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1.
Gianni Podda Carlo Anchisi Luciana Corda Anna Maria Fadda Antonio Maccioni 《Journal of heterocyclic chemistry》1984,21(6):1789-1791
A new series of macrocycles containing the diglycolyl moiety have been prepared. The compounds prepared were: 7,9,18,20-tetrahydrodibenzo[b,k][1,4,7,10,13,16]hexaoxacyclooctadecin-6,10,17,21-tetraone ( 1 ), 1,4,7,10,13,16-hexaoxacyclooctadecane-2,6,11,15-tetraone ( 2 ), 8,7,17,18-tetramethyl-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,6,11,15-tetraone ( 3 ) and 2,5,8,15,18,21 -hexaoxatricyclo[20,4,0,09.14]hexacosan-3,7,16,20-tetraone ( 4 ). The compound 4 has been isolated in the four diastereoisomers: trans-syn-trans 4a , trans-anti-trans 4b , cis-syn-cis 4c and cis-anti-cis 4d . 相似文献
2.
M. D. Thompson J. S. Bradshaw S. F. Nielsen C. T. Bishop F. T. Cox P. E. Fore G. E. Maas R. M. Izatt J. J. Christensen 《Tetrahedron》1977,33(24):3313-3316
A series of macrocyclic ether-esters has been prepared by treating various glycols with adipoyl chloride and various substituted malonyl, succinyl and glutaryl chlorides. The prepared compounds include: 15-ethyl- and 15-phenyl-1,4,7,10,13-pentaoxacyclohexadecane-14,16-dione (5 and 6); 15-methyl-, 15-phenyl-, cis-cyclohexo-[o]-and benzo-[o]-1,4,7,10,13-pentaoxacycloheptadecane-14,17-dione (7–10); trans,trans-1,4,7,10,13,18,21,24,27,30-de-caoxacyclotetratriacontane-15, 32-diene-14,17,31,34-tetraone (11); 1,4,7,10,13-pentaoxacyclooctadecane-14,18-dione (12); 15,15,16,16,17,17-hexafluoro- and 16-methyl-1,4,7,10,13-pentaoxacyclooctadecane-14,18-dione (13 and 14); 1,4,7,10-tetraoxacyclohexadecane-11,16-dione (15); and 1,4,7,10,13-pentaoxacyclononadecane-14,19-dione (16). 相似文献
3.
The solvent extraction of univalent metal cations with N,N'-dibenzyl-1,4,10,13-tetraoxa-7,16 diaza-2,3,11,12-dibenzocycloocta deca-2,11-diene (L(1)), N,N' didodecyl-1,4,10,13-tetraoxa-7,16-diaza-2,3-benzocylooctadeca-2 ene (L(2)) and N,N'-dibenzyl-1,4,10,13-tetraoxa-7,16 diaza-2,3,11,12-dibenzocyclo octadeca-2,11-diene (L(3)) with picrate anion into dichloromethane has been studied at 25 degrees C by UV-visible spectroscopy. The extractability and selectivity of univalent metal picrates (Li(+), Na(+), Ag(+), PhCH(2)NH(3)(+), NH(4)(+)) was evaluated as a function of [ligand]/[metal cation]. L(2) showed the highest extractability and selectivity for Li(+) over the larger studied cations, and also exhibited the highest [Li(+)]/[NH(4)(+)] selectivity as L/M=1. 相似文献
4.
The syntheses of phenol-containing diazamacrocycles and liquid membrane transports of alkali cations
Shu-Lan Ma Xiao-Zhu Wang Cui-Hong Fan Qian-Ling Guo Wen-Xiang Zhu Jing Zhang 《Journal of Molecular Structure》2007,846(1-3):23-27
Two new bisphenol-containing diazacrown ether derivatives, 7,16-bis(2-hydroxy-5-ethylbenzoatebenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (1) and 7,16-bis(2-hydroxy-3,4-dimethylbenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (2), have been synthesized via one-pot Mannich reaction. The compound 1 is structurally characterized. The liquid membrane transports of alkali metal cations using these two new diazamacrocycles and the other previously prepared diazamacrocyclic derivative 7,16-bis(3-hydroxy-6-methyl-2-pyridylmethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (3) as ion-carriers are also studied. The results show that the rates of cation transports are closely related to the number of nitrogen donors and the steric effect of the substituted groups. Compared with other macrocyclic compounds, compound 1 shows a good selectivity for Li+, therefore providing a new efficient carrier for Li+ extraction. 相似文献
5.
Smith Gary L. N. Powell Douglas R. Moser Michelle D. Taylor Richard W. 《Journal of inclusion phenomena and macrocyclic chemistry》2022,102(5-6):515-521
Journal of Inclusion Phenomena and Macrocyclic Chemistry - The crystal structures are reported for 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-6,17-dione, (C12H22N2O6), (I),... 相似文献
6.
