角膜手术后眼模型的构建和人工晶状体设计

根据角膜屈光手术前的角膜地形图、眼内各组分的轴向间距和波前像差,运用ZEMAX光学设计软件,构建了术前的个性化眼模型.结合角膜屈光手术后实际测量的波前像差,建立了术后个性化眼模型.运用该模型,为角膜屈光手术眼设计了双球面人工晶状体.研究表明:对于角膜屈光手术后人眼,用术后个性化眼模型计算的人工晶状体度数可靠.该模型还能够为术后眼设计矫正像散和其他高阶像差的人工晶状体,同时可以用来评估角膜手术联合白内障术后人眼的光学性能,以及手术中各类偏差对视觉质量的影响.     

X-ray diffraction enhanced imaging study of intraocular tumors in human beings

Diffraction enhanced imaging(DEI) with edge enhancement is suitable for the observation of weakly absorbing objects.The potential ability of the DEI was explored for displaying the microanatomy and pathology of human eyeball in this work.The images of surgical specimens from malignant intraocular tumor of hospitalized patients were taken using the hard X-rays from the topography station of Beamline 4W1A at Beijing Synchrotron Radiation Facility(BSRF).The obtained radiographic images were analyzed in correlation with those of pathology.The results show that the anatomic and pathologic details of intraocular tumors in human beings can be observed clearly by DEI for the first time,with good visualization of the microscopic details of eyeball ring such as sclera,choroids and other details of intraocular organelles.And the best resolution of DEI images reaches up to the magnitude of several tens of μm.The results suggest that it is capable of exhibiting clearly the details of intraocular tumor using DEI method.     

一种以超分辨率理论为基础的磁共振眼球成像方法

磁共振成像（MRI）是一种无电离辐射的非介入性的眼内肿瘤检测方法,但分辨率和运动伪影是成像过程中不易克服的困难．以往的扫描方法或是不可避免的引入运动伪影,或是需要受试者做精确的配合,增加了成像的难度,给受试者带来不舒适的体验．本文提出了一种以超分辨率理论为基础的新的磁共振眼球成像方法,使用一种特制的眼球线圈,对眼部区域扫描一系列动态的图像,使得不同方向上的采集分辨率互补．最后经过预处理、配准、超分辨率重建等操作,得到高质量的磁共振眼球图像．实验结果表明,这种方法可以在不需要受试者做额外配合工作的情况下,得到更加清晰的磁共振眼球图像．     

The biomechanical modelling of the refractive surgery

A study reports the numerical modelling of corneal-shaped sculpting according to simulation of the refractive surgery to verify biomechanical as well as geometrical parameters of the eye and to obtain the expected changes in the refractive power of the eyeball model.The finite-element method (FEM) was used to simulate an effect of refractive surgery. The corneal ablation and deformation for myopia correction were modelled.The refractive correction has an insignificant sensitivity on the assumed eccentricity of the corneal anterior profile across the range e=0-0.5. The expected correction occurs for corneal Young's modulus E_C?2 MPa. The including elasticity of the Descemet membrane E_D=2E_C or 5E_C has an insignificant influence on the refraction correction of the cornea with E_C>2 MPa, and has a greater influence for E_C<1 MPa.The understanding of the relationship between geometry, material properties and intraocular pressure (IOP) applied on the human eye has an importance for results of the refractive surgery. Numerical calculations showed that modelled dynamics of the eye is important for obtaining quantitative information about the biomechanical parameters of the biological eye tissues and permits its modelling before refractive surgery.     

Analysis of Purkinje images as an effective method for estimation of intraocular lens implant location in the eyeball

The implantation of an artificial intraocular lens (IOL) into a capsular bag in place of an extracted natural, but nontransparent lens is a standard therapy method in the case of cataract. Any decentration or tilt of the IOL can cause a deterioration of the retinal image quality, thus decreasing the vision quality. The analysis of the relative position of Purkinje images being a reflection of the point light source from the refracting surfaces of the eyeball determines the location of IOL inside the eye and thus enables to state its wrong or correct location. The paper describes the Purkinje experimental setup consisting of an illuminator (several infrared LEDs arranged in a circle), an imaging telecentric lens and image recording CCD camera and reports details of the system calibration The usefulness of the experimental setup has been proven both in laboratory conditions using artificial model of the eyeball and in measurements on human subjects. Simulations of the retinal image with different decentrations or tilts are shown.     

