共查询到20条相似文献,搜索用时 10 毫秒
1.
Mohyeddin Safarzaei Malek Taher Maghsoodlou Ebrahim Mollashahi Nourallah Hazeri Mojtaba Lashkari 《Research on Chemical Intermediates》2018,44(12):7449-7458
A one-pot three-component condensation reaction of 3-amino-5-methylisoxazole, aryl aldehyde and 2-naphthol to afford the corresponding 3-amino isoxazolmethylnaphthols in good to excellent yields. The remarkable features of this new procedure are high conversions, clean reaction condition, short reaction time, nonhazardous and environmentally friendly reaction condition, inexpensive and easily commercially availability of the catalyst and simple work-up procedures. 相似文献
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Song Cao Longjie Zhu Chuanmeng Zhao Xiuhong Tang Huajun Sun Xin Feng Xuhong Qian 《Monatshefte für Chemie / Chemical Monthly》2008,139(8):923-926
A direct and efficient one-pot three-component synthesis protocol was developed for the synthesis of thiohydantoins from readily
and widely available substrates (isothiocyanates, ethyl chloroacetate, and amines) employing solvent-free conditions.
Correspondence: Song Cao, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science
and Technology, Shanghai 200237, China. 相似文献
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A facile method for the regioselective synthesis of tetrasubstituted pyrroles, from readily accessible 1,3-dicarbonyls, benzoin derivatives and ammonium acetate, has been developed. The one-pot three-component reactions were performed to afford tetrasubstituted pyrroles under solvent- and catalyst-free conditions. 相似文献
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K. Praveen Kumar S. Satyanarayana P. Lakshmi Reddy G. Narasimhulu Narender Ravirala B.V. Subba Reddy 《Tetrahedron letters》2012,53(14):1738-1741
Iodine is found to be a highly efficient catalyst for the three-component coupling (3CC) of aldehydes, β-naphthol, and 1,3-dimethylbarbituric acid under solvent-free conditions to afford the corresponding 8,10-dimethyl-12-aryl-12H-naphtho[1′,2′5,6]pyrano[2,3-d]pyrimidine-9,11-diones in good yields with high selectivity. The use of readily available iodine makes this method very simple, convenient, and cost-effective. 相似文献
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A novel and efficient one-pot multi-component reaction of pentafluorobenzaldehyde, alkynes and anilines for the synthesis of 2-pentafluorophenyl substituted quinolines under microwave irradiation and a solvent-free condition is presented. 相似文献
6.
AbstractA new and practical method has been developed for the synthesis of 2,4-disubstituted quinolines via one-pot three-component reaction of o-amino arylketones, aldehydes and ammonium acetate in high yields by using DDQ in CH3CN under mild conditions. Neutral conditions, atom economy, easy work-up procedures and compatible with different functional groups are the salient features of this protocol. 相似文献
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Sixteen 5-unsubstituted-3,4-dihydropyrimidin-2(1H)-ones have been synthesized by microwave-assisted Biginelli reactions in a short and concise manner employing ZnI2 as a catalyst under solvent-free conditions. All products were identified by IR, NMR, elemental analysis and HRMS. The advantages of this novel protocol include the excellent yield, operational simplicity, short time and the avoidance of the use of organic solvents and expensive catalysts. 相似文献
9.
Khalili B Jajarmi P Eftekhari-Sis B Hashemi MM 《The Journal of organic chemistry》2008,73(6):2090-2095
New 2-alkyl-5-aryl-(1H)-pyrrole-4-ol derivatives were synthesized via three-component reaction of beta-dicarbonyl compounds with arylglyoxals in the presence of ammonium acetate in water at room temperature. 相似文献
10.
One-pot three-component Mannich reactions of ketones with aromatic aldehydes and aromatic amines are effectively catalyzed
by molecular iodine at room temperature under solvent-free conditions to afford the corresponding β-amino carbonyl compounds
with moderate to excellent yields. The method has the following advantages: no use of solvent, mild condition, high reaction
speed and small quantity of catalyst. 相似文献
11.
Abbas Ali Jafari Sakineh Amini Fatemeh Tamaddon 《Journal of the Iranian Chemical Society》2013,10(4):677-684
The TfOH/C was readily prepared via simple absorption of triflic acid onto activated charcoal. This solid acid was used as an efficient catalyst for the synthesis of α-aminophosphonates through the Kabachnik–Fields reaction of carbonyl compound, amine and diethyl phosphite under solvent-free conditions. 相似文献
12.
A concise, straightforward and efficient method has been developed for the synthesis of α-aminonitriles by an one-pot three-component condensation of aldehydes or ketones, amines and trimethylsilyl cyanide catalyzed by MgI2 etherate under solvent-free conditions. This protocol has some advantages such as mild reaction condition, simple work-up, short reaction time and high product yields. 相似文献
13.
Teimuri-Mofrad Reza Shahrisa Aziz Gholamhosseini-Nazari Mahdi Arsalani Naser 《Research on Chemical Intermediates》2016,42(4):3425-3439
Research on Chemical Intermediates - A novel series of aminokojic acid derivatives were efficiently synthesized by one-pot condensation of kojic acid, aromatic aldehydes and heteroaromatic amines... 相似文献
14.
Shailesh N. Vajekar 《合成通讯》2020,50(8):1147-1158
AbstractA sustainable one-pot three-component synthesis of novel 1H-pyrazolo[1,2-a]pyridazine-2-carbonitrile derivatives employing a highly efficient, biodegradable, and recyclable choline hydroxide catalyst under solvent-free conditions is demonstrated. The salient features of this protocol are simple workup, mild reaction conditions, short reaction time (10?min), excellent yields (up to 97%), high atom economy, column chromatography-free protocol, and eco-friendliness. Interestingly, the choline hydroxide was recycled up to five cycles without any considerable loss of efficiency. The structures of the products were deduced by their 1H NMR, 13C NMR, and HRLC-MS spectra. 相似文献
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Hai-Tao Zhu Ting-Ting Luo Shi-Hui Shi Ni-Ni Zhou Si-Si Ning Chen Zhang Yu-Gang Xiao Ming-Jin Fan De-Suo Yang 《Tetrahedron letters》2017,58(43):4137-4140
An effective and concise electrophilic cyclization of 1,4-butynediols, 4-aminobut-2-yn-1-ols, pent-2-yne-1,5-diols, 2-propynolphenols and 2-propynolanilines with N-halo succinimides and trimethylsilyl halides opens a one-pot synthetic access to five- and six-membered dihalogenated heterocycles in moderate to good yields. The optimized cyclization conditions are tolerated with many functional groups. 相似文献
17.
A novel synthesis of 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and aldehydes under microwave irradiation and solvent-free conditions in excellent yields. 相似文献
18.
<正>4,6-Diarylpyrimidin-2(1H)-one derivatives have been synthesized from three-component one-pot condensation of acetophe-none derivatives,aldehydes and urea in the presence of trimethylsilyl chloride and a catalytic amount of H_3PMo_(12)O_(40)under solvent-free conditions. 相似文献
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