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在K2CO3作为碱、乙腈作为溶剂的条件下,将2-氯甲基-4-苯基喹啉-3-羧酸乙酯(3)分别与5,7-二氯-8-羟基喹啉(4a)和5,7-二溴-8-羟基喹啉(4b)发生Williamson反应,以高收率得到结构新颖的二氯或二溴取代的双喹啉类目标化合物2-(5,7-二氯/二溴-8-喹啉氧甲基)-4-苯基喹啉-3-羧酸乙酯(2a,2b);其结构经波谱数据和元素分析证实. 相似文献
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设计并合成了两个新的氟代香豆素化合物8-(3-氟苯甲酰基)-7-羟基-4-甲基香豆素(3a)和8-(4-氟苯甲酰基)-7-羟基-4-甲基香豆素(3b),其结构通过元素分析、IR和1HNMR进行了表征,通过X-射线单晶衍射测定了化合物3b的晶体结构,单晶结构分析表明,化合物3b的晶体属于单斜晶系.体外抑菌试验结果显示,目标化合物对大肠杆菌(E.coli)、枯草杆菌(B.subtilis)和金色葡萄球菌(S.aureus)有不同程度的抑制作用;体外抗氧化实验显示,目标化合物对超氧阴离子自由基(O2-·)和二苯代苦味肼基自由基(DPPH·)均有良好的清除能力;运用荧光光谱法研究了不同温度下目标化合物与牛血清白蛋白(BSA)的相互作用,结果表明,目标化合物对BSA的荧光猝灭均属于静态猝灭,相关热力学参数表明,化合物3a(H〈0,S〈0,G〈0)与BSA二者之间主要以氢键或范德华力相结合,化合物3b(H〉0,S〉0,G〈0)与BSA二者之间主要靠疏水作用力相结合;依据Fster's非辐射能量转移理论,求得BSA与化合物3a和化合物3b间的距离(r)分别为2.53和2.65nm,说明两个化合物与BSA之间可能发生了非辐射能量转移. 相似文献
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1,4-二氢-4-芳基-3,5-吡啶二羧酸酯的合成及表征 总被引:1,自引:0,他引:1
基于二氢吡啶化合物的构效关系, 设计了一系列1,4-二氢-4-芳基-3,5-吡啶二羧酸酯新化合物. 含有易于水解基团的1,4-二氢-4-芳基-3,5-吡啶二羧酸酯类化合物在碱性条件下水解合成了重要中间体1,4-二氢-4-芳基-3,5-吡啶二羧酸单酯, 收率93%~99.8%. 该二羧酸单酯与α-溴代芳基乙酮在相转移剂催化下反应合成目标化合物, 收率74%~99%. 中间体和目标化合物经1H NMR, 13C NMR, IR, MS和元素分析等确证. 相似文献
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本文报道了3-亚甲基异苯并呋喃-1(3H)-酮的高效合成方法。其特点是以邻甲基苯甲酸为原料,采用"一锅法"经过酯化,自由基溴代,形成季鏻盐三步反应得到2-[(溴三苯基正膦基)甲基]苯甲酸甲酯;随后经过改进的Wittig反应,酯水解合成了邻乙烯基苯甲酸;再与KI/I2溶液发生环合反应生成3-碘甲基异苯并呋喃-1(3H)-酮;最后发生消除反应得到所需要的产物。该方法具有原料易得、价格低廉、反应条件温和、收率高等优点。化合物结构用1H NMR、13C NMR和IR表征。 相似文献
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Peter Rogl 《Monatshefte für Chemie / Chemical Monthly》1980,111(2):517-527
The crystal structure of LaIr4B4 has been refined from single crystal counter data. LaIr4B4 is tetragonal,P42/n,Z=2, isotypic with NdCo4B4, |F|/|F
o|=0.039 for 312 independent reflections [|F
o|>2 (F
o)]. ThIr4B4 and ThOs4B4 also belong to the NdCo4B4-type structure. URu4B4 and UOs4B4 were found to crystallize with LuRu4B4-type structure. The crystal chemistry of (RE)T
4B4-phases is discussed and simple geometric relations are shown to exist between them.Dedicated to Prof.B. T. Matthias in celebration of his 60th birthday. 相似文献
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Vibrational Spectra of As4S4 and As4Se4 The vibrational spectra of solid α- and β-As4S4 and the Raman spectrum of molten As4S4 have been recorded. The assignments of the frequencies are proposed mainly based on polarization data. The Raman melt spectra suggest that As4S4 molecules (symmetry D2d) are retained in the molten state. A partial decomposition of the melt by prolonged laser irradiation was observed. The Raman spectrum of solid As4Se4 is presented and the frequencies are tentatively assigned to an As4Se4 molecule of the cradle type, possessing D2d symmetry. 相似文献
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Die erstmals dargestellten isotypen Verbindungen Ba4SiAs4, Ba4GeAs4, Sr4SiAs4 und Sr4GeAs4 kristallisieren kubisch, Raumgruppe P4 3n, mit 8 Formeleinheiten in der Elementarzelle: In den Strukturen liegen isolierte, d.h. nur von Ba-Ionen umgebene SiAs - bzw. GeAs -Tetraeder vor. Die Verbindungen sind die bisher eindrucksvollsten Beispiele für Zintlphasen mit komplexen Anionen. Zintl Phases with Isolated SiAs4 or GeAs4 Anions: Preparation and Structure of Ba4SiAs4, Ba4GeAs4, Sr4SiAs4, and Sr4GeAs4 The new compounds Ba4SiAs4, Ba4GeAs4, Sr4SiAs4, and Sr4GeAs4 have been prepared and their structures determined. They crystallize in the cubic system, P4 3n, with axes: data see “Inhaltsübersicht”. There are isolated SiAs or GeAs tetrahedra in the structures. The compounds can be interpreted as Zintl phases with complex anions. 相似文献
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On K4PbO4 and Rb4PbO4 For the first time single crystals of K4[PbO4] have been prepared by heating K4PbO3 in O2. The structure has been refined [K4[PbO4]: 3029 I0(hkl), four circle diffractometer PW 1100, ω-scan, MoKα, R = 6.73%, Rw = 6.64%, P1 ; a = 658.62(15), b = 658.41(12), c = 986.64(21) pm, α = 79.74(2)°, β = 108.45(2)°, γ = 112.49(2)°, dx = 3.79 g · cm?3, dpyk = 3.78 g · cm?3, Z = 2; Rb4[PbO4]: a = 686.94(18), b = 684.43(18), c = 1020.73(21) pm, α = 79.28(2)°, β = 108.40(2)°, γ = 113.02(2)°, dx = 4.87 g · cm?3, dpyk = 4.85 g · cm?3, Z = 2, (from Rb2PbO3 and Rb2O)]. Both compounds are isotypic with K4SnO4. The Effective Coordination Numbers, ECoN, these via Mean Fictive Ionic Radii, MEFIR, are calculated. 相似文献
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