Interactions of porphyrinyl-nucleosides with DNA using the example of porphyrinyl-thymidine

meso-Tri(N-memyl-4-pyridinium)porphyrinyl-p-phenylene-5′-O-thymidine, interacting with plasmid ds DNA showed an 8 nm red-shift of the Soret band. The observed Soret band shift was 4 run less than the shift of the respective meso-tetra(N-methyl-4-pyridinium)porphyrin, which is usually assumed to indicate intercalation. Experimental spectra and the MMX- and AM-1 calculations of a series of model structures further suggest that the investigated porphyrinyl-thymidine also interacts with adenine due to its nucleobase. The possibility of intercalation was also viewed based on interaction of immobilized porphyrin with ds DNA. Theoretical considerations suggested that there are no steric limitations to the formation of a system in which the porphyrinyl-thymidine in question interacts with a molecule of porphyrinyl-adenosine, via A-T base pairing, to join two ds DNA molecules.     

微波作用下1,5-苯并硫氮杂-α-溴代-β-内酰胺衍生物的合成

1,5-苯并硫氮杂     

Synthesis of

A series of 1,1'-dicinnamoylferrocenes were converted to the corresponding [3]ferrocenophane diols (4a-e) in a stereoselective manner by using samarium diiodide to effect the intramolecular coupling reaction, aldol reaction, and reduction in one-pot operation. The major reaction pathway might be derived from a samarium chelated transition state (I(A)()) having the moieties of s-cis enone and (Z)-enolate. A solid-state structure of such [3]ferrocenophane diol product showed that the cyclopentadienyl groups were in an eclipsed orientation and slightly tilted.     

多官能团分枝状化合物的合成研究：Ⅴ.多烯烃体系的合成

以六溴甲基苯为核心,季戊四醇三烯丙基醚为支化单元,采用收敛法合成了六方向,具有１８个末端烯丙基的多烯烃体系。     

N-酰基吡唑类化合物的制备及其在合成中的应用

N-酰基吡唑类化合物作为酰化试剂逐步引起了广泛关注,对其制备以及在醇解,氨解,格氏反应,瑞福尔马斯基反应等方面的用途做了探讨.     

发散法合成树枝状高分子聚酰胺-胺

采用发散法,以乙二胺为原料,通过与丙烯酸甲酯和乙二胺进行Mickeal加成和酰胺化缩合反应,合成了以乙二胺为核、支化代为1.0的树枝状高分子聚酰胺一胺,讨论了反应温度、反应时间和投料摩尔比等因素对反应的影响,同时讨论了该反应的特点。结果表明：适宜的反应温度为25℃,反应时间为24h,投料比为mol0.5代PAMAM：mol乙二胺＝1：24,在此条件下,产品的产率为99.9%,纯度在995以上。     

制备方法对LaFeO3纳米粉体的影响

分别采用熔盐法和溶液燃烧法合成了钙钛矿型LaFeO3纳米粉体,系统研究了两种制备方法对粉体相结构、形貌的影响,用XRD、SEM和TG/DSC对纳米粉体进行了表征.结果表明:熔盐体系、煅烧温度、燃料类型和燃料/氧化剂的摩尔比对合成LaFeO3有重要的影响.450-750℃的熔盐NaNO2体系及650-800℃的熔盐NaN...     

Synthesis of polysaccharides. Communication 16. Synthesis of L-arabinopyranans

Summary The synthesis has been effected of 3-0-acetyl-4-0-trityl- and 4-0-acetyl-3-0-trityl-1,2-0-[(l-exo-cyano)ethylidene]-p-L-arabinopyranose by the polycondensation of which (1 4)-L-arabinopyranan and (1 3)-L-arabinopyranan were obtained containing 1,2-trans- and 1,2-cis-glycosidic bonds at a ratio 31.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 1, pp. 196–199, January, 1986.     

烯胺酮的合成及其在有机合成中的应用

烯胺酮是目前应用较为广泛的有机合成中间体, 对其合成及其作为中间体在有机化合物特别是杂环化合物的合成中的应用进行了综述.     

Synthesis of selenobispyridines

2,3′-Selenobispyridine, 2,4′-selenobispyridine, 3,3′-selenobispyridine and 3,4′-selenobispyridine have been synthesised.     

Synthesis of macrolides

The biologically important macrolide class of natural products, although known for some time, has until recently received little synthetic attention. This was primarily due to the lack of general synthetic methodology and the complex structures involved, but in recent years has changed with the development of new experimental techniques. The recent synthetic advancements in this area, reported from the laboratories of Prof. E.J. Corey of Harvard University were undoubtedly the most powerful single thrust that brought these medicinally useful molecules into focus and propelled them into the forefront of organic synthesis. Following a brief introduction into the macrolide structural spectrum, the general methodology for macrolide synthesis is discussed in detail with several illustrative applications. A number of total syntheses of macrolides is then detailed with particular emphasis on the key macrolide ring-forming reactions.     

Synthesis of oxyavicine

The structure (I) assigned to the alkaloid avicine has been confirmed by a synthesis of oxyavicine (III).     

Synthesis of hydrothioxanthenes

9-Alkylaryl- and 9-aryl-sym-octahydrothioxanthenes disproportionate with hydride ion transfer under the influence of protic acids to give 9-methyl-, 9-ethyl-, 9-propyl-, 9-phenyl-, and 9-(p-tolyl)perhydrothioxanthenes and their sulfones.See [7] for communication VIII.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 196–198, February, 1973.