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Balzs Budai Alexandre Leclair Qian Wang Jieping Zhu 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(30):10411-10415
Reported here is a copper‐catalyzed 1,2‐methoxy methoxycarbonylation of alkenes by an unprecedented use of methyl formate as a source of both the methoxy and the methoxycarbonyl groups. This reaction transforms styrene and its derivatives into value‐added β‐methoxy alkanoates and cinnamates, as well as medicinally important five‐membered heterocycles, such as functionalized tetrahydrofurans, γ‐lactones, and pyrrolidines. A ternary β‐diketiminato‐CuI‐styrene complex, fully characterized by NMR spectroscopy and X‐ray crystallographic analysis, is capable of catalyzing the same transformation. These findings suggest that pre‐coordination of electron‐rich alkenes to copper might play an important role in accelerating the addition of nucleophilic radicals to electron‐rich alkenes, and could have general implications in the design of novel radical‐based transformations. 相似文献