A novel flow cell for use with ion-selective membrane electrodes is reported in which the carrier stream is drawn through a tube that suppresses the pump noise. PVC membrane electrodes based on 7,16-dithenoyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (DTODC), and 7,16-di-(2-thiopheneacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (DTAODC) for lead (II), and 7,16-dithenyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (DTDC) and 7,16-di-(2-methylquinolyl)-1,4,10,13-tertraoxa-7,16-diazacyclootadecane (DQDC), for mercury (II) were prepared and evaluated. The linear ranges were pPb: 5.5-3.0 (DTODC) and 6.0-2.0 (DTAODC); pHg: 5.5-3.0 (DTDC) and 4.5-2.5 (DQDC). With flow rate of 3 ml min(-1) the repeatability of measurements was less than 5% RSD (n = 3). The system was applied to the determination of lead (II) and mercury (II) in spiked natural water samples. 相似文献
7.
J. S. Bradshaw R. E. Asay G. E. Maas R. M. Izatt J. J. Christensen 《Journal of heterocyclic chemistry》1978,15(5):825-831
Two new series of macrocyclic polyether-diester ligands ( 4-15 ) containing a pyridine subcyclic unit have been prepared by treating various oligoethylene glycols and sulfur-containing oligo-ethylene glycols with 2,6- and 3,5-pyridine dicarbonyl chlorides. The compounds prepared from 2,6-pyridine dicarbonyl chloride were: 3,6,9,12-tetraoxa-18-azabicyclo[12.3.1 ]oetadeca-1(18), 14,16-triene-2,13-dione ( 4 ); 3,6,9,12,15-pentaoxa-21-azabieyclo[15.3.1]heneicosa-1(21),17,19-triene-2,16-dione ( 5 ); 3,6,12,15-tetraoxa-9-thia-21-azabicyclo[15.3.1 ]heneicosa-1(21),17,19-tri-ene-2,16-dione( 6 ); 3,9,15-trioxa-6,12-dithia-21-azabicyclo[15.3.1]heneicosa-1(21),17,19-triene-2,16-dione ( 7 ); 3,6,9,12,15,18-hexaoxa-24-azabicyclo[18.3.1 ]tetracosa-1(24),20,22-triene-2,19-dione ( 8 ); 3,6,9,12,15,18,21-heptaoxa-27-azabicyclo[21.3.1]heptacosa-1(27),23,25-triene-2,22-dione ( 9 ); and the corresponding analogues from 3,5-pyridine dicarbonyl chloride ( 10-15 ). The solid potassium thiocyanate complex of compound 5 was also prepared. 相似文献
8.
E. Sonveaux 《Tetrahedron》1984,40(4):793-797
Various N,N'-diaryl derivatives of l,4,10,13-tetraoxa-7,16-diazacyclooctadecane were synthesized. 7,16-diphenyl-l,4,10,13-tetraoxa-7,16-diazacyclooctad On the contrary, diamide derivatives of 7,16-di[(2-amino)phenyl]-l,4,10,13-tetraoxa-7,16- diazacyclooctadecane were deprotonated by Cu(II) and formed stable chelates. Spectral data suggest that monodeprotonation gives dissymmetric 1:1-complexes and dideprotonation gives symmetric 1: 1-complexes. 相似文献
9.
《Journal of Molecular Structure》2002,602(1-3):141-146
A lariat crown ether compound 7,16-bis(2-hydroxy-5-methylbenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane has been prepared via one-pot Mannich reaction. A copper(II) complex with the ligand 7,16-bis(2-hydroxy-5-methyl-3-nitrobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane was unexpectedly synthesized and characterized by elemental analysis, IR and UV spectra. The crystal structure of the complex has been determined by X-ray diffraction. Both crystal structure analysis and spectroscopy study indicated that the side-arm phenols of lariat crown ether are nitrated while complexing with Cu(NO3)2. Structure shows that the copper(II) ion is coordinated to two nitrogen and four oxygen atoms, two from the crown ether and other two from the deprotonated phenolate groups. The coordination polyhedron is a distorted octahedron. 相似文献
10.
Xinhao Yang Naresh Kumar Hua Chi D. Brynn Hibbert Peter W. Alexander 《Electroanalysis》1997,9(7):549-553
Three double-armed diazacrown ethers with two thiophene side groups, 7,16-dithenyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (DTDC), 7,16-dithenoyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (DTODC), and 7,16-di-(2-thiopheneacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (DTAODC), have been synthesized and used as novel neutral lead(II) ionophores in ion selective electrode applications. The relationship between the molecular structure of these ionophores and electrochemical properties (linear range, response time, selectivity) of the membrane electrode is discussed. The optimum conditions for the preparation of the electrodes are described. The optimized dithenoyldiazacrown had a detection limit of pPb = 5.7, and Nernstian range with slope 29.2 mV decade−1 from pPb = 5.0 to 2.7. Mercury and silver ions are the major interferences. These electrodes are applied to potentiometric titrations of lead(II) ions and show promise for the determination of lead ions in water samples. 相似文献
11.
