Selbstheilende Polymere

Even though the field of self‐healing is rarely known so far – self healing materials are already present at our market. Nevertheless just due to modern scientific concepts we are now able to understand the basic mechanistic steps in a more detailed way. Further progress on this field will open access to materials with a wide range of adjustable properties. Therefore, applications of such self healing materials are not limited – assuming the market‐price is competitive and the elongated lifetime delivers an appropriate advantage. Already demonstrated for concrete and clear coatings for cars, the investigations done so far have generated materials with improved properties and prolonged durability.     

Funktionale Polymere im Alltag: Vielseitig

With some selected examples the important role of functional polymers in daily life is demonstrated. Although added in very small amounts, these macromolecules largely influence the physical properties of the total system. Main applications are laundry and detergents, paper and textile manufacturing, pharmaceutical formulations, food processing and cosmetics. In these applications, functional polymers are used due to their ability to disperse, solubilize, agglomerate, adsorb, flocculate, solidify or thicken other molecules in the system.     

Synthesis of Poly(acyclic orthoester)s: Acid-Sensitive Biomaterials for Enhancing Immune Responses of Protein Vaccine

While poly(acyclic orthoester)s (PAOEs) have many appealing features for drug delivery, their application is significantly hindered by a lack of facile synthetic methods. Reported here is a simple method for synthesizing acyclic diketene acetal monomers from diols and vinyl ether, and their polymerization with a diol to first synthesize PAOEs. The PAOEs rapidly hydrolyze at lysosomal pH. With the help of a cationic lipid, ovalbumin, a model vaccine antigen was efficiently loaded into PAOEs nanoparticles using a double emulsion method. These nanoparticles efficiently delivered ovalbumin into the cytosol of dendritic cells and demonstrated enhanced antigen presentation over poly(lactic-co-glycolic acid) (PLGA) nanoparticles. PAOEs are promising vehicles for intracellular delivery of biopharmaceuticals and could increase the utility of poly(orthoesters) in biomedical research.