共查询到20条相似文献,搜索用时 15 毫秒
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Venkata Sreenivasa Rao Chunduru 《合成通讯》2013,43(10):1454-1460
An expeditious, one-pot reaction has been described for the preparation of 1,3,4-thiadiazin-5-yl-chromen-2-one derivatives. These compounds were synthesized by the reaction of 3-(2-bromoacetyl)coumarin with thiocarbohydrazide and various carbonyl compounds. The newly synthesized compounds were characterized by infrared, 1H NMR, and mass spectra. 相似文献
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Zhi-Wei Miao Hua Fu Bo Han Yi Chen Yu-Fen Zhao 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):641-646
N-thiophosphonylamino groups have been greatly overlooked as potentially potent, transition-state analogues, or tetrahedral--intermediate inhibitors of metalloproteases. Alkylthiophosphoramidates derivatives were synthesized y reaction of O-isopropyl phosphorodichloridothioate with an amino acid este followed by hydrolysis in 2M NH 4 OH. The reaction was monitored by 31 P NMR spectroscopy. 相似文献
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9,10-Diaryldecahydroacridine-1,8-diones were synthesized by a three-component reaction of aromatic aldehydes, aromatic amines, and 5,5-dimethyl-1,3-cyclohexanedione using sodium 1-dodecanesulfonic (SDS) as the catalyst in aqueous media. The key intermediates before the cyclization step were obtained and characterized. The structures of all the products were determined by IR and 1H NMR spectra and further confirmed by single-crystal x-ray diffraction analysis. 相似文献
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A simple and efficient one-pot synthesis of 1H-benzimidazole derivatives using thiamine hydrochloride (VB1) as the organocatalyst from o-phenylenediamine and aldehyde in dimethylformamide is described. Compared to classical reaction conditions, this new method consistently has the advantages of excellent yields, metal-ion-free procedure, and good recovery and reusablity of catalyst. 相似文献
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Grigor’ev A. A. Karpov S. V. Vasil’ev A. N. Nasakin O. E. Gracheva Yu. A. Kayukova O. V. Kayukov Ya. S. 《Russian Journal of Organic Chemistry》2018,54(5):795-798
Russian Journal of Organic Chemistry - Successive treatment of 3-acylcyclopropane-1,1,2,2-tetracarbonitriles with sodium hydrogen carbonate and alkylmercaptan in water environment results in the... 相似文献
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Jade Dussart-Gautheret Julia Deschamp Thibaut Legigan Maelle Monteil Evelyne Migianu-Griffoni Marc Lecouvey 《Molecules (Basel, Switzerland)》2021,26(24)
This paper reports on the synthesis of new hydroxymethylene-(phosphinyl)phosphonates (HMPPs). A methodology has been developed to propose an optimized one-pot procedure without any intermediate purifications. Various aliphatic and (hetero)aromatic HMPPs were synthesized in good to excellent yields (53–98%) and the influence of electron withdrawing/donating group substitution on aromatic substrates was studied. In addition, the one-pot synthesis of HMPP was monitored by 31P NMR spectroscopy, allowing effective control of the end of the reaction and identification of all phosphorylated intermediate species, which enabled us to propose a reaction mechanism. Optimized experimental conditions were applied to the preparation of biological relevant aminoalkyl-HMPPs. A preliminary study of the complexation to hydroxyapatite (bone matrix) was carried out in order to verify its lower affinity towards bone compared to bisphosphonate molecules. Moreover, in vitro anti-tumor activity study revealed encouraging antiproliferative activities on three human cancer cell lines (breast, pancreas and lung). 相似文献
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Rearrangement and O-demethylation of codeine (2) and various 6-demethoxythebaine derivatives 6–11 with morphinane skeletone into apomorphine (3) and its halogenated derivatives 20–24 could be efficiently executed in a one-pot operation, by treatment with methanesulfonic acid/methionine. 相似文献
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Xi Guang LIU Jing Ping WU Xiao Mei LIANG Dao Quan WANG* Key Laboratory of Pesticide Chemistry Application Technology College of Applied Chemistry China Agricultural University Beijing 《中国化学快报》2002,13(4)
The avermectins1 are a unique collection of naturally occurring macrocyclic lactones with broad spectrum of anthelmintic and insecticidal activities. Their remarkable biological activity and complex molecular architecture stimulated significant interest in the scientific community. Much research has been carried out on these compounds. Many derivatives of avermectin have much more bioactivities and have been commercially utilized2-5. Here we describe the synthesis of 5-deoxy-5-acyloxyimi… 相似文献
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1-Alkynylphosphonates 3 are prepared in a one-pot procedure from diethyl phosphorochloridates 2 and alkynyllithiums 1, which are readily generated by the reaction of 1-alkynes with n-BuLi. 相似文献
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As a novel class of spirofluorenes,spirobifluorene (SBF) and spiro[fluorene-9,9'-xanthene]derivatives (SFXs) have orthogonal geometric configuration,spiro-conju... 相似文献
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An efficient synthesis of some heterocycles is described by condensation between o-phenylenediamine and 1,3-dicarbonyl compounds catalyzed by L-proline. The reaction is carried out either at room temperature or reflux depending on the substrates. 相似文献
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Thanasekaran Ponpandian 《合成通讯》2014,44(6):868-874
The synthesis of biologically valuable spirooxindoles and 4H-pyrans is described under catalyst-free conditions through sequential Knoevenagel–Michael–cyclization reactions from isatin or aromatic aldehyde, malononitrile, and 1,3-dicarbonyl compounds. The reaction conditions are very simple, providing excellent yield.
[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] 相似文献
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A rapid, one-pot procedure is described for the preparation of the ethyl esters of a number of ring-substituted N-benzoyl glycine (hippuric acid) derivatives from readily-available starting materials. 相似文献
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Reaction of 2-aminothiazoline with an aromatic aldehyde and an activated methylene group (malonitrile, diethylmalonate or ethylcyanoacetate) gave the title compounds. The structures are unambiguously assigned using spectroscopic data and chemical proofs. 相似文献
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The one-pot synthesis of spirooxindoles via three-component reaction of urea, isatin, and 1,3-dicarbonyl compounds in the presence of a catalytic amount of p-toluenesulfonic acid in acetonitrile has been carried out.