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1.
Valentine P. Ananikov Prof. Konstantin A. Gayduk Nikolay V. Orlov Dr. Irina P. Beletskaya Prof. Victor N. Khrustalev Dr. Mikhail Yu. Antipin Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(7):2063-2071
The present study reports the evidence for the multiple carbon–carbon bond insertion into the metal–heteroatom bond via a five‐coordinate metal complex. Detailed analysis of the model catalytic reaction of the carbon–sulfur (C? S) bond formation unveiled the mechanism of metal‐mediated alkyne insertion: a new pathway of C? S bond formation without preliminary ligand dissociation was revealed based on experimental and theoretical investigations. According to this pathway alkyne insertion into the metal–sulfur bond led to the formation of intermediate metal complex capable of direct C? S reductive elimination. In contrast, an intermediate metal complex formed through alkyne insertion through the traditional pathway involving preliminary ligand dissociation suffered from “improper” geometry configuration, which may block the whole catalytic cycle. A new catalytic system was developed to solve the problem of stereoselective S? S bond addition to internal alkynes and a cost‐efficient Ni‐catalyzed synthetic procedure is reported to furnish formation of target vinyl sulfides with high yields (up to 99 %) and excellent Z/E selectivity (>99:1). 相似文献
2.
Dr. Éric Godin Sacha Nguyen Thanh Javier Guerrero-Morales Dr. Jeffrey Santandrea Dr. Antoine Caron Clémentine Minozzi Noémie Beaucage Bastien Rey Mathieu Morency Xavier Abel-Snape Prof. Dr. Shawn K. Collins 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(64):14575-14579
The synthesis of rare macrocyclic alkynediyl sulfides by a Cu-catalyzed Csp−S cross-coupling is presented. The catalytic protocol (Cu(MeCN)4PF6/dtbbpy) promotes macrocyclization of peptides, dipeptides and tripeptides at ambient temperature (14 examples, 23→73 % yields) via thiols and bromoalkynes, and is chemoselective with regards to terminal alkynes. Importantly, the underexplored alkynediyl sulfide functionality incorporates a rigidifying structural element and opens new opportunities for diversification of macrocyclic frameworks through S oxidation, halide addition and azide–alkyne cycloaddition chemistries to integrate sulfones, halides or valuable fluorophores (7 examples, 37→92 % yields). 相似文献
3.
A facile and convenient one-pot synthesis of novel unsymmetrical sulfides, 2′-alkylthio- and 2′-arylthio-1,1,1,3,3,3-hexafluoro-2-phenylpropan-2-oles 1a–k, is presented. Physicochemical characterization; IR infrared; 1H, 13C, and 19F NMR; and mass spectral analyses of the obtained compounds are discussed as well. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] 相似文献
4.
Noha M. Hassanin Tarik E. Ali Hafez M. El-Shaaer 《Phosphorus, sulfur, and silicon and the related elements》2013,188(10):651-655
AbstractNovel 2-sulfido-2,3-dihydro-4H-chromeno[2,3-d][1,3,2]diazaphosphinines are obtained in a simple one-pot procedure via treatment of 2-imino-2H-chromene-3-carboxamide with various phosphorus sulfides. Possible reaction mechanisms are proposed. The structure of the obtained products is confirmed by elemental analyses and spectral tools. 相似文献
5.
Catalytic properties of a series of chiral (pyrrolidine salen)Mn(III) complexes for asymmetric oxidation of aryl methyl sulfides were evaluated. Moderate activity, good chemical selectivity and low enantioselectivity were attained with iodosylbenzene as a terminal oxidant. Enantioselectivity of sulfide oxidation was affected slightly by polar solvent and the sulfoxidation carried out in THF for thioanisole and in CH3CO2Et for electron‐deficient sulfides gave better enatioselctivities. The addition of the donor ligand PPNO (4‐phenylpyridine N‐oxide) or MNO (trimethylamine N‐oxide) only has a minor positive effect on the enantioselectivity. Also explored was the steric effect of the Naza‐substituent in the backbone of (pyrrolidine salen)Mn(III) complexes on the enantioselectivity of sulfide oxidation. The sulfides' access pathway is discussed based on the catalytic results. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
6.
Tomohiro Sugahara Prof. Dr. Kei Murakami Prof. Dr. Hideki Yorimitsu Prof. Dr. Atsuhiro Osuka 《Angewandte Chemie (International ed. in English)》2014,53(35):9329-9333
A combination of a palladium–NHC catalyst and potassium hexamethyldisilazide enables the amination of aryl sulfides with anilines to afford a wide variety of diarylamines. The reaction conditions are versatile enough for the reaction of even bulky ortho‐substituted aryl sulfides. This amination can be applied to the modular synthesis of N‐aryl carbazoles from the corresponding ortho‐bromothioanisoles. As aryl sulfoxides undergo extended Pummerer reactions to afford ortho‐substituted aryl sulfides, the Pummerer products are thus useful substrates for the amination to culminate in efficient syntheses of a 2‐anilinobenzothiophene and an indole as proof‐of‐principle of the utility of the extended Pummerer reaction/amination cascade. 相似文献
7.
