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1.
Pranab Haldar 《Tetrahedron letters》2008,49(22):3659-3662
An efficient and mild protocol for one-pot decarboxylative hydroxylation/alkoxylation of 1,3-diaryl-5-oxo-pyrrolidine-2-carboxylic acids to trans-5-hydroxy-1,4-diarylpyrrolidin-2-ones and 5-alkoxy-1,4-diaryl-1,5-dihydropyrrol-2-ones at room temperature using CAN in organo-aqueous solvent has been developed. 相似文献
2.
Velanganni Paul Alex Raja 《Tetrahedron》2006,62(20):4892-4899
The five-component reaction of ethyl 2-[(2-oxopropyl)sulfanyl]acetate, aromatic aldehydes, and ammonium acetate affords two diastereomers of 5,7-diaryl-5,6,7,8-tetrahydro-1H-pyrido[3,4-b][1,4]thiazin-2(3H)-ones via a novel tandem Mannich-enamine-substitution sequence. Presumably, they are generated from ethyl 2-[(4-oxo-2,6-diaryl-3-piperidinyl)sulfanyl]acetates. During the formation of the trans-5,7-diaryl-5,6,7,8-tetrahydro-1H-pyrido[3,4-b][1,4]-thiazin-2(3H)-ones from ethyl 2-[(4-oxo-2,6-diaryl-3-piperidinyl)sulfanyl]acetates, the configuration at the carbon bearing an aryl group adjacent to the enamide CC double bond is inverted via ring opening and closure. When o-substituted benzaldehydes were employed in this reaction, 5,7-diaryl-5,6-dihydro-1H-pyrido[3,4-b][1,4]thiazin-2(3H)-ones were obtained via air oxidation, along with trans-5,7-diaryl-5,6,7,8-tetrahydro-1H-pyrido[3,4-b][1,4]-thiazin-2(3H)-ones. 相似文献
3.
The homocoupling reaction between the conjugated n-(2-chloroethenyl)pyridine; n, 2-, 3- and 4- (or quinoline; n, 2- and 4-) mediated by zero-valent nickel complexes at room temperature affords to the corresponding 1,4-diaryl-1,3-butadiene, always as the 1E,3E stereoisomer. The yield in 1,4-diaryl-1,3-butadiene increases with the nickel catalyst and hence, the active zero-valent nickel catalyst is not regenerated during the homocoupling reaction.The stereospecific synthesis of (1Z,3Z)-1,4-di(4′-pyridyl)-1,3-butadiene stereoisomer was efficiently carried out by partial hydrogenation of the appropriate 1,4-di(4′-pyridyl)-1,3-butadiyne. 相似文献
4.
An efficient synthetic methodology of converting trans-4,5-diaryl-2-imidazolines to the corresponding cis-4,5-diaryl-2-imidazolines has been developed. This methodology features mild reaction conditions and a simple one-pot two-step procedure. 相似文献
5.
Cong Deng Yan Yang Meng Gao Yan-Ping Zhu An-Xin Wu Jun-Rui Ma Guo-Dong Yin 《Tetrahedron》2012,68(20):3828-3834
2-Methylthio-substituted 1,4-enediones, obtained from readily available aryl methyl ketones, were reacted with primary or secondary amines to afford the desired 1,4-diaryl-2-aminobut-2-ene-1,4-diones in excellent yields with high Z/E-stereoselectivity. 相似文献
6.
P. S. Silaichev N. V. Kudrevatykh A. N. Maslivets 《Russian Journal of Organic Chemistry》2012,48(8):1103-1106
1-Aryl-4,5-diaroyl-1H-pyrrole-2,3-diones react with alkyl vinyl ethers and 3,4-dihydro-2H-pyran affording 1,4-diaryl-7a-aroyl-6-ethoxy-7,7a-dihydropyrano[4,3-b]pyrrole-2,3(1H,6H)-diones and 1,4-diaryl-9baroyl-1,7,8,9,9a-hexahydro-5aH-pyrano[3??,2??:5,6]pyrano[4,3-b]-pyrrole-2,3-diones respectively. 相似文献
7.
M. V. Vovk O. V. Kushnir V. A. Sukach I. F. Tsymbal 《Russian Journal of Organic Chemistry》2010,46(5):709-715
1-Chlorobenzyl isocyanates react with N-arylfumarates with the formation of dialkyl 2-oxo-3,6-diaryl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates that on alkaline hydrolysis are converted into 6-alkoxycarbonyl-1,4-diaryl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acids. The condensation of 1-chloro-1-phenyl-2,2,2-trifluoroethyl isocyanate with N-arylfumarates results in dialkyl 6-oxo-2,3-diaryl-2-trifluoromethyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates. 相似文献
8.