12.
Martine Croisy-Delcey Emile Bisagni Christiane Huel 《Journal of heterocyclic chemistry》1993,30(1):55-60
4-Chloroquinoline-5,8-dione ( 8a ) and 6-bromo-4-chloroquinoline-5,8-dione ( 8b ) were reacted with homophthalic anhydride to give tetracyclic compounds 10 and 11 respectively. The 6,11-dihydroxy derivative 12 was prepared in low yield by photochemical addition of benzocyclobutenedione to 4-chloroquinoline-5,8-dione ( 8a ) and in better yield through a Friedel-Crafts reaction of phthalic anhydride with 4-chloro-5,8-dimethoxyquinoline ( 7a ). Whereas 4-chloro-6-hydroxynaphtho[2,3-g]quinoline-5,12-dione ( 11 ) was substituted by amines in the usual way to the corresponding 4-amino-substituted derivatives, 4-chloro-11-hydroxynaph-tho[2,3-g]quinoline-5,12-dione ( 10 ) led to a mixture of 4-amino derivatives and the unexpected 2,6-disubstituted-imidazo[4,5,l-I-j]naphtho[2,3-g]quinolin-7-ones, 13a-b . 相似文献
13.
Rahul M. Kotkar Ashwini K. Srivastava 《Journal of inclusion phenomena and macrocyclic chemistry》2008,60(3-4):271-279
The electrochemical behavior of nicotinamide was studied at a carbon paste electrode and the electrodes modified with macrocyclic
compounds using voltammetric and impedance measurements. The electrodes so formed were able to bind nicotinamide ions chemically
and gave better voltammetric responses than the unmodified ones. The macrocycles used as modifiers for the electrode preparation
were 18-crown-6, dicyclohexano-18-crown-6, dibenzo-18-crown-6, 7,16-dibenzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane,
1,4,7,10,13,16-hexathiacyclooctadecane (Hexathia), 1,4,7,10-tetratosyl-1,4,7,10-tetraazacyclododecane, 1,4,8,11-tetraazacyclooctadecane,
c-Methylcalix[4]resorcenarene and calix[8]arene. Among these macrocyclic modified electrodes, hexathia showed more affinity
towards nicotinamide and a 2.3-fold increase in voltammetric signal was obtained. Impedance measurement was used to confirm
this enhancement observed on modified electrode. This increase in anodic peak current was then used for finding linear working
range, which was 0.1–500 μg mL−1 with a detection limit of 0.03 μg mL−1 by DPV. Interference from other vitamins like thiamine HCl (Vit. B1), riboflavin (Vit. B2), pyridoxine HCl (Vit. B6) cynocobamine (Vit. B12), para-aminobenzoic acid (PABA) and ascorbic acid (Vit. C) was also studied. The modified electrode could be used for the simultaneous
determination of riboflavin, nicotinamide and pyridoxine HCl. It has also been utilized for the analysis of nicotinamide in
pharmaceutical preparations. 相似文献
14.
A. E. Shchekotikhin Y. N. Luzikov Y. B. Sinkevich V. N. Buyanov M. N. Preobrazhenskaya 《Chemistry of Heterocyclic Compounds》2008,44(10):1245-1249
On chlorination of 4,11-dimethoxynaphtho[2,3-f]indole-5,10-dione with sulfuryl chloride in chloroform, its mono-, di-, and trichloro derivatives are formed depending on
the conditions. Hydrolysis of the di- and trichloro derivatives gives a new polycondensed derivative of isatin, 4,11-dimethoxynaphtho-[2,3-f]isatin-5,10-dione. Its demethylation occurs effectively on extended heating with HBr in acetic acid and leads to 4,11-dihydroxynaphtho[2,3-f]isatin-5,10-dione (4,11-di-hydroxynaphtho[2,3-f]indole-2,3,5,10-tetraone).
*For Communication 6 see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1532–1536, October, 2008. 相似文献
15.
