共查询到20条相似文献,搜索用时 31 毫秒
1.
D. V. Shishkin A. R. Shaimuratova A. N. Lobov N. Z. Baibulatova L. V. Spirikhin M. S. Yunusov N. S. Makara N. Zh. Baschenko V. A. Dokichev 《Chemistry of Natural Compounds》2007,43(2):190-196
Derivatives of N-(2-hydroxyethyl)cytisine, N-(2-hydroxypropyl)-, N-(2-hydroxy-2-(1-adamantyl)ethyl)-, and N-(2-hydroxy-2-phenylethyl)cytisine, were synthesized by reduction of N-(2-oxopropyl)-, N-(2-oxo-2-(1-adamantyl)ethyl)-and N-(2-oxo-2-phenylethyl)cytisine with metal hydrides. The antiarrhythmic and analgesic activities of the prepared compounds
were investigated.
__________
Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 157–162, March–April, 2007. 相似文献
2.
Dmitrieva L. L. Nikitina L. P. Albanov A. I. Sarapulova G. I. Nedolya N. A. Brandsma L. 《Russian Journal of Organic Chemistry》2004,40(2):178-187
Reactions of allyl and 2-(vinyloxy)ethyl isothiocyanates with alyylmagnesium bromide (THF-Et2O, 20-30°C, 1-3 h) after hydrolysis or alkylation of adducts afforded respectively N-allyl- and N-[2-(vinyloxy)ethyl]-3-butenethioamides or N-allyl- and N-[2-(vinyloxy)ethyl]-1-(methylmercapto)-3-buten-1-imines. The reaction carried out in ethyl ether yielded instead of Nt-allyl-3-butenethioamide its isomer N-allyl-2-butenethioamide that cleanly isomerized in the system KOH-DMSOH2O into N-(1-propenyl)-2-butenethioamide. N-[2-(vinyloxy)ethyl]-3-butenethioamide suffers a prototropic rearrangement into N-[2-(vinyloxy)ethyl]-2-butenethioamide only in the system 相似文献
3.
David T. Connor Patricia A. Young Maximillian Von Strandtmann 《Journal of heterocyclic chemistry》1977,14(1):139-141
The reaction of 2-picoline N-Oxide anion with o-substituted henzoates and isatoic anhydrides to give synthetically useful l-(2-methoxyphenyl)-2-(2-pyridinyl)ethanone N-oxides, I-(2-hydroxy-phenyJ)-2-(2-pyridinyl)ethanone N-oxides and I -(2-arninopheny])-2-(2-pyridinyl)ethanone N-oxides is described. 相似文献
4.
The preparation of isonipecotinoyl analogues of aminopterin and methotrexate is described. Condensation of diethyl N-isonipecotinoyl-L-glutamate 4 with 2-amino-5-bromomethyl-3-cyanopyrazine 5 afforded diethyl N-(N-[(2-amino-3-cyanopyrazin-5-yl)methyl]isonipecotinoyl)-L-glutamate 6 . Cyclisation of 6 with guanidine followed by blocking group hydrolysis afforded N-([N-(2,4-diaminopteridin-6-yl)methyl]isonipecotinoyl)-L-glutamic acid 8 . Coupling of N-(2-amino-4(3H)ioxopteridin-6-yl]methyl)isonipecotinic acid 11 with diethyl L-glutamate gave diethyl N-[(N-[2-amino-4(3H)-oxopteridin-6-yl]methyl)isonipecotinoyl]-L-glutamate 12 . Blocking group hydrolysis afforded N-[(N-[2-amino-4(3H)-oxopteridin-6-yl]methyl)isonipecotinoyl]-L-glutamic acid 13 . 相似文献
5.
The reactions of oxybis(diacetoxyborane) with the aldimines, N-(2-hydroxyethyl) salicylaldimine N-(2-hydroxy-1-propyl) salicylaldimine, N-(3-hydroxy-1-propyl) salicylaldimine, N-(o-hydroxyphenyl) salicylaldimine. N-(m-hydroxyphenyl) salicylaldimine, N(2-hydroxyethyl)-2-hydroxy-1-naphthaldimine and N(2-hydroxy-1-propyl) 2-hydroxy-1-naphthaldimine have been carried out in 1: 1 and 1: 2 molar ratios. All the compounds except those derived from N-(3-hydroxy-1-propyl) salicylaldimine have been found to be sparingly soluble in benzene and nonelectrolytes in anhydrous DMF. The newly synthesized derivatives have been characterized by elemental analysis, molecular weight determinations and infrared, proton magnetic resonance, ultraviolet, visible and 11B nuclear magnetic resonance spectral studies. 相似文献
6.
