Validation of a High-Performance Thin-Layer Chromatographic Method,with Densitometric Detection,for Quantitative Analysis of Nebivolol Hydrochloride in Tablet Formulations

JPC – Journal of Planar Chromatography – Modern TLC - A quantitative densitometric high-performance thin-layer chromatographic method for determination of nebivolol hydrochloride in...     

High-Performance Thin-Layer Chromatography Combined with Densitometry for Quantitative Analysis of Phenolic Acids in Complex Mixtures

JPC – Journal of Planar Chromatography – Modern TLC - Protocatechuic acid and caffeic acid in plant extracts, both free and bound as glycosides and ester derivatives, have been...     

Development and Validation of a High-Performance Thin-Layer Chromatographic Fingerprint Method for the Evaluation of QiYi Capsules with the Reference of Myotonin

JPC – Journal of Planar Chromatography – Modern TLC - The newly developed high-performance thin-layer chromatography (HPTLC) method allowed for the differentiation of QiYi capsules from...     

Development and Validation of a Stability-Indicating High-Performance Thin-Layer Chromatographic Method for the Simultaneous Quantification of Sparfloxacin and Flurbiprofen in Nanoparticulate Formulation

JPC – Journal of Planar Chromatography – Modern TLC - A simple, sensitive, precise, rapid, and reliable high-performance thin-layer chromatographic (HPTLC) method for the simultaneous...     

High-Performance Thin-Layer Chromatographic Method for Analysis of Racecadotril in the Bulk Drug

JPC – Journal of Planar Chromatography – Modern TLC - A new simple, rapid, reproducible, and stability-indicatiiig highperformance thin-layer chromatographic method for analysis of...     

Development of a Validated Stability-Indicating High-Performance Thin-Layer Chromatographic Method for the Quantification of Levetiracetam

JPC – Journal of Planar Chromatography – Modern TLC - Levetiracetam (LT) is an FDA-approved orally active anticonvulsant drug. A high-performance thin-layer chromatographic (HPTLC)...     

Development and Validation of a Liquid Chromatographic Method for Determination of Efavirenz in Human Plasma

A simple, rapid, and sensitive high-performance liquid chromatographic method for estimation of efavirenz in human plasma has been developed and validated. Chromatography was performed with C₁₈ analytical column and 50:50 acetonitrile–phosphate buffer (pH 3.5) as mobile phase. Compounds were monitored by UV detection at 247 nm. The retention time for efavirenz was 6.45 min and that for the internal standard, nelfinavir, was 2.042 min. Response was a linear over the concentration range of 0.1 μg–10 μg mL⁻¹ in human plasma. The method was simple, specific, precise and accurate and was useful for bioequivalence and pharmacokinetic studies of efavirenz.     

Development and Validation of a Planar Chromatographic Method with Reflectance Scanning Densitometry for Quantitative Analysis of Anastrozole in the Bulk Material and in Tablet Formulations

JPC – Journal of Planar Chromatography – Modern TLC - A new quantitative densitometric HPTLC method has been developed for analysis and determination of the stability of anastrozole,...     

Development and Validation of a Densitometric HPTLC Method for Quantitative Analysis of Levofloxacin in Human Plasma

JPC – Journal of Planar Chromatography – Modern TLC -     

Development and Validation of High-Performance Thin-Layer Chromatographic Method for the Simultaneous Determination of Rifampicin,Isoniazid, and Pyrazinamide in a Fixed Dosage Combination Tablet

JPC – Journal of Planar Chromatography – Modern TLC -     

Development and Validation of a High-Performance Thin-Layer Chromatographic Method for the Assay of Ternary Mixtures Containing Cetirizine Dihydrochloride in Pharmaceutical Dosage Forms

JPC – Journal of Planar Chromatography – Modern TLC - A highly validated and selective high-performance thin-layer chromatography (HPTLC) method was developed for the determination of...     

High-Performance Thin-Layer Chromatography Combined with Densitometry for Quantitative Analysis of Chlorogenic Acid in Fruits of Peucedanum alsaticum L.

JPC – Journal of Planar Chromatography – Modern TLC - High-performance thin-layer chromatography with densitometric detection has been used for quantitative analysis of chlorogenic acid...     

Development and Validation of a High-Performance Thin-Layer Chromatographic Method for the Simultaneous Estimation of Torsemide and Eplerenone by Quality by Design Approach

JPC – Journal of Planar Chromatography – Modern TLC - This paper includes the development of a novel, systematic, quality by design (QbD)-based high-performance thin-layer...     

Development and Validation of a Stability-Indicating High-Performance Thin-Layer Chromatographic Method for Determination of Pyridostigmine Bromide in the Presence of Its Alkaline-Induced Degradation Product

JPC – Journal of Planar Chromatography – Modern TLC - A validated, sensitive, and highly selective stability-indicating high-performance thin-layer chromatographic (HPTLC) method has...     

Development of a High-Performance Thin-Layer Chromatographic Method for Quantification of Cucurbitacin B in Bottle Gourd (Lagenaria siceraria) for Quality Control

JPC – Journal of Planar Chromatography – Modern TLC - Bottle gourd (Lagenaria siceraria (Molina) Standl.) is an important vegetable cucurbit cultivated in the warmer parts of the world....     

Simple High-Performance Liquid Chromatographic Method for the Analysis of Quinine in Human Plasma without Extraction

Abstract

A simple, rapid and sensitive assay, capable of quantitating quinine (Q) in human plasma samples is reported. The assay uses a reversed-phase C18 HPLC column packed with 5 μ ODS Hypersil. The chromatographic separation was accomplished with an isocratic mobile phase comprising acetonitrile-aqueous phosphate buffer pH 2 (50:50, v/v) containing 25 mM sodium dodecyl sulfate and 3 mM tetrabutylammonium bromide at a flow rate of 0.5 ml/min. The eluant was monitored by a fluorescence detector (excitation wavelength at 350 nm and emission wavelength at 450 nm). The assay was based on a simple plasma protein precipitation technique. To 200 μ of plasma sample, 400 μ of internal standard (cinchocaine 30 μ/ml in methanol) was added. After brief vortexing and centrifugation, the clear supernatant was injected onto the HPLC column. The inter- and intra-assay coefficients of variation were found to be less than 10%. The lowest limit of detection for Q in plasma was 18 ng/ml.     

Simultaneous High-Performance Thin-Layer Chromatographic Determination of Ondansetron and Pantoprazole in Their Pure Forms and Spiked Human Plasma

JPC – Journal of Planar Chromatography – Modern TLC - The therapeutic combination of ondansetron (OND) and pantoprazole (PAN) is widely prescribed for the treatment of many...     

Development and Validation of a High-Performance Thin-Layer Chromatography Based Method for the Quantification of Trigonelline in Fenugreek (Trigonella foenum-graecum) Seeds

JPC – Journal of Planar Chromatography – Modern TLC - The present research work was undertaken to develop and validate a sensitive, fast, and reproducible high-performance thin-layer...     

Development of a New,Rapid, and Sensitive Validated High-Performance Thin-Layer Chromatographic Method for the Estimation of Berberine in Tinospora cordifolia

JPC – Journal of Planar Chromatography – Modern TLC - A straightforward, delicate, and fast elite thin-layer chromatographic system (high-performance thin-layer chromatography [HPTLC])...