A New Eudesmanoilde from Carpesium macrocephalum

A new eudesmanoilde was isolated from the aerial parts of Carpesium macrocephalum. Its structure was elucidated as 2α-acetoxy-11αH-eudesma-4-en-12,8β-olide by spectral methods.     

A New Eudesmanolide and a New Aromatic Derivative from Carpesium cernuun

Carpesium cernuun L. has long been used as chinese folk medicine for its anti-inflammatory, pain-relief, and detoxication properties1. Up to now, no phytochemical studies of Carpesium cernuun has been carried out. Here we report the structure elucidation of a new eudesmanolide 1 and a new aromatic derivative 2, which were obtained from this plant. Compound 1 was isolated as colorless gum, [(]+128.4 (c 0.43, CHCl3). Its EIMS revealed a molecular ion peak m/z 248. Together with the support …     

New Sesquiterpene Lactones from Carpesium Lipskyi

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Two New Eudesmanoildes from Sonchus transcaspicus

Two new sesquiterpene lactone glycosides were isolated from the whole plant ofSonchus transcaspicus. Their structures were elucidated as 1β--O-β-D-glucopyranosy-5α, 6βH-eudesma-3-en-12, 6αt-olide and 1β--O-β-D-glucopyranosy-15-O-(p-hydroxylphenylacetate)-5α，6β H-eudesma-3, ll(13)-dien-12, 6α-olide by spectral methods (HRMS, 1D and 2D NMR).     

A New Xanthanolide from Carpesium longifolium

A new xanthanolide was isolated from the aerial parts of Carpesium longifolium.It‘‘‘‘‘‘‘‘s structure was elucidated as 1β,4β-epoxy-5β-hydroxy-10αH-xantha-11(13)-3n-12,8β-olide by spectral methods(HRMS,1D and 2D NMR).     

Sesquiterpene Lactones from Elephantopus scaber

A new germacranolide sesquiterpene lactone, isoscabertopin, was isolated from Elephantopus scaber together with the known scabertopin. Their structures were determined by spectroscopic methods.     

A New Eremophilanoid Sesquiterpene from Senecio oldhamianus

A new Eremophilanoid sesquiterpene(1) was isolated from the whole plant of Senecio oldhaminus. Its structure was elucidated as 7β,11-epoxy-9α,10α-epoxy-8-oxoeremophilane using spectroscopic methords and X-ray analysis.     

A New Sesquiterpene from the Roots of Lindera strychnifolia

The root of Lindera strychnifolia is used as a palliative and an antispasmodic in traditional chinese medicine. In previous studies of chemical constituents from this plant, more than 20 sesquiterpene lactones have been isolated and their structures were established1-7. In order to compare the difference of chemical constituents extracted by Supercritical Fluid Extraction (SFE) method and by organic solvent, the SFE extract from Lindera strychnifolia was investigated. A novel sesquiterp…     

A New Sesquiterpene Lactone from Ainsliaea bonatii

A new sesquiterpene lactone, Ainsliaolide A, was isolated from Ainsliaea bonatii. The structure was determined on the basis of spectral data.     

Eupatoranolide, a New Sesquiterpene Lactone from Eupatorium adenophorum

Inourinvestigationonthebioactivecomponentsfromplants,thepreliminarybioassaystudiesshowedthatthepetroleumetherextractofEupaloriumadenOPhorumpossessedpotentialinsectantifeedantandinsectcideactivities.Inthepreviouspaper'.weisolatedanewphenylglucosidefromtheaerialpartsofE.adenophorum.FurtherstudyonflowersofE.adenophorumledtotheisolationoftwelvecompounds.Theirstructureswereidentifiedbyspectralanalysisandchemicalreactionasanewsesquiterpenelactonenamedeupatoranolide,2-acetoxy-3,4,6,11-tetradehydroc…     

Two New Eremophilane Sesquiterpene Lactones from Ligularia myriocephala Ling

Two new eremophilane sesquiterpene lactones, 1β-angeloyloxy-6β, 10β-dihydroxy-8β- methoxyeremophila-7（ll）en-8α,12-olide and 1β-angeloyloxy-6β,10α-dihydroxy-8α-methoxyeremo- phila-7（ 11）en-8β, 12-olide were isolated from the extract of the whole plant of Ligularia myriocephala Ling. Their structures and stereochemistry were elucidated by various spectroscopic methods including intensive 2D-NMR techniques （COSY, gHMQC, gHMBC and ^1H-^1H NOESY） and HR-ESIMS.     

Sesquiterpene lactone glycosides from the roots of Ferula varia

Seven new sesquiterpene lactone glycosides (1-7) were isolated from the H2O-soluble fraction from the MeOH extract of the roots of Ferula varia. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of compounds 1 and 2 were determined by modified Mosher's method.     