The structure of the novel produets, 2,4-ltis-(N-benzy1-4-nitroanilino)-Δ2-1,3,4-oxadiazolin-5-one (VII), 2-benzy1-1-(N-benzy1-4-chloroanilino)-4-(4-chlorophenyl)-1,2,4-triazolidin-3,5-dione (XIVa), and 2-benzy1-1-(N-benzylanilino)-4-pheny1-1,2,4-triazolidin-3,5-dione (XIVb), obtained upon thermal reaction of N-bcnzyl-N-(4-nitrophenyl)carbamoyl azide (la), N-benzyl-N-(4-chloro-phenyl)carbamoyl azide (Ib) and N-benzyl-N-phcnylcarbamoyl azide (le), respectively, were determined. 相似文献
7.
David T. Connor Patricia A. Young Maximillian Von Strandtmann 《Journal of heterocyclic chemistry》1977,14(1):143-146
The synthesis of pyridine N-oxide substituted chromones, chromanones, coumarins, quinolines, dihydroquinolines and cinnolines from l-(2-hydroxyphenyl)-2-(2-pyridinyl)ethanone N-oxide, 1-(2-aminophenyl)-2-(2-pyridinyl)ethanone N-oxide and 1-[2-(methylamino)phenyl]-2-(2-pyri-dinyl)ethanone N-oxide is described. 相似文献
8.
Various N-[(2-haloaryl)methyl]pyridinium, N-(arylmethyl)-2-halopyridinium and N-(2-halobenzyl)iso-quinolinium salts have been synthesized and their intramolecular photocyclization reactions studied. Upon irradiation the aqueous solution of N-[(2-haloaryl)methyl]pyridinium, and N-arylmethyl-2-halopyridinium salts 1, 2 were cyclized to give isoindolium salts. In contrast to the pyridinium salts 1, 2 , the aqueous solution of N-(2-halobenzyl)isoquinolinium salts 3 appear not to undergo photocyclization. N-Benzyl-2-chloropyridinium salts 1c is more reactive than N-(2-chlorobenzyl)pyridinium salt 1a in the photocyclization. N-(2-Chlorobenzyl)-2-chloropyridinium salt 1d is three times more reactive than 1c . A mechanism of π-complex formation of the halogen moiety of the pyridinium ring with the phenyl ring is suggested for the reactive pyridinium salt. The triplet energy of the isoquinolinium salts 3 is tool low to photocyclize. 相似文献
9.
Krystyna Bogdanowicz-Szwed Artur Budzowski 《Monatshefte für Chemie / Chemical Monthly》2004,135(1):97-108
Summary. The hetero-Diels-Alder reaction of N-aryl-3-(2-thienyl)-2-propenethioamides with N-phenylmaleimide and maleimide yielded a mixture of endo- and exo-2-arylimino-4-(2-thienyl)tetrahydrothiopyran[2,3-c]pyrroles. Cycloaddition to diethyl fumarate required acylation and furnished a mixture of diastereoisomeric 5-(N-acetylphenylamino)-2,3-bis-(ethoxycarbonyl)-4-(2-thienyl)-3,4-dihydro-2H-thiopyrans. Reactions of 3-(2-furyl)-2-propenethioamides with N-arylmaleimides furnished the correspondent 2-arylimino-4-(2-furyl)tetrahydrothiopyran[2,3-c]pyrroles. In the cycloadditions of the heterodienes with N-arylmaleimides the endo-cycloadducts were formed as the major products. 相似文献
10.