Cathodic reduction of phenacyl bromides N-acyl hydrazones lead to dimeric 1,4-diaryl-1,4-butanedione di-N-acylhydrazones, which give the corresponding 1-N-acylamino-2,5-diarylpyrroles in good yields. 相似文献
9.
Richard L. Riggs Alexandra M.Z. Slawin David M. Smith Nicholas J. Westwood Katie E. Stuart 《Tetrahedron》2005,61(47):11230-11243
Novel synthetic methodologies leading towards 2,3,5-triaryl- and 2,3,5,6-tetraaryl-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-diones (tri- and tetra-aryl-DPPs) and their derivatives have been investigated. Direct arylation of 3,6-diphenyl-DPP was possible using 1-fluoro-2,4-dinitrobenzene. Acylation of ethyl 2-aryl-4,5-dihydro-5-oxopyrrole-3-carboxylates with N-arylbenzimidoyl chlorides in the presence of a strong base gives the novel 2,3,6-triaryl-DPPs together with the corresponding uncyclised enamines. A new and simple method for the synthesis of ethyl 1,2-diaryl-4,5-dihydro-5-oxopyrrole-3-carboxylates has led to an alternative route to triaryl-DPPs via reaction with benzonitrile under basic conditions, and combination of this with the benzimidoyl chloride methodology has enabled the synthesis of variously substituted 2,3,5,6-tetraphenyl-DPPs. 相似文献
10.
Masahiko Iyoda Masahiro Sakaitani Atsuko Kojima Masaji Oda 《Tetrahedron letters》1985,26(31):3719-3722
The active nickel complex generated in situ by reduction of NiBr2(PPh3)2 with zinc in the presence of Et4NI is a useful reagent for the dehalogenative coupling of phenacyl halides to 1,4-diaryl-1,4-diketones and for the dechlorination of 3,4-dichlorobicyclo[4.2.0]-octane-2,5-diones to bicyclo[4.2.0]oct-3-ene-2,5-diones. 相似文献
11.
Carlos Seoane Jos L. Soto Pilar Zamorano Margarita Quinteiro 《Journal of heterocyclic chemistry》1981,18(2):309-314
Ring transformations of 4H-pyrans into pyridines are reported. Treatment of 2-amino-4,6-diaryl-3,5-dicyano-4H-pyrans (I) with nitrosylsulfuric acid brings about their transformation into 3,5-dicyano-4,6-diaryl-2-pyridones (VI) which can also be obtained from α-benzoylcinnamonitriles (IX) and cyanoacetamide. Similarly, 2-amino-4,6-diaryl-5-carbethoxy-3-cyano-4H-pyrans (II) lead to 4,6-diaryl-5-carbethoxy-3-cyano-2-pyridones (VII). Treatment of both series of pyrans with sulfuric acid results in the formation of the corresponding 3,4-dihydro-2-pyridones (IV and V). Reaction of pyrans II with ammonium acetate in acetic acid yields 2-amino-4,6-diaryl-5-carbethoxy-3-cyanopyridines (XII). Pyrans I undergo an entirely different type of reaction upon treatment with this reagent leading to 2,4,6-triaryl-3,5-dicyano-1,4-dihydropyridines (XV). 相似文献
12.
Prakasam Thirumurugan 《Tetrahedron letters》2009,50(28):4145-3867
A series of 4-aryl-6-(1H-indol-3-yl)-2,2-bipyridine-5-carbonitrile derivatives were synthesized via a one-pot multi-component reaction of aromatic aldehydes, 3-(cyanoacetyl)indole and 2-acetyl pyridine in ammonium acetate by conventional heating and microwave irradiation under solvent-free condition. Also a series of 6,6′-di(1H-indol-3-yl)-4,4′-diaryl-2,2′-bipyridine-5,5′-dicarbonitrile derivatives were synthesized using cinnamils, 3-(cyanoacetyl)indole and ammonium acetate. The methodology affords high yields of product at short reaction time. 相似文献
13.
A series of novel ethyl 7,9-diaryl-1,4-diazaspiro[4.5]dec-9-ene-6-carboxylates was synthesized by the reaction of ethyl 4,6-diaryl-2-oxocyclohex-3-ene-1-carboxylates
with ethylenediamine in the presence of p-toluenesulfonic acid without a solvent under focused microwave irradiation. The
title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microorganisms. 相似文献
14.