A highly efficient metal-free catalytic system, 1,3-dibromo-5,5-dimethylhydantoin (DBDMH)–tert-butylnitrite (TBN)–H2O, has been developed for an environmentally friendly and economical aerobic acid-free oxidation of sulfides. TBN was identified as an efficient NO equivalent for the activation of molecular oxygen. Under optimal conditions, a variety of sulfides substrates were converted into their corresponding sulfoxides in good yields by molecular oxygen. 相似文献
8.
N. Guravaiah 《合成通讯》2013,43(6):808-813
A novel method has been reported involving the synthesis of z-styryl sulfides by the reaction of phenylacetylene with 2-mercpto benzimidazoles and benzthiazole using NaOH as a base in absolute ethanol. On further oxidation with H2O2, these resulted in the formation of the desired styryl sulfones in good yields with retention of stereochemistry. 相似文献
9.
P. Haranath V. Sreedhar Kumar C. Suresh Reddy C. Naga Raju C. Devendranath Reddy 《合成通讯》2013,43(10):1697-1708
6‐Substituted‐dibenzo[d, f][1,3,2]dioxaposphepin‐6‐oxides, sulfides, and selenides (5a–i, 6a–d, and 7a–d) were synthesized by reacting 2,2′‐biphenol (1) with phosphorus tribromide in the presence of triethylamine at 0–30°C and subsequent reaction of the monobromide (2) with different Grignard reagents (3) at room temperature. The products (4) were converted to corresponding oxides, sulfides, and selenides (5a–i, 6a–d, and 7a–d) by oxidation with H2O2 at room temperature and refluxing with sulfur and selenium respectively. The chemical structures of all the products were confirmed by analytical, IR, NMR (1H, 13C, and 31P), and mass spectral data. Most of these compounds exhibited moderate antimicrobial activity. 相似文献
10.
The oxidation of 4‐substituted phenyl phenyl sulfides was carried out with several oxo(salen)manganese(V) complexes in MeCN/H2O 9 : 1. The kinetic data show that the reaction is first‐order each in the oxidant and sulfide. Electron‐attracting substituents in the sulfides and electron‐releasing substituents in salen of the oxo(salen)manganese(V) complexes reduce the rate of oxidation. A Hammett analysis of the rate constants for the oxidation of 4‐substituted phenyl phenyl sulfides gives a negative ρ value (ρ=?2.16) indicating an electron‐deficient transition state. The log k2 values observed in the oxidation of each 4‐substituted phenyl phenyl sulfide by substituted oxo(salen)manganese(V) complexes also correlate with Hammett σ constants, giving a positive ρ value. The substituent‐, acid‐, and solvent‐effect studies indicate direct O‐atom transfer from the oxidant to the substrate in the rate‐determining step. 相似文献
11.
Prof. Bao Li Junrui Wang Guangliang Tu Guodong Ju Kehan Zhou Prof. Yingsheng Zhao 《European journal of organic chemistry》2023,26(12):e202201458
Diaryl sulfides are a class of important synthetic chemical units. Herein, we report a new method for direct preparation of diphenyl sulfides using P-toluenesulfonyl chloride as an effective thiophenyl radical precursor with assistance from Hemin. Various substituted anisoles and benzenesulfonyl chlorides are well tolerated, resulting in moderate to good yields of diaryl sulfides. The potential of the proposed method is validated by good yields obtained in gram scale reactions. 相似文献
12.
E. I. Kapinus T. I. Viktorova T. A. Khalyavka 《Theoretical and Experimental Chemistry》2006,42(5):282-286
The photocatalytic degradation of dyes at the nanosized sulfides of transition metals in aqueous solutions was investigated.
The rate of degradation increases with decrease in the synthesis temperature of the nanoparticles and with the addition of
alcohol. The substitution of Cd2+ cations by Ag+ or Cu2+ leads to a decrease in the photoactivity of the CdS, while substitution by In3+ leads to an increase. The substitution of Ni2+ and Co2+ cations in the corresponding sulfides by Cd2+ leads to an increase in the rate of degradation.
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Translated from Teoreticheskaya i éksperimental’naya Khimiya, Vol. 42, No. 5, pp. 276–280, September–October, 2006. 相似文献
13.
A. V. Mashkina B. P. Borodin V. N. Yakovleva 《Reaction Kinetics and Catalysis Letters》1996,59(2):309-314
Methanol reacts with primary alkanethiols (R=C1–C3) over alumina catalysts to yield dialkyl sulfides. Methanethiol is completely converted to dimethyl sulfide. Ethane-and 2-propanethiols give methyl alkyl sulfides. However, the process is complicated by side reactions producing olefins and dimethyl sulfide. If mixed thiols are used, their transformations hinder each other. 相似文献
14.
