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研究了3-(2'-苯基-1', 2', 3'-连三唑-4'-基)-4-氨基-5-巯基-1, 2, 4-三唑(1)与取代苯甲酸和脂肪酸(2a-r)在POCl3催化下的反应, 共合成得到18个新的3-(2'-苯基-1', 2', 3'-连三唑-4'-基)-6-烷基/芳基-均三唑并[3, 4-b]-1, 3, 4-噻二唑(3a-r), 经元素分析,IR, 1H NMR和MS进行了结构确证。 相似文献
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本文报道了由(2, 2-二硝基-3-羟基)丙基取代硝胺经相应三氟甲基磺酸酯合成(3-叠氮基-2, 2-二硝基)丙基取代硝胺的合成方法。 相似文献
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色满-4-酮并[2,3-b]喹啉酮衍生物的合成 总被引:1,自引:2,他引:1
以丙酮和适当的芳香醛以及丙二酸二乙酯为原料,合成出未见报道的5-芳基- 1,3-环已二酮作为合成块。利用Friedlaender合成法与2-氨基-3-甲酰基色满-4- 酮缩合,首次完成色满-4-酮并[2,3-b]喹啉酮新四环系化合物的合成。所合成的化 合物均经~1H NMR,~(13)C NMR,IR光谱和元素分析予以证实。化合物2a的结构也从 色谱-质谱联机分析的质谱数据得到进一步确认。化合物的药理学离体实验表明, 化合物2a具有较强的抑制肿瘤细胞生长的活性。 相似文献
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2-溴-1, 4-二羟基蒽醌与氨基醇, 缩合可以生成2-取代氨基-1, 4-二羟基蒽醌, 但在较高温度下并延长反应时间, 部分产物可以进行分子内脱水而进一步环化为2, 3-二氢蒽并(1, 2-b)(1, 4)恶嗪-7, 12-二酮的衍生物。用MS和NMR确定其结构。 相似文献
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由苯氧乙酸出发,经多步反应,制得3-苯氧甲基-4-氨基-5-巯基-1,2, 4-三唑,它与2-氯-2',4'-二氟苯乙酮进行环化反应,生成3-苯氧甲基-6-( 2,4-二氟苯基)-7H-1,2,4-三唑并[3,4-b][1,3,4]噻二嗪,通过元素分析、红外 光谱、核磁共振氢谱与碳谱、质谱进行表征,并利用单晶X射线衍射法测定其结构 。晶体属单斜晶系、P2_(1/c)空间群,a = 1.339(3) nm, b = 1.4683(4) nm, c = 0.8606(2) nm, β = 108.49(2)°, Z = 4, F(000) = 736, R_1 = 0.0509。还 对均三唑并噻二唑两类稠杂环的晶体结构作了比较。 相似文献
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We have established that when 5-chloro-6-[cyano(2,3-dihydro-1-R-benzo[d]azol-2-yl)methyl]-2,3-pyrazinedicarbonitriles are reacted with nucleophilic reagents (aliphatic and aromatic amines, hydrogen sulfide), annelation of the five-membered ring occurs on the [b] face of the pyrazine with formation of 6-amino-7-hetaryl-5-R-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitriles and 6-amino-7-(1H-benzo[d]imidazol-2-yl)thieno[2,3-b]pyrazine-2,3-dicarbonitrile respectively. Further heating with excess of acylating reagent leads to formation of a novel heterocyclic system 1H-benzo[4,5]imidazo[1,2-c]pyrazino[2',3':4,5]pyrrolo[3,2-e]pyrimidine. Reaction of vicinal dinitriles with hydrazine hydrate leads to the novel system 1H-pyrrolo[2',3':5,6]pyrazino[2,3-d]pyridazine. 相似文献
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An efficient method for the synthesis of novel benzo[b]pyrido[3',2':4,5] thieno[2,3-e][1,6] naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-(3-aminothieno[2,3-b]pyridin-2-yl)quinoline-2-ones, which could be obtained from the alkylation of 4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization, and aromatic aldehydes under p-TsOH as catalysis in good yields. 相似文献
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通过氮杂Wittig反应合成了一系列结构新颖的未见文献报道的取代四氢苯并[4',5']噻吩并[3',2':5,6]吡啶并[4,3-d]嘧啶-4(3H)-酮化合物6, 产物的结构通过核磁共振氢谱、质谱、红外光谱、元素分析的确证. 为进一步了解此类化合物的结构, 对化合物6c进行了X射线单晶衍射. 初步杀菌活性测定结果表明, 该类化合物具有较好的杀菌活性和选择性. 如6f在50 mg/L浓度时, 对黄瓜灰霉菌的抑制率为98%. 相似文献
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It has been found that malonodinitrile and 2-(6-R1-oxo-3,4-dihydro-2-quinazolyl)acetonitrile in the presence of triethylamine undergo hetarylation by 5,6-dichloro-2,3-pyrazinedicarbonitrile at the active methylene group to give the triethylammonium salt of 2-(3-chloro-5,6-dicyano-2-pyrazinyl)malononitrile or 5-chloro-6-cyano(6-R1-4-oxo-1,2,3,4-tetrahydro-2-quinazolylidene)methyl-2,3-pyrazinedicarbonitriles. Reaction of these with primary amines leads to annelation of the pyrrole ring at the pyrazine [b] edge to give 6-amino-5-R-5H-pyrrolo[2,3-b]pyrazine-2,3,7-tricarbonitriles and 6-amino-5-R2-7-(6-R1-4-oxo-3,4-dihydro-2-quinazolyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitriles respectively. 相似文献
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S. Yu. Ryabova L. M. Alekseeva N. S. Masterova V. G. Granik 《Russian Chemical Bulletin》2007,56(8):1588-1594
Derivatives of the new heterocyclic system 1,11-dihydro-4H-pyrimido[5′,4′: 5,6]pyrido[3,2-b]indol-4-one were synthesized by the reactions of 2-(2-cyanoprop-2-enylidene)indolin-3-ones, bearing the primary and secondary
amino groups in position 3 of the side chain, with DMF diethyl acetal. A scheme of formation of the synthesized compounds
was proposed and confirmed.
Dedicated to Academician V. A. Tartakovsky on the occasion of his 75th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1529–1535, August, 2007. 相似文献