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1.
From Mitrephora maingayi, a new C21-type Annonaceous acetogenin (1) has been isolated, along with a biogenetically related known compound, oropheic acid (2). Their structures were elucidated on the basis of extensive spectroscopic analysis. The insecticidal activity of 1 was also assessed. 相似文献
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Calamistrin E, the First Annonaceous Acetogenin with Double Bond in Aliphatic Chain from Genus Uvaria 总被引:1,自引:0,他引:1
Annonaceous acetogenins are considered as the main components with cytotoxicity inthe plants of Annonaceae family. The genus Uvaria is one of the main plants containingAnnonaceous acetogenins, and more than fifty acetogenins have been isolated from eightspecies of the title genus"', however, acetogenins with double bond in the aliphatic chainhas not yet been reported. In this paper we report the structure elucidation of calamistrinE (l), a new acetogenin bearing one double bond besides a tetr… 相似文献
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[reaction: see text] A synthesis of the Annonaceous acetogenin asimicin and a side-chain analogue has been achieved by a highly convergent route in which Grubbs cross-metathesis plays a key role. 相似文献
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A convergent total synthesis of the Annonaceous acetogenin squamostolide, in a longest linear sequence of nine steps from d-mannitol, is reported. Central to the efficiency of the synthesis is a highly selective tandem ring-closing/cross metathesis step in which lactone formation and fragment coupling are accomplished. 相似文献
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Annonaceous acetogenins (polyketides) are a group of extensively investigated naturalcompounds possessing antitumor, antiparasitic and pesticidal activities. Over 350acetogenins have been isolated and most of them have one to three tetrahydrofuran (THF)cores, several hydroxyls and a terminal y-lactone ring. As part of our investigation ofthe title species, we have reported four new C,, acetogeninst muricatalin',muricatalicin=, annonacin-B' and murihexol 2' and four known acetogenins4 annonac… 相似文献
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Han H Sinha MK D'Souza LJ Keinan E Sinha SC 《Chemistry (Weinheim an der Bergstrasse, Germany)》2004,10(9):2149-2158
The asymmetric total synthesis of the 34-hydroxyasimicin and its 3-(4-benzoylphenyl)propionate ester was achieved by means of a convergent synthetic strategy. This ester, which contains eight asymmetric centers, represents the first photoaffinity-labeling agent that is derived from an Annonaceous acetogenin. The key transformations in the synthesis include the Sharpless asymmetric dihydroxylation reaction, the Wittig olefination reaction, an oxidative cyclization reaction with rhenium(vii) oxide, the Williamson etherification reaction, and a palladium-catalyzed cross-coupling reaction. Use of the target molecule for photoaffinity-labeling studies of bovine mitochondrial NADH-ubiquinone oxidoreductase (Complex I) may shed light on the structure/function of this intricate enzyme and on the origin of the high antitumor activity exhibited by the Annonaceous acetogenins. 相似文献
7.
A total synthesis of the Annonaceous acetogenin mucocin has been accomplished. The synthesis follows a convergent strategy, wherein at a very late stage the left part of the molecule is connected with the right part. The key reaction is the stereocontrolled addition of an organomagnesium compound 2 to the aldehyde 3. The THP ring of mucocin is build by a 6-endo epoxide cyclization of an epoxyacetonide precursor (16 --> 17). The new modular synthetic approach developed herein should be useful for the synthesis of other related natural products as well as pharmacologically interesting analogues. 相似文献
8.
[Structure: See text] Double asymmetric [3 + 2]-annulation reactions of chiral beta-silyloxyallylsilanes with chiral 2-tetrahydrofuranyl carboxaldehydes have been studied, leading to the stereocontrolled synthesis of six diastereomeric bis-tetrahydrofuran structures corresponding to the core subunits of members of the Annonaceous acetogenin family of natural products. Transition-state models are proposed to account for the stereoselectivity of the double-stereodifferentiating [3 + 2]-annulation reactions. 相似文献
9.
