共查询到17条相似文献,搜索用时 46 毫秒
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手性金属催化剂在不对称环丙烷化反应中的应用进展 总被引:1,自引:0,他引:1
手性金属催化剂在不对称环丙烷化反应中的应用一直是不对称合成领域的一个热点。对三十多年来的这一领域的手性金属催化剂的发展作了详细的归纳和评述。 相似文献
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手性铜络合物催化2,5—二甲基—2,4—己二烯不对称环丙烷化反应的研究(Ⅰ) 总被引:3,自引:0,他引:3
手性铜络合物催化2,5-二甲基-2,4-己二烯不对称环丙烷化反应的研究(Ⅰ)陈惠麟王胜国郑卓(中国科学院大连化学物理研究所大连116023)关键词手性铜(Ⅱ)络合物环丙烷化不对称反应分类号O643.32第一菊酸乙酯[2,2-二甲基-3-(2-甲基丙烯... 相似文献
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手性联萘胺衍生物为配体的铜络合物催化下某些烯烃的不对称环丙烷化反应 总被引:2,自引:0,他引:2
以1,1'-联萘-2,2'-二胺为手性源合成了8对16种光活性铜络合物,考察了它们对1,1-二苯乙烯、苯乙烯和2,5-二甲基-2,4-己二烯等3种烯烃的不对称环丙烷化反应的光学诱导活性.结果表明,以旋光活性联萘胺同水杨醛及2-羟基萘甲醛缩合而得到的Schiff碱为配体的铜络合物的催化效果最佳.催化剂对2,5-二甲基-2,4-己二烯的催化效果优于其它两种烯烃. 相似文献
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新型手性双二茂铁希呋碱亚胺配体的合成及其在不对称环丙烷化反应中的应用 总被引:3,自引:1,他引:3
以手性二茂铁乙胺为手性前体分别与吡啶二醛和吡啶二酮进行希呋碱缩合反应,合成了两种二茂铁手性亚胺膦配体,并经元素分析,^1HNMR,^31PNMR等手段进行了表征,用这类化合物作为手性配体,研究了其金属Ru(Ⅱ)配合物对苯乙烯与重氮乙酸乙酯的不对称环丙烷反应的催化作用,结果表明该类化合物的Ru(Ⅱ)配合物具有很高的催化活性。 相似文献
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IntroductionAsymmetriccatalyticcyclopropanationofolefinswithdiazocompoundsisoneofthemostusefulmethodsforthesynthesisofchiralcyclopropanes .1Anumberofefficientchiralligands ,particularlybisnitrogenligands ,havebeendeveloped ,andexcellentenantioselectiviti… 相似文献
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《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(2):568-575
The reaction of ester‐stabilized sulfonium ylides with cyclopentenone to give (+)‐ 5 ((1S,5R,6S)‐ethyl 2‐oxobicyclo[3.1.0]hexane‐6‐carboxylate), an important precursor to the pharmacologically important compound (+)‐LY354740, has been studied using chiral sulfides operating in both catalytic (sulfide, Cu(acac)2, ethyl diazoacetate, 60 °C) and stoichiometric modes (sulfonium salt, base, room temperature). It was found that the reaction conditions employed had a major influence over both diastereo‐ and enantioselectivity. Under catalytic conditions, good enantioselectivity with low diastereoselectivity was observed, but under stoichiometric conditions low enantioselectivity with high diastereoselectivity was observed. When the stoichiometric reactions were conducted at high dilution, diastereoselectivity was reduced. This indicated that base‐mediated betaine equilibration was occurring (which is slow relative to ring closure at high dilution). Based on this model, conditions for achieving high enantioselectivity were established as follows: use of a preformed ylide, absence of base, hindered ester (to reduce ylide‐mediated betaine equilibration), and low concentration. Under these conditions high enantioselectivity (95 % ee) was achieved, albeit with low diastereocontrol. Our model for selectivity has been applied to other sulfonium ylide mediated cyclopropanation reactions and successfully accounts for the diastereoselectivity observed in all such reported reactions to date. 相似文献
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Dr. Frady G. Adly Dr. Michael G. Gardiner Dr. Ashraf Ghanem 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(10):3447-3461
A novel approach to the design of dirhodium(II) tetracarboxylates derived from (S)‐amino acid ligands is reported. The approach is founded on tailoring the steric influences of the overall catalyst structure by reducing the local symmetry of the ligand's N‐heterocyclic tether. The application of the new approach has led to the uncovering of [Rh2(S‐tertPTTL)4] as a new member of the dirhodium(II) family with extraordinary selectivity in cyclopropanation reactions. The stereoselectivity of [Rh2(S‐tertPTTL)4] was found to be comparable to that of [Rh2(S‐PTAD)4] (up to >99 % ee), with the extra benefit of being more synthetically accessible. Correlations based on X‐ray structures to justify the observed enantioinduction are also discussed. 相似文献