基于个体眼光学结构的波前眼镜设计

提出一种在个体眼光学结构基础上根据波前数据设计波前眼镜的新方法。建立了个性化的眼光学结构,并将眼球和镜片视为统一的镜一眼光学系统,用光学设计的优化方法给出镜片的结构数据,并分析了±7°视场和眼球旋转±20°时,该镜一眼系统的成像情况。与波前拟合的方法相比,该方法设计的波前眼镜离焦差为（-0．057±0．015）m^-1,像散差为（0．015±0．013）m^-1散光轴位差为（0．100±0．316）°。镜一眼系统的矫正视力均大于1．25,其中8只被试眼的视力可达1．5以上。10只被试眼在转动±20°情形下的0°视场成像相比于直视的情况均略有下降,而7°视场的成像质量相比于直视的情况下降则更为明显。由该方法给出的验光结果客观可信,可用于对佩戴波前眼镜后人眼的视觉质量的预先评估。     

On the Becker/Döring Theory of Nucleation of Liquid Droplets in Solids

Nucleation of liquid precipitates in semi-insulating GaAs is accompanied by deviatoric stresses resulting from the liquid/solid misfit. A competition of surface tension and stress deviators at the interface determines the nucleation barrier.The evolution of liquid precipitates in semi-insulating GaAs is due to diffusional processes in the vicinity of the droplet. The diffusion flux results from a competition of chemical and mechanical driving forces.The size distribution of the precipitates is determined by a Becker--Dö-ring system. The study of its properties in the presence of deviatoric stresses is the subject of this study. The main tasks of this study are: (i) We propose a new Becker/Döring model that takes thermomechanical coupling into account. (ii) We compare the current model with already existing models from the literature. Irrespective of the incorporation of mechanical stresses, the various models differ due to different environments where the evolution of precipitates takes place. (iii) We determine the structure of equilibrium solutions according to the Becker/Döring model, and we compare these solutions with those that result from equilibrium thermodynamics.     

Acoustic behaviour of high pressure air-filled porous media

This paper deals with the acoustic behaviour of porous media when the saturating fluid is high pressured. These observations are performed by ultrasonic transmission through a porous sample with variations of the static pressure of the saturating fluid. Previous works have experimentally demonstrated that a high frequency asymptotic equivalent fluid model allows to model the behaviour of such media for low pressure (between 0.2 and 6 bars). In this paper, in order to characterize high damping materials, measurements are performed for higher static pressure (up to 18 bars). It is shown that the behaviour of transmission coefficient and speed with pressure follows Biot’s theory. Moreover, measurements are dependant on temperature variations. Temperature variations have been accounted for in this study, but this does not explain entirely the high sensitivity of the transmission coefficient with static pressure. It remains that the mechanical properties of the porous medium vary strongly with the thermodynamic variables.     

Individual eye model based on wavefront aberration

Based on the widely used Gullstrand-Le Grand eye model, the individual human eye model has been established here, which has individual corneal data, anterior chamber depth and the eyeball depth. Furthermore, the foremost thing is that the wavefront aberration calculated from the individual eye model is equal to the eye's wavefront aberration measured with the Hartmann-shack wavefront sensor. There are four main steps to build the model. Firstly, the corneal topography instrument was used to measure the corneal surfaces and depth. And in order to input cornea into the optical model, high-order aspheric surface-Zernike Fringe Sag surface was chosen to fit the corneal surfaces. Secondly, the Hartmann-shack wavefront sensor, which can offer the Zernike polynomials to describe the wavefront aberration, was built to measure the wavefront aberration of the eye. Thirdly, the eye's axial lengths among every part were measured with A-ultrasonic technology. Then the data were input into the optical design software–ZEMAX and the crystalline lens's shapes were optimized with the aberration as the merit function. The individual eye model, which has the same wavefront aberrations with the real eye, is established.     

A 2D equivalent circuit of piezoelectric ceramic ring for transducer design

In this paper a 2D equivalent circuit of longitudinally polarized piezoelectric ceramic rings is established, which is obtained as an approximated analytical solution of 3D constitutive equations in the hypothesis of axial symmetry when the shearing stress and torsion are ignored. The mechanical part of the equivalent circuit can be divided into two branches; one branch characterizes the longitudinal extensional vibration, the other represents the radial vibration. The two branches, which are coupled to an electrical port by two transformers separately, mechanically couple to each other by some mechanical impedance at the same time. Similar circuit is also presented when piezoelectric disk is concerned. Based on this model it is able to compute all the relations between the input applied voltage and the output forces and velocities on every external surface analytically. Compared with the 1D equivalent circuits, the 2D equivalent circuit gives a more comprehensive predicts of the thickness and radial modes with sufficient accuracy when the ring or disk is thin. When the ring or disk is so thick that the 1D theory is not validated, an effective predict of the coupled vibration can also be presented. Comparisons with the experimental results show this model is rather accuracy in frequency calculation.     

