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Our deductions of the chirality of α-diketones from the skewed glyoxal model [2] have recently been questioned [1]. In particular it has been suggested [1] that the longest-wave-length Cotton effect is not determined by the chirality of the chromophore, but rather by contributions from substituents. Arguments against this view are given here and it is concluded that the skewed glyoxal model is still the best starting point for discussion of the optical activity of α-diketones. To settle the question unambiguously, further spectroscopic data are necessary, however. 相似文献
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Acetoacetanilide, benzoylacetanilide and their derivatives have been examined in ultraviolet region in a series of solvents covering a broad polarity range e. e. from chloroform (Z, 63.2) to methanol (Z .83.6). Transition energies and oscillator strengths have been calculated and transition energy (ET) has been plotted against Z-values, a new empirical measurement of solvent polarity. A linear relationship was observed between the transition energy and Z-values for π → π* and n → π* transitions. These transitions are identified as charge transfer (c-t) transitions and with the solvents having carbonyl oxygen and sulphur atom a c-t complex formation has been suggested. Strong electron-donating substituents on phenyl group of the nitrogen atom also showed a weak to moderate n → π* transitions. These substituents have no influence on the position of the λmax in the same solvent. Stabilization energy of the excited state of these ligands and hence the dipole moments of the excited states have been calculated in comparison with pyridinium iodide. Solvent sensitivities of these ligands have also been calculated. 相似文献
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Unsubstituted and substituted linear polythienyls including thiophenes in both even and odd numbers are conveniently prepared from the Michael addition of thiophenecarboxaldehydes to Mannich bases and the vinyl sulfone. Cyclization of the resulting 1,4-diones with Lawesson's reagent gives α-polythienyls. 相似文献
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γ-Aminobutyrohydroxamate resin that simulate siderophore analogues was prepared. The structure and conversion of functional groups of the resin were confirmed with IR spectra and elemental analysis. The influence of pH on adsorption of metal ions to the resin was examined. Uptake of metal ions increased with pH and was quantitative in the pH range of 4 to 6 for most of the lanthanides. These metal ions showed high exchange rates towards the resin. The complexation behavior of the resin was also investigated by means of IR and potentiometry. The dissociation constant, pKa of the hydroxamic hydroxyl group is 9.36. Stability constants of the insoluble lanthanide complexes on the resins were measured potentiometrically at 25 ± 0.1 °C and ionic strength of 0.1 M KCl. The results were compared with those of the corresponding soluble lanthanide complexes. It was found that a higher stability of the resin resulted in an increase of the stability constants. The phenomena might be due to the length of the spacer in providing the proper geometry of the resin ligand for intramolecular metal complexation. 相似文献
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Disubstituted acetylenes are oxidized with PhIO in presence of Ru-catalysts to afford α-diketones in 65–85% yield. Under the same conditions terminal acetylenes are cleaved to carboxylic acids. 相似文献
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Two new β3‐homohistidine‐ and β3‐homocysteine‐containing β‐peptides have been prepared by solid‐phase synthesis. A β‐octapeptide ( 2 ) contains seven β3‐amino acids and one β2‐amino acid. The β2/β3 segment has been placed in the middle of this peptide, which contains β3‐amino acids of alternating configuration, to induce the formation of a hairpin secondary structure. A β‐decapeptide ( 3 ) has been designed to fold to a 314‐helical secondary structure with neighboring His side chains in 6‐ and 9‐positions. Circular‐dichroism (CD) measurements show the capability of both peptides to bind Zn2+ ions in aqueous solution. In the case of the β‐octapeptide, binding of Zn2+ causes a dramatic change of the CD spectrum, indicating a change or a stabilization of its secondary structure. Zn2+ Ions clearly stabilize the 314‐helix of the β‐decapeptide, in neutral and basic solution. For the construction of the two new β‐peptides, we needed to have a supply of the β‐amino acid derivatives Fmoc‐β3hCys(Trt)‐OH and Fmoc‐β3hHis(Trt)‐OH, the preparation of which is described herein. 相似文献
