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《液相色谱法及相关技术杂志》2012,35(7):969-1001
Abstract Methods for the quantitative determination of NAPROXEN and its main metabolite in plasma and urine are described. The separation is based on reversed phase liquid chromatography with LiChrosorb RP 8 (5 μm) as the support and methanol/phosphate buffer pH 7 as mobile phase, in some cases with addition of tetrabutyl ammonium ion as ion-pairing agent to improve the chromatographic selectivity. With UV-detector and a simple filter fluorometer an extraction-evaporation procedure is used for both plasma and urine determinations, while the high selectivity and sensitivity of a sophisticated fluorescence detector permits the direct injection of diluted samples on to the column. Use of an internal standard improves the within-run precision (srel%), which for plasma determinations of NAPROXEN are - with UV-detection, 0.2 – 1.7% (range 10 – 40 μg/ml), with filter fluorometer, 2.4 – 5.9% (range 12 – 58 μg/ml), and with fluorescence detector, 0.8 – 4.1% (range 5 – 20 μg/ml). 相似文献
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The optically active naproxen was synthesized in good chemical yield and high optical purity starting from a chiral α-ketoalcohol which was prepared from enzymatic resolution of the corresponding racemic acetate using lipase as a catalyst. 相似文献
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This review describes the synthesis and reactions of naproxen derivatives and highlights the effects of compounds containing the naproxen moiety in important biological applications. 相似文献
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Naproxen oral absorption characteristics 总被引:1,自引:0,他引:1
R A Runkel K S Kraft G Boost H Sevelius E Forchielli R Hill R Magoun J B Szakacs E Segre 《Chemical & pharmaceutical bulletin》1972,20(7):1457-1466
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《液相色谱法及相关技术杂志》2012,35(18):3387-3396
Abstract The enantiomers of underivatized Naproxen are resolved on a previously described commercially available HPLC chiral stationary phase (CSP). This same CSP also separates the enantiomers of a variety of ester and amide derivatives of Naproxen. 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - Asensitive, selective, and precise high-performance thin-layer chromatography (HPTLC) method was developed for simultaneous... 相似文献
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Quazi Ahmed Theodor Wagner-Jauregg Ernst Pretsch Josef Seibl 《Helvetica chimica acta》1973,56(5):1646-1655
The N-substituted 1-benzimidazolyl-succinimides 6a – v (Scheme 1, Table 1 and 2) have been prepared by the reaction of benzimidazole and its derivatives with maleimides. Reduction of the N-cyclohexyl and N-cyclo-octyl substituted 1-benzimidazolyl-succinimides 6i – k with lithium aluminium hydride gives the normally expected substituted (N-alkyl-3-pyrrolidinyl)benzimidazoles 14i – k . However by LiAlH4-reduction of the N-phenyl substituted 1-benzimidazolylsuccinimides 6a – h mainly the 1-aryl-9-alkyl-2, 3, 3a, 4, 9, 9a-hexahydro-1H-pyrrolo[2, 3-b]quinoxalines 7a – h are obtained. The mechanism of this unusual reduction has been elucidated. 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - Aegle marmelos (Rutaceae) has gained traditional therapeutic importance owing to their coumarins (umbelliferone, psoralene, marmin,... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - 相似文献
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Rajendra Prasad Nandi Dr. Pagidi Sudhakar Dr. Neena K. Kalluvettukuzhy Prof. Pakkirisamy Thilagar 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(69):16306-16317
Herein, the design, synthesis, optical properties, and mechanofluorochromism characteristics of a series of conjugates having covalently linked triarylborane (TAB) and anil/boranil units (TAB-anil: 1 a – 3 a and TAB-boranil: 1 – 3 ) are reported. The electronic interactions between TAB and anil/boranil in 1 a – 3 a and 1 – 3 were fine-tuned by changing the boryl moiety's position on the phenyl spacer connecting the BMes2 (Mes=mesityl) and anil/boranil units. A boryl moiety at the meta position ( 1 a ) of the phenyl spacer stabilizes the enolic form (E-OH), whereas a boryl moiety at the para position ( 2 a and 3 a ) stabilizes the keto form (Z-NH) in the solid state. However, in solution 1 a , 2 a , and 3 a exhibit keto–enol tautomerism in both ground and excited states. Compounds 1 a – 3 a and 1 – 3 show red-shifted absorption compared with 4 a and 4 , which are devoid of TAB moieties, which indicate effective participation of an empty p orbital on the boron center in 1 a – 3 a and 1 – 3 . Compounds 1 and 2 showed fluorescence variations in response to external stimuli such as mechanical grinding. Long phosphorescence lifetimes of 18–46 ms were observed for compounds 1 – 3 . The observed optical properties of 1 a – 3 a and 1 – 3 are rationalized in the context of quantum mechanical calculations. 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - Athin-layer chromatographic (TLC) method was used for the quantification of four dominant flavonoids (rutin, narcissin,... 相似文献
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《Journal of heterocyclic chemistry》2017,54(6):3342-3349
New series of chromenes 2 – 4 , pyridines 5 – 8 , and pyranopyrazoles 9a,b were synthesized via one‐pot multicomponent reaction of 4‐tosyloxybenzaldehyde ( 1 ) and malononitrile with phenols, amines or hydrazines, and ethyl acetoacetate, respectively. Compound 9a was reacted with acetic anhydride, formic acid, or formamide to afford N ‐acetyl derivative 10 and pyrazolopyranopyrimidines 11 – 13 , respectively. Imidazole derivatives 14 and 15a – d were obtained by multicomponent reaction between compound 1 with ammonium acetate and benzil or aromatic amines in (1:2:1) or (1:1:1:1) ratio, respectively. The structures of new compounds were elucidated by elemental and spectral analyses. 相似文献
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Agbaba Danica Novovic Dragana Karljiković-Rajić Katarina Marinković Valentina 《平面色谱法杂志一现代薄层色谱法》2004,17(3):169-172
JPC – Journal of Planar Chromatography – Modern TLC - A method has been developed for separation of omeprazole and pantoprazole, and their impurities omeprazole sulfone and... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - We report improved separation of the highly toxic contact herbicides paraquat, diquat, difenzoquat, mepiquat, and chloromequat by... 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - A new, simple, accurate, and rapid high-performance thin-layer chromatographic method has been developed for the determination of... 相似文献
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MarcS. Robillard BartA.J. Jansen Martin Lochner Herv Geneste Yi Li Jaap Brouwer Manfred Hesse Jan Reedijk 《Helvetica chimica acta》2001,84(10):3023-3030
The synthesis of three bis[(tert‐butoxy)carbonyl]‐protected (tetramine)dichloroplatinum complexes 2a – c of formula cis‐[PtCl2(LL)] and of their cationic deprotected analogs 3a – c and their evaluation with respect to in vitro cytotoxicity, intramolecular stability, DNA binding, and cellular uptake is reported. The synthesis comprises the complexation of K2[PtCl4] with di‐N‐protected tetramines 1a – c to give 2a – c and subsequent acidolysis, yielding 3a – c . The cytotoxicity of the complexes is in direct relation to the length of the polyamine. Complexes 3a – c display a significant higher affinity for CT DNA as well as for cellular DNA in A2780 cells than cisplatin. 相似文献
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JPC – Journal of Planar Chromatography – Modern TLC - The epimers of cefaclor have been separated, identified, and analyzed quantitatively by TLC. The stationary phase was silica gel 60... 相似文献