Claudio Toniolo Giovanni Valle Marco Crisma Vittorio Moretto Jan Izdebski Jacek Pelka Conrad H. Schneider 《Helvetica chimica acta》1990,73(3):626-634
An X-ray diffraction analysts of two N-acyl derivatives of symmetrical dialkylureas, N-[Nα-(benzyloxycarbonyl)-L -valyl] -N, N′-diisopropylurea ( 1 ) and N-{Nα(tert-butyloxy)carbonyl -L -valyl}-N-N′-dicyclohexylurea ( 2 ), and one N-acyl derivative of an unsymmetrical N-N′-dialkylurea, N-[Nα-(benzyloxycarbonyl)-L -valyl] -N′-(tert-butyl)-N-ethylurea ( 3 ), has been performed. It was established that it is the least hindered O-acylisourca N-atom that attacks intramolecularly the carbonyl group of the Nα-protected amino acid activated by the unsymmetrical carbodiimide to form the major rearrangement product. The occurrence and nature of intra- and intermolecularly H? bonded forms of the N-acylureas in the crystal state were also assessed. It was also shown that soluble N-acylureas may compete with intermolecular (peptide)N? H…O?C(peptide) H-bonds in CH2Cl2. 相似文献
11.
Summary Complexes of nickel(II) with N-(2-carboxyphenyl)benzamide (CPBH), 2-amino-N-(2-carboxyphenyl)benzamide (ACPBH), N-isoxazolyl benzamide (IB), N-anilinobenzamide (AB), N-(2-pyridyl)-3-carboxypropanamide (PCPA) and N-(2-pyridyl)-2-carboxybenzamide (PCBA) have been isolated and characterized by elemental analyses, magnetic susceptibility measurements, thermal studies, i.r. and electronic spectral studies. The electrochemical behaviour of some complexes has also been investigated. 相似文献
12.
Indole-1(and 3)-N,N-dimethylthiocarboxamide, 3-(1-pyrrolidinothiocarbonyl)indole and -1-methylindole (HL) react with hexachlorotetrakis(tri-n-butylphosphine)dirhodium(III) to give cyclorhodated complexes, [Rh(L)Cl2(PBu3)2] with L acting as a C—S chelate ligand (PBu3 = tri-n-butylphosphine) and indole-2-N,N-dimethylthiocarboxamide forms [Rh(L)Cl2(PBu3)2] with L acting as an N—S chelate. 1-Methylindole-2-N,N-dimethylthiocarboxamide and 2-(1-pyrrolidinothiocarbonyl)-1-methylindole did, however, not react under similar conditions. The complexes were characterized by spectroscopic methods and the structures of the four complexes with HL = indole-1- and 3-N,N-dimethylthiocarboxamide, and 3-(1-pyrrolidinothiocarbonyl)indole and -1-methyl-indole were confirmed by X-ray analysis. The octahedral complex [Rh(L)Cl2(PBu3)2] had trans-(PBu3)2 and cis-(Cl)2 arrangements and L was coordinated through the S and indole ring C2 atoms to form a five-membered chelate ring. The unreactivity of 1-methylindole-2-N,N-dimethylthiocarboxamide and 2-(1-pyrrolidino)thiocarbonyl-1-methyl-indole may be due to steric hindrance caused by the additional 1-methyl substituent. 相似文献
13.
The cyclopalladation of two different types of aniline derivatives is described: the acetylated anilines N-(3-methylphenyl)acetamide ( 2a ), 3-(acetylamino)-4-chlorobenzoic acid ( 2c ), and N-(2-chlorophenyl)acetamide ( 2d ) are cyclometalated easily with palladium(II) acetate and trifluoroacetic acid to yield the corresponding complexes 4a, 4c , and 4d , respectively, whereas the acetylated meta-toluidine N-(2-chloro-5-methylphenyl)acetamide ( 2b ) cannot be metalated at the only accessible site between the acetylamino and the methyl group. This aromatic C? H bond can be activated, however, with the second type of meta-toluidine derivatives: the 2-chloro-5, N-dimethyl-N-nitrosoaniline ( 3b ) readily undergoes cyclopalladation to yield the corresponding PdII complex di-μ-trifluoro-acetato-bis[3-chloro-6-methyl-2-(N-methyl-N- nitrosoamino)phenyl-C,N? O]dipalladium(II) ( 5b ) containing a five-membered palladacycle with coordination of PdII at the nitroso N-atom, which is established by 15N-NMR spectroscopy. 相似文献
14.
