Synthese disubstituierter Pyridine über Radikalreaktionen

The synthesis of disubstituted pyridines by radical reactions and their respective reactivities are reported.     

Synthese disubstituierter Pyridine über Radikalreaktionen, 2. Mitt.

The synthesis of benzyl and phenethyl substituted 3-pyridine carbonitriles and 3-pyridine carboxylic acid methylesters resp. by homolytic alkylation is reported.     

Über Pterin-Chemie 87. Mitteilung. Regiospezifische Synthese von (Polyhydroxypropyl)-pterinen: Herstellung von D-Anapterin und L-Primapterin

Regiospecific Synthesis of (Polyhydroxypropyl)-pterins: Synthesis of D -Anapterin and L -Primapterin Condensation of 2,5,6-triaminopyrimidin-4-one( 5 ) with the semicarbazone of pentoses proceeds regiospecifically with formation of 7-(polyhydroxypropyl)pterins. D -Anapterin (=7-(D -erythro-1′,2′,3′-trihydroxypropyl)pterin; D - 3 ) was obtained in 40% yield, and L -primapterin (=7-(L -erythro-1′,2′-dihydroxypropyl)pterin; L - 4 )in 10% yield.     

Absorptionsspektren in der Gasphase einiger einfach substituierter Benzolderivate

Ohne Zusammenfassung     

Heterocyclen, 51. Mitt.: Synthesen einiger disubstituierter 1,3,5-Triazine

Zusammenfassung Von 2-Mercapto-4-methoxy-6-morpholino-1,3,5-triazin ausgehend wurde eine Reihe disubstituierter 1,3,5-Triazine mit verschiedenen funktionellen Gruppen synthetisiert.

---

2-Mercapto-4-methoxy-6-morpholino-1,3,5-triazine has been used as starting material for the synthesis of several disubstituted 1,3,5-triazines with different functional groups.

     

Über Pterinchemie. 68 Mitteilung [1]. Regiospezifische Deuterierungen von Folsäure

Regiospecific deuteriation of folic acid Introduction of a nitroso function at the N (10)-position of folic acid activates the C(9)-hydrogen atoms in such a way, that the exchange of H with D at this position, in NaOD-solution, is extremely facilitated. This fact is utilized in the synthesis of 9,9-dideuterio-folic acid (IV), 7,9,9-trideuterio-folic acid (VII) and 7-deuterio-folic acid (IX). These three products are necessary for the ¹H-NMR.-spectroscopical determination of the conformation of 5,6,7,8-tetrahydrofolic acid and its derivatives.     

Kombinatorische Synthese

Industrial drug research is undergoing radical changes. Advances in molecular biology and gene technology have resulted in the development of test systems with which a very large number of substances can be screened for their biological activity. In order to keep pace with this high-throughput screening procedure, preparative chemists need to reconsider conventional synthetic strategies.