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1.
A scheme for synthesizing 5,6,7,8-tetrahydroquinazoline systems from ketene aminal1
via its diphenylboron chelate2 has been suggested. The interaction ofp-toluamidine with the condensation product of the chelate with dimethylformamide dimethylacetal results in the formation of 8-(N-benzoyldiaminomethylene)-2-p-tolyl-5,6,7,8-tetrahydroquinazoline-7-one, which is easily debenzoylated by sodium ethoxide. 8-Diaminomethylene-5,6,7,8-tetrahydroquinazolinone derivatives can be used for the preparation of boron chelate complexes.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 888–890, May, 1994. 相似文献
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A novel one-pot pseudo-five-component synthesis of 4,5,6,7-tetrahydro-1H-1,4-diazepine-5-carboxamide derivatives 总被引:2,自引:0,他引:2
Shaabani A Maleki A Mofakham H Moghimi-Rad J 《The Journal of organic chemistry》2008,73(10):3925-3927
A novel one-pot pseudo-five-component synthesis of 4,5,6,7-tetrahydro-1 H-1,4-diazepine-5-carboxamide derivatives starting from simple and readily available inputs including 2,3-diaminomaleonitrile, a cyclic or acyclic ketone, an isocyanide, and water in the presence of a catalytic amount of p-toluenesulfonic acid in aqueous medium at ambient temperature in high yields is described. 相似文献
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Nourchaine Jelaiel Corinne ComoyBrigitte Fernette Mohamed Lofti Efrit Yves Fort 《Tetrahedron》2011,67(48):9440-9445
We described in this paper an efficient synthesis of variously substituted 4-phosphinoyl-4,5,6,7-tetrahydro-2H-indazol-3-ylamines involving nucleophilic addition of hydrazine on β-ketothioamides as key-step. 相似文献
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V. A. Dorokhov L. S. Vasil'ev N. Kyu Khoa N. Kong Hao V. S. Bogdanov 《Russian Chemical Bulletin》1997,46(11):1967-1969
A method for the synthesis of 2,2′-bipyridin-4-one from 4-amino-4-(2-pyridyl)-but-3-en-2-onevia its diphenylboron, chelates was proposed.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2071–2073, November, 1997. 相似文献
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Vladimir Kepe Marijan Ko
evar Slovenko Polanc 《Journal of heterocyclic chemistry》1996,33(6):1707-1710
A one-pot synthesis of various 2H-pyran-2-one derivatives 5–19 starting from methyl ketones 1 , N,N-dimethylformamide dimethyl acetal and N-acylglycines 3 in acetic anhydride is described. 相似文献
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We describe the preliminary results of one-pot syntheses of various N-substituted 2-methyl-4,5,6,7-tetrahydroindole derivatives from 2-(2-bromoallyl)cyclohexanone and the corresponding primary amines in good yields. Aliphatic amines were directly converted to tetrahydroindoles, whereas aromatic amines needed an extra base treatment step to complete the transformation. 相似文献
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K. Murugavel S. Amirthaganesan R. T. Sabapathy Mohan 《Chemistry of Heterocyclic Compounds》2010,46(3):302-306
A new series of t-4-aryl-3,c-6-dihydroxy-6-methyl-4,5,6,7-tetrahydro-1H-indazole-r-5-carboxylic acid isopropyl esters has
been synthesized by adopting a conventional method from cyclic β-keto esters. 1H, 13C NMR, and IR spectra for all the compounds were investigated. HMBC, HSQC, COSY, and NOESY spectra of the representative compounds
were studied. The stereochemistry of a six-membered ring of the fused indazoles resembled that of keto esters. From the HMBC
correlations the indazole structure was confirmed as 1H-indazole. 相似文献
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Susan Lefkopoulou Julia Stephanidou-Stephanatou Constantine Tsoleridis Nicholas E. Alexandrou 《Helvetica chimica acta》1985,68(6):1748-1753
The thermal base-catalysed and photochemical transformation (Boulton-Katritzky rearrangement) of the title tetrahydrobenzo[c][1,2,5]oxadiazoles to tetrahydro-2H-benzo[d][1,2,3]triazoles is studied. Attempts to induce analogous rearrangement in tetrahydro-2H-benzo[d][1,2,3]triazol-4-one arylhydrazones or oximes failed. Some CNDO/2 calculation are also carried out. 相似文献
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Gein V. L. Nosova N. V. Lezhnina D. D. Gein O. N. Voronina E. V. Starovoytova M. O. Dmitriev M. V. 《Russian Journal of General Chemistry》2021,91(1):57-63
Russian Journal of General Chemistry - The reaction of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate in ethanol gave... 相似文献
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Russian Journal of General Chemistry - 相似文献
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S. T. Kocharyan N. P. Churkina T. L. Razina V. E. Karapetyan S. M. Ogandzanyan V. S. Voskanyan A. T. Babayan 《Chemistry of Heterocyclic Compounds》1994,30(10):1165-1169
We propose a method for synthesis of derivatives of pyrrolinone by reaction of the methyl ester of 3-substituted 2-oxo-3-pentonoic acid with primary amines or acetylhydrazine.Institute of Organic Chemistry, National Academy of Sciences of the Armenian Republic, Yerevan 375094. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1345–1350, October, 1994. Original article submitted July 4, 1994. 相似文献
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The trifluoromethyl containing heterocycles, 2-hydroxy-4-aryl-3-(thien-2-oyl)-2-(trifluoromethyl)-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one derivatives 4, were synthesized via a one-pot three-component reaction of aldehyde 1 with 1,3-cyclohexanedione 2 and 4,4,4-trifluoro-1-(thien-2-yl)butane-1,3-dione 3 in the presence of a catalytic amount of Et3N. The effect of bases and solvents on the reaction efficiency and yield was briefly investigated. Treatment of 4 with an excess amount of NH4OAc in ethanol afforded 2-trifluoromethyl-1H-quinolin-5-one derivatives 5. Refluxing of 4 with TsOH in CHCl3 gave the corresponding dehydrated products 8. 相似文献