As a continuation of our work on the reaction of N-pyridylmethyl-3,5-dimethylbenzamide N-oxides with acetic anhydride, we now report a study of the reaction of N-(2-pyridylmethyl)-3,5-dimethylbenzam.de N-oxide ( 5 ) and N-(3-pyridylmethyl)-3,5-dimethylbenzamide N-oxide ( 6 ) with acetic anhydride. Compound 5 gave N,N′-di(3,5.dimethylbenzoyl)-1,2-di(2.pyridyl)ethenediamine ( 7 ) and 3,5-dimethylbenzamtde ( 8 ). Compound 6 afforded three products formulated as 2-acetoxy-3-(3,5-dimethylbenzoylaminomethyl)pyridine ( 12 ), 3-(3,5-dimethylbenzoylaminomethyl)-2-pyridone ( 13 ) and 5-(3,5-dimethylbenzoylaminomethyl)-2-pyridone ( 14 ). Analytical and spectral data are presented which support the structures proposed. 相似文献
15.
Thanun M. Pyriadi H. Kaleefa 《Journal of polymer science. Part A, Polymer chemistry》1984,22(1):129-134
Several N-substituted chloromaleimides were prepared by dehydrating the corresponding chloromaleamic acids. Treatment of chloromaleimides with allylamine or cyclopropylamine produced N-aryl-2-(allylamino)maleimides and N-aryl-2-(cyclopropylamino)maleimides, respectively. Neither the N-substituted chloromaleimides nor the N-aryl-2-(allylamino) or N-aryl-2-(cyclopropylamino)maleimides polymerized free radically or anionically. The difficulty of achieving good pi-pi overlap and stiric effects at the propagation step prevented the cyclopolymerization of the prepared 1,5-dienes. 相似文献
16.
Avdeenko A. P. Marchenko I. L. Konovalova S. A. 《Russian Journal of Organic Chemistry》2002,38(4):546-552
The study of chlorination of N-(N-arylsulfonylarylimidoyl)-1,4-benzoquinone imines and of N-(N-arylsulfonylarylimidoyl)-1,4-aminophenols revealed that the dominant stage in the process was the formation of cyclohexene structures, 4-(N-arylsulfonylarylimidoyl)imino-2,5,6-trichloro-2-cyclohexene-1- ones, resulting from addition of a Cl2 molecule across the C = C bond of the quinoid ring. These substances suffer a prototropic rearrangements yielding N-(N-arylsulfonylarylimidoyl)-2,3,6-trichloro-4-aminophenols. The latter are the most common reaction products. The products of deeper chlorination were also obtained. 相似文献
17.
█tl="American"█The synthesis of the three N,N′-di(4-coumaroyl)tetramines, i.e., of (E,E)-N-{3-[(2-aminoethyl)amino]propyl}-3,3′-bis(4-hydroxyphenyl)-N,N′-(ethane-1,2-diyl)bis[prop-2-enamide] ( 1a ), (E,E)-N-{4-[(2-aminoethyl)amino]butyl}-3,3′-bis(4-hydroxyphenyl)-N,N′-(ethane-1,2-diyl)bis[prop-2-enamide] ( 1b ), and (E,E)-N-{6-[(2-aminoethyl)amino]hexyl}-3,3′-bis(4-hydroxyphenyl)-N,N′-(ethane-1,2-diyl)bis[prop-2-enamide] ( 1c ), is described. It proceeds through stepwise construction of the symmetric polyamine backbone including protection and deprotection steps of the amino functions. Their behavior on TLC in comparison with that of 1,4-di(4-coumaroyl)spermine (=(E,E)-N-{4-[(3-aminopropyl)amino]butyl}-3,3′-bis(4-hydroxyphenyl)-N,N′-(propane-1,3-diyl)bis[prop-2-enamide]; 2 ) is discussed. 相似文献
18.
