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1.
Quinoxalino[2,3-b]-1,4-thiazines were obtained by the reaction of 2-aminoquinoxaline-3-thione and its 6,7-dimethyl derivative with -halocarbonyl compounds. Hydrolysis of these compounds in alkaline and acid media gave 2-amino-3-quinoxalone and quinoxaline-2,3-dione. The IR and UV spectra are presented.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 853–856, June, 1971. 相似文献
2.
P. L. Ovechkin L. A. Ignatova B. V. Unkovskii 《Chemistry of Heterocyclic Compounds》1972,8(7):856-858
The synthesis of 3,4,4,6-tetramethyl-2-arylimino-2,3-dihydro-4H-1,3-thiazines, which have a fixed imino structure, was accomplished by two methods: by intramolecular rearrangement of 1,4,6,6-tetramethyl-3-aryl-1,2,3,6-tetrahydropyrimidine-2-thiones and by amination of 3,4,4,6-tetramethyl-2,3-dihydro-4H-1,3-thiazine-2-thione methiodide.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 941–943, July, 1972. 相似文献
3.
[reaction--see text] A variety of 2-substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines B have been synthesized from the readily available 2-nitro-3-oxiranylmethoxypyridine 1 via a Smiles rearrangement. We demonstrate how variations of reaction conditions affect the product distribution of A and B. 相似文献
4.
Saverio Florio John L. Leng Charles J. M. Stirling 《Journal of heterocyclic chemistry》1981,18(4):857-859
The title amides react easily with methanolic sodium methoxide at room temperature affording 2,3-dihydrobenzo-1,4-thiazine 1-oxide and 1,1-dioxide and methylacetate. An unusual mechanism of deacylation is proposed. 相似文献
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Massimo Nicola Giovanni Gaviraghi Mario Pinza Giorgio Pifferi 《Journal of heterocyclic chemistry》1981,18(4):825-828
The synthesis of 4-acyl-2,3-dihydro-4H-1,4-oxazines ( 6a-h ) via acid dehydration of 4-acyl 2- and 3-morpholinols is described. During dehydration of 2-morpholinols 3d,e , N-alkylisoquinolones 7a-e were also isolated. 相似文献
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2,3-Diaryl-1,4-diazolyl-2,3-epoxybutanes have been prepared from dimethylstilbenes. An efficient although neglected synthesis of the required olefins has been recovered from the literature. The target compounds show moderate antifungal activity. 相似文献
9.
P. L. Ovechkin L. A. Ignatova A. E. Gekhman B. V. Unkovskii 《Chemistry of Heterocyclic Compounds》1974,10(3):310-312
N-Aryl-N′-(2-methyl-4-hydroxy-2-pentyl)thioureas are cyclized in acidic media to 4,4,6-trimethyl-2-arylimino-5,6-dihydro-4H-1,3-thiazines, the methylation of which with methyl iodide gives 4,4,6-trimethyl-2-methylarylamino-5,6-dihydro-4H-1,3-thiazines. 3,4,4,6-Tetramethyl-2-aryliminotetrahydro-1,3-thiazines were synthesized by cyclization of Naryl-N′-methyl-N′-(2-methyl-4-hydroxy-2-pentyl)thioureas. 相似文献
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2-Methylthio-4H-1,3-thiazines or their mixtures with 5-alkylidene-4H-5,6-dihydro-1,3-thiazines were obtained by cyclization of methyl N-3-oxoalkyldithiocarbamates in sulfuric acid. The regiospecificity of the reaction is determined by the structures of the starting compounds. The structures of the synthesized thiazines were confirmed by spectral methods of analysis (IR and 1H and 13C spectroscopy).Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 991–993, July, 1992. 相似文献
13.
Encarna Matesanz Jesús AlcázarJ.Ignacio Andrés Jose M. BartoloméMarcel De Bruyn Javier FernándezKristof Van Emelen 《Tetrahedron letters》2003,44(11):2275-2277
New synthesis approaches that have led to a series of novel aza analogues of the 2-substituted-2,3-dihydro-1,4-benzodioxin core, bearing versatile bromomethyl group on the non aromatic oxygenated ring, are described. According to their structures these novel scaffolds can be useful intermediates for the preparation of potential new therapeutic agents. 相似文献
14.
