精品课程教材《高分子物理实验》建设的体会——三个及时融入

中国科学技术大学"高分子物理实验"课程是2006年安徽省精品课程,作者结合教学研究和精品课程建设经验,总结出了"三个及时融入"的教材建设理念,本文结合实例对该理念的具体含义进行了阐述.     

以建设《高分子化学》优秀课程为契机,加强专业建设

通过优秀课程建设,能够带动专业建设工作和教师队伍的培养工作,使教学质量再上一个新台阶.本文以建设<高分子化学>精品课程为模板,介绍了<高分子化学>优秀课程的建设过程,通过积极与工厂进行产、学、研密切合作,在生产实习教学环节实施、教师工程实践能力培养、学生工程实践能力和实验动手能力培养等方面形成了特色,在学科体系建设、理...     

《高分子化学实验》课程交互式教学改革及其效果的调查研究

《高分子化学实验》课程是高等院校高分子专业本科生学习高分子科学的关键实践环节。实验课内容需与高分子化学课程中理论知识紧密联系的要求决定了实验课内容的基础性和规范性。在规定的教学内容内,培养学生动手能力,激发学生兴趣、培养学生创新思维是本实验课程教学的核心目标。本教学改革通过:(1)在既定教学内容上调节实验变量、增加实验结果未知性;(2)增加实验过程中的教师与学生、学生与学生的交流强度;(3)增加课程的平时成绩权重的成绩评定方法等改善教学效果,并通过问卷调查的形式分析和评价交互式教学效果。本文的措施和结论为高分子化学实验课程的教学提供了有益的参考价值。     

用新理念编写《环境化学实验》

实验教材建设是课程建设的重要内容之一,也是提高教学质量的重要保证。本文在充分调研国内外同类教材的基础上,开展了对教材内容、体系和结构及同类教材比较等方面的研究,介绍了《环境化学实验》教材编写的新理念、新思路及教材的内容、特点及在培养学生创新精神与实践能力方面取得的效果。     

微型高分子化学实验与思维创新教育

通过微型高分子化学实验,实现本科生人手一套实验装置,独立进行高分子材料的设计合成及改性。在此基础上,组建思维创新实验室,以发明创造成果、创业计划、专利样板等为教材,进行思维创新训练。学生自主提出实验设想,把微型实验与思维创新教育结合起来,探索一条有效培养大学生创新精神和实践能力的教学方法途径。     

"高分子物理实验"精品课程建设的探索

介绍作者在"高分子物理实验"精品课程建设中所做的一些工作,如:坚持对实验教学进行研究、探索实验教学新模式、建设教材、构建网络教学环境等.     

Teaching System Construction of Polymer Chemistry Experiment and its Function on Training Creative Applying Talents

高分子化学是材料化学专业重要的技术基础课,是一门以实验为基础的学科,因此,高分子化学实验是高分子科研和高分子教学的重要组成部分,是学生在掌握高分子化学的基础上,学习高分子合成的各种实验技术、聚合实施方法,培养学生进行高分子材料研究和技术开发的基本能力。从市场就业对高分子材料方向的人才需求出发,以培养创新性应用型人才为目标,通过开展实验技术讲座、改进基础性实验为综合性实验和设计性实验、增加研究性实验对高分子化学实验教学体系进行了改革,实验内容体现材料的应用性和工程价值,培养了学生的创新能力、工程实践能力。     

“高分子物理实验”精品课程建设的探索

介绍作者在“高分子物理实验”精品课程建设中所做的一些工作，如：坚持对实验教学进行研究、探索实验教学新模式、建设教材、构建网络教学环境等。     

“高分子物理”及“高分子物理实验”2门精品课程的建设

"高分子物理"(在中国科学技术大学叫"高聚物的结构与性能")和"高分子物理实验"课是该校高分子科学与工程系本科生的必修课。为了讲好和全面建设这两门课,作者倡导并积极开展教学研究,发表39篇教学研究论文,作者把这些研究心得和成果及时引入教学中,先后编写和出版了十几本教材及教学参考书,教学质量不断提高,并逐步形成了有鲜明特色的教学,在国内高校产生了很好的影响。通过多方面的建设,2005年"高聚物的结构与性能"被评为国家级精品课程,2006年"高分子物理实验"被评为安徽省精品课程。     

全新设计的现代高分子化学实验课程建设

理科院系高分子化学实验教学发展缓慢,急需紧跟学科发展的前沿、注入新鲜而实用的内容。全新设计建设的现代高分子化学实验覆盖众多传统实验课鲜有涉及、但在科研中极为重要的前沿理念与技术,旨在提高学生科研素养和对学科前沿的把握能力,其成功开发为理科院系针对创新型人才培养的高分子化学实验提出了全新思路。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.