Diversity of Sesquiterpenoids from Carpesium cernuum

Two new sesquiterpene lactones, 6β‐hydroxy‐8α‐ethoxyeremophil‐7(11)‐en‐12,8β‐olide ( 1 ) and 4β,10β‐dihydroxy‐1αH,5αH,11αH‐guaian‐12,8β‐olide ( 2 ), together with 22 known sesquiterpenoids with various structural types, were isolated from Carpesium cernuum (Compositae). Their structures and configurations were elucidated by extensive 1D‐ and 2D‐NMR spectroscopic analysis in combination with MS experiments, and comparison with literature data of related compounds.     

Eudesmanolides and Guaianolides from Carpesium triste

A new eudesmanolide, 1‐oxo‐11αH‐eudesma‐2,4(14)‐dien‐12,8β‐olide ( 1 ), and four new guaianolides, 9β,10β‐epoxy‐4α‐hydroxy‐1βH,11αH‐guaian‐12,8α‐olide ( 2 ), 9β,10β‐epoxy‐4α‐hydroxy‐1βH,11βH‐guaian‐12,8α‐olide ( 3 ), 4α,9α‐dihydroxy‐1βH,11αH‐guai‐10(14)‐en‐12,8α‐olide ( 4 ), and 4α,9α‐dihydroxy‐1βH,11βH‐guai‐10(14)‐en‐12,8α‐olide ( 5 ), together with one known eudesmanolide and two known germacranolides, were isolated from the whole plants of Carpesium triste. Their structures and relative configurations were elucidated on the basis of spectroscopic methods, including 2D‐NMR techniques.     

Tourneforin,a novel eudesmanolide from <Emphasis Type="Italic">Artemisia tournefortiana</Emphasis>

A novel eudesmane sesquiterpene lactone, the structure of which was established by XSA, was isolated from Artemisia tournefortiana. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 456–457, September–October, 2007.     

Germacranolides from Carpesium divaricatum: Some New Data on Cytotoxic and Anti-Inflammatory Activity

Carpesium divaricatum Sieb. & Zucc., a traditional medicinal plant used as an inflammation-relieving remedy, is a rich source of terpenoids. At least 40 germacrane-type sesquiterpene lactones, representatives of four different structural groups, were isolated from the plant. Cytotoxicity against cancer cells in vitro is the most frequently described biological activity of the compounds. However, little is known about the selectivity of the cytotoxic effect. The anti-inflammatory activity of the germacranolides is also poorly documented. The objective of the present study was to assess the cytotoxic activity of selected C. divaricatum germacranolides-derivatives of 4,5,8,9-tetrahydroxy-3-oxo-germacran-6,12-olide towards cancer and normal cell lines (including cells of different p53 status). Moreover, to assess the anti-inflammatory effect of the compounds, the release of four proinflammatory cytokines/chemokines (IL-1β, IL-8, TNF-α and CCL2) by lipopolysaccharide-stimulated human neutrophils was measured by ELISA. The investigated sesquiterpene lactones demonstrated nonselective activity towards prostate cancer (Du145 and PC3) and normal prostate epithelial cells (PNT2) as well as against melanoma cells (A375 and HTB140) and keratinocytes (HaCaT). Cytotoxic activity against osteosarcoma cells was independent of their p53 status. In sub-cytotoxic concentrations (0.5–2.5 µM) the studied compounds significantly decreased cytokine/chemokine release by lipopolysaccharide-stimulated human leukocytes.     

Sesquiterpene Esters from Salvia roborowskii

Two new sesquiterpene esters,3β,6β,8α-triacetyl-4β,5α-epoxy-1-oxogermacr10(14)-ene(1)and 3β,6β,8α-triacetyl-4β,5α-epoxygermacr-1(10)-ene(2) were isolated from the whole plant of Salvia roborowskii Maxim.Their structures were elucidated by means of spectral data(2DNMR and HRMS).     

A New Sesquiterpene from Ligularia Songarica

ThechemicalstudiesofLigulariasongaricahavenotbeenreportedtillnow.Inourpreliminarystudyontherootsofthisplant,anewbisabolanesesquiterpenewasobtainedanditsstructurewasidentifiedasSp-acetoxy-40,8-diangeloyloxy-26,3p,;10,Ildiepoxy-bisabola-7(14)-ene1.,Com...     

Sesquiterpene Lactones from Notoscris Porphyrolepis

The genus Noloserl's comprising of 14 species is native to China. and Noloserisporphl)rolopis Shin is mainly distributed in southwestern Chinal. So far there are manyreports on sesquiterpenes isolated from Asteraceae=, but nothing is known aboutsecondary metabolites of Notoseris. From the aerial parts of N. porphJ)rolepis. two newguaianolides A and B, named notoserolides A (2) and B (3), along with 12 knowncompounds, austricin (l), artesin'. magnolialide', deoxylactucin', jacquinelin'.cre…     

A New Sesquiterpene from Saussurea parviflora

A new sesquiterpene:11,12,13-trihydroxy-4(15),7(8)-eudesmdien-9-one was isolated from Saussurea parviflora. The structure was elucidated on the basis of spectral evidence.