,自引:1,他引:2
以1,4-二甲氧基苯为原料,经傅氏酰基化反应、黄鸣龙改良还原、醚键的断裂三步反应合成了3个苯烷基对苯二酚。产物的结构由元素分析、IR和^1H NMR确认。 相似文献
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Synthesis of Heterodinuclear Hemisalen Complexes on a Hexaarylbenzene Scaffold and their Application for the Cross‐Pinacol Coupling Reaction 下载免费PDF全文
Akihiro Miyasaka Dr. Toru Amaya Prof. Toshikazu Hirao 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(6):1615-1621
Intermolecular cross‐pinacol coupling reaction between aliphatic and aromatic aldehydes by using heterodinuclear hemisalen complexes 1 cis with vanadium(V) and titanium(IV) on a hexaarylbenzene scaffold is reported. Our ligand design is based on the individual activation of two aldehydes by vanadium and titanium, which are positioned with a suitable space on the rigid scaffold. Ligands such as 1 cis were synthesized by Diels–Alder addition and decarbonylation reaction, followed by condensation of dialdehyde 3 cis with various aminophenols. The influence of the substituents on the ligands on the pinacol coupling reaction was investigated. As a result, the reductive coupling reaction between aliphatic and aromatic aldehydes by using a catalytic amount of 1 cis in the presence of Me3SiCl and Zn provided the corresponding cross‐coupled 1,2‐diol in good yields with high cross‐selectivity. 相似文献
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由于结构中特殊的四面体层,使得"114"化合物在磁性和存储氧性质方面有潜在的应用价值。本文以传统的高温固相法合成新型化合物YBaZn_3GaO_7,在其八面体位掺杂有效半径更小的Sc~(3+),得到全固熔化合物Y_(1-x)Sc_xBaZn_3GaO_7(x=0~1)。结构精修确定此系列"114"化合物空间群为P6_3mc。解析其结构后发现,随着掺杂量的增多结构有明显的演变趋势。从YBaZn_3GaO_7到ScBaZn_3GaO_7晶胞参数线性减小,通过对各配位元素键长的分析,说明随着掺杂量增加,结构畸变减小,应力减小,四面体配位中的Zn~(2+)和Ga~(3+)得到整合,从而得到结构更加稳定的"114"化合物。 相似文献
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ASHNAGAR Alamdar GHARIB NASERI Nahid SHEERI Behrang 《中国化学》2007,25(3):382-384
Knovenagel reaction of barbituric acid with different aldehydes were used to synthesize new barbiturates. This is a novel method which can be used to synthsis various types of new generation of barbiturates which are different from the previously reported. 相似文献
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This paper involves the preparation of thioureas, which couple with per‐O‐acetylated galactosyl isothiocyanate 1 and 2‐aminobenzothiazole 2 to give incorporating galactosylthiourea derivatives 3. Nucleophilic addition of active primary amine to 3 in the presence of HgCl2 afforded the per‐O‐acetylated guanidinogalactoside 4a‐4d, 5a‐5d, 6a‐6d, 7a‐7d in good yield. These adducts were subjected to deacetylation in MeOH/NaOMe and furnished the corresponding unprotected guanidinogalactosides 8a‐8d, 9a‐9d, 10a‐10d, 11a‐11d. The structures of all newly synthesized compounds were established by IR, 1H NMR, MS and elemental analysis. 相似文献
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利用环己二酮单腙芳构化反应, 得到9H, 9H, 11H, 11H, 12H, 12H-六氢化苯并[9,10]-(1H, 1H, 3H, 3H, 4H, 4H, 5H, 5H, 7H, 7H, 8H, 8H-十二氢)菲-2, 6, 10-三酮腙, 然后与季戊四醇反应, 得到9H, 9H, 11H, 11H, 12H, 12H-六氢化苯并[9,10]-(1H, 1H, 3H, 3H, 4H, 4H, 5H,5H, 7H, 7H, 8H, 8H-十二氢)菲-2,6,10-三酮缩三(2,2-二羟甲基-1,3-丙二醇), 再与9-[4-(2,6-二硫杂环己基)苯基]-3-[4-(二甲酯基甲基)苯基]-2,4,8,10-四氧杂螺[5.5]十一烷反应, 制成标题化合物. 中间体和标题化合物经过IR, 1H NMR, MS和元素分析表征. 相似文献
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