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1.
V. D. Dyachenko E. N. Karpov I. A. Feskov 《Russian Journal of General Chemistry》2013,83(9):1716-1723
New 4-alkyl-6-amino-N 3,N 5-diaryl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamides have been prepared via enantioselective reaction of 3-amino-N-aryl-3-thioxopropanamides with N-aryl-2-cyanoacetamide and aliphatic aldehydes. The prepared products can be regioselectively alkylated at sulfur atom. 相似文献
2.
Dyachenko V. D. Nesterov V. N. Dyachenko I. V. 《Russian Journal of General Chemistry》2011,81(4):751-755
2-Alkylthio-6-amino-3,5-dicyano-1,4-dihydropyridine-4-spirocycloalkanes were synthesized via the reaction of cycloalkylidene
malononitriles with cyanothioacetamide and alkyl halides. The structure of 6-amino-2-(2-methylbenzylthio)-3,5-dicyano-1,4-dihydropyridine-4-spirocyclopentane
was determined by the X-ray diffraction analysis. 相似文献
3.
V. D. Dyachenko D. A. Krasnikov M. V. Khorik 《Chemistry of Heterocyclic Compounds》2008,44(7):815-819
N(3)-Aryl-N(5)-phenyl-6-amino-4-aryl(2-furyl)-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamides have been obtained by the interaction
of N-phenyl-3-aryl(2-furyl)-2-cyanoacrylamides with 3-amino-3-thioxopropananilides under the conditions of the Michael reaction.
N(3)-Aryl-N(5)-phenyl-2-alkylthio-6-amino-4-aryl(2-furyl)-3,4-dihydropyridine-3,5-dicarboxamides and N(3), N(5)-diphenyl-6-benzylthio-4-(2-furyl)-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamides were synthesized by alkylation of the
products.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1018–1023, July, 2008. 相似文献
4.
A. D. Dyachenko S. M. Desenko V. D. Dyachenko E. B. Rusanov 《Chemistry of Heterocyclic Compounds》2003,39(6):744-748
3-Carbamoyl-6-methyl-5-phenylcarbamoyl-2-thioxo-1,2,3,4-tetrahydropyridine-4-spirocyclohexane has been synthesized by the condensation of cyclohexylidenecyanothioacetamide with acetoacetanilide and piperidine. The structure of the product was established by X-ray structural analysis. 相似文献
5.
6.
V. D. Dyachenko S. G. Krivokolysko V. N. Nesterov Yu. T. Struchkov V. P. Litvinov 《Russian Chemical Bulletin》1996,45(10):2405-2410
The reaction of cyano(cyclohexylidene)thioacetamide with cyanothioacetamide or malononitrile andN-methylmorpholine yieldsN-methylmorpholinium 6-amino-3,5-dicyano-1,4-dihydropyridine-4-spirocyclohexane-2-thiolate. Its structure was established based on the results of alkylation and X-ray structural analysis.Deceased.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2535–2540, October, 1996. 相似文献
7.
A. A. Krauze Z. A. Kalme Yu. É. Pelcher É. É. Liepin'sh I. V. Dipan G. Ya. Dubur 《Chemistry of Heterocyclic Compounds》1983,19(11):1202-1207
3-Cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thiones have been synthesized for the first time by the condensation of arylideneacetophenones or 1-piperidino-1-phenyl-2-benzoylethane with cyanothioacetamide and the 1, 1-dicyano-2-aryl-3-benzoylpropane with hydrogen sulfide in the presence of bases. It has been established by PMR spectroscopy that 3-cyano-3,4-dihydropyridine-2-thiones exist in solutions in the form of mixture of cis and trans isomers.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1515–1520, November, 1983. 相似文献
8.
9.
Reactions of aromatic aldehydes with cyanothioacetamide and dimethyl malonate in the presence ofN-methylmorpholine affordedN-methylmorpholinium 4-aryl-5-cyano-3-methoxycarbonyl-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates. The latter were used to
synthesize substituted 6-(alkylthio)-2-oxo-1,2,3,4-tetrahydropyridines.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 485–487, March, 2000. 相似文献
10.
The reactions of 3- or 4-hydroxybenzaldehydes with cyanothioacetamide and Meldrum's acid in the presence ofN-methylmorpholine affordedN-methylmorpholinium 5-cyano-4-(3-or 4-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates, respectively. The resulting
compounds were used in the synthesis of substituted 6-alkylthio-1,2,3,4-tetrahydropyridin-2-ones.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2333–2336. December, 1999. 相似文献
11.
Alberto Bargagna Sergio Cafaggi Pietro Schenone 《Journal of heterocyclic chemistry》1980,17(3):507-511
Cycloaddition of dichloroketene to N,N-disubstituted 1-amino-4-methyl-1-penten-3-ones and 1-amino-4,4-dimethyl-1-penten-3-ones occurred in moderate to fair yield only in the case of aromatic N-substitution to give N,N-disubstituted 6-alkyl-4-amino-3,3-dichloro-3,4-dihydro-2H-pyran-2-ones, which were dehydrochlorinated with DBN to afford in good yield N,N-disubstituted 6-alkyl-4-amino-3-chloro-2H-pyran-2-ones. In the case of aliphatic N,N-disubstitution, cyclo-addition led directly to 6-alkyl-4-dialkylamino-3-chloro-2H-pyran-2-ones only for N,N-disubstituted 1-amino-4,4-dimethyl-1-penten-3-ones. The reaction between 1-dimethylamino-4-methyl-1-penten-3-one and dichloroketene gave 3-chloro-4-dimethylamino-3,6-dihydro-6-isopropylidene-2H-pyran-2-one in low yield. 相似文献
12.