Iraj Mohammadpoor-Baltork Hamid Reza Memarian Kiumars Bahrami Karim Esmayilpour 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):2751-2766
A wide variety of sulfides are efficiently oxidized to their corresponding sulfoxides and sulfones in excellent yields using n-butyltriphenylphosphonium dichromate (BTPPDC) in the presence of aluminium chloride in acetonitrile solution and under microwave irradiation. In addition, selective oxidation of sulfides in the presence of functional groups such as a carbon–carbon double bond, ketone, oxime, aldehyde, ether, and acetal can be considered as a noteworthy advantage of this method. 相似文献
15.
Takeshi Takeda Satoshi YoshidaTakuya Nishimura Akira Tsubouchi 《Tetrahedron letters》2012,53(30):3930-3933
The addition of allyltitanium reagents, generated by the desulfurizative titanation of allylic sulfides with the titanocene(II) reagent Cp2Ti−1-butene, to α-chiral ketones produced tertiary homoallylic alcohols bearing three adjacent chiral centers with high diastereoselectivity. 相似文献
16.
Reactions, of various vinyl dienyl ketones (see la – e , li ) with FeCl, give rise to β,γ-unsaturated α-vinyl-cyclo-pentenones (see 2a – e , 2i , Table 2). The reaction succeeds for vinyl dienyl ketones with substituents on either double bond. Aryl dienyl and alkyl dienyl ketones (see 1f – h ) do not cyclize cleanly. The effects of substituents on the rate of reaction is discussed in terms of the mechanism of the rearrangement. A 13C-labeling study establishes the pathway as an unusual 1-hydroxypentadienyl-cation electrocyclization to a cyclopentenyl cation which collapses via a pinacol rearrangement to the α-vinyl ketone. 相似文献
17.
One-Pot Synthesis and Asymmetric Oxidation of 2-Nitro-4-(Trifluoromethyl)Benzene Containing Sulfides
Konstantin S. Rodygin Svetlana A. Rubtsova Alexander V. Kutchin Pavel A. Slepukhin 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):1885-1894
Abstract An efficient one-pot method for the preparation of 2-nitro-4-(trifluoromethyl)benzene containing sulfides from 1,1′-disulfanediylbis[2-nitro-4-(trifluoromethyl)benzene] is proposed. The corresponding enantiomerically enriched sulfoxides with up to 78% enantiomeric excess are prepared by the asymmetric oxidation of sulfides using a modified Sharpless method. The yield of sulfoxides is shown to decrease with an increase in the bulk of the aliphatic group and with a decrease of the inductive effect of the hydrocarbonic moiety on the sulfur atom. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT 相似文献
18.
Xue-Jun Liu Ru-Yu Chen Dong-Lu Bai 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):2607-2616
A series of novel 2-(thymin-1′-ylmethoxy)ethyl alkyl sulfides have been synthesized in three steps from thymine. They have been oxidized into sulfoxide and sulfone derivatives by means of NaIO 4 and H 2 O 2 30%/diethyl azodicarboxylate (DEAD), respectively, in high yields. All products were characterized by 1 H NMR and IR spectra and elemental analyses. The preliminary bioassay indicates that the compound 6g exhibited potential antitumor activity. 相似文献
19.
Masahito Ochiai Prof. Dr. Masao Naito Kazunori Miyamoto Prof. Dr. Satoko Hayashi Prof. Dr. Waro Nakanishi Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(29):8713-8718
Exposure of sulfides and sulfoxides to trifluoromethanesulfonylimino(aryl)‐λ3‐bromane in dichloromethane at 0 °C results in a facile transfer of the sulfonylimino group to sulfur atoms and affords N‐triflylsulfilimines and ‐sulfoximines in high yields under transition‐metal‐free conditions. Imination of (R)‐methyl p‐tolyl sulfoxide proceeded with predominant retention of configuration at the stereogenic sulfur center. The Hammett plot afforded ρ values of ?0.58 for para‐substituted thioanisoles and ?0.49 for their equivalent sulfoxides, which suggests a buildup of positive charge on the sulfur atoms of sulfides and sulfoxides in the transition state. Calculations suggest a bimolecular nucleophilic‐substitution mechanism on the negatively charged nitrogen atom of the sulfonylimino‐λ3‐bromane, which involves the attack of a sulfide from the opposite side to bromine(III). 相似文献
20.
Kandasamy Jeyakumar 《Tetrahedron letters》2006,47(27):4573-4576
Selective oxidation of sulfides to sulfoxides and sulfones is achieved by H2O2 using MoO2Cl2 as the catalyst. Various substituted sulfides having functional groups such as methyl, methoxy, bromo, nitro, alkene, alkyne, alcohol, ester, aldehyde and remarkably an oxime are successfully and selectively oxidized without affecting the sensitive functionalities. 相似文献