基于个体眼光学结构的角膜与晶状体的像差补偿

研究角膜对晶状体波前像差的影响对现行的个性化视觉矫正手术有-定的参考价值.运用光学设计软件Zemax,根据个体人眼的角膜地形图、眼内各部分轴向间距和全眼波前像差数据,为22只人眼构建了个体眼光学结构.基于个体眼光学结构和衍射光学理论计算了眼内、外不同位置处的波前,获得了角膜对晶状体波前像差的影响.结果表明,角膜和品状体像差存在补偿和叠加两种关系.大多数眼睛,角膜对晶状体像差有一定补偿作用.总体像散的均方根(RMS)值比品状体像散的RMS值减小0.08～1.48μm,相当于10.1%～77.5%.总体高阶像差的RMS值比晶状体高阶像差的RMS值减小了0.06～0.85 μm,相当于3.8%～79.4%,平均减小了50.7%.其中,球差和彗差的Zernike系数绝对值总体比晶状体分别减小了0.02～0.60μm和0.01～0.39μm,相当于4.3%～98.4%和2.5%～91.4%.     

Intraocular lens design for treating high myopia based on individual eye model

In this research, we firstly design the phakic intraocular lens (PIOL) based on individual eye model with optical design software ZEMAX. The individual PIOL is designed to correct the defocus and astigmatism, and then we compare the PIOL power calculated from the individual eye model with that from the experiential formula. Close values of PIOL power are obtained between the individual eye model and the formula, but the suggested method has more accuracy with more functions. The impact of PIOL decentration on human eye is evaluated, including rotation decentration, flat axis decentration, steep axis decentration and axial movement of PIOL, which is impossible with traditional method. To control the PIOL decentration errors, we give the limit values of PIOL decentration for the specific eye in this study.     

Crystal resonator design for space applications

Summary Crystal resonators may be used on various vehicles. They are submitted to accelerations, shocks, vibrations and to external pressure and temperature variations (acceleration variations may be some 10g, pressure variations may reach one atmosphere and temperature 100°C). The goal of this paper is to describe an attempt to reduce the various environmental effects especially by use of a mounting structure external to the resonator. Each effect needs a particular study. 1) Shocks and vibrations. A particular fixation structure has been designed. Resonators can support a shock equivalent to 1000g over 0.1 ms in any direction. Also the mounting structure resonant frequency can be rejected over 3000 Hz. 2)g sensitivity.g sensitivity has been reduced. Theoretical and experimental results are given. 3) External pressure and temperature variations. Crystal enclosure is submitted to variations of pressure and temperature which yield enclosure deformations. The study of the resonator dependence by respect to its enclosure has been performed. A quartz structure surrounding the vibrating crystal has been designed and specific enclosures have been tried thus yielding reduced mechanical strains due to external pressure and temperature variations. These structures are described and discussed. Based on the results of the previous study of a series of 10 sample resonators has been manufactured. The performances are presented and compared to results obtained with previous designs. The authors of this paper have agreed to not receive the proofs for correction.     

Effects of mesonic correlations in the QCD phase transition

The finite-temperature phase transition of strongly interacting matter is studied within a nonlocal chiral quark model of the NJL type coupled to a Polyakov loop. In contrast to previous investigations which were restricted to the mean-field approximation, mesonic correlations are included by evaluating the quark-antiquark ring sum. For physical pion masses, we find that the pions dominate the pressure below the phase transition, whereas above T _c the pressure is well described by the mean-field-approximation result. For large pion masses, as realized in lattice simulations, the meson effects are suppressed. The text was submitted by the authors in English.     