The N(1)- and N(2)-(2′-deoxyribofuranosides) 1 and 2 , respectively, of 8-aza-7-deazaguanine were prepared via phase-transfer glycosylation in the presence or absence of Bu4NHSO4 as catalyst of 6-amino-4-methoxy-lH-pyrazolo[3,4-d]pyrimidine ( 7c ) with 2-deoxy-3,5-di-O-(p-toluoyl)-α-D -erythro-pentofuranosyl chloride ( 10 ). On a similar route, but without catalyst and employing THF as organic phase, the 6-amino-4-chloronucleosides 11b and 12b were synthesized from 7a and converted into the N(1)-and N(2)-substituted 4-thioxo analogues 17a and 18a , respectively. The ratio of N(1)- to N(2)-glycosylation was 2:1 for 7c and 1:1 for 7a , viz. depending on the nucleobase structure. The rate of the H+-catalyzed N-glycosyl hydrolysis was strongly decreased for the N(2)-(β-D -2′-deoxyribofuranosides) as compared to the N(1)-compounds. However, the N(1)-nucleoside 1 , which is an isostere of 2′-deoxyguanosine, is sufficiently stable to be employed later in solid-phase oligonucleotide synthesis. 相似文献
19.
Kartar S. Arora C. G. Overberger 《Journal of polymer science. Part A, Polymer chemistry》1986,24(3):511-524
The synthesis of N,N-diethyl-9-carbazolylacetamide ( 6 ), (R,S)- and (R)-N,N-diethyl-2-(9-carbazolyl)propanamide ( 7 ), N,N′-dimethyl-N,N′-di-(9-carbazolylacetyl)-1,2-ethanediamine ( 11 ), and (R)-N,N′-dimethyl-N,N′-di[2-(9-carbazolyl)propanoyl]-1,2-ethanediamine ( 13 ) is reported. The racemic compound, (R,S)-2-(9-carbazolyl)propanoic acid ( 2 ), was resolved by partial crystallization of the diastereomeric salts formed between 2 and (+)-α-methylbenzylamine. The 1H-NMR spectra of 6 and 7 showed magnetic nonequivalence of the chemically equivalent protons of the methyl and methylene groups in 6 and 7 due to partial double bond character of the amide bond. The upfield resonances corresponding to the two sets of methyl and methylene protons were assigned by the aromatic solvent-induced shift (ASIS) method to the protons anti to the carbonyl oxygen in the conformation of amide bond in 6 and 7 . The 1H-NMR spectra of 11 and (R)- 13 were used to determine the population of anti-anti, anti-syn (syn-anti) and syn-syn conformers in the structures of these dimer model compounds; the relative conformer populations were 0.45:0.47:0.08 and 0.28±0.02:0.29±0.01:0.43±0.01 in 11 and (R)- 13 . 相似文献
20.
R. R. Gataullin A. M. Sotnikov L. V. Spirikhin I. B. Abdrakhmanov 《Russian Journal of Organic Chemistry》2005,41(5):715-722
N-Mesyl-2-(1-methyl-1-butenyl)-6-methylaniline reacted with Br2 to afford N-mesyl-2-(3-bromo-1-penten-2-yl)aniline that under treatment with NH3 or amines underwent cyclization into N-mesyl-7-methyl-3-methylene-2-ethylindoline. The reaction of N-mesyl-2-(1-methyl-1-buten-1-yl)-4-methyl- and 2-(1-methyl-1-buten-1-yl)aniline with Br2 gave rise to the corresponding N-mesyl-2-(2-bromo-1-methyl-1-buten-1-yl)anilines. Under the similar conditions N-tosyl-2-(1-cyclohexen-1-yl)aniline was converted into N-tosyl-2-(6-bromo-1-cyclohexen-1-yl)aniline that under treatment with NH3 furnished N-tosyl-1,2,3,9a-tetrahydrocarbazole. The reaction of N-mesyl-1,2,3,9a-tetrahydrocarbazole with CuBr2 in MeOH afforded N-mesyl-4-methoxy-1,2,3,4-tetrahydrocarbazole. N-Mesyl-6-methyl-2-(1-cyclopenten-1-yl)aniline in reaction with Br2 in the presence of NaHCO3 was oxidized into the corresponding cyclopentenone, and with NBS it gave N-mesyl-2-(2-bromo-1-cyclopenten-1-yl)aniline.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 5, 2005, pp. 730–737.Original Russian Text Copyright © 2005 by Gataullin, Sotnikov, Spirikhin, Abdrakhmanov. 相似文献