共查询到20条相似文献,搜索用时 15 毫秒
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用二氧化硫脲合成4—甲基—4‘—氨基二苯醚的研究 总被引:1,自引:0,他引:1
4甲基4′氨基二苯醚是合成农药、染(颜)料、医药的重要中间体.传统的制备方法是由4 甲基4′硝基化合物(简称硝基物)在盐酸存在下用二氯化锡还原得到[1] ,该方法工艺成熟、产品质量好,但产率低,污染严重.陈其亮等报道了由硝基物催化加氢的方法[2],但存在设备投资大,操作繁锁等缺点.二氧化硫脲(Thiourea dioxide ,简称TD)是一种非常优良的还原剂,已广泛应用于有机合成的许多方面[3,4],但应用于标题化合物的制备未见报道,本文对此进行了研究,收到较好效果.合成路线如下: 相似文献
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BaiShuGUO YuSheYANG RuYunJI 《中国化学快报》2003,14(4):365-367
An improved method for preparation of 4-methyl-2-phenyl piperazine and is derivatives with higher yield and inexpensive reagents was developed,the products were characterized by^H-NMR and MS. 相似文献
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The condensation reaction between 5-amino-4,6-dichloro-2-methylprimidine and 1-acetyl-2-imidazolin-2-one using POCl3 as solvent gave 4,6-dichloro-2-methyl-5-(1-acetyl-tetra-hydro-imidazo-2-ylidene)-aminopyrimidine predominantly and 4,6-dichloro-2-methyl-5-{1-1-(2-oxo-tetrahydro-imidazolyl)]-acetene}-aminopyrimidine as by-product. No 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine was found. The result indicated an esterifi-cation-addition-elimination mechanism. 相似文献
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A New Technique of Synthesizing 10—Hydroxy—5—methyl—5,10—dihydrophenophosphazine 10—Oxide 总被引:1,自引:0,他引:1
ZhiGangYIN DeFengZHAO 《中国化学快报》2003,14(4):347-350
10-Hydroxy-5-methyl-5,10-dihydrophenophosphazine 10-oxide(1)was prepared by a new technique of treating 10-methoxy-5,10-dihydrophenophosphazine 10-oxide(2)with an equivalent of NaH in anhydrous DMF,and then at 120℃ for 3-4h,which not only avoided poisonous and expensive methyl iodide used in literature,but made the consumption of NaH greatly decrease as well.The possible reaction mechanism was also described.The chemical structure of 1 was confiremed by IR,NMR,and mass spectroscopy. 相似文献
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3-甲基-4-甲硫基苯酚,是倍硫磷、克线磷等农药的关键中间体。有关它的制备方法报道较多。文献[1]曾作过总结,归纳起来主要是采用间甲酚进行甲硫基化反应而制得。目前常用的甲硫基化剂有二甲基二硫醚(DMDS),二甲 相似文献
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Treatment of 4-amino-3-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-5-mercapto-1,2,4-triazoles/2-amino-5-(1-aryl-5-methyl-1,2,3-triazole-4-yl)-1,3,4-thiadiazoles with benzaldehyde,acetone and ω-bromoacetophenone was tested and compared.The title compounds Schiff bases,amides,imidazolo [2,1-b]-1,3,4-thiadiazoles and 7H-s-triazolo[3,4-b]-1,3,4-thiadiazines have been confirmed by elemental analyses,^1H NMR,IR and MS spectra.All the compounds have also been screened for their antibacterial activities against B.subtilis,S.aureus and E.coli. 相似文献
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Thirteen new 2-alkylaminoimidazolones(4) wre rapidly synthesized by a new solution-phase parallel synthetic method,which includes aza-Wittig reaction of iminophosphorane(1) with aromatic isocyanate to give carbodi-imide(2) and subsequent reaction of 2 with various aliphatic primary amine in a parallel fashion.The products were confirmed by ^1H NMR,MS,IR and X-ray crystallographic analysis.The unusual selectivity of the cyclization was probably due to the deometry of the guanidine intermediate. 相似文献
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