基于暗瞳图像的人眼视线估计

虹膜外边缘受眼睑遮挡较为严重时, 会给虹膜中心的准确提取造成很大的困难. 为此, 提出利用放置在相机轴外的红外光源产生的暗瞳图像估计瞳孔中心, 该方法避免了提取虹膜外边缘遇到的遮挡问题. 首先利用角膜反射光斑在相机像面中的位置估计角膜所在球体中心的三维空间坐标, 作为眼球的平动信息; 然后考察瞳孔中心与角膜球体中心在相机成像面投影位置的相对偏移, 作为眼球的转动信息; 最后利用人工神经网络完成视线特征向量与注视点坐标间的映射. 在人眼区域定位的问题上, 利用两部大视场相机, 采用自适应增强算法和主动表观模型算法实现眼部区域的准确定位, 该步骤可以将提取反射光斑和瞳孔中心需要考虑的图像区域限定在较小的范围内. 实验结果表明, 本文视线估计方法在水平方向上的平均误差为0.62°, 在竖直方向上的平均误差为1.05°, 是解决视线点估计的有效方法. 关键词： 暗瞳 人工神经网络 自适应增强 主动表观模型     

A Review of IR Transmitting,Hollow Waveguides

Abstract

An analysis and experimental data of the time-dependent response of an all-fiber ring resonator in which the ring is illuminated by a phase modulated input beam are presented. The resonator is operated as a high-resolution optical-scanning spectrometer. Since the resolution limit is a function of the finesse and cavity-loop length, we will show that it is not possible to design a high-resolution ring resonator that will not produce a distorted output signal when the phase modulation rate is comparable to the response time of the ring.     

Wavefront aberrations in the accommodated human eye based on individual eye model

In this research, we firstly construct individual eye models based on the wavefront and the measured cornea structure of the eyes. Then we analyze the influence of accommodation on the wavefront aberrations based on individual eye model. The individual eye model has the same wavefront aberration as that measured from Hartmann–Shack wavefront sensor. The optical design software ZEMAX is used to construct the individual eye models for 20 normal eyes. Accommodative conditions are from 0 to –4 diopter in steps of one diopter. The variations of the total, the spherical, the coma and the higher-order root-mean-square wavefront aberrations, as accommodations, are illustrated. Influence of accommodation on wavefront aberration varies from individual to individual, and the variation magnitude is independent of the magnitude of the wavefront aberration of the eye.     

Effects of antisymmetric interactions in molecular iron rings

The level crossing mechanism between the ground and the first excited state of Na:Fe₆ antiferromagnetically coupled iron rings is studied by torque magnetometry down to 40 mK and in magnetic fields up to 28 T. The step width at the crossing field B_c assumes a finite value at the lowest temperatures. This fact is ascribed to the presence of level anticrossing, not expected for a ring with axial, i.e. S₆ point group, symmetry. Assuming a reduced symmetry, we revised the model Hamiltonian of such a spin system by introducing a Dzyaloshinsky-Moriya (DM) term and we show, by exact diagonalization, that DM term can account for the mixing of states with different parity. In particular, analytical as well numerical analysis show that the introduction of the DM term may contribute to the broadening of the torque step as well as for the finite energy gap at B_c observed by heat capacity in a similar ring Li:Fe₆ as previously reported [#!aclbg!#]. Received 3 September 2002 Published online 31 December 2002     

Static and dynamic liver stiffness: An ex vivo porcine liver study using MR elastography

Magnetic resonance elastography (MRE) is an MRI-based noninvasive technique for quantitatively assessing tissue stiffness. The hypothesis of this study is that stiffness increases with portal pressure. We further hypothesized that the rate of stiffness change with pressure would be larger in liver tissue treated to simulate the stiffening effects of fibrosis. In agreement with our hypothesis, the formalin-treated livers were stiffer than the untreated livers, and in both groups the liver stiffness increased with portal venous pressure. The rate of stiffness change with portal pressure was significantly greater after formalin treatment. In this study, we have developed an ex vivo liver model incorporating portal venous pressure variations and observed significant changes in liver stiffness due to portal pressure. This model could be useful for understanding and investigating the changes in the static and dynamic components of liver stiffness.     

Long-term frequency stabilization of a 16 m(2) ring laser gyroscope

A 16 m(2) helium-neon-based ring laser gyroscope has been frequency stabilized to within 60 kHz over a period of three months. This is achieved using the beat frequency of the ring laser and an iodine-stabilized reference laser as a feedback signal on a pressure vessel enclosing the entire laser, under servo control. We demonstrate that we can compensate for, and thereby negate the influence of, atmospheric pressure variations, which are considerable sources of long-term instability.