Isothiazolopyridines, pyridothiazines and pyridothiazepines are important compounds that possess valuable biological activities. This paper reports on the synthesis of these compounds using both conventional chemical methods and modern microwave techniques. 3-Bromo-6-hydroxy-4-methyl-2-thioxo-2,3-dihydropyridine-3-carboxamide, 5-arylazo-6-hydroxy-4-methyl-2-thioxo-1,2-dihydropyridine-3-carboxamides, 3,5-bis-arylazo-6-hydroxy-4-methyl-2-thioxo-2,3-dihydropyridine-3-caboxamide, 4-methyl-2,3,6,7-tetra-hydroisothiazolo[5,4-b]-pyridine-3,6-dione, 2,2'-(methylene-bis-(sulfanediyl))bis(4-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide), 2-hydroxy-5-methyl-4H-pyrido[3,2-e][1,3]-thiazine-4,7(8H)-dione and 2-arylmethylene-8-hydroxy-6-methyl-2,3,4,5-tetrahydropyrido-[3,2-f][1,4]thiazepine-3,5-diones have been prepared from 6-hydroxy-4-methyl-2-thioxo-2,3-dihydropyridine-3-carboxamide. Some of these compounds were prepared using microwave-assisted reaction conditions, that provided higher yields in shorter times than the conventional methods. 相似文献
16.
Some new substituted dihydrothieno[2',3':4,5]thieno[2,3-c]quinolin-6-ones 9- 12 and tetrahydrodithieno[2,3-b: 2',3'-d]thieno[2',3'-c:2',3'-c']diquinolin-6,14-dione (17) were prepared from the corresponding new anilides 5-8 and from the corresponding dianilide 15, respectively, by a multistep combination of chemical and photochemical reactions. All the prepared compounds are of particular interest because they might serve as DNA intercalators in anticancer therapy. 相似文献
17.
2-(3- and 2-Pyridylcarbonyl)benzoic acids (2,3), 2-(2-pyridylcarbonyl)thiophene-3-carboxylic acid (6), 2-(3-quinolylcarbonyl)benzoic acid (10), and most of the corresponding esters (compounds 1,7 and 9 ) are readily synthesized and involved in a deprotonation-condensation sequence. Biologically active aza-anthraquinones such as benzo[g]isoquinoline-5,10-dione (2-azaanthraquinone, 4 ) and benzo[g]quinoline-5,10-dione (1-azaanthraquinone, 5) are prepared using the strategy. Extension to other heterocyclic quinones such as thieno[3,2-g]quinoline-4,9-dione (8) and benzo[j]phenanthridine-7,12-dione (11) is also investigated. 相似文献
18.
A new PVC membrane electrode for the triiodide ion based on a charge-transfer complex of iodine with 7,16-dibenzyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane as a membrane carrier was prepared. The electrode exhibits a Nernstian response for triiodide ions over a wide concentration range (1.0 x 10(-1)-1.0 x 10(-5) M) with a slope of 59.3 +/- 0.9 mV decade(-1) and a detection limit of 6.3 x 10(-6) M. It has a response time of 30 s and can be used for at least 3 months without any divergence in the potential. The potentiometric response is independent of the pH, in the pH range 1.6 - 10.0. The proposed electrode has shown very high selectivity for the triiodide ion over a wide variety of other anions. This electrode was successfully applied as an indicator electrode in the potentiometric titration of ascorbic acid and hydroquinone from pharmaceutical preparations as well as ascorbic acid in orange juice and dissolved O2 in tap water. 相似文献
19.
Hans Junek Peter Biza Michael Geringer 《Monatshefte für Chemie / Chemical Monthly》1992,123(6-7):581-585
Summary An improved synthesis of 7,16-diphenyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadecan (5) is presented and the reaction with 4-dicyanomethylene-3-methyl-1-phenyl-2-pyrazolin-5-on to the colorless adduct6 described. By heating or photolysis6 can be converted to the deeply colored polymethine7. Complex formation constants with potassium ion by1H-NMR-measurements have been determined.
Prof. Dr. E. Ziegler zum 80. Geburtstag gewidmet 相似文献
20.
Masamitsu Shirai Takao Orikata Makoto Tanaka 《Journal of polymer science. Part A, Polymer chemistry》1985,23(2):463-477
Polymers that have crown ether groups as cation binding sites and cinnamic acid ester groups as photodimerizable groups were prepared by the cationic polymerizations of 2-vinyloxyethyl 4′-(2,3-benzo-1,4,7,10,13-pentaoxa-2-cyclopentadecene)acrylate and 2-vinyloxyethyl 4′-(2,3-benzo-1,4,7,10,13,16-hexaoxa-2-cyclooctadecene)acrylate. When irradiated with ultraviolet (UV) light the cinnamic acid ester groups of the polymers caused dimerization in dilute solution without the formation of insoluble materials. The irradiation was carried out in a dioxane solution and an aqueous solution in the presence and absence of salts. The effect of phototransformation of polymers on the cation binding properties was investigated by a method of picrate salts extraction. The binding ability of the phototransformed polymers for alkali and alkaline earth metal cations was higher than that of the native polymer. Furthermore the cation binding ability of the phototransformed polymers was less sensitive to temperature than that of the native polymer. The effect of the degree of photodimerization of the polymers and the concentration of KCl that exists during irradiation on the cation binding ability was also investigated. 相似文献