Anabela Rodrigues 《Tetrahedron》2004,60(38):8489-8496
N,N-Bis-(tert-butoxycarbonyl)-2,5-bis-methoxycarbonyl-1,4-dihydropyrazine can be obtained in high yield by treatment of the methyl ester of N-(4-toluenesulfonyl)-N-(tert-butoxycarbonyl)-α,β-didehydroalanine with dimethylaminopyridine and potassium carbonate. This compound was used as substrate in Michael addition reactions with several types of nucleophiles. The electrochemical behaviour of this pyrazine derivative was also studied by cyclic voltammetry and by controlled potential electrolysis. 相似文献
15.
L. G. Levkovskaya L. A. Serochkina O. S. Anisimova N. P. Solov'eva Yu. N. Sheinker T. S. Safonova 《Chemistry of Heterocyclic Compounds》1987,23(12):1360-1364
1,2-Dioxo-3a-alkyl-7-chloroimidazolidino[3,2-f]pyrido[2,3-b]-1,4-thiazines react with o- and p-nitroanilines, alkyl and acyl halides, and heterocyclic amines to give C(2)- and N(3)-substituted 3a-alkyl-7-chloroimidazolidino[3,2-f]pyridol[2,3-b]-1,4-thiazines.For Communication 44, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1688–1693, December, 1987. 相似文献
16.
W. Marjit Singh 《合成通讯》2013,43(8):1433-1442
The reaction of 2-arylsulphanyl-1,4-napththoquinone with aromatic thiols and sodium dithionate leads to bis-2,3-(arylsulphanyl)naphthalene-1,4-diols in high yield. Corresponding oxidized products, namely 2,3-diarylsulphanyl-1,4-naphthoquinones, are prepared in near quantitative yield by a copper(II)-catalyzed aerial oxidation reaction of bis-2,3-(arylsulphanyl)naphthalene-1,4-diols under mild condition. 相似文献
17.
The title compounds were synthesized from 3-[bis(2-hydroxyethyl)amino]quinolin-2(1H)-one 11a and 3-[bis(2-hydroxyethyl)amino]pyridin-2(1H)-one 18 respectively. The preparation involved a tandem chlorination/cyclization reaction. 相似文献
18.
E. L. Esmans R. A. Dommisse F. C. Alderweireldt 《Journal of mass spectrometry : JMS》1975,10(10):854-858
The mass spectra of 4-substituted-1,2,6-trimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridines have been studied. The detailed fragmentation mechanisms, supported by high resolution measurements, the study of metastable ions and the use of deuterium labelling, are discussed. 相似文献
19.
MRia Balogh Istvn Hermecz Zoltn Mszaros KLman Simon Levente Pusztay GBor Horvth Peter Dvortsak 《Journal of heterocyclic chemistry》1980,17(2):359-368
Ethyl 5-substituted-4-oxo-1,4-dihydro-3-pyridinecarboxylates were synthetized by reacting 1,3,5-triazine with 4-substituted ethyl acetoacetate derivatives in ethanol, in the presence of sodium ethoxide. The l-alkyl-5-substituted-4-oxo-1,4-dihydro-3-pyridinecarboxylic acids required for the antimicrobial studies were prepared by N-alkylation (with triethyl phosphate or alkyl halides) and alkaline hydrolysis of the pyridone esters. 相似文献
20.
2,3-Epoxy-4-hydroxynonanal (EHN) is a potential product of lipid peroxidation that gives rise to genotoxic etheno adducts. We have synthesized all four stereoisomers of EHN and individually reacted them with 2'-deoxyguanosine. In addition to 1,N(2)-etheno-2'-deoxyguanosine, 12 stereoisomeric products were isolated and characterized by (1)H NMR and circular dichroism spectroscopy. The stereochemical assignments were consistent with selective NOE spectra, vicinal coupling constants, and molecular mechanics calculations. Reversed-phase HPLC conditions were developed that could separate most of the adduct mixture. 相似文献