A. A. Panasenko A. F. Kaprosh M. A. Rekhter E. P. Styngach M. Z. Krimer G. N. Grushetskaya 《Russian Chemical Bulletin》1994,43(3):391-394
13C NMR spectra (20 and 75 MHz, in DMSO-d6) of a series of 1,3-diaryl-3-(1H-1,2,4-triazol-1-yl)- and 1,3-diaryl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-ones were registered. It was shown that the chemical shifts of both the carbon atom of the alkene group and C(3) reflect regio- and stereoisomerism of these compounds. Taking this into account the isomeric structures of several 1,3-diaryl-3-(1H-1,2,4-triazol-1-yl)prop-2-en-1-ones were identified and the configurations relative to the double bond of a number of 1,3-diaryl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-ones were determined. 相似文献
15.
Alexander I. Zbruyev 《Tetrahedron》2007,63(20):4297-4303
A convenient and effective synthetic approach to potentially radiochromic polyarene derivatives of bi- and tricyclic aziridines utilizing modified Suzuki-Miyaura cross-coupling with catalysis in micellar media has been developed. A series of polyarene substituents were introduced into 1,5-diaryl-3,5a-dihydro-1H-azireno[1,2-c]imidazoles, 1,6-diaryl-1,3,4,6a-tetrahydroazireno[1,2-a]pyrazines, and 1,2-diaryl-1,1a-dihydroazireno[1,2-a]quinoxalines without degradation of the highly reactive aziridine ring system. 相似文献
16.
Dietmar Seyferth 《Journal of organometallic chemistry》1979,175(1):C7-C8
trans-β-Phenylethenylboronic acid, trans-β-p-methylphenylethenylboronic acid and trans-β-p-methoxyphenylethenylboronic acid on treatment with catalytic amounts of palladium chloride in presence of excess of lithium chloride and triethylamine give the corresponding (E, E)-1,4-diaryl-1,3-butadienes in virtually quantitative yield. 相似文献
17.
Charles M. Buess Vernon O. Brandt R. C. Srivastava W. Robert Carper 《Journal of heterocyclic chemistry》1972,9(4):887-889
2 Seven5-diaryl-1,4-dithiins were prepared from phenacyl halides via the corresponding Bunte salts. The mass spectra showed a number of similarities within this series of compounds. Various dipositive ions were observed in all cases while the unsubstituted and p-methyl derivatives formed tripositive ions. Ir, nmr, and chemical analysis were also completed and reported. 相似文献
18.
Neelakandan Vidhya LakshmiRajendren Tamilisai Paramasivan T. Perumal 《Tetrahedron letters》2011,52(41):5301-5307
A series of spiro-oxindole derivatives containing spirobenzo[1,4]thiazin-3-one ring were synthesized regioselectively via a multicomponent 1,3-dipolar cycloaddition of isatin, 2-(4-methyl-benzylidene)-4H-benzo[1,4]thiazin-3-one and sarcosine or l-proline in toluene under reflux condition. Also spiro-acenaphthylen-1-ones containing spirobenzo[1,4]thiazin-3-one ring have been synthesized using 2-(4-methyl-benzylidene)-4H-benzo[1,4]thiazin-3-one as dipolarophile. The methodology affords high yields of products in short reaction time. 相似文献
19.
Richard F. Smith John L. Deutsch Patricia A. Almeter Donald S. Johnson Suzanne M. Roblyer Thomas C. Rosenthal 《Journal of heterocyclic chemistry》1970,7(3):671-676
The hetero-ring proton of anhydro-1,4-diphenyl-3-mercapto-s-triazolium hydroxide (I) is more highly deshielded than its 3-hydroxy analog (II). The chemical shifts of the hetero-ring proton for compounds I and II were found to be solvent dependent due to hydrogen bond formation. Two series of anhydro-1,4-diaryl-3-hydroxy-s-triazolium hydroxides have been synthesized and their NMR spectra determined. The chemical shift of the hetero-ring proton of these compounds was found to correlate with the Hammett sigma constants of the meta- and para- substituents in the aryl groups. 相似文献
20.
An organocatalyzed asymmetric Michael addition of α-cyano acetates to (E)-1,4-diaryl-2-buten-1,4-diones was realized. The reactions afforded various enantioenriched α,α-disubstituted α-cyano acetates with good yields (up to 99%), moderate to good diastereoselectivities (up to 13.3:1) and moderate to good enantioselectivities (up to 94% ee). Furthermore, one of the products was subjected to Paal–Knorr cyclization to provide an α-furanyl-α,α-disubstituted α-cyano acetate in good yield with moderate enantioselectivity. Thus an indirect asymmetric α-heteroarylation of α-cyano acetates has been well established. 相似文献