Magdi F. Iskander Josefe Stephanos Nagwa El Kady Mohyi El Essawi Ahmed El Toukhy Laila El Sayed 《Transition Metal Chemistry》1989,14(1):27-33
Summary Mono-, bis- and tris-ligand nickel(II) and cobalt(II) complexes with 4 amino-3-alkyl-5-thio-1,2,4-triazolines (HRL) (R=H, Me, or Et) and 4-amino-5-oxo-3-thioxo-6-methyl-2,3,4,5-tetrahydro-1,2,4-triazine (HL') have been prepared and characterized. In these complexes both HRL and HL' are in the neutral thione form. Nickel(II) and cobalt(II) complexes with mononegative thiolate ligands have been also isolated.The reaction of HL' with copper(II) salts in a molar ration of 11 results in the formation of [Cu(HL')X] (X=Cl or Br) and Cu(L')X (X=NO3 or CH3COO). However, in the presence of a large excess of HL' the reaction proceeds with partial reduction of CuII and both [Cu(HL')X2] and [Cu(HL')2]X have been isolated and characterized. The mechanism of copper(II) reduction by HL' is discussed. 相似文献
13.
14.
A. A. Krauze É. É. Liepin'sh Yu. É. Pelcher Z. A. Kalme I. V. Dipan G. Ya. Dubur 《Chemistry of Heterocyclic Compounds》1985,21(1):77-83
The condensation of ethyl arylidenacetoacetate with cyanothioacetamide and of arylidenecyanothioacetamides with ethyl acetoacetate or of arylidenecyanothioacetamides with ethyl -aminocrotonate gave 3-cyano-4-aryl-5-ethoxycarbonyl-6-methyl-3,4-dihydropyridine-2-thiones. PMR spectroscopy showed that the 3-cyano-4-aryl-3,4-dihydropyridine-2-thiones are formed as a mixture of cis and trans isomers.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 95–102, January, 1985. 相似文献
15.
Sung Hoon Kim Yong Hoon Ra Yoon Young Lee Kyongtae Kim Joong Hyup Kim 《Journal of heterocyclic chemistry》1994,31(6):1361-1368
The reactions of 1-alkylamino-1-alkylthio-3-phenylpropene-3-thiones 3 with thiophosgene and phosgene in toluene, followed by treatment of the reaction mixture with triethylamine gave 3-alkyl-2,3-dihydro-4-oxo-6-phenyl-2-thioxo- 4 , 3-alkyl-2,3-dihydro-2,4-dioxo-6-phenyl-4H-1,3-thiazines 5 , respectively in good to excellent yields. Similarly treatment of compounds 3 with N-arylimidoyl dichloride in benzene at room temperature gave 3-alkyl-2-arylimino-2,3-dihydro-4-oxo-6-phenyl-4H-1,3-thiazines 6 in excellent yields. The reactions of compounds 3 with oxalyl chloride in toluene gave also 5 in good yields. 相似文献
16.
L. A. Rodinovskaya A. M. Shestopalov V. N. Nesterov 《Chemistry of Heterocyclic Compounds》1996,32(10):1182-1188
Condensation of thiocarbamoylacetamide with arylidenemalononitrile or the three-component condensation of thiocarbamoylacetamide with aldehydes and malononitrile in the presence of triethylamine occurred regioselectively to give triethylammonium-6-amino-4-aryl-3-carbamoyl-5-cyano-1,4-dihydropyridine-2-thiolates. Protonation of the latter occurred stereoselectively to give 3,4-trans-6-aryl-3-carbamoyl-5-cyano-1,2,3,4-tetrahydropyridin-2(1H)-thiones. The1H NMR spectrum and single x-ray crystallography indicate that the dihydropyridine ring has he sofa conformation with trans-pseudodiaxial orientation of the Ar and CONH2 groups and trans-pseudoequatorial orientation of atoms 3-H and 4-H.N. D. Zelinskii Organic Chemistry Institute, Russian Academy of Sciences, Moscow, 117913. A. N. Nesmeyanov Institute of Elementoorganic Chemistry, Russian Academy of Sciences, Moscow, 117813. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1376–1382, Octoberm 1996. Original article submitted June 10, 1996. 相似文献
17.
18.
A synthesis of 2-amino-3-benzyl-3,5-dicyano-6-methoxy-4-phenyl-3,4-dihydropyridines from benzylmalononitriles and benzylidenemalononitrile is described. The structures of the new compounds have been elucidated on the basis of spectral data (ir, nmr, ms), and in two cases (Vb and Ve) by chemical degradation. 相似文献
19.
V. N. Nesterov S. G. Krivokolysko V. V. Dotsenko V. P. Litvinov 《Russian Chemical Bulletin》1997,46(5):990-996
The reaction of arylcyanomethylenethiocetamides with Meldrum, acid gave Michael adducts as ammonium salts. When heated in
alcohol, these salts undergo cyclization to ammonium 4-aryl-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates. The structure
ofN-methylmorpholinium 4-(2′-chlorophenyl)-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolate was established by X-ray structural
analysis.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1029–1034, May, 1997. 相似文献