Thayana da C. Alves Mariele R. S. Gonçalves Francyne C. S. Correia Virgínia C. da Silva Paulo T. de Sousa Jr. Mário G. de Carvalho Raimundo Braz‐Filho Evandro L. Dall'Oglio 《Helvetica chimica acta》2014,97(11):1469-1474
From the hexane and MeOH extracts of Annona coriacea Mart . (Annonaceae) seeds, two novel acetogenins, coriapentocins A and B ( 1 and 2 , resp.) were isolated. The known acetogenin bullacin ( 3 ) was also isolated from the hexane extract. The structures of compounds 1 – 3 were elucidated by NMR and MS analysis, and relative configurations were established by comparison with literature data. 相似文献
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Yao Zhu-Jun 《合成化学》2004,12(Z1)
Annonaceous acetogenins, isolated from the Annonaceae plants, have been attracting worldwide attention in recent years due to their biological activities, especially as growth inhibitors of certain tumor ceils [ 1 ]. They have been shown to function by blocking complex I in mitochondria [2] as well as ubiquinone-linked NADPH oxidase in the cells of specific tumor cell lines, including some multidrug-resistant ones [3]. These features make these acetogenins excellent leads for the new antitumor agents. In our previous work, the compounds 1a to 1d (Figure 1), which relies on structure simplification while maintaining all essential functionalities of the acetogenins, was in vitro tested against several human solid tumor cell lines and showed interesting cell selectivity [4]. All four analogues show remarkable activity against the HCT-8 and HT-29 cell lines, while compound 1c was found the best [4bi. In order to further investigate the effects of key structural features, a convergent parallel fragments assembly strategy was developed [4e]. In addition, the biological relevancies of typical annonaceous acetogenin mimetics were also studied [4f]. 相似文献
14.
Alexandra G. Durn M. Teresa Gutirrez Francisco J. R. Mejías Jos M. G. Molinillo Francisco A. Macías 《Molecules (Basel, Switzerland)》2021,26(10)
Annona cherimola Mill., or the custard apple, is one of the species belonging to the Annonaceae family, is widely used in traditional medicine, and has been reported to be a valuable source of bioactive compounds. A unique class of secondary metabolites derived from this family are Annonaceous acetogenins, lipophilic polyketides considered to be amongst the most potent antitumor compounds. This review provides an overview of the chemical diversity, isolation procedures, bioactivity, modes of application and synthetic derivatives of acetogenins from A. cherimola Mill. 相似文献
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CHEN Wen-Sen South China Institute of Botany Chinese Academy of sciences Guangzhou Guangdong ChinaYAO Zhu-Jun ZHANG Yi-Bin XU Yong-Zhen WU Yu-LinState Key Laboratory of Bio-organic & Natural Products Chemistry Shanghai Instutute of Organic Chemistry Chinese Academy of Sciences Fenglin Lu Shanghai China 《中国化学》1995,13(3):263-266
Atemoyacin A, a new annonaceous acetogenin was isolated from the alcoholic extract of the seeds of Annona atemoya Hort (Annonaceae). Its structure and relative configuration were elucidated on the basis of the spectral analysis. 相似文献
17.
A new acetogenin, polyporolide (1), was isolated from the mycelial solid cultures of a Polyporus basidiomycete. Its structure was elucidated as 4-hydroxy-5-(1-hydroxyhexyl)-dihydrofuran-2-one by spectroscopic methods. Its toxicity to brine shrimps was assessed. 相似文献
18.
Evans PA Cui J Gharpure SJ Polosukhin A Zhang HR 《Journal of the American Chemical Society》2003,125(48):14702-14703
The enantioselective total synthesis of the annonaceous acetogenin (-)-mucocin (1) was accomplished using a triply convergent 12-step sequence (longest linear sequence) in 13.6% overall yield. This represents the first application of the temporary silicon-tethered (TST) ring-closing metathesis (RCM) cross-coupling reaction and the enantioselective alkyne/aldehyde addition to the synthesis of a complex annonaceous acetogenin. Moreover, all three fragments required for the coupling reactions are conveniently prepared in 5-6 steps from two readily available enantiomerically enriched epoxides. Finally, this synthesis stimulated the development of a new approach for the construction of 3-hydroxy-2,6-disubstituted tetrahydropyrans, using the bismuth tribromide-mediated reductive etherification reaction, which represents a motif that is prevalent in a wide range of pharmacologically significant natural products. 相似文献
19.
(+)-Muconin (1), isolated from the leaves of Rollinia mucosa (Jacq.) Baill. (Annonaceae), is a sequential THF/THP-possessing acetogenin that exhibits potent and selective in vitro cytotoxicity toward pancreatic and breast tumor cell lines. In this study, a new route was established for obtaining (+)-muconin (1) starting with (-)-muricatacin (2), a compound recently synthesized via the novel alpha-C-H hydroxyalkylation and alpha'-C-H oxidation of tetrahydrofuran. 相似文献
20.
Jiang S Liu ZH Sheng G Zeng BB Cheng XG Wu YL Yao ZJ 《The Journal of organic chemistry》2002,67(10):3404-3408
The (4R)-hydroxylated analogues of annonaceous acetogenin mimicking compound 2 were designed and synthesized structurally on the basis of the naturally occurring annonaceous acetogenin bullatacin, which was discovered as a typical member of the novel family of polyketides with potent cytotoxicity, antitumoral, and other biological activities. The preliminary screenings show that the IC(50) values of 2 were 1.6 x 10(-3) and 8 x 10(-2) microg/mL against HT-29 and HCT-8, respectively. A remarkable enhancement effect was observed by the activity comparison of 1c and its (4R)-hydroxylated analogue 2. 相似文献