共查询到20条相似文献,搜索用时 15 毫秒
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JPC – Journal of Planar Chromatography – Modern TLC - 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A sensitive, selective, precise, and stability-indicating high-performance thin-layer chromatographic method has been established... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A high-performance thin-layer chromatographic method has been developed for determination of a new antiamoebic drug, satranidazole,... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A normal-phase high-performance thin-layer chromatographic (HPTLC) method has been established for quantitative estimation of... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - Dyslipidemia, which may be manifested by elevation of the total cholesterol concentration in the blood, is one of the most common... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A high performance thin layer chromatographic method has been developed for the determination of idebenone in pharmaceutical... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A sensitive, accurate, precise, and specific high-performance thinlayer chromatographic (HPTLC) method for analysis of bicalutamide... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - The discovery of potent antidiabetic drugs is of necessity owing to the rapid prevalence of diabetes worldwide. The investigation... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A new simple, rapid, reproducible, and stability-indicatiiig highperformance thin-layer chromatographic method for analysis of... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A normal-phase TLC method has been established for the estimation of rosuvastatin calcium in its bulk drug and pharmaceutical... 相似文献
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A novel stability-indicating high-performance liquid chromatographic assay method was developed and validated for quantitative
determination of nitazoxanide in bulk drugs and in pharmaceutical dosage form in the presence of degradation products generated
from forced decomposition studies. An isocratic, reversed phase LC method was developed to separate the drug from the degradation
products, using an Ace5- C18 (250 mm × 4.6 mm, 5 μm) column, and 50 mM ammonium acetate (pH 5.5 by acetic acid) and acetonitrile
(55:45 v/ v) as a mobile phase. The detection was carried out at a wavelength of 240 nm. The nitazoxanide was subjected to stress conditions
of hydrolysis (acid, base), oxidation, photolysis and thermal degradation. Degradation was observed for nitazoxanide in base,
acid and in 30% H 2O 2 conditions. The drug was found to be stable in the other stress conditions attempted. The degradation products were well
resolved from the main peak. The percentage recovery of nitazoxanide was from (100.55 to 101.25%) in the pharmaceutical dosage
form. The developed method was validated with respect to linearity, accuracy (recovery), precision, system suitability, specificity
and robustness. The forced degradation studies prove the stability indicating power of the method. 相似文献
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A novel stability-indicating LC assay method was developed and validated for quantitative determination of olmesartan in bulk drugs and in pharmaceutical dosage form in the presence of degradation products generated from forced degradation studies. An isocratic, reversed phase LC method was developed to separate the drug from the degradation products, using an Ace5-C18 (250 mm × 4.6 mm, 5 μm) column, and 50 mM ammonium acetate (pH-5.5 by acetic acid) and acetonitrile (70:30 v/v) as a mobile phase. The detection was carried out at the wavelength of 235 nm. The olmesartan was subjected to stress conditions of hydrolysis (acid, base), oxidation, photolysis and thermal degradation. Degradation was observed for olmesartan in acid, base and in 30% H2O2 conditions. The drug was found to be stable in the other stress conditions attempted. The degradation products were well resolved from the main peak. The percentage recovery of olmesartan ranged from (99.89 to 100.95%) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision, specificity and robustness. The forced degradation studies prove the stability-indicating power of the method. 相似文献
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A sensitive and reproducible method is described for the quantitative determination of metadoxine in the presence of its degradation products. The method was based on high performance liquid chromatographic separation of the drug from its degradation products on the reversed phase, kromasil column [C 18 (5-micron, 25 cm × 4.6 mm, i.d.)] at ambient temperature using a mobile phase consisting of methanol and water (50: 50, v/v). Flow rate was 1.0 mL min ?1 with an average operating pressure of 180 kg cm ?2 and t R was found to be 2.85 ± 0.05 min. Quantitation was achieved with UV detection at 286 nm based on peak area with linear calibration curves at concentration range 10–100 μg mL ?1. This method has been successively applied to pharmaceutical formulation. No chromatographic interference from the tablet excipients was found. The method was validated in terms of precision, robustness, recovery and limits of detection and quantitation. Drug was subjected to acid, alkali and neutral hydrolysis, oxidation, dry heat, wet heat treatment and photo and UV degradation. As the proposed method could effectively separate the drug from its degradation products, it can be employed as stability indicating one. Moreover, the proposed HPLC method was utilized to investigate the kinetics of the acidic, alkaline and oxidative degradation processes at different temperatures and their respective apparent pseudo first order rare constant, half-life and activation energy was calculated with the help of Arrhenius plot. In addition the pH-rate profile of degradation of metadoxine in constant ionic strength buffer solutions with in the pH range 2–11 was studied. 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A simple and sensitive thin-layer chromatographic method has been established for analysis of bupropion hydrochloride in... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - The objective of this study was to develop a new rapid and robust high-performance thin-layer chromatographic (HPTLC) method for... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A simple, specific, and precise high-performance thin-layer chromatographic (HPTLC) method for the analysis of azathioprine, both... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A high-performance thin-layer chromatographic method has been developed for determination of four carbamate residues in vegetables.... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A simple, sensitive, and precise high-performance thin-layer chromatographic method has been developed for the estimation of... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A highly validated and selective high-performance thin-layer chromatography (HPTLC) method was developed for the determination of... 相似文献
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