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Dr. Tridib Sarma B. Sathish Kumar Dr. Pradeepta K. Panda 《Angewandte Chemie (International ed. in English)》2015,54(49):14835-14839
An unprecedented cis‐bimetallic complex of dinaphthoporphycene (DNP), namely [Pd2(μ‐DNP)(μ‐OAc)2], is reported. The most striking feature of this complex is that two palladiums coordinate to the macrocycle on the same side and are closely held together (Pd? Pd: 2.67 Å) by two bridging acetate ligands exhibiting significant metal–metal bonding interaction (bond order 0.18 evaluated by NBO analysis). Interestingly, replacing acetate with acetylacetonate (acac) could stabilize an unusual mono‐palladium complex of DNP, where Pd coordinates unsymmetrically to two ring Ns above the macrocyclic plane, as well as coordinating with two Os of the acac ligand. Remarkably, the rigid DNP core displays enhanced complexation induced aromaticity (as per NICS and HOMA analysis), despite undergoing severe core deformation during complexation with metal ion(s) as noticed from their solid‐state structures. 相似文献
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The electrochemical oxidation of gliclazide has been investigated at glassy carbon electrode in phosphate buffer solutions over the pH range 2.7–11.8 using cyclic and differential pulse voltammetry (DPV). Gliclazide exhibited one anodic peak in the pH range of 2.7–6.3 and a second peak was produced above pH 6.3. The oxidation processes have been shown to be irreversible and diffusion controlled. The formation of an inclusion complex of gliclazide with β‐cyclodextrin (β‐CD) has been investigated by cyclic and differential pulse voltammetry. A phase solubility study with spectrophotometric detection has been also applied. The stability constant of the complex was determined to be 839 and 360 M?1 using the differential pulse voltammetric method and the phase solubility method, respectively. 相似文献
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Jurij Svete Branko Stanovnik Miha Tiler Ljubo Goli
Ivan Leban 《Journal of heterocyclic chemistry》1989,26(1):145-153
From heteroarylaminomethyleneoxazolones 4 , obtained from N-heteroarylformamidines 2 and 2-phenyl-5-oxo-4,5-dihydro-1,3-oxazole ( 3 ), the following β-heteroarylamino-α,β-dehydro-α-amino acid derivatives were prepared: methyl 8 and ethyl esters 9 , amides 10 and 11 , hydrazides 12 , and azides 15 . By catalytic hydrogenation the compounds 4 were converted into β-heteroarylamino substituted amides 18 and β-heteroarylamino-α-amino acids 20 . 相似文献
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The simple method to prepare the β-cycloalkyl aspartate and γ-cycloalkyl glutamate by enzymatic reactions has been developed. Compared with conventional chemical methods, the enzymatic method is more facile. 相似文献
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Acid dissociation constants of substituted-5-pyrazolone dyes have been determined potentiometrically in 75% (v/v) dioxane-water mixture at 30°C and <0.1 ionic strength. The stability constants of their 1:1 and 1:2 chelates with tweleve trivalent lanthanide ions have been determined under the same conditions. The data were correlated and the results were taken to explain the stabilization of such. chelates by dative π -bonding between Ln (III) and the ligand. 相似文献
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Kota Yoshida Prof. Dr. Atsuhiro Osuka 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(27):9396-9403
β,β‐(1,4‐Dithiino)subporphyrin dimers 7‐syn and 7‐anti were synthesized by the nucleophilic aromatic substitution reaction of 2‐bromo‐3‐(4‐methoxyphenylsulfonyl)subporphyrin 4 with 2,3‐dimercaptosubporphyrin 5 under basic conditions followed by axial arylation. Additions of C60 or C70 to a dilute solution of 7‐anti (ca. 10?6 m ) in toluene did not cause appreciable UV/Vis spectral changes, while similar additions to a concentrated solution (ca. 10?3 m ) resulted in precipitation of complexes. In contrast, dimer 7‐syn captured C60 and C70 in different complexation stoichiometries in toluene; a 1:1 manner and a 2:1 manner, respectively, with large association constants; Ka=(1.9±0.2)×106 m ?1 for C60@ 7‐syn , and K1=(1.6±0.5)×106 and K2=(1.8±0.9)×105 m ?1 for C70@( 7‐syn )2. These association constants are the largest for fullerenes‐capture by bowl‐shaped molecules reported so far. The structures of C60@ 7‐anti , C70@ 7‐anti , C60@ 7‐syn , and C70@ 7‐syn have been determined by single‐crystal X‐ray diffraction analysis. 相似文献